| Movie | 2021 | Buddy Guy: The Blues Chase The Blues Away | | |
| Movie | 2008 | Where the Light Is: John Mayer Live in Los Angeles | Self | |
| Movie | 2006 | Herbie Hancock: Possibilities | Self | |
| Movie | 2009 | John Mayer Trio - Live at Bowery Ballroom, New York | Self | |
| Movie | 2003 | John Mayer: Any Given Thursday | Self - Vocals, Guitar | |
| Movie | 2011 | Billy Joel - Live at Shea Stadium | Self - Musical Guest | |
| Movie | 2023 | Dead & Company: 2023-06-01 Coastal Credit Union Music Park at Walnut Creek, Raleigh, NC, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-05-19 Kia Forum, Inglewood, CA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-05-20 Kia Forum, Inglewood, CA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-05-23 Ak Chin Pavilion, AZ | Self | |
| Movie | 2023 | Dead & Company: 2023-05-26 Dos Equis Pavilion, Dallas, TX | Self | |
| Movie | 2023 | Dead & Company: 2023-05-28 Lakewood, ATL | Self | |
| Movie | 2023 | Dead & Company: 2023-05-30 at PNC Music Pavilion, Charlotte, NC, USA | Self | |
| Movie | 2023 | Dead & Company:2023-06-03 Jiffy Lube Live, Bristow, VA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-05 The Pavilion at Star Lake, Burgettstown, PA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-07 Hollywood Casino Amphitheatre, Maryland Heights, MO, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-15 Citizens Bank Park, Philadelphia, PA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-17 Saratoga Performing Arts Center, Saratoga Springs, NY, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-18 Saratoga Performing Arts Center, Saratoga Springs, NY, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-13 Riverbend Music Center, Cincinnati, OH, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-09 Wrigley Field, Chicago, IL, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-10 Wrigley Field, Chicago, IL, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-21 Citi Field, New York, NY, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-22 Citi Field, New York, NY, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-24 Fenway Park, Boston, MA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-25 Fenway Park, Boston, MA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-06-27 Ruoff Music Center, Noblesville, IN, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-07-01 Folsom Field, Boulder, CO, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-07-02 Folsom Field, Boulder, CO, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-07-03 Folsom Field, Boulder, CO, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-07-08 The Gorge Amphitheatre, George, WA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-07-14 Oracle Park, San Francisco, CA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-07-15 Oracle Park, San Francisco, CA, USA | Self | |
| Movie | 2023 | Dead & Company: 2023-07-16 Oracle Park, San Francisco, CA, USA | Self | |
| Movie | 2010 | John Mayer: Live in Rock in Rio Lisboa 2010 | Self | |
| Movie | 2023 | Dead & Company: 2023-07-07 The Gorge Amphitheatre, George, WA, USA | Self | |
| Movie | 2012 | The Zen of Bennett | Self | |
| Movie | 2012 | B.B. King: The Life of Riley | Self | |
| Movie | 2013 | John Mayer: Rock In Rio 2013 | Self - Vocals, Guitars | |
| Movie | 2022 | Dirty Daddy: The Bob Saget Tribute | Self | |
