| Movie | 2022 | No Place Like Home | Narrator | |
| Movie | 2010 | Marijuana: A Chronic History | Herself | |
| Movie | 1994 | Teresa's Tattoo | Hooker | |
| Movie | 2020 | Together in Pride: You Are Not Alone | Self | |
| Movie | 2002 | Melissa Etheridge Live... and Alone | Singer | |
| Movie | 2023 | Dolly Parton - From Rhinestones to Rock & Roll | Self | |
| Movie | 2003 | Totally Gay! | Self | |
| Movie | 2009 | Bruce Springsteen - 32nd Annual of Kennedy Center Honors | Self | |
| Movie | 1987 | Scenes from the Goldmine | Shop Clerk | |
| Movie | 2024 | Runaway Radio | Self | |
| Movie | 2022 | 2022 Rock & Roll Hall of Fame Induction Ceremony | Self | |
| Movie | 2015 | Melissa Etheridge - A Little Bit Of Me - Live In L.A. | Herself | |
| Movie | 1993 | For Our Children | Self | |
| Movie | 2024 | Live from Detroit: The Concert at Michigan Central | Self | |
| Movie | 2000 | Arista Records' 25th Anniversary Celebration | Self | |
| Movie | 2009 | VH1 Divas 2009 | Self | |
| Movie | 1999 | After Stonewall | Narrator (voice) | |
| Movie | 2017 | The Legend of 420 | Herself | |
| Movie | 2016 | Bryan Adams - Wembley Live 1996 | Self | |
| Movie | 2004 | Melissa Etheridge - Lucky Live | | |
| Movie | 2001 | The Concert for New York City | Self | |
| Movie | 1999 | The Sissy Duckling | Mama Duck (voice) | |
| Movie | 2021 | Ahead of the Curve | Self | |
| Movie | 1999 | Jackie's Back! | Melissa Etheridge | |
| Movie | 2024 | LOUDER: The Soundtrack of Change | Self | |
| Movie | 2003 | Late Night with Conan O'Brien: 10th Anniversary Special | Self | |
| Movie | 2001 | Last Party 2000 | Self | |
| Movie | 1993 | Camp Christmas | Self - Hostess | |
| Movie | 2024 | Norman's Rare Guitars Documentary | Self | |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 2005 | The Tyra Banks Show | | 1 |
| TV Show | 2005 | Hogan Knows Best | | 1 |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 2019 | Tamron Hall | Self - Guest | 2 |
| TV Show | 2003 | Anderson Cooper 360° | | 1 |
| TV Show | 1989 | MTV Unplugged | Self | 1 |
| TV Show | 1981 | Wetten, dass..? | Self | 1 |
| TV Show | 1993 | Intimate Portrait | Self | 1 |
| TV Show | 2021 | Turning the Tables with Robin Roberts | Self | 1 |
| TV Show | 1996 | Saturday Night Special | | 1 |
| TV Show | 1999 | Beyond Chance | | 66 |
| TV Show | 2008 | The Bonnie Hunt Show | Self | 1 |
| TV Show | 1956 | Tony Awards | Self - Presenter | 1 |
| TV Show | 2012 | Infinity Hall Live | Herself | 1 |
| TV Show | 1993 | Frasier | Cleo (voice) | 1 |
| TV Show | 2010 | Who Do You Think You Are? | Self | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 2 |
| TV Show | 2010 | America: The Story of Us | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 7 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 2002 | CMT Crossroads | Self | 1 |
| TV Show | 2024 | Melissa Etheridge: I'm Not Broken | Self | 2 |
| TV Show | 1997 | King of the Hill | Topaz / Singing Hippie (voice) | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self | 2 |
| TV Show | 1974 | 3 nach 9 | Self | 1 |
| TV Show | 1994 | NeXt | Self | 1 |
| TV Show | N/A | Live Earth: A Concert for a Climate in Crisis | Self | 12 |
| TV Show | 2002 | Sucré salé | Self | 1 |
| TV Show | 2021 | Hacks | Melissa Etheridge | 1 |
| TV Show | 1974 | American Music Awards | Self - Musical Guest | 1 |
