| Movie | 2003 | Britney Spears: In the Zone | Self (archive footage) | |
| Movie | 2006 | Why I Wore Lipstick to My Mastectomy | Moneisha | |
| Movie | 1984 | A Soldier's Story | Big Mary | |
| Movie | 2006 | Idlewild | The Real Angel Davenport | |
| Movie | 1985 | Live Aid | Self | |
| Movie | 1989 | Sing | Mrs. DeVere | |
| Movie | 2004 | Celia Cruz | ¡Azúcar! | Self | |
| Movie | 2010 | Sesame Street: 40 Years of Sunny Days | Self (uncredited) (archive footage) | |
| Movie | 1990 | Fire and Rain | Lucille Jacobson | |
| Movie | 2022 | Soul of a Nation Presents: Sound of Freedom – A Juneteenth Celebration | Self | |
| Movie | 1986 | Unnatural Causes | Jeanette Thompson | |
| Movie | 1986 | Sisters In The Name of Love | Self | |
| Movie | 1977 | Rolling Stone Magazine: The 10th Anniversary | Self - Performer | |
| Movie | N/A | Patti Labelle | Live In New York | Self | |
| Movie | 1990 | Night of 100 Stars III | Self | |
| Movie | 1998 | Patti Labelle | Live One Night Only | Self | |
| Movie | 2024 | The World According to Allee Willis | Self | |
| Movie | 2022 | A New Orleans Noel | Loretta Brown | |
| Movie | 2001 | Santa, Baby! | Melody Songbird (voice) | |
| Movie | 2023 | The Philly Sound... Heard 'Round the World | Self | |
| Movie | 1995 | Sinatra: 80 Years My Way | Self - Performer | |
| Movie | 1986 | Patti Labelle | Look To The Rainbow Tour | Self | |
| Movie | N/A | Denyce Graves | Breaking the Rules | Self | |
| Movie | 1985 | Night of 100 Stars II | Self | |
| Movie | 2002 | Sylvester: Mighty Real | Self | |
| Movie | 1990 | Parker Kane | Cartier | |
| Movie | 1993 | For Our Children | Self | |
| Movie | 1990 | The Real Story of Itsy Bitsy Spider | Miss Widow (voice) | |
| Movie | 2016 | A Tale of James Brown | Self | |
| Movie | 2011 | Mama, I Want to Sing! | Sister Carrie | |
| Movie | 2005 | Preaching to the Choir | Sister Jasmine | |
| Movie | 1997 | Happy Birthday Elizabeth: A Celebration of Life | Self | |
| Movie | 2004 | VH1 Divas 2004 | Self | |
| Movie | 2016 | VH1 Divas Holiday: Unsilent Night | Self | |
| Movie | 2005 | Life O' The Party: On the Road with Prince and the New Power Generation | Self | |
| Movie | 2006 | The Who: Tommy Live With Special Guests | Self | |
| Movie | 2007 | Cover | Mrs. Persons | |
| Movie | 2008 | Semi-Pro | Jackie's Mom | |
| Movie | 2013 | Six by Sondheim | Self (archive footage) | |
| Movie | 2018 | Christmas Everlasting | Mrs. Swinson | |
| Movie | 2016 | National Museum of African American History and Culture Grand Opening Ceremony | Self | |
| Movie | 1982 | Working | Cleaning Woman | |
| Movie | 2019 | The Apollo | Self | |
| Movie | 1990 | Sing! Sesame Street Remembers Joe Raposo and His Music | Self | |
| Movie | 2023 | National Memorial Day Concert | Self | |
| Movie | 1988 | Sesame Street: Put Down the Duckie | Self | |
| Movie | 2019 | A Family Christmas Gift | Dora | |
| Movie | 2019 | Sesame Street's 50th Anniversary Celebration | Self | |
| Movie | 2019 | Live in Front of a Studio Audience: "All in the Family" and "Good Times" | Self - Performer | |
| Movie | 2005 | Live Aid: 20 Years Ago Today | Self | |
| Movie | 1994 | Fertile La Toyah Video Magazine #2: The Kinky Issue! | | |
| Movie | 2004 | Live Aid | Self | |
| Movie | 1999 | Goodnight Moon & Other Sleepytime Tales | Self | |
| Movie | 2018 | Mr. SOUL! | Self (archive footage) | |
| Movie | 1989 | The Who | Live, Featuring the Rock Opera Tommy | The Acid Queen | |
| Movie | 1985 | Musical Comedy Tonight III | | |
