| Movie | 2004 | Spider-Man 2 | Mr. Jacks | |
| Movie | 2020 | Community Table Read | Jeff Winger | |
| Movie | 2009 | The Informant! | Robert Herndon | |
| Movie | 2025 | California King | Zane | |
| Movie | 2018 | We Brought Back MST3K | Self | |
| Movie | 2008 | Open Season 2 | Elliot (Voice) | |
| Movie | 2011 | What's Your Number? | Roger the Boss | |
| Movie | 2023 | It's a Wonderful Knife | David Carruthers | |
| Movie | 2012 | Ted | Rex | |
| Movie | 2011 | The Big Year | Barry Loomis | |
| Movie | 2011 | Spy Kids: All the Time in the World | Wilbur Wilson | |
| Movie | 2022 | I Am Phenomenal | Bill Winger | |
| Movie | 2023 | Office Race | Spencer | |
| Movie | 2023 | Attack of the Doc! | Self | |
| Movie | 2014 | Deliver Us from Evil | Butler | |
| Movie | 2014 | Blended | Mark | |
| Movie | 2024 | Parachute | Jamie Collins | |
| Movie | 2014 | A Merry Friggin' Christmas | Boyd Mitchler | |
| Movie | 2014 | Adult Beginners | Hudson | |
| Movie | N/A | Untitled Community Movie | Jeff Winger | |
| Movie | 2023 | Mortal Kombat Legends: Cage Match | Johnny Cage (voice) | |
| Movie | 2006 | Mini's First Time | Host | |
| Movie | 2019 | Dark Harbor | Greg | |
| Movie | 2023 | The Seven Faces of Jane | Michael | |
| Movie | 2024 | Better Off | Self | |
| Movie | 2013 | The Mighty T | Narrator | |
| Movie | 2025 | Tim Travers & the Time Travelers Paradox | James Bunratty | |
| Movie | 2018 | A Futile and Stupid Gesture | Chevy Chase | |
| Movie | 2016 | The Human Face of Big Data | Narrator | |
| Movie | 2024 | The Dawgfather: The Legend of Don James | Narrator (voice) | |
| Movie | 2018 | Assassination Nation | Nick Mathers | |
| Movie | 2018 | Stuck | Judge Lepetri | |
| Movie | 2018 | The Happytime Murders | Agent Campbell | |
| Movie | 2018 | Game Over, Man! | Joel McHale | |
| Movie | 2015 | Brooks McBeth: This Ain't Shakespeare | Himself - Special Guest | |
| Movie | 2019 | Trouble | Norbert (voice) | |
| Movie | 2019 | Joel McHale: Live from Pyongyang | Self | |
| Movie | 2020 | Psych 2: Lassie Come Home | Lassiter's Father | |
| Movie | 2020 | Mortal Kombat Legends: Scorpion's Revenge | Johnny Cage (voice) | |
| Movie | 2020 | Becky | Jeff | |
| Movie | 2021 | Happily | Tom | |
| Movie | 2014 | Harmontown | Self | |
| Movie | 2008 | The Onion Movie | Office Worker | |
| Movie | 2021 | Queenpins | Rick | |
| Movie | 2020 | All in Washington: A Concert for COVID-19 Relief | Self | |
| Movie | 2021 | Roll Up Your Sleeves | Self | |
| Movie | 2021 | Mortal Kombat Legends: Battle of the Realms | Johnny Cage (voice) | |
| Movie | 2005 | Lords of Dogtown | TV Reporter | |
| Movie | 2023 | JEREMY | Self | |
| Movie | 2024 | The Real Full Monty | Self (uncredited) | |
| Movie | 2026 | Scream 7 | Mark Evans | |
| Movie | 2022 | Celebrating Betty White: America's Golden Girl | Self | |
| Movie | 2014 | Advanced Television Production - 5 Days, 2 Scripts, No Sleep | Self | |
| Movie | 2016 | Six Seasons and a Finale | Self | |
| Movie | N/A | Reimagined | Hamilton Lydell | |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2002 | CSI: Miami | Greg Welch | 1 |
| TV Show | 1997 | The View | Self | 3 |
| TV Show | 2003 | Last Comic Standing | Himself | 1 |
| TV Show | 2020 | Medical Police | Joel McHale | 1 |
| TV Show | 2003 | Oliver Beene | | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 3 |
| TV Show | 1984 | Almost Live! | Self / Various | 286 |
| TV Show | 2007 | Pushing Daisies | Harold Hundin | 1 |
| TV Show | 1998 | Will & Grace | Ian | 1 |
| TV Show | 2021 | Fast Foodies | Self | 1 |
| TV Show | 2000 | The Huntress | Quicky the Clown | 1 |
| TV Show | 2021 | Crime Scene Kitchen | Self - Host | 29 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 2009 | Community | Jeff Winger | 110 |
| TV Show | 2017 | Will & Grace | Phil | 2 |
| TV Show | 2010 | The Marriage Ref | Self - Panelist | 1 |
| TV Show | 2009 | The Tonight Show with Conan O'Brien | Self | 1 |
| TV Show | 2003 | E!'s 101 | Self | 65 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self | 1 |
| TV Show | 2007 | The IT Crowd | Roy | 1 |
| TV Show | 2009 | Web Soup | Himself | 1 |
| TV Show | 1993 | Diagnosis: Murder | Richard | 1 |
