| Movie | 2001 | Monsters, Inc. | Mike (voice) | |
| Movie | 1991 | City Slickers | Mitch Robbins | |
| Movie | 1989 | When Harry Met Sally... | Harry Burns | |
| Movie | 1995 | Forget Paris | Mickey Gordon | |
| Movie | 2007 | Sicko | Self (archive footage) | |
| Movie | 1987 | The Princess Bride | Miracle Max | |
| Movie | 1997 | Deconstructing Harry | Larry / The Devil | |
| Movie | 1994 | City Slickers II: The Legend of Curly's Gold | Mitch Robbins | |
| Movie | 2001 | America's Sweethearts | Lee Phillips | |
| Movie | 1987 | Throw Momma from the Train | Larry Donner | |
| Movie | 1999 | Analyze This | Dr. Ben Sobel | |
| Movie | 2002 | Analyze That | Dr. Ben Sobel | |
| Movie | 1997 | Fathers' Day | Jack Lawrence | |
| Movie | 2006 | Comic Relief 2006 | | |
| Movie | N/A | Which Witch? | | |
| Movie | 2002 | Mike's New Car | Mike (voice) | |
| Movie | 2023 | It Ain't Over | Self | |
| Movie | 1991 | Voices That Care | Self - Choir Member | |
| Movie | 1986 | Running Scared | Danny Costanzo | |
| Movie | 2013 | Monsters University | Mike (voice) | |
| Movie | 1994 | In Search of Dr. Seuss | The Voice of America (voice) | |
| Movie | 1998 | My Giant | Sam 'Sammy' Kamin | |
| Movie | 2001 | The Journey | Self | |
| Movie | 1999 | Get Bruce! | Self | |
| Movie | 1980 | Animalympics | Rugs Turkell (voice) | |
| Movie | 2011 | Pixar 25 Magic Moments | Self | |
| Movie | 1992 | Mr. Saturday Night | Buddy Young Jr. | |
| Movie | 2012 | Small Apartments | Burt Walnut | |
| Movie | 2020 | Bugs Bunny's 80th What's Up, Doc-umentary! | Narrator (voice) | |
| Movie | 2007 | Cutting Edge Comedians of the '60s & '70s | Self (archive footage) | |
| Movie | 2012 | Parental Guidance | Artie Decker | |
| Movie | 1978 | Rabbit Test | Lionel Carpenter | |
| Movie | 1988 | Memories of Me | Abbie | |
| Movie | 2011 | Method to the Madness of Jerry Lewis | Self | |
| Movie | 2005 | Mantle | Self | |
| Movie | 2006 | Tony Bennett: An American Classic | Self | |
| Movie | 1978 | Human Feelings | Miles Gordon | |
| Movie | 2021 | Hannibal Hopkins & Sir Anthony | Self (archive footage) | |
| Movie | 1989 | Billy Crystal: Midnight Train to Moscow | Self | |
| Movie | 1986 | Billy Crystal: Don't Get Me Started | Self | |
| Movie | 1979 | Breaking Up Is Hard to Do | Danny Doyle | |
| Movie | 1998 | Inside the Golden Statue | Self | |
| Movie | 2014 | And the Oscar Goes To... | Self (archive footage) | |
| Movie | 2007 | Mr. Warmth: The Don Rickles Project | Self | |
| Movie | 2014 | Party Central | Mike (voice) | |
| Movie | 1989 | Comic Relief III | | |
| Movie | 1977 | SST: Death Flight | David | |
| Movie | 2014 | Billy Crystal: 700 Sundays | Self | |
| Movie | 1996 | Hamlet | First Gravedigger | |
| Movie | 2013 | The Improv: 50 Years Behind the Brick Wall | Self | |
| Movie | 1997 | Sports on the Silver Screen | Self (archive footage) | |
| Movie | 2017 | City Slickers In Westworld | Mitch Robbins | |
| Movie | 1998 | Saturday Night Live: The Best of Eddie Murphy | Self (archive footage) | |
| Movie | 2022 | Robin Williams: Laugh Until You Cry | Self | |
| Movie | 2011 | The Love We Make | Self | |
| Movie | 2006 | Cars | Mike Car (voice) | |
| Movie | 1984 | This Is Spinal Tap | Morty the Mime | |
| Movie | 2022 | Mr. Saturday Night | Buddy Young, Jr. | |
| Movie | 1985 | Richard Lewis: I'm In Pain | Self | |
| Movie | 1985 | Night of 100 Stars II | Self | |