| Movie | 2019 | Dead & Company: 2019.10.31 - Madison Square Garden, NYC | Self | |
| Movie | 2019 | Dead & Company: 2019.11.01 - Madison Square Garden, NYC | Self | |
| Movie | 2018 | Dead & Company: 2018.06.29 - The Gorge Amphitheater, George, WA | Self | |
| Movie | 2021 | Dead & Company: 2021.09.11 - Riverbend Music Center, Cincinnati, OH | Self | |
| Movie | 2022 | Vengeance | John | |
| Movie | 2018 | Shawn Mendes: Live in Los Angeles | Self | |
| Movie | 2010 | John Mayer - VH1 Storytellers | Self | |
| Movie | 2014 | Zombeavers | Luke | |
| Movie | 2007 | Eric Clapton's Crossroads Guitar Festival 2007 | Self | |
| Movie | 2018 | Dead & Company: 2018-08-25 LOCKN' Music Festival, Arrington, VA | Self | |
| Movie | 2019 | Dead & Company: 2019-11-08 Hampton Coliseum, Hampton, VA | Self | |
| Movie | 2019 | Dead & Company: 2019-11-09 Hampton Coliseum, Hampton, VA | Self | |
| Movie | 2020 | Dead & Company: 2020-01-16 Moon Palace, Cancun, MX | Self | |
| Movie | 2020 | Dead & Company: 2020-01-18 Moon Palace, Cancun, MX | Self | |
| Movie | 2020 | Dead & Company: 2020-01-19 Moon Palace, Cancun, MX | Self | |
| Movie | N/A | Dead & Company: 2023-01-14 Playing In The Sand, Riviera Maya, MX | Self | |
| Movie | 2023 | Dead & Company: 2023-01-16 Playing In The Sand, Riviera Maya, MX | Self | |
| Movie | 2023 | Dead & Company: 2023-01-17 Playing In The Sand, Riviera Maya, MX | Self | |
| Movie | 2023 | Dead & Company: Cornell '23 | Self | |
| Movie | 2023 | Dead & Company: 2023-06-03 Jiffy Lube Live, Bristow, VA | Self | |
| Movie | 2021 | Dead & Company: 2021-08-16 Coastal Credit Union Music Park at Walnut Creek, Raleigh, NC | Self | |
| Movie | 2021 | Dead & Company: 2021-08-18 Jiffy Lube Live, Bristow, VA | Self | |
| Movie | 2021 | Dead & Company: 2021-08-20 Citi Field, New York, NY | Self | |
| Movie | 2021 | Dead & Company: 2021-08-21 Citizens Bank Park, Philadelphia, PA | Self | |
| Movie | 2021 | Dead & Company: 2021-08-23 Bethel Woods Center For The Arts, Bethel, NY | Self | |
| Movie | 2021 | Dead & Company: 2021-08-25 Darien Lake Amphitheater, Darien Center, NY | Self | |
| Movie | 2021 | Dead & Company: 2021-08-27 Saratoga Performing Arts Center, Saratoga Springs, NY | Self | |
| Movie | 2021 | Dead & Company: 2021-08-28 Hersheypark Stadium, Hershey, PA | Self | |
| Movie | 2021 | Dead & Company: 2021-09-02 Xfinity Center, Mansfield, MA | Self | |
| Movie | 2021 | Dead & Company: 2021-09-03 Xfinity Center, Mansfield, MA | Self | |
| Movie | 2012 | The Rolling Stones: One More Shot | Self | |
| Movie | 2014 | John Mayer: Someday I'll Fly | Self | |
| Movie | 2021 | Dead & Company: 2021-09-05 Xfinity Theatre, Hartford, CT | Self | |
| Movie | 2021 | Dead & Company: 2021-09-07 Blossom Music Center, Cuyahoga Falls, OH | Self | |
| Movie | 2005 | John Mayer - Live at Soundstage | Self | |
| Movie | 2007 | John Mayer - Austin City Limits | Self | |
| Movie | 2021 | Dead & Company: 2021.10.27 - North Island Credit Union Amphitheatre - Chula Vista, CA | Self | |
| Movie | 2021 | Dead & Company: 2021.10.29 - Hollywood Bowl - Hollywood, CA | Self | |
| Movie | 2021 | Dead & Company: 2021.10.30 Hollywood Bowl - Hollywood, CA | Self | |
| Movie | 2021 | Dead & Company: 2021.09.18 - Wrigley Field - Chicago, IL | Self | |
| Movie | 2021 | Dead & Company: 2021-09-10 DTE Energy Music Theatre, Clarkston, MI | Self | |
