| Movie | 1998 | There's Something About Mary | Brenda | |
| Movie | 2000 | The Way of the Gun | Raving Bitch | |
| Movie | 2005 | Rent | Alexi Darling | |
| Movie | 2001 | Heartbreakers | Linda | |
| Movie | 2001 | Say It Isn't So | Gina | |
| Movie | 2001 | The N.Y. Friars Club Roast of Hugh Hefner | Self | |
| Movie | 2006 | The Secret Policeman's Ball: The Ball in the Hall | Self | |
| Movie | 1998 | Bulworth | 2nd American Politics Assistant | |
| Movie | 2010 | Saint John of Las Vegas | Jill | |
| Movie | 2006 | I Want Someone to Eat Cheese With | Beth | |
| Movie | 2001 | Evolution | Denise | |
| Movie | 2006 | School for Scoundrels | Becky | |
| Movie | 2010 | I Am Comic | Self | |
| Movie | 2007 | Super High Me | Self | |
| Movie | 2005 | The Aristocrats | Self | |
| Movie | 2005 | Sarah Silverman: Jesus Is Magic | Self | |
| Movie | 2021 | The Super Bob Einstein Movie | Self | |
| Movie | 2011 | The Muppets | Greeter | |
| Movie | 2021 | Don't Look Up | Sarah Benterman | |
| Movie | 2007 | Certifiably Jonathan | Self | |
| Movie | 2000 | Screwed | Hillary | |
| Movie | 1998 | Overnight Delivery | Turran | |
| Movie | 2023 | Sarah Silverman: Someone You Love | Self | |
| Movie | 2012 | Wreck-It Ralph | Vanellope von Schweetz (voice) | |
| Movie | 2004 | Stories of Lost Souls | Herself | |
| Movie | 2010 | Peep World | Cheri | |
| Movie | 1997 | Who's the Caboose? | Susan | |
| Movie | 2011 | Take This Waltz | Geraldine | |
| Movie | 2014 | The Unbelievably Sweet Alpacas | Happy | |
| Movie | 2000 | What Planet Are You From? | Woman on plane | |
| Movie | 2012 | The Bitter Buddha | Self | |
| Movie | 2014 | A Million Ways to Die in the West | Ruth | |
| Movie | 2013 | Sarah Silverman: We Are Miracles | Self | |
| Movie | 2022 | The Bob's Burgers Movie | Ollie Pesto (voice) | |
| Movie | 2014 | Harmontown | Self | |
| Movie | 2007 | Mr. Warmth: The Don Rickles Project | Self | |
| Movie | 2009 | Funny People | Sarah Silverman | |
| Movie | 2023 | Albert Brooks: Defending My Life | Self | |
| Movie | 2023 | Once Upon a Studio | Vanellope (voice) (archive sound) | |
| Movie | 2015 | Gravy | Bethany | |
| Movie | 2007 | The Comedians of Comedy: Live at The Troubadour | Self | |
| Movie | 2012 | The Secret Policeman's Ball | Self | |
| Movie | 2002 | Saddle Rash | Hanna Headstrong (voice) | |
| Movie | 2023 | No One Asked You | Self | |
| Movie | 2004 | The Friday the 13th Chronicles | Self | |
| Movie | 2023 | Maestro | Shirley Bernstein | |
| Movie | 2005 | Comedy Central Roast of Pamela Anderson | Self | |
| Movie | 2003 | Supermarket | Self | |
| Movie | 2014 | Rubberhead | Self | |
| Movie | 2013 | Comedy Central Roast of James Franco | Self | |
| Movie | 2004 | Hair High | Cherri (voice) | |
| Movie | 2002 | Run Ronnie Run | Network Executive #3 | |
| Movie | 2015 | I Smile Back | Laney Brooks | |
| Movie | 2008 | Largo | Self | |
| Movie | 2014 | Women Aren't Funny | Self | |
| Movie | 2017 | Punching Henry | Sharon Levine | |
| Movie | 2022 | Prophets of Change | Narrator | |
| Movie | 2015 | Ashby | June Wallis | |
| Movie | 2014 | Cops, Cum, Dicks, and Flying | Lieutenant Silverman | |
| Movie | 2008 | Comedy Central Roast of Bob Saget | Self | |
| Movie | 2022 | Menorah in the Middle | Rachel Baum | |
| Movie | 2016 | Popstar: Never Stop Never Stopping | Paula Klein | |
| Movie | 2022 | David Baddiel: Jews Don't Count | Self | |
| Movie | 2013 | The Unbelievers | Self | |
| Movie | 2015 | Tig | Self | |
| Movie | 1999 | The Bachelor | Carolyn | |
| Movie | 2017 | Dying Laughing | Self | |
| Movie | 2017 | The Book of Henry | Sheila | |
| Movie | 2016 | The Last Laugh | Self | |
| Movie | 2017 | Battle of the Sexes | Gladys Heldman | |
| Movie | 2016 | You Can Never Really Know Someone | Gretchen | |
| Movie | 2016 | 50 Years of Star Trek | Self | |
| Movie | N/A | Tangles | | |
