| Movie | 2005 | Munich | Louis | |
| Movie | 2008 | Les amants cinéma | Self | |
| Movie | 2007 | The Diving Bell and the Butterfly | Jean-Dominique Bauby | |
| Movie | 2008 | Quantum of Solace | Dominic Greene | |
| Movie | 2007 | Actresses | Denis | |
| Movie | 2006 | The Singer | Bruno | |
| Movie | 2008 | A Christmas Tale | Henri | |
| Movie | 2014 | You I Tourneur | | |
| Movie | 2021 | Hervé Guibert, la mort propagande | Self | |
| Movie | 2006 | A Curtain Raiser | Pierre | |
| Movie | 2008 | On War | Bertrand | |
| Movie | 2010 | The Extraordinary Adventures of Adèle Blanc-Sec | Dieuleveult | |
| Movie | 2007 | A Secret | François Grimbert at 37 years old | |
| Movie | 2010 | On Tour | Joachim Zand | |
| Movie | 2007 | Michou d'Auber | Jacques | |
| Movie | 2007 | Heartbeat Detector | Simon Kessler | |
| Movie | 2008 | Mesrine: Public Enemy #1 | François Besse | |
| Movie | 2004 | Kings & Queen | Ismaël Vuillard | |
| Movie | 2003 | A Man, a Real One | Boris | |
| Movie | 2023 | Ne soyez pas vous-même | Self | |
| Movie | 2009 | Wild Grass | Bernard de Bordeaux | |
| Movie | 2009 | Park Benches | Father with pram | |
| Movie | 2023 | A Prince | Alberto (voice) | |
| Movie | 2005 | The Moustache | Serge Schaeffer | |
| Movie | 2012 | Cosmopolis | André Petrescu | |
| Movie | 2009 | Happy End | Robinson | |
| Movie | 2023 | A Brighter Tomorrow | Pierre | |
| Movie | 2023 | Mars Express | Chris Royjacker (voice) | |
| Movie | 2007 | The Story of Richard O | Richard O. | |
| Movie | 2003 | My Children Are Different | Gérald | |
| Movie | 2009 | Face | Man in Bushes | |
| Movie | 1996 | My Sex Life... or How I Got Into an Argument | Paul Dédalus | |
| Movie | 2011 | Chicken with Plums | Nasser-Ali Khan | |
| Movie | 2002 | Special Delivery | Stéphane | |
| Movie | 2006 | The Big Apartment | Martin | |
| Movie | 1999 | Late August, Early September | Gabriel | |
| Movie | 2000 | The False Servant | Lélio | |
| Movie | 1998 | Alice and Martin | Benjamin Sauvagnac | |
| Movie | 2012 | You Ain't Seen Nothin' Yet | M. Henri | |
| Movie | 2014 | The Grand Budapest Hotel | Serge X. | |
| Movie | 2017 | Julian Schnabel: A Private Portrait | Self | |
| Movie | 2002 | Shipwrecked on Route D17 | René | |
| Movie | 1996 | Diary of a Seducer | Sebastien | |
| Movie | 1997 | Genealogies of a Crime | Yves | |
| Movie | 2011 | The Silence of Joan | Preacher | |
| Movie | 2006 | The Signs | The Man | |
| Movie | 2010 | Joann Sfar (drawings) | Himself | |
| Movie | 2025 | Filmlovers! | Paul Dédalus (The Filmmaker) | |
| Movie | 2000 | Roland's Pass | Roland | |
| Movie | 2012 | Camille Rewinds | Le prof de français sadique | |
| Movie | 1998 | Only God Sees Me | Eude | |
| Movie | 2023 | A Difficult Year | Henri Tomasi | |
| Movie | 2013 | Jimmy P. | Georges Devereux | |
| Movie | 2013 | Biette | Self | |
| Movie | 2013 | Venus in Fur | Thomas | |
| Movie | 2013 | Love Is the Perfect Crime | Marc | |
| Movie | 2014 | If You Don't, I Will | Pierre | |
| Movie | 2023 | Spirit of Ecstasy | World Aid's Boss | |
| Movie | 2003 | A Sight for Sore Eyes | The art teacher | |
| Movie | 2013 | Break of Day | Patrick | |
| Movie | 2014 | The Blue Room | Julien Gahyde | |
| Movie | 1992 | Chasing Butterflies | | |
| Movie | 1999 | Farewell, Home Sweet Home | a drinker at bar | |
| Movie | 2002 | Monday Morning | voice | |
| Movie | 2006 | Les mâtines | Serge | |
| Movie | 2013 | The Anonymous | Roger Marion | |
| Movie | 2024 | Serpent's Path | Laval | |
| Movie | 2016 | Truffaut / Godard, scénario d'une rupture | Self | |
| Movie | 2012 | Lines of Wellington | Barão Marbot | |
| Movie | 2015 | The Forbidden Room | Thadeusz M___ / Ostler | |
| Movie | 2014 | Bird People | Le narrateur (voice) | |
| Movie | 2004 | Au large de Bad Ragaz | Alex | |
| Movie | 1999 | Three Bridges on the River | Arthur Echéant | |
| Movie | 2023 | Une Française à Kaboul : L'Aventure d'une vie | Voix off | |
| Movie | 1995 | Tom est tout seul | Friend of Tom (uncredited) | |
| Movie | 2001 | Boyhood Loves | Paul | |
| Movie | 2015 | Edgar Morin, chronique d'un regard | Narration (voice) | |
| Movie | 2015 | My Golden Days | Paul Dédalus | |
| Movie | 2014 | Illustrious & Unknown: The Man Who Saved the Louvre | Self - Narrator (voice) | |
