| Movie | 1970 | Catch-22 | Maj. Major Major | |
| Movie | 2003 | Elf | Papa Elf | |
| Movie | 1997 | In & Out | Tom Halliwell | |
| Movie | 1990 | The Rescuers Down Under | Bernard (voice) | |
| Movie | 1977 | The Rescuers | Bernard (voice) | |
| Movie | 1962 | Hell Is for Heroes | Pvt. James E. Driscoll | |
| Movie | 1998 | Rudolph the Red-Nosed Reindeer: The Movie | Leonard (voice) | |
| Movie | 1968 | Hot Millions | Willard C. Gnatpole | |
| Movie | 2012 | Excavating the 2000 Year Old Man | Self | |
| Movie | 2004 | The Librarian: Quest for the Spear | Judson | |
| Movie | 2006 | The Librarian: Return to King Solomon's Mines | Judson | |
| Movie | 2021 | Dean Martin: King of Cool | Self | |
| Movie | 2008 | The Librarian: The Curse of the Judas Chalice | Judson | |
| Movie | 1970 | On a Clear Day You Can See Forever | Dr. Mason Hume | |
| Movie | 1992 | Holiday Greetings from 'The Ed Sullivan Show' | Self - Host | |
| Movie | 1980 | Little Miss Marker | Regret | |
| Movie | 1972 | Don Rickles: Alive And Kicking | Self | |
| Movie | 2007 | Cutting Edge Comedians of the '60s & '70s | Self (archive footage) | |
| Movie | 1999 | Yesterday's Tomorrows | Self | |
| Movie | 1980 | First Family | President Manfred Link | |
| Movie | 1991 | The Bob Newhart Show 19th Anniversary Special | Bob Hartley | |
| Movie | 1974 | Thursday's Game | Marvin Ellison | |
| Movie | 2007 | Mr. Warmth: The Don Rickles Project | Self | |
| Movie | 2023 | Once Upon a Studio | Bernard (voice) (archive sound) | |
| Movie | 1980 | Marathon | Walter Burton | |
| Movie | 2014 | Don Rickles: One Night Only | Self | |
| Movie | 2002 | NBC 75th Anniversary Special | Self | |
| Movie | 2023 | Bob and Don: A Love Story | Self | |
| Movie | 1992 | Bob Newhart: Button-Down Concert | Self | |
| Movie | 1971 | Decisions! Decisions! | John Hobson | |
| Movie | 1983 | All-Star Party for Frank Sinatra | Self | |
| Movie | 2003 | Legally Blonde 2: Red, White & Blonde | Sid Post | |
| Movie | 2001 | The Sports Pages | Doc Waddems | |
| Movie | 1986 | TV's Funniest Comedians - 14 Stars Do Classic Routines | Self | |
| Movie | 1985 | Night of 100 Stars II | Self | |
| Movie | 2002 | Added Attractions: The Hollywood Shorts Story | Self (uncredited) | |
| Movie | 2016 | Must See TV: An All Star Tribute to James Burrows | Self | |
| Movie | 1983 | George Burns Celebrates 80 Years in Show Business | Self | |
| Movie | 2024 | Bob Newhart: A Legacy of Laughter | Self (archive footage) | |
| Movie | 2011 | Five | Dr. Roth | |
| Movie | 1968 | The Dean Martin Christmas Show | Self | |
| Movie | 1966 | Christmas with Crosby & Kate | Himself | |
| Movie | 2013 | Richard Pryor: Omit the Logic | Self | |
| Movie | 1986 | Rickles... On the Loose | Self | |
| Movie | 1965 | Salute to Stan Laurel | Self | |
| Movie | 1992 | Bob Newhart: Off the Record | | |
| Movie | 2011 | Horrible Bosses | Lou Sherman | |
| Movie | 1991 | The Entertainers | Todd Wilson | |
| Movie | 1971 | Cold Turkey | Merwin Wren | |
| Movie | 2005 | Bob Newhart: Unbuttoned | | |
| Movie | 1977 | Disney's Greatest Villains | Bernard (voice) (archive footage) | |
| Movie | 1989 | Oh No, Not Them | Self (uncredited) | |
| Movie | 1976 | Bob Hope's World of Comedy | Self (archive footage) | |