| Movie | 2005 | The Who | Tommy and Quadrophenia Live | The Acid Queen | |
| Movie | 2002 | The Making and Meaning of 'We Are Family' | Self | |
| Movie | 1994 | Sesame Street | All-Star 25th Birthday: Stars and Street Forever! | Self (archive footage) | |
| Movie | 1985 | All-Star Rock 'N' Wrestling Saturday Spectacular | Self | |
| Movie | 2023 | Let the Canary Sing | Self | |
| Movie | 2024 | The Simpsons: O C'mon All Ye Faithful | Patti LaBelle (voice) | |
| Movie | 1987 | Happy 100th Birthday, Hollywood | Self | |
| Movie | 2001 | Michael McDonald: A Gathering of Friends | Self | |
| Movie | 1995 | Some Enchanted Evening: Celebrating Oscar Hammerstein II | Self | |
| Movie | 2004 | Sesame Street: What's the Name of That Song? | Self | |
| TV Show | 1987 | A Different World | Adele Wayne | 8 |
| TV Show | 1996 | The Rosie O'Donnell Show | Self - Guest | 1 |
| TV Show | 2003 | All of Us | | 1 |
| TV Show | 1952 | Today | Self | 1 |
| TV Show | 1993 | The Nanny | Patti LaBelle | 1 |
| TV Show | 1999 | The Early Show | Self | 1 |
| TV Show | 2019 | Tamron Hall | Self - Guest | 2 |
| TV Show | 1980 | Solid Gold | Self | 1 |
| TV Show | 2005 | Hi-Jinks | | 1 |
| TV Show | 2020 | VERZUZ | Self | 1 |
| TV Show | 1973 | Rock Concert | Self | 1 |
| TV Show | 1992 | Out All Night | Chelsea Paige | 20 |
| TV Show | 1993 | Intimate Portrait | Self | 2 |
| TV Show | 2007 | Clash of the Choirs | Self | 4 |
| TV Show | 2010 | The Marriage Ref | Self - Panelist | 1 |
| TV Show | 2021 | That's My Jam | Self - Guest | 1 |
| TV Show | 2019 | The Masked Singer | Flower (archive footage) | 1 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 1972 | The Midnight Special | Self | 1 |
| TV Show | 2006 | Celebrity Cooking Showdown | Self | 5 |
| TV Show | 2005 | Dancing with the Stars | Self - Contestant | 6 |
| TV Show | 1998 | VH1 Divas | | 1 |
| TV Show | 1989 | The Arsenio Hall Show | | 1 |
| TV Show | 2011 | American Horror Story | Dora Ross | 4 |
| TV Show | 2016 | Martha & Snoop's Potluck Dinner Party | Self | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2022 | Sherri | Self - Guest | 2 |
| TV Show | 2016 | Greenleaf | Maxine Patterson | 6 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 11 |
| TV Show | 1961 | The Mike Douglas Show | Self | 1 |
| TV Show | 2001 | Good Day Live | Self | 1 |
| TV Show | 2019 | A Black Lady Sketch Show | Patti LaBelle | 1 |
| TV Show | 2021 | The Wonder Years | Mother Williams | 2 |
| TV Show | 2019 | The Masked Singer | Flower | 1 |
| TV Show | 2018 | The Neighborhood | Marilyn | 1 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 1998 | VH1 Divas | Self -Performer | 1 |
| TV Show | 2018 | The Kominsky Method | Self | 1 |
| TV Show | 2016 | Star | Christine Brown | 5 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 1 |
| TV Show | 2016 | To Tell the Truth | Self - Panelist | 1 |
| TV Show | 1971 | Great Performances | Self | 2 |
| TV Show | 2013 | Beat Bobby Flay | Self | 1 |
| TV Show | 2020 | Bottomless Brunch at Colman's | Self | 1 |
| TV Show | 1998 | Hollywood Squares | Self | 5 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 2 |
| TV Show | 2001 | BET Awards | Self - Performer | 1 |
| TV Show | 1959 | The Grammys | Self | 1 |
| TV Show | 2025 | KPOPPED | Self | 1 |
| TV Show | 2004 | Dog Whisperer | Self - Owner of Nasir | 1 |
| TV Show | 2004 | Dog Whisperer | Self | 1 |
| TV Show | 2015 | Celebrity Family Feud | Self - Contestant | 1 |
| TV Show | 2018 | American Idol | Self - Performer | 1 |