| Movie | 1996 | Caesar's Writers | Self - Host | |
| Movie | 2003 | Christmas in Hollywood | Self (archive footage) | |
| Movie | 2001 | Muhammad Ali - Through The Eyes Of The World | Self | |
| Movie | 1986 | Kraft Salutes the George Burns 90th Birthday Special | Self | |
| Movie | 2007 | The Pixar Story | Self - Mike Wazowski | |
| Movie | 2012 | 12-12-12 | The Concert for Sandy Relief | Self | |
| Movie | 2019 | Untogether | David | |
| Movie | 2010 | I'm Still Here | Billy Crystal | |
| Movie | 2016 | The Comedian | Billy Crystal | |
| Movie | 1999 | American Movie | Academy Awards Emcee (uncredited) | |
| Movie | 1980 | Enola Gay: The Men, the Mission, the Atomic Bomb | Lt. Jacob 'Jake' Beser | |
| Movie | 2002 | Billy Connolly: A BAFTA Tribute | Self | |
| Movie | 1989 | Saturday Night Live: 15th Anniversary | Self | |
| Movie | 2017 | Sammy Davis, Jr.: I've Gotta Be Me | Self | |
| Movie | 2015 | Kareem: Minority of One | Self | |
| Movie | 2015 | First Pitch | | |
| Movie | 2017 | This Is Bob Hope... | Narrator (voice) | |
| Movie | 2018 | Andre the Giant | Self | |
| Movie | 2018 | Robin Williams: Come Inside My Mind | Self | |
| Movie | 2001 | The Concert for New York City | Self | |
| Movie | 2001 | As You Wish: The Story of 'The Princess Bride' | Self | |
| Movie | 2006 | Kings of Comedy USA | Self (archive footage) | |
| Movie | 2010 | Tooth Fairy | Jerry (uncredited) | |
| Movie | 2000 | The Adventures of Rocky & Bullwinkle | Mattress Salesman (uncredited) | |
| Movie | 2020 | Standing Up, Falling Down | Marty | |
| Movie | 2019 | Still Laugh-In: The Stars Celebrate | Self | |
| Movie | 2011 | When Harry Met Sally 2 with Billy Crystal & Helen Mirren | Harry | |
| Movie | 2014 | Eat Drink Laugh: The Story of The Comic Strip | Self | |
| Movie | 1998 | The Warner Bros. Story: 75 Years of Laughter | Self - Host | |
| Movie | 1998 | Warner Bros. 75th Anniversary: No Guts, No Glory | Self - Host (segment "75 Years of Laughter") | |
| Movie | 1997 | Stand Tall | Self | |
| Movie | 1994 | A Century of Cinema | Self | |
| Movie | 2020 | Feeding America Comedy Festival | Self | |
| Movie | 2021 | Here Today | Charlie Burnz | |
| Movie | 1991 | Branford Marsalis: Steep | Self | |
| Movie | 2020 | AGFA Mystery Mixtape #4: Follow Your Own Star | Self | |
| Movie | 2020 | A Virtual Princess Bride Reunion | Miracle Max | |
| Movie | 2001 | How Harry Met Sally… | Self | |
| Movie | 2020 | In Search of the Sanderson Sisters: A Hocus Pocus Hulaween Takeover | Miracle Max | |
| Movie | 1999 | Goodnight Moon & Other Sleepytime Tales | Narrator (voice) | |
| Movie | 1982 | Doug Henning's World of Magic | Self | |
| Movie | 1999 | Saturday Night Live: 25th Anniversary Special | Self | |
| Movie | 1984 | Billy Crystal: A Comic's Line | Self | |
| Movie | 2021 | Roll Up Your Sleeves | Self | |
| Movie | 1994 | Sesame Street | All-Star 25th Birthday: Stars and Street Forever! | Self (archive footage) | |
| Movie | 1988 | Grand Slam! | Self | |
| Movie | 1990 | Comic Relief '90 | Self | |
| Movie | 1988 | An All-Star Toast to the Improv | Self | |
| Movie | 1986 | The Best of Comic Relief | Self | |
| Movie | 2025 | FireAid Benefit Concert | Self | |
| Movie | 1992 | When It Was a Game 2 | Self (voice) | |
| Movie | 2000 | When It Was a Game 3 | Self (voice) | |
| Movie | 2020 | The AGFA Mystery Mixtape Vault | (archive footage) | |