| Movie | 2017 | Michael Bolton's Big, Sexy Valentine's Day Special | Misty | |
| Movie | 2017 | Sarah Silverman: A Speck of Dust | Self | |
| Movie | 2017 | Night of Too Many Stars: America Unites for Autism Programs | Self | |
| Movie | 2018 | Mister Rogers: It's You I Like | Self | |
| Movie | 2018 | Seth Rogen's Hilarity for Charity | Self | |
| Movie | 2003 | School of Rock | Patty Di Marco | |
| Movie | 1990 | Caesar's Salad | Woman with Poet | |
| Movie | 2007 | Futurama: Bender's Big Score | Michelle (voice) | |
| Movie | 2008 | A Bad Situationist | Jamy Shonelike | |
| Movie | 2011 | Strange Powers: Stephin Merritt and the Magnetic Fields | Self | |
| Movie | 2018 | Ralph Breaks the Internet | Vanellope von Schweetz (voice) | |
| Movie | 1998 | Saturday Night Live: A Tribute to Chris Farley | Self | |
| Movie | 2022 | Marry Me | Parker Debbs | |
| Movie | 2018 | Origin Story | Self | |
| Movie | 2019 | Tiny Changes | Self | |
| Movie | 2019 | Laughing Matters | Self | |
| Movie | 2020 | Have a Good Trip: Adventures in Psychedelics | Self | |
| Movie | 2009 | Funny People: Live | Self | |
| Movie | 2020 | This Is Stand-Up | Self | |
| Movie | 2020 | Feeding America Comedy Festival | Self | |
| Movie | 2011 | Give It Up for Greg Giraldo | Self | |
| Movie | 2013 | Sarah Silverman's Perfect Night | Self | |
| Movie | 2013 | Fête des Pets | | |
| Movie | 2020 | In Search of the Sanderson Sisters: A Hocus Pocus Hulaween Takeover | Sarah Silverman | |
| Movie | 2007 | Fired! | Self | |
| Movie | 2020 | Yearly Departed | Self | |
| Movie | 1999 | Late Last Night | Jen | |
| Movie | 2005 | Last Laugh '05 | Self | |
| Movie | 2015 | $aving Dat Money | Sarah Silverman | |
| Movie | 2005 | Zach Galifianakis: Look Who it Isn't | Self | |
| Movie | N/A | Viral | | |
| Movie | 2021 | Space Jam: A New Legacy | Warner Bros. Executive | |
| Movie | 2020 | Mentally Al | | |
| Movie | 2020 | Bernie Blackout | Self | |
| Movie | 2025 | Sarah Silverman: PostMortem | Self | |
| Movie | N/A | Tardy Delivery | herself | |
| Movie | 2025 | From Darkness to Light | Self (archive footage) | |
| Movie | 2016 | Hero With A Thousand Faces | Self | |
| Movie | 2007 | Saturday Night Live in the '90s: Pop Culture Nation | Self | |
| Movie | 2003 | Bad Santa | Santa Instructor (uncredited) | |
| TV Show | 2002 | Greg the Bunny | Alison Kaiser | 33 |
| TV Show | 1989 | The Simpsons | Rachel, Lisa's Imaginary Friend (voice) | 1 |
| TV Show | 2007 | The Sarah Silverman Program. | Sarah Silverman | 32 |
| TV Show | 1989 | Seinfeld | Emily | 1 |
| TV Show | 1995 | Mr. Show with Bob and David | Various | 20 |
| TV Show | 2005 | American Dad! | Stripper (voice) | 1 |
| TV Show | 2002 | Tough Crowd with Colin Quinn | | 57 |
| TV Show | 1995 | Star Trek: Voyager | Rain Robinson | 2 |
| TV Show | 2002 | Monk | Marci Maven | 3 |
| TV Show | 2002 | Crank Yankers | | 68 |
| TV Show | 1998 | V.I.P. | Lucy Stanton | 1 |
| TV Show | 2004 | Tom Goes to the Mayor | Barb Dunderbarn (voice) | 1 |
| TV Show | 2016 | Full Frontal with Samantha Bee | Self | 1 |
| TV Show | 2012 | Inside Comedy | Self | 1 |
| TV Show | 2005 | Too Late with Adam Carolla | | 1 |
| TV Show | 2012 | Finding Your Roots | Self | 1 |
| TV Show | 1995 | JAG | Tina Schiparelli | 1 |
| TV Show | 1995 | Brotherly Love | Rosa | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 3 |
| TV Show | 2002 | Saddle Rash | | 1 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 2004 | Pilot Season | Susan Underman | 6 |
| TV Show | 2010 | The Marriage Ref | Self - Panelist | 1 |
| TV Show | 2015 | Man Seeking Woman | Josh's Right Hand (voice) | 1 |
| TV Show | 2011 | Bob's Burgers | Ollie (voice) | 67 |
| TV Show | 2004 | Drawn Together | Bleh (voice) | 1 |
| TV Show | 1992 | The Larry Sanders Show | Wendy Traston | 2 |
| TV Show | 2013 | Norm Macdonald Live | Self | 2 |
| TV Show | 1992 | The Larry Sanders Show | Sarah Silverman | 1 |