| Movie | 2021 | Dead & Company: 2021-09-13 Hollywood Casino Amphitheatre, St. Louis, MO | Self | |
| Movie | 2021 | Dead & Company: 2021-09-15 Ruoff Home Mortgage Music Center, Noblesville, IN | Self | |
| Movie | 2021 | Dead & Company: 2021-09-17 Wrigley Field, Chicago, IL | Self | |
| Movie | 2021 | Dead & Company: 2021-10-11 PNC Music Pavilion, Charlotte, NC | Self | |
| Movie | N/A | Dead & Company 2016-07-10 Alpine Valley Music Theatre, Elkhorn, WI | Self | |
| Movie | N/A | Dead & Company 2016-07-15 Fenway Park, Boston, MA | Self | |
| Movie | 2015 | Get Hard | John Mayer | |
| Movie | 2015 | Rock and Roll Hall of Fame Induction Ceremony | Self | |
| Movie | 2010 | John Mayer - Battle Studies | Self | |
| Movie | 2017 | Dead & Company: 2017.06.03 - Shoreline Amphitheatre - Mountain View, CA | Self | |
| Movie | 2006 | Cars Wal-Mart Exclusive Geared UP | | |
| Movie | 2013 | Eric Clapton's Crossroads Guitar Festival 2013 | Self | |
| Movie | 2017 | California Typewriter | Self | |
| Movie | 2010 | David Blaine: What Is Magic? | Self | |
| Movie | 2009 | Chris Botti in Boston | Self | |
| Movie | 2009 | Michael Jackson Memorial | Self | |
| Movie | 2014 | Katy Perry: Getting Intimate | Self | |
| Movie | 2006 | John Mayer Live From Webster Hall | Self | |
| Movie | 2014 | The Night That Changed America: A Grammy Salute to the Beatles | Self | |
| Movie | 2019 | Travis Scott: Look Mom I Can Fly | Self | |
| Movie | 2006 | Live from Abbey Road: Best of Season 1 | Self | |
| Movie | 2020 | Chuck Leavell: The Tree Man | Self | |
| Movie | 2014 | The Mona Lisa Myth | Additional voice-over | |
| Movie | 2017 | Dead & Company: 2017.12.02 - Austin, TX | Self | |
| Movie | 2018 | Mac Miller: Celebration of Life | Self | |
| Movie | 2024 | John Mayer SOLO live in Amsterdam - 21-22 March 2024 | Self | |
| Movie | 2025 | FireAid Benefit Concert | Self | |
| Movie | 2024 | Eric Clapton’s Crossroads Guitar Festival 2023 | Self | |
| Movie | 2004 | Eric Clapton's Crossroads Guitar Festival | Self | |
| Movie | 2020 | Eric Clapton's Crossroads Guitar Festival 2019 | Self | |
| Movie | 2010 | Eric Clapton's Crossroads Guitar Festival 2010 | Self | |
| TV Show | 2004 | I Love the '90s | Self | 10 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 3 |
| TV Show | 2000 | CSI: Crime Scene Investigation | Self | 1 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | Self | 4 |
| TV Show | 1999 | The Early Show | Self | 1 |
| TV Show | 2009 | The Jay Leno Show | Self | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Musical Guest | 6 |
| TV Show | 1975 | Austin City Limits | Self | 2 |
| TV Show | 2007 | Control Room Presents | Self | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 2 |
| TV Show | 1959 | The Grammys | Self | 5 |
| TV Show | 2009 | Skavlan | Self - Guest | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Tony's Buddy | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 8 |
| TV Show | 2015 | Hot Ones | Self | 1 |
| TV Show | 2009 | Rob Dyrdek's Fantasy Factory | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Musical Guest | 3 |
| TV Show | 2002 | CMT Crossroads | Self | 2 |
| TV Show | 2004 | On Air with Ryan Seacrest | Self - Performer | 1 |
| TV Show | 2011 | Impractical Jokers | Self | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | | 1 |
