| Movie | 2021 | The History of Metal and Horror | Self | |
| Movie | 2004 | Metallica: Some Kind of Monster | Self | |
| Movie | 2007 | Megadeth: That One Night - Live in Buenos Aires | Lead Vocals/Guitar | |
| Movie | 2006 | Megadeth: Arsenal Of Megadeth | Vocal, guitar | |
| Movie | 2008 | Megadeth: Blood in the Water - Live in San Diego | Vocals, Guitars | |
| Movie | 2010 | The Big Four: Live in Sofia | Vocals, guitars | |
| Movie | 1988 | The Decline of Western Civilization Part II: The Metal Years | Self | |
| Movie | 1987 | Metallica - Cliff 'Em All | Himself | |
| Movie | 2008 | Aural Amphetamine: Metallica and the Dawn of Thrash | Self | |
| Movie | N/A | Megadeth: A Secret Place | | |
| Movie | N/A | Megadeth: Wacken Open Air 2023 | | |
| Movie | 2019 | Murder in the Front Row: The San Francisco Bay Area Thrash Metal Story | Self | |
| Movie | 2017 | Megadeth Bloodstock 2017 | Lead Vocals/Guitar | |
| Movie | N/A | Megadeth - Live at Resurrection Fest EG 2018 | Lead Vocals/Guitar | |
| Movie | 2023 | Megadeth - Live at Wacken Open Air 2023 | Lead Vocals / Guitars | |
| Movie | 1992 | Megadeth - Live at Hammersmith Odeon | Self | |
| Movie | 2023 | Megadeth - They Only Come Out At Night: Live At Budokan 2023 | Self | |
| Movie | N/A | Megadeth - Crush the World: Live at Buenos Aires 2024 (Night 1) | Self | |
| Movie | N/A | Megadeth - Crush the World: Live at Buenos Aires 2024 (Night 2) | Self | |
| Movie | 1991 | Megadeth: Rock in Rio 1991 | Vox, Guitars | |
| Movie | 2012 | Megadeth: [2012] Guitar Center Sessions | Vox, Guitars | |
| Movie | 1990 | Megadeth: [1990] Rust in Detroit | Vox, Guitars | |
| Movie | 2011 | Megadeth: [2011] SWU Festival | Vox, Guitars | |
| Movie | 2024 | Megadeth - Hellfest 2024 | Self | |
| Movie | 2010 | Megadeth - The Big Four - Live from Sofia, Bulgaria | Guitars/Lead Vocals | |
| Movie | 2016 | Megadeth: Hellfest 2016 | Vocals, Guitars | |
| Movie | 1990 | Hard 'N Heavy Volume 7 | Self | |
| Movie | 1998 | Megadeth: Monsters Of Rock 1998 | Vocals, Guitar | |
| Movie | 2017 | Halloween Pussy Trap Kill! Kill! | The Mastermind (voice) | |
| Movie | 2011 | Megadeth: Maquinaria Festival | Guitars/Vocals | |
| Movie | 2006 | Get Thrashed | Self | |
| Movie | 2013 | Megadeth: Countdown to Extinction - Live | Vocals, Guitars | |
| Movie | 2011 | Metallica: The 30th Anniversary Event | Self | |
| Movie | 2010 | Megadeth - Rust in Peace Live | Guitar/Vocals | |
| Movie | 2002 | Megadeth: Rude Awakening | Vocals, Guitars | |
| Movie | 2016 | Graspop Metal Meeting 2016 Compilation | Self | |
| Movie | 1983 | Metallica: [1983] Kiss the Stone | Guitars | |
| Movie | 2006 | Heavy Metal: Louder Than Life | Self | |
| Movie | 2017 | Megadeth: Live at Wacken Open Air 2017 | Vocals, Guitars | |
| Movie | 1990 | Kerrang! Video Kompilation 5 | Himself | |
| Movie | 2019 | Where In The Hell Is The Lavender House: The Longmont Potion Castle Story | Self | |
| Movie | 2020 | Flying V | Self | |
| Movie | 2021 | Woodstock 99: Peace, Love, and Rage | Self | |
| Movie | N/A | This Was My Life: Nick Menza's Metal Memories with Megadeth and Beyond | | |
| TV Show | 2005 | Hell's Kitchen | Self - Restaurant Patron | 1 |
| TV Show | 2003 | Duck Dodgers | Himself (voice) | 2 |
| TV Show | 1997 | Classic Albums | Self - Megadeth | 1 |
| TV Show | 1996 | Never Mind the Buzzcocks | Self | 1 |
| TV Show | 1995 | The Drew Carey Show | Self | 1 |
