| Movie | 1998 | Guns N' Roses - Welcome to the Videos | Himself | |
| Movie | 1988 | Live at the Ritz: Guns 'N' Roses | Self | |
| Movie | 1992 | Guns N' Roses: Use Your Illusion I - World Tour - 1992 In Tokyo | | |
| Movie | 1992 | Guns N' Roses: Use Your Illusion II - World Tour - 1992 In Tokyo | | |
| Movie | 2007 | Guns N Roses: Live Rarities | | |
| Movie | 2005 | Ozzfest: 10th Anniversary | Himself | |
| Movie | 2021 | Michael Monroe Documentary | Self | |
| Movie | 1993 | Guns N' Roses: Makin' F@*!ing Videos Part IV Estranged | Himself | |
| Movie | 2011 | Slash: Made in Stoke 24/7/11 | Guitars | |
| Movie | 2010 | Lemmy | Self | |
| Movie | 2017 | Anna Nicole Smith: Behind Closed Doors | Self (archive footage) | |
| Movie | 2022 | Live at Studios 60 | Himself | |
| Movie | 1991 | Guns N' Roses: Welcome to the Riot Show | Himself | |
| Movie | 2012 | B.B. King - Live at the Royal Albert Hall 2011 | Self | |
| Movie | 1996 | The Rocker: A Portrait of Phil Lynott | Self | |
| Movie | 2007 | Guns N' Roses: 2 Classic Albums Under Review: Use Your Illusion I and II | Self | |
| Movie | 1992 | Metallica: A Year and a Half in the Life of Metallica | Self | |
| Movie | 2010 | Ghost Blues: The Story of Rory Gallagher | self | |
| Movie | 1991 | Alice Cooper: Prime Cuts | Self | |
| Movie | 2023 | Michael Monroe -dokumenttielokuva | Self | |
| Movie | 1994 | Carole King: In Concert | Himself | |
| Movie | 2012 | Slash: The Making of Apocalyptic Love | Guitar | |
| Movie | 1992 | Guns N' Roses - Live in Paris | Himself | |
| Movie | 2010 | Slash: Rock Am Ring 2010 | Guitarist | |
| Movie | 2012 | Wild Thing | Self | |
| Movie | 2007 | Velvet Revolver - Rock am Ring | Himself | |
| Movie | 2009 | Brüno | Self - 'Dove of Peace' | |
| Movie | 2003 | Guns n' Roses: Sex N' Drugs N' Rock N' Roll | Himself (archive footage) | |
| Movie | 2003 | Michael Jackson: Number Ones | Self (archive footage) | |
| Movie | 1998 | Pleasure Machines: The History of Pinball | Self | |
| Movie | 2011 | Comedy Central Roast of Charlie Sheen | Self - Guitar Player | |
| Movie | 2022 | Guns N' Roses - Rock in Rio 2022 | | |
| Movie | 2009 | Rock Prophecies | Self | |
| Movie | 1993 | Guns N' Roses: Makin' F@*!ing Videos Part II - November Rain | Himself | |
| Movie | 1994 | Guns N' Roses: Estranged - Part IV of the Trilogy!!! | Himself | |
| Movie | 1993 | Guns N' Roses: Makin' F@*!ing Videos Part I - Don't Cry | Himself | |
| Movie | 2023 | Rock: the origin | Self (archive footage) | |
| Movie | 1999 | Hendrix: Band of Gypsys | Self | |
| Movie | 2022 | Guns N’ Roses: Live In New York 1991 | | |
| Movie | 1991 | Guns N' Roses: Rock in Rio II - First Night | | |
| Movie | 1996 | Guns N' Roses: Live at the Music Machine - Los Angeles, CA | | |
| Movie | 2015 | Slash feat Myles Kennedy & The Conspirators : Live At The Roxy | Guitars | |
| Movie | 2015 | Slash feat. Myles Kennedy & The Conspirators - Rock am Ring 2015 | Himself | |
| Movie | 1999 | The Underground Comedy Movie | Miss America Bag Lady Pageant Host | |
