| Movie | 1992 | Twin Peaks: Fire Walk with Me | Laura Palmer | |
| Movie | 1997 | David | Batseba | |
| Movie | 1996 | Mother Night | Helga Noth / Resi Noth | |
| Movie | 1994 | Backbeat | Astrid Kirchherr | |
| Movie | 1998 | Vampires | Katrina | |
| Movie | 1995 | Fall Time | Patty / Carol | |
| Movie | 1997 | This World, Then the Fireworks | Lois Archer | |
| Movie | 2010 | Winter's Bone | April | |
| Movie | 1998 | Kiss the Sky | Andy | |
| Movie | 2011 | Texas Killing Fields | Lucie Sliger | |
| Movie | 1992 | Jersey Girl | Tara | |
| Movie | 2005 | Paradise Texas | Betsy Kinney | |
| Movie | 1999 | Angel's Dance | Angelica Chaste | |
| Movie | 1995 | Notes from Underground | Liza | |
| Movie | 1997 | The Blood Oranges | Fiona | |
| Movie | 1994 | Guinevere | Guinevere | |
| Movie | 2006 | The Secrets of Comfort House | Wendy Brown | |
| Movie | 2002 | Children on Their Birthdays | Elinore Murphy | |
| Movie | 2001 | Hitched | Eve Robbins | |
| Movie | 2001 | An Introduction to David Lynch | Self | |
| Movie | 2001 | Reflections on the Phenomenon of Twin Peaks | Self | |
| Movie | 2001 | Postcards From The Cast | Self | |
| Movie | 2007 | Secrets from Another Place: Creating Twin Peaks | | |
| Movie | 2014 | Twin Peaks: The Missing Pieces | Laura Palmer | |
| Movie | 1995 | Homage | Lucy Samuel | |
| Movie | 2014 | Jackie & Ryan | Miriam | |
| Movie | 1995 | Follow The River | Mary Ingles | |
| Movie | 2019 | A Talk with Kyle MacLachlan and Sheryl Lee | Self | |
| Movie | 2025 | I Live Here Now | Martha | |
| Movie | 1997 | Bliss | Maria | |
| Movie | 1994 | Don't Do It | Michelle | |
| Movie | 1990 | Wild at Heart | The Good Witch | |
| Movie | 1998 | Dante's View | Sam Kingsley | |
| Movie | 2016 | Café Society | Karen Stern | |
| Movie | 1994 | Red Shoe Diaries 4: Auto Erotica | Kate Lyons (archive footage) | |
| Movie | 2014 | Moving Through Time: Fire Walk With Me Memories | Herself | |
| Movie | 1989 | Twin Peaks | Laura Palmer / Maddy Ferguson | |
| Movie | 2006 | Working with a Master: John Carpenter | Self | |
| Movie | 2018 | #SquadGoals | Emily Hodges | |
| Movie | 2014 | The Makings of You | Judy | |
| Movie | 2017 | Dead Ink Archive | Alley | |
| Movie | 2014 | Between Two Worlds | Self | |
| Movie | 2016 | Rebirth | Air | |
| Movie | 2025 | I Know Catherine, the Log Lady | Self | |
| Movie | 2021 | Welcome Home: Mary Reber and the Twin Peaks Palmer House | Self | |
| Movie | 2017 | I Had Bad Milk in Dehradun | Self | |
| Movie | 2017 | Behind the Red Curtain | Self | |
| Movie | 2017 | The Man with the Gray Elevated Hair | Self | |
| Movie | 2014 | White Bird in a Blizzard | May | |
| Movie | 2004 | Love, Death, Elvis & Oz: The Making of Wild at Heart | | |
| Movie | 1993 | Mr. Jones | June (uncredited) | |
| TV Show | 2003 | One Tree Hill | Ellie Harp | 9 |
| TV Show | 2004 | House | Stephanie Green | 1 |
| TV Show | 1998 | L.A. Doctors | Sarah Church | 24 |
| TV Show | 2004 | CSI: NY | Ellen Garner | 1 |
| TV Show | 2002 | Without a Trace | Tina Hodges | 1 |
| TV Show | 2007 | Dirty Sexy Money | Andrea Smithson | 11 |
| TV Show | 1993 | Dr. Quinn, Medicine Woman | Catherine / Shivering Deer | 1 |
| TV Show | 2003 | Kingpin | Marlene McDillon Cadena | 6 |
| TV Show | 2006 | Psych | Donna Gooden | 1 |
| TV Show | 2012 | Perception | Lacey Penderhalt | 1 |
| TV Show | 1991 | Love, Lies and Murder | Patti Bailey | 2 |
| TV Show | 1990 | Twin Peaks | Laura Palmer / Maddy Ferguson | 10 |
| TV Show | 2015 | Rosewood | Brenda Downs | 1 |
| TV Show | 1990 | Twin Peaks | Laura Palmer (archive footage) | 1 |
| TV Show | 1990 | Twin Peaks | Laura Palmer / Carrie Page | 1 |
| TV Show | 1990 | Twin Peaks | Maddy Ferguson | 8 |
| TV Show | 1990 | Twin Peaks | Laura Palmer | 3 |
| TV Show | 1992 | Red Shoe Diaries | Kate Lyons | 1 |
| TV Show | 1997 | David | Bathsheba | 2 |
| TV Show | 1997 | Davide | Betsabea | 2 |
