| Movie | 2003 | Party Monster | Christina | |
| Movie | 1997 | Lost Highway | Porno Star #1 | |
| Movie | 2007 | Rise: Blood Hunter | Juan Ton | |
| Movie | 2007 | Sympathy for the Devil | Self | |
| Movie | 2002 | Scoring Resident Evil | Self | |
| Movie | 1997 | Nine Inch Nails: Closure | Self | |
| Movie | 2007 | Disinfo.Con | Self | |
| Movie | 2003 | Doppelherz | Himself | |
| Movie | 1998 | Marilyn Manson: Dead to the World | Himself | |
| Movie | 1999 | Jawbreaker | The Stranger | |
| Movie | 2002 | Beat the Devil | Marilyn Manson | |
| Movie | 2007 | Marilyn Manson: The Early Years | Himself | |
| Movie | 2022 | Kanye West: DONDA Experience Performance 2 22 22 | Self | |
| Movie | 2012 | Wrong Cops: Chapter 1 | David Dolores Frank | |
| Movie | 2013 | Wrong Cops | David Dolores Frank | |
| Movie | N/A | Marilyn Manson Ozzfest 2001 | Himself | |
| Movie | 2000 | Eminem E | Himself | |
| Movie | 2002 | Bowling for Columbine | Self | |
| Movie | 1998 | Groupie | Himself | |
| Movie | 2009 | Marilyn Manson Live at Rock am Ring | Himself | |
| Movie | 2016 | Let Me Make You a Martyr | Pope | |
| Movie | 2000 | Demystifying the Devil: Biography Marilyn Manson | Self | |
| Movie | 2016 | Street Level | Benny | |
| Movie | 2004 | The Heart Is Deceitful Above All Things | Jackson | |
| Movie | 2002 | Marilyn Manson - Guns, God and Government World Tour | Vocals | |
| Movie | 2002 | Eminem: All Access Europe | Himself | |
| Movie | 2002 | The Many Moods Of Boyd Rice | Himself | |
| Movie | 2004 | Nice to Meet You, Please Don't Love Me! | Himself | |
| Movie | 2000 | Autopsy | Corpse | |
| Movie | 2017 | Bomb City | Television Narrator | |
| Movie | 2009 | Marilyn Manson: Inner Sanctum | Himself | |
| Movie | 1999 | Marilyn Manson: God Is In the TV | Himself | |
| Movie | 2004 | Marilyn Manson: Lest We Forget | | |
| Movie | 2015 | Rammstein in Amerika | Self | |
| Movie | 2013 | Das Foto-Shoot | Genius | |
| Movie | 2002 | The Death Parade | Self | |
| Movie | 2015 | MARILYN MANSON: Rock On The Range Festival 2015 | | |
| Movie | 2020 | The Nine Lives of Ozzy Osbourne | Self | |
| Movie | 2020 | The New Mutants | Smiling Man (voice) | |
| Movie | 2014 | Goth at the BBC | Self | |
| Movie | 1997 | Marilyn Manson: Hamilton, Ontario | Himself | |
| Movie | 2003 | Marilyn Manson: Grotesk Burlesk | | |
| Movie | 1995 | Marilyn Manson - Hollywood 1995 | Himself | |
| Movie | 1999 | Marilyn Manson On Tour: Symphonies of Destruction | Himself | |
| Movie | N/A | Bush: Alleys and Motorways | Self | |
| Movie | 2024 | Marilyn Manson: Vida y circos | Marilyn Manson | |
| Movie | N/A | Guns, God and Government - DVD release | Self | |
| Movie | 2009 | Guns, God and Government – Live in L.A. | Self | |
| TV Show | 2001 | Friday Night with Jonathan Ross | Self | 1 |
| TV Show | 2017 | American Gods | Johan Wengren | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 2017 | American Gods | Johan | 1 |
| TV Show | 2005 | Too Late with Adam Carolla | | 1 |
| TV Show | 2006 | The Henry Rollins Show | | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 1 |
| TV Show | 2000 | Diary | Self | 1 |
| TV Show | 2003 | The New Tom Green Show | Self | 1 |
| TV Show | 2011 | Once Upon a Time | The Shadow | 1 |
| TV Show | 2008 | Sons of Anarchy | Ron Tully | 6 |
| TV Show | 2002 | Clone High | Marilyn Manson (voice) (uncredited) | 1 |
| TV Show | 2007 | The Graham Norton Show | Self | 1 |
| TV Show | 2001 | The Hire | Self | 1 |
| TV Show | 2002 | Through the Night with... | Self | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | The Dark Man | 1 |
| TV Show | 2007 | Californication | Himself | 2 |
| TV Show | 1984 | MTV Video Music Awards | Self | 2 |
| TV Show | 2009 | Eastbound & Down | Roller Rink Server | 1 |
| TV Show | 1998 | SexTV | | 1 |
| TV Show | 2009 | Celebrity Ghost Stories | Self | 1 |
| TV Show | 1992 | ECHO-Verleihung | Self | 1 |
| TV Show | 2006 | Scream Awards | Himself - Presenter | 1 |
| TV Show | 2020 | The New Pope | Marilyn Manson | 1 |
| TV Show | 2016 | Ride with Norman Reedus | Self | 1 |
| TV Show | 2014 | Wrong Cops, The Series | David Dolores Frank | 7 |
| TV Show | 2017 | The Defiant Ones | Self (archive footage) | 1 |
| TV Show | 2009 | Söndagsparty med Filip & Fredrik | | 1 |
| TV Show | 2002 | Clone High | Marilyn Manson (voice) | 1 |
| TV Show | 2024 | Marilyn Manson: Unmasked | | 3 |
| TV Show | 2006 | El hormiguero | Self - Guest | 1 |
| TV Show | 2002 | The Osbournes | Self | 1 |
