| Movie | 1998 | American History X | Doris | |
| Movie | 1977 | Annie Hall | Actress in Rob's TV Show | |
| Movie | 1997 | Nowhere | Dark's Mom | |
| Movie | 1979 | Hair | Sheila Franklin | |
| Movie | 1987 | Maid to Order | Stella Winston | |
| Movie | 1990 | Pacific Heights | Ann Miller (uncredited) | |
| Movie | 1983 | National Lampoon's Vacation | Ellen Griswold | |
| Movie | 1990 | Daddy's Dyin'... Who's Got the Will? | Evalita | |
| Movie | 1984 | Finders Keepers | Standish Logan | |
| Movie | 1988 | High Spirits | Sharon Brogan Crawford | |
| Movie | 1989 | National Lampoon's Christmas Vacation | Ellen Griswold | |
| Movie | 1997 | Vegas Vacation | Ellen Griswold | |
| Movie | 1985 | National Lampoon's European Vacation | Ellen Griswold | |
| Movie | 1994 | Lightning Jack | Lana Castel | |
| Movie | 1985 | Get Out of My Room | | |
| Movie | 2008 | The House Bunny | Mrs. Hagstrom | |
| Movie | 2010 | Hotel Hell Vacation | Ellen Griswold | |
| Movie | 1991 | The Miracle | Renee Baker | |
| Movie | 2006 | Gamers | Gordon's Mom | |
| Movie | 1980 | Coal Miner's Daughter | Patsy Cline | |
| Movie | 2007 | Battle for Terra | Interrogator Wright (voice) | |
| Movie | 2024 | Summer Camp | Jane | |
| Movie | 1981 | Honky Tonk Freeway | Carmen Odessa Shelby | |
| Movie | 1977 | The Sentinel | Sandra | |
| Movie | 1999 | Get Bruce! | Self | |
| Movie | 1987 | Aria | Gilda | |
| Movie | 1981 | Paternity | Maggie | |
| Movie | 1998 | Illuminata | Astergourd | |
| Movie | 2022 | Violent Night | Gertrude | |
| Movie | 1999 | Sam Kinison: Why Did We Laugh? | Self | |
| Movie | 1986 | Big Trouble | Blanche Rickey | |
| Movie | 1991 | The Pope Must Die | Veronica Dante | |
| Movie | 1987 | In the Mood | Francine Glatt | |
| Movie | 1977 | First Love | Shelley | |
| Movie | 2012 | I Heart Shakey | Sheila | |
| Movie | 2001 | Women in Film | Phyllis Wolf | |
| Movie | 1989 | Cold Front | Amanda O'Rourke | |
| Movie | 1984 | A Streetcar Named Desire | Stella DuBois Kowalski | |
| Movie | 1997 | A Rat's Tale | Mrs. Dollart | |
| Movie | 1997 | Pterodactyl Woman from Beverly Hills | Pixie Chandler | |
| Movie | 1993 | Judgment Day: The John List Story | Helen List | |
| Movie | 2001 | On the Edge | Bag Lady (segment "Happy Birthday") | |
| Movie | 1987 | The Man Who Fell to Earth | Eva Milton | |
| Movie | 1994 | The Crazysitter | Edie | |
| Movie | 2024 | The Trainer | Jack's Mother | |
| Movie | 2013 | Bounty Killer | Lucille | |
| Movie | 1991 | Lonely Hearts | Alma | |
| Movie | 2013 | All American Christmas Carol | Wanda / Ghost of Christmas Future | |
| Movie | 2007 | Game of Life | Kathy | |
| Movie | 1994 | Jonathan Stone: Threat of Innocence | Annie Hayes | |
| Movie | 1996 | Eye for an Eye | Dolly Green | |
| Movie | 1992 | A Child Lost Forever: The Jerry Sherwood Story | Jerry Sherwood | |
| Movie | 1997 | Love Always | Miranda | |
| Movie | 1994 | Menendez: A Killing in Beverly Hills | Kitty Menendez | |
| Movie | 2015 | Vacation | Ellen Griswold | |
| Movie | 1982 | Highpoint | Lise | |
| Movie | 1996 | Widow's Kiss | Vivian Fairchild | |
| Movie | 1978 | Every Which Way but Loose | Echo | |
| Movie | 1996 | Edie & Pen | Barlady | |
| Movie | 2004 | Hair High | Darlene (voice) | |
| Movie | 1999 | Lansky | Teddy Lansky | |
| Movie | 2015 | Accidental Love | Helen Eckle | |
| Movie | 2025 | No Address | Dora | |
| Movie | 1992 | Man Trouble | Andy Ellerman | |
| Movie | 1996 | Sweet Temptation | Jesse Larson | |
| Movie | 2024 | Drugstore June | Marla | |
| Movie | 1988 | Trading Hearts | Donna Nottingham | |
| Movie | 2017 | Under the Bed | Sandra Monroe | |
| Movie | 2018 | Frat Pack | Moira | |
| Movie | 2016 | Dreamland | Marie | |
| Movie | 2015 | Drunk Stoned Brilliant Dead | Self - Actress | |