| TV Show | 1989 | The Simpsons | Sarah Silverman (voice) | 1 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 1 |
| TV Show | 1998 | Hollywood Squares | Self - Panelist | 2 |
| TV Show | 2008 | Childrens Hospital | Britches | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 8 |
| TV Show | 2016 | Lady Dynamite | Sarah Silverman | 20 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2016 | Chelsea | Self | 2 |
| TV Show | 1993 | Frasier | Jane | 1 |
| TV Show | 2021 | The Center Seat: 55 Years of Star Trek | Self | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 3 |
| TV Show | 2018 | The Zen Diaries of Garry Shandling | Self | 2 |
| TV Show | 2011 | Bob's Burgers | Lead Singer (voice) | 1 |
| TV Show | 2017 | The History of Comedy | Self | 14 |
| TV Show | 2011 | Bob's Burgers | Ms. Schnur (voice) | 5 |
| TV Show | 2011 | Bob's Burgers | Ollie (voice) / Carly (voice) / Meredith (voice) | 1 |
| TV Show | 1992 | MTV Movie & TV Awards | Self - Host | 1 |
| TV Show | 2017 | I Love You, America | Self - Host | 21 |
| TV Show | 2020 | Home Movie: The Princess Bride | The Grandfather | 1 |
| TV Show | 2005 | The Most Extraordinary Space Investigations | Jelly Roll | 5 |
| TV Show | 1999 | WWE SmackDown | Self | 1 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 6 |
| TV Show | 2024 | Stupid Pet Tricks | Self - Host | 10 |
| TV Show | 2013 | Masters of Sex | Helen Schiff | 7 |
| TV Show | 2003 | Celebrity Poker Showdown | Self | 1 |
| TV Show | 2017 | The Jim Jefferies Show | Self | 1 |
| TV Show | 2017 | The Jim Jefferies Show | T5 Trailer Actor | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 4 |
| TV Show | 2012 | Comedians in Cars Getting Coffee | Self | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2009 | The League | Heather | 1 |
| TV Show | 2016 | Bajillion Dollar Propertie$ | Zars St. Lars | 1 |
| TV Show | 2005 | Channel 101: The Musical | Herself | 2 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 20 |
| TV Show | 2016 | Great Minds with Dan Harmon | Betsy Ross | 1 |
| TV Show | 2024 | Dinner Time Live with David Chang | Self | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 9 |
| TV Show | 2007 | The Graham Norton Show | Self | 1 |
| TV Show | 2024 | John Mulaney Presents: Everybody's in L.A. | Self | 1 |
| TV Show | 2003 | Comedy Central Roasts | Self | 4 |
| TV Show | 2005 | 8 Out of 10 Cats | Self | 1 |
| TV Show | 1999 | Futurama | Michelle (voice) | 2 |
| TV Show | 1996 | The Daily Show | Self - Guest Host | 8 |
| TV Show | 2008 | Match Game | Panelist | 1 |
| TV Show | 2014 | Off Camera with Sam Jones | Self | 1 |
| TV Show | 2023 | History of the World: Part II | Lieutenantman Silverman | 1 |
| TV Show | 2021 | Santa Inc. | Candy Smalls (voice) | 8 |
| TV Show | 1995 | The Naked Truth | Ali Walters | 1 |
| TV Show | 1993 | Droopy, Master Detective | Melody WOOO-WOOO Stardust (voice) | 1 |
| TV Show | 1989 | The Simpsons | Nikki McKenna (voice) | 1 |
| TV Show | 2010 | Conan | Self | 4 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self | 1 |
| TV Show | 2009 | The Good Wife | Stephanie Engler | 1 |
| TV Show | 2024 | The Charlie Puth Show | Sarah Silverman | 1 |
| TV Show | 1995 | Dr. Katz, Professional Therapist | Sarah (voice) | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 2 |
| TV Show | 2025 | Everybody's Live with John Mulaney | Self - Comedian | 1 |
| TV Show | 2023 | Off Script with The Hollywood Reporter | Self | 1 |
| TV Show | 1959 | The Grammys | Self | 1 |
| TV Show | 2004 | Entourage | Sarah Silverman | 1 |
| TV Show | 2020 | Who Wants to Be a Millionaire | Self - Contestant | 1 |
| TV Show | 1999 | Mark Twain Prize | Self | 1 |
| TV Show | 2011 | Bob's Burgers | OIlie (voice) | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 1 |
| TV Show | 2000 | Aqua Teen Hunger Force | Robositter (voice) | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 1 |