| Movie | 1992 | Sidekicks | Kelly Stone | |
| Movie | 1986 | Wise Guys | Moe Dickstein | |
| Movie | 1988 | Dead Heat | Det. Doug Bigelow | |
| Movie | 1986 | The Joe Piscopo New Jersey Special | Self | |
| Movie | 1995 | Captain Nuke and the Bomber Boys | Mr. Wareman | |
| Movie | 2012 | Joe Piscopo: A Night at Club Piscopo | Self | |
| Movie | 1984 | Johnny Dangerously | Vermin | |
| Movie | 1987 | The Beach Boys: 25 Years Together - A Celebration In Waikiki | Self | |
| Movie | 1994 | Huck and the King of Hearts | Max | |
| Movie | 2000 | Baby Bedlam | Jack | |
| Movie | 1995 | Open Season | Hamlet | |
| Movie | 2007 | Dead Lenny | Louis Long | |
| Movie | 1984 | The Joe Piscopo Special | | |
| Movie | 2006 | WWE: Hulk Hogan: The Ultimate Anthology | Joe Piscopo | |
| Movie | 2006 | The Last Request | Angelo | |
| Movie | 1977 | American Tickler | Eastern Regional Director | |
| Movie | 1987 | The Joe Piscopo Halloween Party | Self / Joey / DeNiro / Various Roles | |
| Movie | 1995 | Two Bits & Pepper | Zike / Spider | |
| Movie | 2013 | How Sweet It Is | Jack Cosmo | |
| Movie | 1990 | The Real Story of Rain Rain Go Away | Prince Vince (voice) | |
| Movie | 2001 | Bartleby | Rocky | |
| Movie | 2017 | Gilbert | Self | |
| Movie | 1989 | Saturday Night Live: 15th Anniversary | Self | |
| Movie | 1986 | Let's Go Mets | Self | |
| Movie | 1984 | The House of God | Dr. Fishberg | |
| Movie | 2025 | Ladies & Gentlemen... 50 Years of SNL Music | Self - SNL Cast Member 1980 - 1984 | |
| Movie | 1990 | Joe Piscopo in Concert | Self | |
| Movie | 2022 | Uncancelling Columbus | | |
| Movie | 2005 | Saturday Night Live in the '80s: Lost and Found | Self | |
| Movie | 2025 | John Candy: I Like Me | Self - Actor, Saturday Nigh Live (archive footage) | |
| Movie | 1982 | Catch A Rising Star: 10th Anniversary Special | Self | |
| TV Show | 1996 | Arli$$ | Danny Richter | 1 |
| TV Show | 1990 | Law & Order | Jarret Whitestone | 1 |
| TV Show | 1987 | Star Trek: The Next Generation | The Comic | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 72 |
| TV Show | 1995 | Cybill | Joe Piscopo | 1 |
| TV Show | 2004 | The Celebrity Apprentice | | 1 |
| TV Show | 2006 | Celebrity Paranormal Project | Self | 1 |
| TV Show | 1999 | 100 Deeds for Eddie McDowd | Salli | 40 |
| TV Show | 1976 | Battle of the Network Stars | | 1 |
| TV Show | 1993 | The Pink Panther | The Dogfather (voice) | 60 |
| TV Show | 1999 | Chicken Soup for the Soul | Golfer | 23 |
| TV Show | 2001 | Good Day Live | Self | 1 |
| TV Show | 1992 | Batman: The Animated Series | Manager (voice) | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2012 | Gotham Comedy Live | Self - Host | 1 |
| TV Show | 1990 | Law & Order | Jeff Stahl | 1 |
| TV Show | 1990 | Law & Order | Art Cahill | 1 |
| TV Show | 1985 | George Burns Comedy Week | | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Albert Romano | 1 |
| TV Show | 1992 | Wild West C.O.W.-Boys of Moo Mesa | Sheriff Terrorbull (voice) | 26 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 1 |
| TV Show | 1992 | Goof Troop | Myron the Bulk (voice) | 1 |
| TV Show | 1992 | Goof Troop | Tan Roadster (voice) | 1 |