| Movie | 2022 | Liger | Mark Anderson | |
| Movie | 2019 | Pariah: The Lives and Deaths of Sonny Liston | Self | |
| Movie | 2013 | Scary Movie 5 | Mike Tyson | |
| Movie | 1999 | Play It to the Bone | Mike Tyson | |
| Movie | 2008 | Tyson | Self | |
| Movie | 1998 | WWE Royal Rumble 1998 | "Iron" Mike Tyson (Appearance) | |
| Movie | 2022 | Vendetta | Roach | |
| Movie | 2021 | Untold: Deal with the Devil | Self - Heavyweight Boxer | |
| Movie | 2023 | Stand | Self - Muslim (archive footage) | |
| Movie | 2021 | The Making of 'Rocky vs. Drago' | Self (archive footage) | |
| Movie | 2023 | Medellin | Robbie | |
| Movie | 2011 | The Hangover Part II | Mike Tyson | |
| Movie | 1991 | Voices That Care | Self - Choir Member | |
| Movie | 2009 | The Hangover | Mike Tyson | |
| Movie | 2004 | When Will I Be Loved | Mike Tyson | |
| Movie | 1998 | Austin 3:16 Uncensored | Himself | |
| Movie | 2025 | Teofilo: Boxing's Most Revolutionary Champion | Self | |
| Movie | 1998 | WWE WrestleMania XIV | Mike Tyson (Ringside Enforcer) | |
| Movie | 2011 | When Harry Met Sally 2 with Billy Crystal & Helen Mirren | State Trooper | |
| Movie | 2023 | Untold: Jake Paul the Problem Child | Self | |
| Movie | 1989 | Great Sports Moments of the 80's | Self (archive footage) | |
| Movie | 2012 | WWE Tagged Classics: Austin 3:16 Uncensored / Three Faces Of Foley / Chris Jericho: Break Down The Walls / Kurt Angle: Its True | Actor | |
| Movie | 2019 | TYSON | Self | |
| Movie | 2013 | Mike Tyson: Undisputed Truth | Self | |
| Movie | N/A | Kickboxer: Armageddon | Briggs | |
| Movie | 2023 | Once Within a Time | The Mentor | |
| Movie | 2023 | Unstuffed: A Build-A-Bear Story | Self | |
| Movie | 2013 | No Más | | |
| Movie | 2001 | Killer Instinct - The Rise and Fall of Mike Tyson | | |
| Movie | 2015 | Champs | Self | |
| Movie | 2012 | WWE Hall Of Fame 2012 | | |
| Movie | 2021 | Biography: Shawn Michaels | Self - International Boxing & WWE Hall of Famer | |
| Movie | 2005 | Mike Tyson vs. McBride | Self | |
| Movie | 1988 | Mike Tyson vs. Michael Spinks | Himself | |
| Movie | 1993 | Fallen Champ: The Untold Story of Mike Tyson | Self (archive footage) | |
| Movie | 1990 | Mike Tyson vs. Buster Douglas | Self | |
| Movie | 2006 | ESPN Classic Ringside: Mike Tyson | Mike Tyson | |
| Movie | 2011 | Comedy Central Roast of Charlie Sheen | Self - Roaster | |
| Movie | 2021 | You're Watching Video Music Box | Self | |
| Movie | 1987 | Mike Tyson vs. Pinklon Thomas | | |
| Movie | 2014 | I Am Ali | Self | |
| Movie | 2015 | Brand: A Second Coming | Self | |
| Movie | 2005 | The Outsider | Self | |
| Movie | N/A | Bunny-Man | Bunny-Man | |
| Movie | 2012 | Yo! The Story of ‘Yo! MTV Raps’ | Self | |
| Movie | 2024 | Asphalt City | Chief Burroughs | |
| Movie | 2015 | Entourage | Mike Tyson | |
| Movie | 2024 | Jake Paul vs. Mike Tyson | Self | |
| Movie | 2022 | Woooooo! Becoming Ric Flair | Self | |
| Movie | 2024 | Battle of the Baddest | Self | |
| Movie | 1989 | Mike Tyson vs Frank Bruno | Self | |
| Movie | 1999 | Black and White | Mike Tyson | |
| Movie | 2016 | I Am JFK Jr. | Self | |
| Movie | 2015 | Mr. Calzaghe | Himself | |
| Movie | 2004 | Planet Max 19 | Self | |
| Movie | 2015 | Ip Man 3 | Frank | |
| Movie | 2015 | Gates of the Sun | Mike Tyson | |
| Movie | 2016 | Nine Legends | Self | |
| Movie | 2013 | Wolfpack Only: The Hangover Retrospective | Self | |
| Movie | 2016 | Meet the Blacks | James Clown | |
| Movie | 2015 | The Making of Trump | Self | |
| Movie | 2009 | Jason Marriner Football Hooligan | Self | |
| Movie | 2016 | Back in the Day | Mike | |