| TV Show | 2004 | The Soup | Self - Host | 625 |
| TV Show | 2019 | Straight Up Steve Austin | Self | 1 |
| TV Show | 2011 | Billy on the Street | Self | 1 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 1 |
| TV Show | 2005 | Iron Chef America | Himself | 2 |
| TV Show | 2015 | Dr. Ken | Ross | 1 |
| TV Show | 2020 | Josh Gates Tonight | Self | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 2 |
| TV Show | 2023 | Celebrity Prank Wars | Self | 1 |
| TV Show | 2016 | The Great Indoors | Ashley Jack Gordon | 22 |
| TV Show | 2015 | The Late Late Show with James Corden | Self | 2 |
| TV Show | 2016 | Join or Die with Craig Ferguson | Self | 1 |
| TV Show | 2020 | I Can See Your Voice | | 4 |
| TV Show | 2022 | Is It Cake? | Self - Judge | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 1 |
| TV Show | 2017 | Mystery Science Theater 3000 | Doug McClure | 1 |
| TV Show | 2023 | House of Villains | Self - Host | 21 |
| TV Show | 2023 | Krapopolis | Games Commentator (voice) | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 2 |
| TV Show | 2017 | The Gong Show | Self - Judge | 1 |
| TV Show | 2017 | The F Word | Self | 2 |
| TV Show | 2018 | The Joel McHale Show with Joel McHale | Self - Host | 19 |
| TV Show | 2012 | Randy Cunningham: 9th Grade Ninja | First Ninja (voice) | 4 |
| TV Show | 2019 | Love, Death & Robots | Sergeant Morris (voice) | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 4 |
| TV Show | 2015 | Lip Sync Battle | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 5 |
| TV Show | 2016 | Match Game | Self - Panelist | 9 |
| TV Show | 2022 | The Bear | David Fields | 6 |
| TV Show | 2019 | The Masked Singer | Self - Guest Panelist | 10 |
| TV Show | 2020 | I Can See Your Voice | Self - Guest Host | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 2 |
| TV Show | 2013 | Rick and Morty | Hemorrhage (voice) | 1 |
| TV Show | 2017 | Santa Clarita Diet | Chris | 2 |
| TV Show | 2020 | DC's Stargirl | Sylvester Pemberton / Starman | 7 |
| TV Show | 2022 | Celebrity Beef | Self - Host | 8 |
| TV Show | 2017 | Ryan Hansen Solves Crimes on Television | Joel McHale | 1 |
| TV Show | 2018 | The Rookie | Brad Hayes | 1 |
| TV Show | 2010 | Regular Show | DVD (voice) | 1 |
| TV Show | 2008 | Water And Power | Joel McHale | 1 |
| TV Show | 2020 | DC's Stargirl | Sylvester Pemberton | 13 |
| TV Show | 2009 | RuPaul's Drag Race | Self - Guest Judge | 1 |
| TV Show | 2016 | To Tell the Truth | Self - Panelist | 12 |
| TV Show | 2016 | Milo Murphy's Law | Victor (voice) | 1 |
| TV Show | 2019 | Card Sharks | Self - Host | 21 |
| TV Show | 2023 | Animal Control | Frank Shaw | 31 |
| TV Show | 2019 | What Just Happened??! with Fred Savage | | 1 |
| TV Show | 2019 | Lights Out with David Spade | Self - Panelist | 1 |
| TV Show | 2014 | BoJack Horseman | Alex (voice) | 1 |
| TV Show | 2016 | The $100,000 Pyramid | Self | 3 |
| TV Show | 2008 | Sons of Anarchy | Warren | 2 |
| TV Show | 2014 | black-ish | Joel McHale | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 1 |
| TV Show | 2020 | Dummy | Agent Jason | 1 |
| TV Show | 1993 | The X-Files | Tad O'Malley | 3 |
| TV Show | 2022 | Password | Self - Celebrity Guest | 2 |
| TV Show | 2024 | Dinner Time Live with David Chang | Self | 1 |
| TV Show | 2020 | Tiger King | Self - Host | 1 |
| TV Show | 2019 | The Twilight Zone | | 1 |
| TV Show | 2017 | Dimension 404 | Mr. Maker | 1 |
| TV Show | 2007 | Thank God You're Here | Self | 1 |
| TV Show | 2021 | Celebrity Wheel of Fortune | Self - Contestant | 1 |
| TV Show | 2014 | Running Wild with Bear Grylls | Self | 1 |
| TV Show | 2010 | Conan | Self | 7 |
| TV Show | 1989 | The Simpsons | Joel McHale (voice) | 1 |
| TV Show | 2020 | Who Wants to Be a Millionaire | Self - Contestant | 3 |
| TV Show | 2020 | The Cabin with Bert Kreischer | Self | 1 |
| TV Show | 2016 | American Housewife | Doyle Bradford | 1 |
| TV Show | 2023 | Dr Phil LIVE! | Self | 1 |
| TV Show | 2021 | Yellowjackets | Kody | 3 |
| TV Show | 2015 | Difficult People | Felix | 1 |
| TV Show | 2018 | What the Fit | Self | 1 |
| TV Show | 2025 | The 1% Club | Self - Host | 10 |
| TV Show | 2024 | Grave Conversations | Self | 1 |