| TV Show | 1989 | The Simpsons | Bob Newhart (voice) | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 2 |
| TV Show | 2004 | Desperate Housewives | Morty Flickman | 3 |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 1981 | This Week | | 1 |
| TV Show | 1972 | The Bob Newhart Show | Robert Hartley | 142 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 2005 | Committed | Blinky | 1 |
| TV Show | 1959 | Playboy's Penthouse | Self | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | Self | 1 |
| TV Show | 2012 | Inside Comedy | Self | 1 |
| TV Show | 1982 | Newhart | Dick Loudon | 184 |
| TV Show | 2020 | The Holiday Movies That Made Us | Self (archive footage) | 1 |
| TV Show | 1982 | Late Night with David Letterman | Self - Guest | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 1 |
| TV Show | 1995 | MADtv | Self - Special Guest | 1 |
| TV Show | 1994 | ER | Ben Hollander | 3 |
| TV Show | 2010 | Conan | Self | 1 |
| TV Show | 2005 | Sit Down Comedy with David Steinberg | | 1 |
| TV Show | 1964 | The Hollywood Palace | Self | 3 |
| TV Show | 1968 | Rowan & Martin's Laugh-In | Self (uncredited) | 2 |
| TV Show | 1970 | The Don Knotts Show | Self | 1 |
| TV Show | 1969 | The Glen Campbell Goodtime Hour | Self | 3 |
| TV Show | 1992 | Bob | Bob McKay | 33 |
| TV Show | 1956 | The Dinah Shore Chevy Show | Self | 1 |
| TV Show | 1967 | Captain Nice | Lloyd Larchmont | 1 |
| TV Show | 1972 | The Don Rickles Show | Brother-in-law | 8 |
| TV Show | 1997 | George & Leo | George Stoody | 22 |
| TV Show | 1969 | Playboy After Dark | | 1 |
| TV Show | 1949 | The Emmy Awards | Self | 1 |
| TV Show | 1957 | Tonight Starring Jack Paar | Self | 6 |
| TV Show | 1961 | The Bob Newhart Show | Self - Host | 34 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 2 |
| TV Show | 2007 | The Big Bang Theory | Arthur Jeffries | 6 |
| TV Show | 1963 | The Judy Garland Show | Self | 1 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 29 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self - Guest Host | 97 |
| TV Show | 1988 | Murphy Brown | Dr. Bob Hartley | 1 |
| TV Show | 1948 | The Ed Sullivan Show | Self | 5 |
| TV Show | 1950 | The Bob Hope Show | Self | 1 |
| TV Show | 1963 | Bob Hope Presents the Chrysler Theatre | Charles Fenton | 1 |
| TV Show | 1967 | The Carol Burnett Show | Self | 1 |
| TV Show | 2003 | NCIS | Walter Magnus | 1 |
| TV Show | 2017 | Young Sheldon | Professor Proton | 3 |
| TV Show | 1950 | What's My Line? | Self - Mystery Guest | 1 |
| TV Show | 1967 | The Smothers Brothers Comedy Hour | Self - Cameo | 1 |
| TV Show | 1968 | The Dick Cavett Show | Self - Guest | 1 |
| TV Show | 2010 | Hot in Cleveland | Bob Sr. | 2 |
| TV Show | 1974 | Dinah! | Self | 1 |
| TV Show | 1967 | The Smothers Brothers Comedy Hour | Self | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee | 1 |
| TV Show | 2014 | The Librarians | Judson | 3 |
| TV Show | 1962 | The Alfred Hitchcock Hour | Gerald Swinney | 1 |
| TV Show | 1961 | The Mike Douglas Show | Self - Co-Host | 4 |
| TV Show | 1961 | The Mike Douglas Show | Self | 3 |
| TV Show | 1959 | The Grammys | Self | 1 |
| TV Show | 1968 | Rowan & Martin's Laugh-In | Self | 1 |