| Movie | 1996 | Mike Tyson vs. Evander Holyfield I | Himself | |
| Movie | 1991 | The Record Breakers | Self (archive footage) | |
| Movie | 1990 | Spike Lee Presents Mike Tyson | Themself | |
| Movie | 2021 | Crack: Cocaine, Corruption & Conspiracy | Self (archive footage) | |
| Movie | 2015 | Chasing Tyson | Self | |
| Movie | 1995 | Kings of The Ring - History of Heavyweight Boxing 1919-1990 | Himself (Archival Footage) | |
| Movie | 2013 | Sport in America: Our Defining Stories | Self | |
| Movie | 2018 | Kickboxer: Retaliation | Briggs | |
| Movie | 2017 | Chris Brown: Welcome to My Life | Self | |
| Movie | 2017 | Tour de Pharmacy | Mike Tyson | |
| Movie | 2017 | Whitney: Can I Be Me | Self (archive footage) (uncredited) | |
| Movie | 2017 | China Salesman | Kabbah | |
| Movie | 1986 | Mike Tyson vs. Alfonzo Ratliff | | |
| Movie | 2000 | Mike Tyson vs Andrew Golota | Self | |
| Movie | 1989 | Mike Tyson vs Carl Williams | Self | |
| Movie | 1996 | Mike Tyson vs Bruce Seldon | Self | |
| Movie | 2001 | Mike Tyson vs Brian Nielsen | Himself | |
| Movie | 1990 | Mike Tyson vs. Alex Stewart | | |
| Movie | 1985 | Mike Tyson vs. Hector Mercedes | | |
| Movie | 2006 | Mike Tyson vs Corey Sanders | Self | |
| Movie | 2003 | Mike Tyson vs Clifford Etienne | Self | |
| Movie | 1995 | Mike Tyson vs Buster Mathis, Jr. | Self | |
| Movie | 2007 | Fool N Final | Mike Tyson | |
| Movie | 2018 | Girls vs Gangsters | Dragon | |
| Movie | 2010 | One Night in Vegas | Self | |
| Movie | 2002 | Bolivia | Mike Tyson (archive footage) | |
| Movie | 2018 | Public Disturbance | Barry Black | |
| Movie | 2011 | The Cookout 2 | Fat Burger Griller | |
| Movie | 2018 | 42 to 1 | | |
| Movie | 2010 | Tyson: Unleashed | Self | |
| Movie | 2019 | A Madea Family Funeral | Roy | |
| Movie | 2006 | Rocky Balboa | Mike Tyson | |
| Movie | 2013 | Grudge Match | Mike Tyson | |
| Movie | 1998 | The Mike Tyson Story | Himself | |
| Movie | 2019 | I Am Durán | Self | |
| Movie | 2020 | Reality Queen! | Mike Tyson | |
| Movie | 2019 | Pharaoh's War | Rick | |
| Movie | 1990 | Superstar: The Life and Times of Andy Warhol | Self (with wife Robin Givens) (archive footage) (uncredited) | |
| Movie | 2019 | One Night: Joshua vs. Ruiz | Self | |
| Movie | 2003 | 2PAC 4Ever | Himself | |
| Movie | 2007 | WWE: The Best of Raw 15th Anniversary | Himself | |
| Movie | 1999 | Mike Tyson vs. Orlin Norris | Himself | |
| Movie | 1997 | Mike Tyson vs. Evander Holyfield II | Himself | |
| Movie | 2000 | Mike Tyson vs Julius Francis | Himself | |
| Movie | 2000 | Mike Tyson vs. Lou Savarese | Himself | |
| Movie | 2004 | Mike Tyson vs. Danny Williams | Self | |
| Movie | 2020 | AEW Double or Nothing | | |
| Movie | 2013 | LT: The Life & Times | Self | |
| Movie | 1986 | Mike Tyson vs Trevor Berbick | Self | |
| Movie | 1988 | Mike Tyson vs Larry Holmes | Self | |
| Movie | 1991 | Mike Tyson vs Donovan Razor Ruddock II | | |
| Movie | 1991 | Mike Tyson vs Donovan Razor Ruddock I | | |
| Movie | 2011 | Stone Cold Steve Austin: The Bottom Line on the Most Popular Superstar of All Time | Self (archive footage) | |
| Movie | 2020 | The Wait: Mike Tyson's First Fight Out of Prison | Boxer | |
| Movie | 2020 | Lennox Lewis: The Untold Story | Self | |
| Movie | 2020 | Mike Tyson vs. Roy Jones Jr. | Self | |
| Movie | 2018 | Kadyrov, The Dictator of Chechnya | Self | |
| Movie | 1987 | Mike Tyson vs Tony Tucker | | |
| Movie | 1982 | Mike Tyson vs Kelton Brown - US Junior Olympic Tournament | | |
| Movie | 2001 | Crocodile Dundee in Los Angeles | Mike | |
| Movie | 2021 | Bruno v Tyson | Self | |
