| Movie | 1999 | Inspector Gadget | Gadgetmobile (voice) | |
| Movie | 2023 | Sign the Show | Self | |
| Movie | 2001 | The Brothers | Derrick West | |
| Movie | 2003 | Chasing Papi | Rodrigo | |
| Movie | 2000 | The Original Kings of Comedy | Self | |
| Movie | 2004 | Soul Plane | Johnny | |
| Movie | 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self | |
| Movie | 2009 | Why We Laugh: Black Comedians on Black Comedy | Self | |
| Movie | 2021 | 2021 and Done with Snoop Dogg & Kevin Hart | Self | |
| Movie | 2005 | Shackles | Ben Cross | |
| Movie | 2007 | D.L. Hughley: Unapologetic | Himself | |
| Movie | 2011 | Cat Run | Dexter | |
| Movie | 2012 | I Ain't Scared of You: A Tribute to Bernie Mac | Self | |
| Movie | 1994 | HBO Comedy Half-Hour: D.L. Hughley | | |
| Movie | 2012 | D.L. Hughley: The Endangered List | Himself | |
| Movie | 2012 | D.L. Hughley: Reset | Himself | |
| Movie | 2005 | D.L. Hughley: Shocked & Appalled | | |
| Movie | 2001 | Laughing Out Loud: America's Funniest Comedians | Self (archive footage) | |
| Movie | 2014 | D.L. Hughley: Clear | Himself | |
| Movie | 2009 | All Star Comedy Jam: Live from South Beach | | |
| Movie | 1992 | One Night Stand: D.L. Hughley | Himself | |
| Movie | 2006 | The Adventures of Brer Rabbit | Brer Fox (voice) | |
| Movie | 2006 | We Don't Die, We Multiply: The Robin Harris Story | Himself | |
| Movie | 2017 | Dying Laughing | Self | |
| Movie | 2003 | Latham Entertainment Presents: An All New Comedy Experience | Himself | |
| Movie | 2006 | Def Comedy Jam Classics: Volume Two | Self | |
| Movie | 2017 | Def Comedy Jam 25 | Self | |
| Movie | 2003 | Scary Movie 3 | John Wilson | |
| Movie | 1999 | D.L. Hughley: Going Home | Himself | |
| Movie | 2018 | D.L. Hughley: Contrarian | Himself | |
| Movie | 2003 | Inspector Gadget 2 | Gadgetmobile (voice) | |
| Movie | 2004 | Before They Were Kings: Vol. 1 | Self | |
| Movie | 2006 | Cloud 9 | Tenspot | |
| Movie | 2003 | D.L. Hughley Live | | |
| Movie | 2020 | This Is Stand-Up | Self | |
| Movie | 2002 | Platinum Comedy Series: Roasting Shaquille O'Neal | Self | |
| Movie | 2004 | Last Laugh '04 | Self | |
| Movie | 2025 | N.W.A.: Not Without Alonzo | | |
| Movie | 1999 | Def Comedy Jam: All Stars 1 | | |
| TV Show | 1992 | ComicView | | 12 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | | 2 |
| TV Show | 2006 | Studio 60 on the Sunset Strip | Simon Stiles | 22 |
| TV Show | 1990 | The Fresh Prince of Bel-Air | Keith Cambell | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | Self | 9 |
| TV Show | 1994 | Sister, Sister | Hank | 1 |
| TV Show | 1999 | The Parkers | | 1 |
| TV Show | 2001 | Scrubs | Kevin Turk | 1 |
| TV Show | 2006 | 1 vs. 100 | | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 4 |
| TV Show | 1998 | The Hughleys | Darryl Hughley | 89 |
| TV Show | 2008 | D. L. Hughley Breaks the News | | 17 |
| TV Show | 1995 | The Watcher | | 1 |
| TV Show | 1989 | One Night Stand | | 1 |
| TV Show | 1997 | Premium Blend | | 97 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 1997 | The Wonderful World of Disney | | 1 |
| TV Show | 1995 | Double Rush | Marlon | 13 |
| TV Show | 2007 | S.O.B.: Socially Offensive Behavior | | 1 |
| TV Show | 2005 | Weekends at the D.L. | | 38 |
| TV Show | 2010 | Glory Daze | | 2 |
| TV Show | 2021 | Johnson | Eugene Johnson | 40 |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 2018 | The Neighborhood | Self | 1 |
| TV Show | 1998 | Hollywood Squares | Self - Panelist | 8 |
| TV Show | 1997 | The Chris Rock Show | | 1 |
| TV Show | 2012 | Gotham Comedy Live | Self - Host | 1 |
| TV Show | 2005 | Dancing with the Stars | Self - Contestant | 9 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 2001 | Russell Simmons' Def Comedy Jam All Stars | Himself | 14 |
| TV Show | 2016 | Match Game | Self - Panelist | 1 |
| TV Show | 2022 | Right to Offend: The Black Comedy Revolution | Self | 2 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2018 | The Fix | Self - Team Captain | 10 |
| TV Show | 2016 | To Tell the Truth | Self - Panelist | 3 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 16 |
| TV Show | 1996 | The Daily Show | Self - Guest Host | 4 |
| TV Show | 2010 | Hawaii Five-0 | Skeet | 1 |
| TV Show | 2017 | The Comedy Get Down | D.L. Hughley | 10 |
| TV Show | 2016 | Heartbeat | Dr. Hackett | 10 |
| TV Show | 2016 | The $100,000 Pyramid | Self | 1 |