| Movie | 2023 | Bad Woman Blues- Beth Hart | Self | |
| Movie | 2016 | Gutterdämmerung | The Thief | |
| Movie | 2016 | It's So Easy and Other Lies | Self | |
| Movie | 2012 | Louder Than Love: The Grande Ballroom Story | Self | |
| Movie | 1988 | Guns 'N' Roses: Live at the Ritz 1988 | | |
| Movie | 2008 | Anvil! The Story of Anvil | Himself | |
| Movie | 2014 | Lennon or McCartney | Self | |
| Movie | 2013 | When Albums Ruled the World | Himself | |
| Movie | 2007 | Velvet Revoler - Myspace Live Stream | Self | |
| Movie | 2022 | Freddie Mercury: The Final Act | Self | |
| Movie | 1997 | Private Parts | Slash | |
| Movie | 2014 | Play It Loud: The Story of Marshall | Self | |
| Movie | 2012 | Sunset Strip | Self | |
| Movie | 1992 | Guns N' Roses - Estadio River Plate - Buenos Aires, Argentina | Himself | |
| Movie | 1990 | Hard 'N Heavy Volume 7 | Self | |
| Movie | 1991 | Hard 'N Heavy Volume 12 | Self | |
| Movie | 2006 | Kiss: VH1 Rock Honors 2006 | Guitars | |
| Movie | 2014 | The Distortion of Sound | Self | |
| Movie | 2017 | Guns N' Roses: Rock in Rio 2017 | lead and rhythm guitar, talkbox | |
| Movie | 1992 | The Freddie Mercury Tribute Concert | Self | |
| Movie | 2008 | The Black List: Volume One | Self | |
| Movie | 2014 | The Life, Blood and Rhythm of Randy Castillo | Self | |
| Movie | 2005 | Classic Albums: Motörhead - Ace of Spades | Self | |
| Movie | 2018 | Jeff Beck: Still on the Run | Self | |
| Movie | 1993 | Guns N' Roses: Live At Saskatoon | | |
| Movie | 2019 | Slash feat. Myles Kennedy and The Conspirators - Rock am Ring 2019 | Himself | |
| Movie | 2019 | #NoJoke | Self | |
| Movie | 2014 | As the Palaces Burn | Himself | |
| Movie | 2019 | Slash featuring Myles Kennedy & The Conspirators - Living The Dream Tour | | |
| Movie | 2019 | The Rainbow | Self | |
| Movie | 2001 | Michael Jackson: 30th Anniversary Celebration | Self | |
| Movie | 2012 | Slash ft. Myles Kennedy and The Conspirators - Live at Sydney | | |
| Movie | 1992 | Guns N' Roses Live in Chicago 1992 | | |
| Movie | 2004 | Guns N' Roses: Legends Never Die | Self / Lead Guitar | |
| Movie | 2011 | Phineas and Ferb The Movie: Across the 2nd Dimension | Self (uncredited) | |
| Movie | 1988 | The Dead Pool | Musician at Funeral (uncredited) | |
| Movie | 2002 | Queen - The Freddie Mercury Tribute Concert 10th Anniversary Documentary | Self | |
| Movie | 2018 | Guns N' Roses - Appetite for Destruction | Self | |
| Movie | 1993 | Guns N' Roses Made In Argentina | Himself | |
| Movie | 1988 | Guns N' Roses Live In Philadelphia | Himself | |
| Movie | 1992 | Guns N' Roses: Live In Oklahoma City | Himself | |
| Movie | 1991 | Guns N' Roses Home Coming | Himself | |
| Movie | 1991 | Guns N' Roses: Rock in Rio II - Second Night | | |
| Movie | 1991 | Guns N' Roses: Live in Indiana | | |
| Movie | 2003 | Jackass Backyard BBQ | Himself | |
| Movie | 1987 | Guns N' Roses - Live at The Ritz, NY | | |
| Movie | 1987 | Guns N' Roses: A Night in the Jungle | | |
| Movie | N/A | Until the Music Ends | Self | |
| Movie | 1992 | Guns N' Roses: Live Tokyo '92 | | |