| Movie | 2015 | The Comments | Barb | |
| Movie | 2014 | The Michaels | Millie Barnworth | |
| Movie | 1995 | Talking With | Alain (segment "Marks") | |
| Movie | 1987 | Hands of a Stranger | Mary Hearn | |
| Movie | 1986 | Slow Burn | Laine Fleischer | |
| Movie | N/A | Unfriendly Fire | Gen. Lisa Hertz | |
| Movie | 1983 | Sleeping Beauty | Henbane | |
| Movie | 2009 | Aussie and Ted's Great Adventure | Aunt Zelda | |
| Movie | 1993 | The Switch | Dee (uncredited) | |
| Movie | 1998 | With Friends Like These | Theresa Carpenter | |
| Movie | 1998 | Merchants of Venus | Mistress Cody | |
| Movie | 2017 | Wakefield | Babs | |
| Movie | 2019 | The Unicorn | Edie | |
| Movie | 1985 | The Legend of Sleepy Hollow | Katrina Van Tassel | |
| Movie | 2008 | Harold & Kumar Escape from Guantanamo Bay | Sally | |
| Movie | 2017 | When Patsy Cline Was... Crazy | Self | |
| Movie | 1999 | Sugar Town | Jane | |
| Movie | 2017 | Lady-Like | Dean Melissa | |
| Movie | 2011 | Inside Story: National Lampoon's Vacation | Self | |
| Movie | 2002 | The N.Y. Friars Club Roast of Chevy Chase | Self - Roaster | |
| Movie | 2006 | Relative Strangers | Angela Minnola | |
| Movie | 2014 | Playing It Cool | Lyle's Girlfriend | |
| Movie | 2021 | The Good House | Mamie Lang | |
| Movie | 1985 | Doubletake | Caroline Wallace | |
| Movie | 2008 | Family Guy Presents: Blue Harvest | Ellen Griswold (voice) | |
| Movie | N/A | Masha's Mushrooms | Paige | |
| Movie | 2001 | Summer Catch | Lusty House Mother | |
| Movie | 1992 | Trial: The Price of Passion | Johnnie Faye Boudreau | |
| Movie | N/A | Capps Crossing: Wrong Side of Dead | Sandra | |
| Movie | 2020 | The Tribe Remembers | Self | |
| Movie | 2004 | King of the Corner | Betsy Ingraham | |
| Movie | 2009 | Hollywood Singing & Dancing: A Musical History - 1970's | Self | |
| Movie | 2009 | Hollywood Singing and Dancing: A Musical History - The 1930s: Dancing Away the Great Depression | Self | |
| Movie | 2009 | Hollywood Singing & Dancing: A Musical History - 1980s, 1990s and 2000s | Self | |
| Movie | 2026 | Sleepwalker | Gloria | |
| Movie | N/A | The Heart Brake | Ann | |
| Movie | N/A | The Prince | | |
| Movie | N/A | Last Hand | Lilith Fudent | |
| Movie | N/A | Patsy Cline: Walkin' After Midnight | | |
| Movie | N/A | Grace Period | | |
| Movie | 2005 | Special Thanks To Roy London | | |
| Movie | 2025 | I'm Chevy Chase and You're Not | Self | |
| Movie | 2013 | The Good Mother | Judge Kennedy | |
| TV Show | 1989 | The Simpsons | Lurleen Lumpkin (voice) | 3 |
| TV Show | 1999 | Family Guy | Ellen Griswold (voice) | 1 |
| TV Show | 2004 | Entourage | Barbara Miller | 25 |
| TV Show | 1989 | Tales from the Crypt | Janice Baird | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Rebecca Balthus | 5 |
| TV Show | 1982 | Faerie Tale Theatre | Henbane | 1 |
| TV Show | 2000 | Talk to Me | | 3 |
| TV Show | 2010 | Scooby-Doo! Mystery Incorporated | Sheila Altoonian (voice) | 1 |
| TV Show | 2009 | Cougar Town | Sheila Keller | 1 |
| TV Show | 2023 | True Lies | Susan Trilby | 4 |
| TV Show | 2013 | Mom | Lorraine | 3 |
| TV Show | 2016 | Party Girl | Fay | 10 |
| TV Show | 1993 | Frasier | Audrey (voice) | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Serafina Carisi | 1 |
| TV Show | 1976 | Captains and the Kings | Miss Emmy | 8 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 2018 | Insatiable | Stella Rose Buckley | 5 |
| TV Show | 2009 | Celebrity Ghost Stories | Self | 1 |
| TV Show | 1985 | Tall Tales & Legends | Katrina Van Tassel | 1 |
| TV Show | 2016 | Shooter | National Security Advisor Gregson | 6 |
| TV Show | 2010 | Scooby-Doo! Mystery Incorporated | Mom (voice) | 1 |
| TV Show | 2014 | Friends with Better Lives | Gretchen | 1 |
| TV Show | 1971 | Great Performances | Self | 1 |
