| Movie | 2009 | Julie & Julia | Regina | |
| Movie | 2010 | Killers | Kristen | |
| Movie | 2012 | The Guilt Trip | Amanda | |
| Movie | 2006 | For Your Consideration | Young Actress | |
| Movie | 2013 | C.O.G. | Martha | |
| Movie | 2013 | Ass Backwards | Chloe | |
| Movie | 2014 | Gone Girl | Noelle Hawthorne | |
| Movie | 2008 | The Great Buck Howard | Charity | |
| Movie | 2014 | Jason Nash Is Married | Rose | |
| Movie | 2010 | Saturday Night | Self | |
| Movie | 2015 | The Breakup Girl | Kate Lanley | |
| Movie | 2024 | The Listener | Ruby | |
| Movie | 2009 | Bride Wars | Stacy | |
| Movie | 2016 | Me Him Her | | |
| Movie | 2009 | Saturday Night Live: The Best of Amy Poehler | Various (archive footage) | |
| Movie | 2016 | The Meddler | Trish | |
| Movie | 2007 | The Brothers Solomon | Fertility Clinic Receptionist | |
| Movie | 2015 | Bad Night | Billy | |
| Movie | 2018 | Origin Story | Self | |
| Movie | 2024 | Adult Best Friends | Alex | |
| Movie | 2016 | Why Him? | Missy Pederman | |
| Movie | 2010 | Freak Dance | Rich Lady | |
| Movie | 2014 | Lennon or McCartney | Self (voice) | |
| Movie | 2017 | Michael Bolton's Big, Sexy Valentine's Day Special | Casey Wilson | |
| Movie | 2017 | The Disaster Artist | Casting Director #2 | |
| Movie | 2018 | The Long Dumb Road | Sharon | |
| Movie | 2010 | The Women of SNL | Various (archive footage) | |
| Movie | 2019 | Always Be My Maybe | Chloe | |
| Movie | 2019 | Daddio | Abby | |
| Movie | 2021 | Long Weekend | Rachel | |
| Movie | 2020 | Omniboat: A Fast Boat Fantasia | | |
| Movie | 2006 | Derek & Simon: A Bee and a Cigarette | Anna | |
| Movie | 2017 | Don't Mess with Julie Whitfield | Julie Whitfield | |
| Movie | 2022 | Family Squares | Katie | |
| Movie | 2020 | Happy Endings Special Charity Event | Penny Hartz | |
| Movie | 2011 | Home for Actresses | Casey | |
| TV Show | 2007 | Human Giant | Young Mom | 1 |
| TV Show | 2008 | Saturday Night Live Weekend Update Thursday | | 9 |
| TV Show | 2009 | Glenn Martin, DDS | | 2 |
| TV Show | 2017 | Atypical | Ms. Whitaker | 6 |
| TV Show | 2005 | American Dad! | Lindsay (voice) | 1 |
| TV Show | 2009 | The Middle | Reverend Tammy | 1 |
| TV Show | 2011 | Happy Endings | Penny Hartz | 57 |
| TV Show | 2011 | Retired at 35 | | 1 |
| TV Show | 2005 | How I Met Your Mother | Krirsten | 1 |
| TV Show | 1999 | Family Guy | Dottie (voice) | 1 |
| TV Show | 2014 | Marry Me | Annie | 14 |
| TV Show | 2013 | The Birthday Boys | | 1 |
| TV Show | 2014 | The Hotwives of Orlando | Tawny St. John | 7 |
| TV Show | 2012 | Comedy Bang! Bang! | Eugenia Clemente | 1 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 1 |
| TV Show | 2019 | The Righteous Gemstones | Kristy Downes | 2 |
| TV Show | 2005 | American Dad! | Trish / Molly (voice) | 1 |
| TV Show | 2005 | American Dad! | Italian Woman (voice) | 1 |
| TV Show | 2005 | American Dad! | Rowdy Strip Club Patron (voice) | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | Marie | 1 |
| TV Show | 2012 | The Mindy Project | Elena | 1 |
| TV Show | 2016 | One Mississippi | Brooke | 12 |
| TV Show | 2012 | Littlest Pet Shop | Felina Meow (voice) | 2 |
| TV Show | 2022 | About Last Night | Self | 1 |
| TV Show | 2021 | Physical | Deb | 4 |
| TV Show | 2022 | Human Resources | Empathy Mulholland (voice) | 1 |
| TV Show | 2023 | The Great American Baking Show | Host | 6 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | | 1 |
| TV Show | 2005 | American Dad! | Trish / Space Camp Employee (voice) | 1 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 2015 | Celebrity Family Feud | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 13 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2016 | A Little of Your Time with Quinn Marcus | Herself | 1 |
| TV Show | 2009 | The League | Claire | 1 |
| TV Show | 2013 | Turbo FAST | Ember (voice) | 1 |
| TV Show | 2011 | NTSF:SD:SUV:: | Ghost Gabber | 1 |
| TV Show | 2016 | Bajillion Dollar Propertie$ | Jen | 1 |
| TV Show | 2021 | Home Economics | Harmony | 2 |
| TV Show | 2005 | Grey's Anatomy | Courtney Hall | 1 |
| TV Show | 2016 | Match Game | Self - Panelist | 2 |
| TV Show | 2013 | The Jeselnik Offensive | Self | 1 |
| TV Show | 2014 | black-ish | Patrice | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 34 |
| TV Show | 2019 | Mrs. Fletcher | Jane Rosen | 7 |
| TV Show | 2005 | American Dad! | Trish (voice) | 9 |
| TV Show | 1999 | Family Guy | Jess (voice) | 2 |
| TV Show | 2013 | Drunk History | Dolly Parton | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 1 |
| TV Show | 2019 | Harley Quinn | Betty (voice) | 2 |
| TV Show | 2015 | Fresh Off the Boat | Helen | 1 |
| TV Show | 2015 | Grace and Frankie | Taneth | 1 |
| TV Show | 2023 | History of the World: Part II | Gloria | 1 |
| TV Show | 2023 | History of the World: Part II | Mother Mary | 1 |
| TV Show | 2018 | Heathers | Lexi Anne | 2 |
| TV Show | 2019 | Black Monday | Tiffany 'Tiff' Georgina | 24 |
| TV Show | 2024 | Kite Man: Hell Yeah! | Adult Daughter / Betty (voice) | 1 |
| TV Show | 2021 | The Shrink Next Door | Bonnie Herschkopf | 8 |
| TV Show | 2015 | The Hotwives of Las Vegas | Jenfer Beudon | 7 |
| TV Show | 2024 | Georgie & Mandy's First Marriage | Beth | 4 |
| TV Show | 2023 | Based on a True Story | Booby Bev | 1 |
| TV Show | 2025 | Hollywood Squares | Self | 2 |
| TV Show | 1999 | Family Guy | Shelly Barnes (voice) | 1 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Wife | 1 |
| TV Show | 2019 | The Masked Singer | Self - Guest Panelist | 1 |
| TV Show | 2013 | The Millers | Beth | 1 |
| TV Show | 2020 | Solar Opposites | Jen / Stacey Grabowski (voice) | 1 |