| Movie | 2021 | Make It or Die Trying: The Frank Warren Story | Self | |
| Movie | 2012 | WWE: The Attitude Era | Mike "The Baddest Man On The Planet" Tyson | |
| Movie | 2021 | Meeting Stone Cold | Self | |
| Movie | 2002 | Lennox Lewis vs. Mike Tyson | Self | |
| Movie | 1986 | Mike Tyson vs Marvis Frazier | | |
| Movie | 1996 | Mike Tyson vs. Frank Bruno II | Self | |
| Movie | 1985 | Mike Tyson vs Robert Colay | | |
| Movie | 1986 | Mike Tyson vs David Jaco | | |
| Movie | 1985 | Mike Tyson vs Ricardo Spain | | |
| Movie | 1986 | Mike Jameson vs. Mike Tyson | | |
| Movie | 1985 | Mike Tyson vs. Michael Johnson | | |
| Movie | 1985 | Mike Tyson vs Don Halpin | | |
| Movie | 1986 | James Tillis vs. Mike Tyson | | |
| Movie | 1986 | Mike Tyson vs. Steve Zouski | | |
| Movie | 1985 | Mike Tyson vs Sammy Scaff | | |
| Movie | 1986 | Mike Tyson vs. Jesse Ferguson | | |
| Movie | 2022 | Biography: D-Generation X | Himself | |
| Movie | N/A | Bruno vs. Tyson | Self | |
| Movie | 2016 | The Keys of Christmas | Bouncer | |
| Movie | 2020 | Tyson vs. Jaws: Rumble on the Reef | Self | |
| Movie | 1995 | Mike Tyson's Greatest Hits | Self | |
| Movie | 2012 | The Rock vs. John Cena: Once In A Lifetime | Self | |
| Movie | 2025 | Trainwreck: Mayor of Mayhem | Self (archive footage) | |
| Movie | 2003 | 101 Most Shocking Moments in Entertainment | | |
| Movie | 2024 | The Final Round | Self (archive footage) | |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 2005 | The Colbert Report | | 1 |
| TV Show | 2001 | Beyond the Glory | | 1 |
| TV Show | 2011 | Taking on Tyson | | 6 |
| TV Show | 1999 | Teen Choice Awards | Self | 1 |
| TV Show | 2013 | Being Mike Tyson | Self | 6 |
| TV Show | 2004 | The Celebrity Apprentice | Tyson (archive footage) | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 1 |
| TV Show | 2013 | Norm Macdonald Live | Self | 1 |
| TV Show | 2021 | Once Upon a Time in Queens | Self | 4 |
| TV Show | 2015 | Lip Sync Battle | Self | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Reggie Rhodes | 1 |
| TV Show | 1993 | Raw | | 1 |
| TV Show | 2005 | Hell's Kitchen | Self - Restaurant Patron | 1 |
| TV Show | 2016 | Little Big Show | | 1 |
| TV Show | 2017 | Superhuman | Self - Panelist | 8 |
| TV Show | 2006 | Bailando por un sueño | | 1 |
| TV Show | 1988 | Shark Week | Self | 1 |
| TV Show | 1985 | Mike Tyson - Heavyweight Fights | Himself | 9 |
| TV Show | 2011 | Breaking In | Mike Tyson | 1 |
| TV Show | 2011 | Franklin & Bash | Mike Tyson | 1 |
| TV Show | 2014 | Mike Tyson Mysteries | Mike Tyson (voice) | 70 |
| TV Show | 1988 | Yo! MTV Raps | Self | 1 |
| TV Show | 2024 | In the Know | Self | 1 |
| TV Show | 2002 | Kuba Wojewódzki | Self | 1 |
| TV Show | 2021 | Hart to Heart | Self | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2017 | OBJECTified | Self | 1 |
| TV Show | 2016 | Emigratis | | 1 |
| TV Show | 2016 | To Tell the Truth | Self - Panelist | 2 |
| TV Show | 2003 | High Chaparall | | 1 |
| TV Show | 2005 | How I Met Your Mother | Mike Tyson | 1 |
| TV Show | 2018 | The Last O.G. | Triple O.G. | 2 |
| TV Show | 2003 | Comedy Central Roasts | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2019 | All Elite Wrestling: Dynamite | Mike Tyson | 3 |
| TV Show | 2010 | Conan | Self | 2 |
| TV Show | 2023 | Dear Mama | Self | 5 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 4 |
| TV Show | 2024 | Countdown: Paul vs. Tyson | Self | 3 |
| TV Show | 2025 | Paul American | Self | 1 |
| TV Show | 2014 | WWE Wrestlemania Rewind | Mike Tyson | 2 |
| TV Show | 2021 | Scott the Woz | Self (archive footage) | 1 |