| Movie | 1985 | Favourites of the Moon | Julien | |
| Movie | 2015 | Families | Jérôme Varenne | |
| Movie | 2015 | Winter Song | Bâtisseur | |
| Movie | 2020 | Ça a recommencé, l’émerveillement | Le mécanicien | |
| Movie | 2001 | Zaïde, un petit air de vengeance | Luigi Scarofolo | |
| Movie | 2006 | Fragments sur la grâce | | |
| Movie | 2023 | Goodbye Vinyle | Maurice Faugère | |
| Movie | 2021 | Pierre & Jeanne | | |
| Movie | 2002 | L'héroïque cinématographe | | |
| Movie | 2015 | The Very Private Life of Mister Sim | Samuel | |
| Movie | 2016 | Daguerrotype | Vincent | |
| Movie | 2016 | The Son of Joseph | Oscar Pormenor | |
| Movie | 2000 | The Marcorelle Affair | Fourcade | |
| Movie | 2016 | The Dunce | Boris | |
| Movie | 2016 | Struggle for Life | Galgaric | |
| Movie | 2016 | Seances | | |
| Movie | 2016 | Never Ever | Jacques Rey | |
| Movie | 2015 | Of Shadows and Wings | Narrator | |
| Movie | 2017 | Sleeping Beauty | Gérard Illinski, le précepteur | |
| Movie | 2017 | Ismael's Ghosts | Ismaël Vuillard | |
| Movie | 2025 | Why War | | |
| Movie | 2011 | The Rabbi's Cat | Prince (voice) | |
| Movie | 2017 | Barbara | Yves Zand | |
| Movie | 2017 | Tomorrow and Thereafter | Le père | |
| Movie | 1992 | The Sentinel | Un étudiant en médecine | |
| Movie | 2018 | Jusqu’au 23 Juillet | Self - Interviewee | |
| Movie | 2018 | Sink or Swim | Bertrand | |
| Movie | 2012 | The Rest of the World | Paul | |
| Movie | 2018 | The Exiled | Self | |
| Movie | 2018 | At Eternity's Gate | Dr. Paul Gachet | |
| Movie | 2018 | John McEnroe: In the Realm of Perfection | Narrator (voice) | |
| Movie | 2012 | The Sinkholes | Georges | |
| Movie | 1998 | L'interview | Julien Bernardini | |
| Movie | 2018 | Amalric, l’art et la matière | Self | |
| Movie | 1993 | Les Yeux au Plafond | | |
| Movie | 2019 | A Tramway in Jerusalem | | |
| Movie | 2005 | I Saw Ben Barka Get Killed | Philippe Bernier | |
| Movie | 2004 | Les parallèles | Simon | |
| Movie | 2019 | An Officer and a Spy | Bertillon | |
| Movie | 2021 | The French Dispatch | The Commissaire | |
| Movie | 2016 | Un, parfois deux | | |
| Movie | 2020 | Wonders in the Suburbs | Benoit Survenant | |
| Movie | 2015 | L'homme tango | | |
| Movie | 2006 | Marie Antoinette | Man at Masked Ball | |
| Movie | 2012 | Citizens of Cosmopolis | Self | |
| Movie | 2014 | The Dune | Moreau | |
| Movie | 2020 | Sound of Metal | Richard Berger | |
| Movie | 2019 | A Beautiful Summer | | |
| Movie | 2018 | Islander | Narrator (voice) | |
| Movie | 2009 | Calder: Sculptor of Air | Récitant / Narrator (voice) | |
| Movie | 2004 | The Bridge of Arts | Un spectateur du Nô | |
| Movie | 2020 | Monsieur Deligny, vagabond efficace | Narrator | |
| Movie | 2022 | Sigmund Freud: A Jew Without God | Sigmund Freud (voice) | |
| Movie | 2021 | Oxygen | M.I.L.O | |
| Movie | 2021 | Tralala | Tralala | |
| Movie | 2021 | Mother Schmuckers | Le père | |
| Movie | 2020 | Charlie Chaplin, The Genius of Liberty | Narrator (voice) | |
| Movie | 2008 | 57,000 Kilometers Between Us | Simon | |
| Movie | 2015 | Divine Comédie, des planches à l'écran | Self | |
| Movie | 2020 | The Black Book | (voice) | |
| Movie | 2019 | The Collection | Harry | |
| Movie | 2021 | Les Damnés de la Commune | Adolphe Thiers (voice) | |
| Movie | 2012 | Bond on Location | Self / Dominic Greene | |
| Movie | 2009 | Director Marc Forster | | |
| Movie | 1998 | On a très peu d'amis | Ivan | |
| Movie | N/A | Spectrographies | | |
| Movie | 2025 | A Private Life | Simon Cohen-Solal | |
| Movie | 2025 | Ange | Marco | |
| Movie | 2007 | Salut Vladimir ! | | |
| Movie | 2024 | Before It's Too Late | Mathieu Amalric | |
| Movie | N/A | Voilà, c’est fini | | |
| Movie | 2025 | The Phoenician Scheme | Marseille Bob | |
| Movie | 2025 | Zelensky | Narrator (voice) | |
| Movie | 2025 | Nino | Homme bains publics | |
| TV Show | 2011 | Platane | Mathieu Amalric | 1 |
| TV Show | 2008 | Dieu seul me voit (Versailles-Chantiers) - version interminable | 'Atchoum' | 6 |
| TV Show | 2020 | The Middleman | Olivier Tronier | 4 |
| TV Show | 2015 | The Bureau | Jean-Jacques, dit « JJA » | 20 |
| TV Show | 2015 | Wolf Hall | Eustace Chapuys | 2 |
| TV Show | 2025 | Comment Volodia devint Zelensky | Narrator | 2 |