| Movie | 2004 | The Story of Bohemian Rhapsody | Self | |
| Movie | 1992 | Buffy the Vampire Slayer | DJ (uncredited) | |
| Movie | 2021 | What Drives Us | Self | |
| Movie | 2008 | VH1 Rock Honors: The Who | Self | |
| Movie | 2020 | Chris Jericho's 30th Anniversary Celebration | Himself | |
| Movie | 2010 | Slash (with Myles Kennedy) : The MAX Sessions | | |
| Movie | 2002 | When Rock Ruled the World | Self | |
| Movie | 2015 | Slash feat. Myles Kennedy and The Conspirators: Live @ Hellfest 2015 | Guitars | |
| Movie | 2014 | Slash: Raised On the Sunset Strip | Self | |
| Movie | 2015 | Slash feat. Myles Kennedy & The Conspirators: Rock on the Range Festival 2015 | Self | |
| Movie | 2012 | Slash: Apocalyptic Love - Live from New York | Self | |
| Movie | 2018 | Stuntman | Self | |
| Movie | 1992 | Guns N' Roses: November Rain | Self | |
| Movie | 2024 | 2024 Rock & Roll Hall of Fame Induction Ceremony | Self | |
| Movie | 2009 | O Melhor do Flash Back - 92 Clipes Para Recordar | Self (archive footage) | |
| Movie | 2020 | The Postal Service Zoom Auditions | Self | |
| Movie | 2025 | FireAid Benefit Concert | Self | |
| Movie | 2008 | Stars and Their Guitars: A History of the Electric Guitar | Self | |
| Movie | 1999 | MJ & Friends: Live in Seoul | Self - Guitarist | |
| Movie | 1999 | MJ & Friends: Live in Munich | Self - guitarist | |
| Movie | N/A | guns n' roses it's so easy | | |
| Movie | 1986 | Guns N' Roses - Anything Goes Live At The Roxy | | |
| Movie | 1991 | Guns N' Roses - CNE Grandstand Toronto | | |
| Movie | 1988 | Guns N’ Roses at the Felt Forum NY | | |
| Movie | N/A | Back to the Beginning: Ozzy's Final Bow | Self | |
| TV Show | 2003 | Jimmy Kimmel Live! | | 1 |
| TV Show | 1989 | Tales from the Crypt | Hank | 1 |
| TV Show | 2005 | Tommy Lee Goes to College | | 1 |
| TV Show | 2010 | Music Nuggets | Self | 1 |
| TV Show | 2002 | The Anna Nicole Show | | 1 |
| TV Show | 2003 | Kid Notorious | Slash (voice) | 9 |
| TV Show | 2006 | VH1 Rock Honors | | 1 |
| TV Show | 2009 | The Tonight Show with Conan O'Brien | Self | 1 |
| TV Show | 2002 | CMT Music Awards | Self | 1 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self | 1 |
| TV Show | 2009 | Live from Studio Five | Self | 1 |
| TV Show | 2011 | Talking Dead | Self | 1 |
| TV Show | 2009 | Skavlan | Self - Guest | 1 |
| TV Show | 2012 | Anger Management | Lester | 1 |
| TV Show | 2009 | MTV World Stage | Self | 1 |
| TV Show | 1984 | MTV Video Music Awards | Self | 3 |
| TV Show | 1994 | Space Ghost Coast to Coast | Self | 1 |
| TV Show | 1996 | Never Mind the Buzzcocks | Self | 1 |
| TV Show | 2002 | Top Gear | Self | 1 |
| TV Show | 1953 | The Oscars | Self - Performer | 1 |
| TV Show | 2016 | Milo Murphy's Law | (voice) | 1 |
| TV Show | 1994 | MTV Europe Music Awards | Self - Performer | 1 |
| TV Show | 1997 | Classic Albums | Self | 1 |
| TV Show | 1995 | The Drew Carey Show | Self | 1 |
| TV Show | 1989 | MTV Rockumentary | | 1 |
| TV Show | 2006 | Metalocalypse | | 1 |
| TV Show | 1995 | The Music Biz | Self | 1 |
