| Movie | 2008 | John Oliver: Terrifying Times | Self | |
| Movie | 2011 | The Smurfs | Vanity Smurf (voice) | |
| Movie | 2010 | The Rally to Restore Sanity and/or Fear | Self - Correspondent | |
| Movie | 2013 | The Smurfs 2 | Vanity Smurf (voice) | |
| Movie | 2017 | Oh, Hello: Nick Kroll and John Mulaney as Gil Faizon and George St. Geegland | Self | |
| Movie | 2013 | The Smurfs: The Legend of Smurfy Hollow | Vanity Smurf (voice) | |
| Movie | 1997 | Backstage... at the Cambridge Footlights | Self | |
| Movie | 2012 | The Secret Policeman's Ball | Self | |
| Movie | 2014 | The Concert for Valor | Self | |
| Movie | 2019 | Wonder Park | Steve (voice) | |
| Movie | 2008 | The Love Guru | Dick Pants | |
| Movie | 2019 | The Lion King | Zazu (voice) | |
| Movie | 2017 | Night of Too Many Stars: America Unites for Autism Programs | Self | |
| Movie | 2014 | Harmontown | Self | |
| Movie | 2017 | Cross Wars | Narrator (voice) | |
| Movie | 2015 | The True Cost | Self | |
| Movie | 2021 | Sesame Street: 50 Years of Sunny Days | Self | |
| Movie | 2023 | Last Squeak Tonight with John Oliver | Self | |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 2020 | The Not-Too-Late Show with Elmo | Self | 1 |
| TV Show | 2005 | The Colbert Report | Self | 1 |
| TV Show | 2009 | Important Things with Demetri Martin | The King / The Prince / William Shakespeare | 17 |
| TV Show | 2010 | John Oliver's New York Stand-Up Show | Self - Host | 26 |
| TV Show | 2009 | Community | Professor Ian Duncan | 17 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self - Host | 350 |
| TV Show | 2009 | Community | Xim-Xam / Mix-Max (voice) | 1 |
| TV Show | 2021 | LuLaRich | Self | 1 |
| TV Show | 2013 | Rick and Morty | Dr. Xenon Bloom (voice) | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 12 |
| TV Show | 2012 | Gravity Falls | Wax Sherlock Holmes (voice) | 1 |
| TV Show | 1999 | People Like Us | | 1 |
| TV Show | 2004 | Green Wing | Car Salesman | 1 |
| TV Show | 2004 | The Soup | Self | 2 |
| TV Show | 2015 | Danger Mouse | Augustus P. Crumhorn IV (voice) | 4 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self - Guest | 6 |
| TV Show | 2011 | Bob's Burgers | Ian (voice) | 2 |
| TV Show | 2012 | Randy Cunningham: 9th Grade Ninja | Coach Green (voice) | 4 |
| TV Show | 2012 | Comedians in Cars Getting Coffee | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 8 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 2 |
| TV Show | 2017 | The Russell Howard Hour | Self | 2 |
| TV Show | 2000 | My Hero | Man from the BBC | 1 |
| TV Show | 2015 | Hot Ones | Self | 1 |
| TV Show | 2005 | Mock the Week | Self | 7 |
| TV Show | 2005 | Robot Chicken | Serpentor/British gentleman | 1 |
| TV Show | 2008 | Water And Power | The Daily Show's John Oliver | 1 |
| TV Show | 2014 | The Men in Blazers Show | Self | 9 |
| TV Show | 2022 | The Horne Section TV Show | John Oliver | 12 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self - Guest | 17 |
| TV Show | 2011 | Billy on the Street | Self | 1 |
| TV Show | 1989 | The Simpsons | Booth Wilkes-John (voice) | 1 |
| TV Show | 2017 | Big Mouth | Harry (voice) | 3 |
| TV Show | 2019 | Love, Death & Robots | Thumb Bringer (voice) | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self - Guest | 1 |