| Movie | 2024 | King Kong: Monster and Myth | Self - Actor (archive footage) | |
| Movie | 2007 | Pixar Short Films Collection: Volume 1 | | |
| Movie | 2009 | Pixar Short Films | Mike (voice) | |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 17 |
| TV Show | 1994 | The Critic | | 0 |
| TV Show | 1994 | Friends | Tim (uncredited) | 1 |
| TV Show | 1971 | All in the Family | Al Bender | 1 |
| TV Show | 1977 | Soap | Jodie Dallas | 85 |
| TV Show | 1993 | Frasier | Jack (voice) | 1 |
| TV Show | 2012 | Inside Comedy | Self | 1 |
| TV Show | 2009 | The Jay Leno Show | Self | 1 |
| TV Show | 2002 | Liberty's Kids | John Adams (voice) | 40 |
| TV Show | 1997 | The View | Self - Guest | 2 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 4 |
| TV Show | 2021 | The Story of Late Night | Self | 6 |
| TV Show | 2020 | Never Have I Ever | Himself | 1 |
| TV Show | 1961 | The Mike Douglas Show | Self - Co-Host | 1 |
| TV Show | 2018 | Shut Up and Dribble | Self - Entertainer | 2 |
| TV Show | 1992 | The Larry Sanders Show | Billy Crystal | 1 |
| TV Show | 1975 | Doug Henning's World of Magic | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 2 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 2 |
| TV Show | 2015 | The Comedians | Billy | 13 |
| TV Show | 1998 | Hollywood Squares | Self - Panelist | 3 |
| TV Show | 2015 | The Late Late Show with James Corden | Self | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | Self - Guest | 1 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 1975 | Saturday Night Live with Howard Cosell | | 4 |
| TV Show | 1961 | The Mike Douglas Show | Self | 4 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 3 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2021 | Back on the Record with Bob Costas | Self | 1 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 5 |
| TV Show | 2024 | Before | Dr. Eli Adler | 10 |
| TV Show | 1982 | Faerie Tale Theatre | Larry | 1 |
| TV Show | 2004 | The Tony Danza Show | Self - Guest | 1 |
| TV Show | 1996 | Muppets Tonight | Self | 2 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 1988 | Flitterabend | Self | 1 |
| TV Show | 2008 | Web Therapy | Garreth Pink | 2 |
| TV Show | 2015 | The Late Show with Stephen Colbert | | 1 |
| TV Show | 1992 | Shelley Duvall's Bedtime Stories | Narrator (Voice) | 1 |
| TV Show | 1986 | Comic Relief | Self - Host | 8 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2001 | The Bernie Mac Show | Self | 1 |
| TV Show | 1976 | Donny & Marie | Self | 1 |
| TV Show | 1977 | The Love Boat | Newton Weems | 1 |
| TV Show | 2015 | Jay Leno's Garage | Self | 1 |
| TV Show | 2009 | Modern Family | Self | 1 |
| TV Show | 2021 | Monsters at Work | Mike (voice) | 20 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 3 |
| TV Show | 2001 | Primetime Glick | | 1 |
| TV Show | 1994 | Inside the Actors Studio | Self | 1 |
| TV Show | 2005 | Costas Now | Self | 1 |
| TV Show | 2007 | The Graham Norton Show | Self | 1 |
| TV Show | 2009 | Studio 42 with Bob Costas | Self | 1 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 4 |
| TV Show | 1994 | Baseball | Self | 3 |
| TV Show | 1953 | The Oscars | Self - Presenter | 1 |
| TV Show | 1994 | The Critic | Gary Grossman (voice) | 1 |
| TV Show | 1962 | The Merv Griffin Show | Self | 1 |
| TV Show | 1959 | The Grammys | Self | 1 |
| TV Show | 2011 | Web Therapy | Garreth Pink | 3 |
