| Movie | 1988 | Dangerous Liaisons | Le Chevalier Raphael Danceny | |
| Movie | 1991 | My Own Private Idaho | Scott Favor | |
| Movie | 1991 | Point Break | Agent Johnny Utah | |
| Movie | 2005 | Constantine | John Constantine | |
| Movie | 2008 | Street Kings | Detective Tom Ludlow | |
| Movie | 2006 | The Lake House | Alex Wyler | |
| Movie | 2000 | The Gift | Donnie Barksdale | |
| Movie | 1999 | The Matrix | Neo | |
| Movie | 2003 | The Matrix Reloaded | Neo | |
| Movie | 2003 | The Matrix Revolutions | Neo | |
| Movie | 2005 | Thumbsucker | Perry | |
| Movie | 1989 | Parenthood | Tod Higgins | |
| Movie | 2008 | The Day the Earth Stood Still | Klaatu | |
| Movie | 1994 | Speed | Jack Traven | |
| Movie | 1989 | Bill & Ted's Excellent Adventure | Ted 'Theodore' Logan | |
| Movie | 1991 | Bill & Ted's Bogus Journey | Ted | |
| Movie | 1993 | Little Buddha | Siddhartha | |
| Movie | 1990 | I Love You to Death | Marlon James | |
| Movie | 1997 | The Devil's Advocate | Kevin Lomax | |
| Movie | 2001 | Sweet November | Nelson Moss | |
| Movie | 2006 | A Scanner Darkly | Bob Arctor | |
| Movie | 2000 | The Watcher | David Allen Griffin | |
| Movie | 2000 | The Replacements | Shane Falco | |
| Movie | 2009 | The Private Lives of Pippa Lee | Chris Nadeau | |
| Movie | 2001 | Hardball | Conor O'Neill | |
| Movie | 1986 | River's Edge | Matt | |
| Movie | 2003 | Something's Gotta Give | Dr. Julian Mercer | |
| Movie | 1993 | Much Ado About Nothing | Don John | |
| Movie | 2003 | Kid's Story | Neo (voice) | |
| Movie | 1996 | Chain Reaction | Eddie Kasalivich | |
| Movie | 1986 | Babes in Toyland | Jack Fenton / Jack-be-Nimble | |
| Movie | 1995 | A Walk in the Clouds | Paul Sutton | |
| Movie | 1996 | Feeling Minnesota | Jjaks Clayton | |
| Movie | 1995 | Johnny Mnemonic | Johnny Mnemonic | |
| Movie | 1994 | Even Cowgirls Get the Blues | Julian Gitche | |
| Movie | 1997 | The Last Time I Committed Suicide | Harry | |
| Movie | 1986 | The Brotherhood of Justice | Derek | |
| Movie | 2001 | The Matrix Revisited | Self - Neo | |
| Movie | 1990 | Tune in Tomorrow... | Martin Loader | |
| Movie | 1986 | Flying | Tommy | |
| Movie | 2013 | 47 Ronin | Kai | |
| Movie | 1988 | The Night Before | Winston Connelly | |
| Movie | 2025 | Good Fortune | Gabriel | |
| Movie | 1986 | Youngblood | Heaver | |
| Movie | 2023 | The Keanu Reeves Story | Self | |
| Movie | 1993 | Freaked | Ortiz the Dog Boy (uncredited) | |
| Movie | 2006 | The Great Warming | Narrator (voice) | |
| Movie | 1988 | Permanent Record | Chris Townsend | |
| Movie | 2010 | Henry's Crime | Henry Torne | |
| Movie | 2003 | The Animatrix | Neo ("Kid's Story") (voice) | |
| Movie | 2013 | Man of Tai Chi | Donaka Mark | |
| Movie | 2019 | John Wick: Chapter 3 - Parabellum | John Wick | |
| Movie | 2012 | Side by Side | Self / Host | |
| Movie | 2012 | Generation Um... | John | |
| Movie | 1986 | Young Again | Mick Riley | |
| Movie | 1986 | Under the Influence | Eddie Talbot | |
| Movie | 1996 | This Road Will Never End | Self (archive footage) | |
| Movie | 2004 | The Matrix Recalibrated | Self | |
| Movie | 2014 | John Wick | John Wick | |
| Movie | 2015 | Knock Knock | Evan Webber | |
| Movie | 2006 | Thumbsucker - Behind the Scenes | Self | |
| Movie | 2020 | Time Flies When You Are Having Fun! A Look Back at a Most "Excellent Adventure" | Self | |
| Movie | 2022 | Dracula Unearthed | Johnathan Harker (archive footage) | |
| Movie | 1990 | Howie Meets the Ghost of Environmental Disasters Yet to Come | Doomsayer | |
| Movie | 2002 | Bowling for Columbine | Neo (archive footage) | |
| Movie | 2016 | The Neon Demon | Hank | |
| Movie | 2017 | As Above, So Below: The Underworld of 'John Wick' | Save | |
| Movie | 2017 | Wick's Toolbox | Self | |
| Movie | 2017 | The Bad Batch | The Dream | |
| Movie | 2016 | The Whole Truth | Richard Ramsey | |
| Movie | 2016 | Exposed | Detective Scott Galban | |
| Movie | 2025 | Ballerina | John Wick | |
| Movie | N/A | Outcome | Reef | |
| Movie | 2015 | Deep Web | Narrator | |
| Movie | 2019 | Iron Fists and Kung Fu Kicks | Self (archive footage) | |
| Movie | 2017 | John Wick: Chapter 2 | John Wick | |
| Movie | 1999 | Me and Will | Keanu Reeves - Dogstar | |
| Movie | 2022 | Keanu Reeves: Pop Messiah | Self (archive footage) | |
| Movie | 1985 | One Step Away | Ron Petrie | |
| Movie | 2012 | Final Cut: Ladies and Gentlemen | (archive footage) | |
| Movie | 1988 | The Prince of Pennsylvania | Rupert Marshetta | |
| Movie | 2024 | Sonic the Hedgehog 3 | Shadow (voice) | |
| Movie | 1989 | Life Under Water | Kip | |
| Movie | 1991 | Providence | Eric | |
| Movie | 2014 | 21 Years: Richard Linklater | Self - Actor | |
| Movie | 2016 | Anyone Can Quantum | Future Keanu / Narrator | |
| Movie | N/A | The Entertainment System Is Down | | |
| Movie | 1992 | Blood Lines: Dracula - The Man. The Myth. The Movies. | Self | |
| Movie | 2024 | How to Rob a Bank | Johnny Utah (archive footage) | |
| Movie | 2016 | Keanu | Keanu (voice) | |
| Movie | 2017 | To the Bone | Dr. William Beckham | |
| Movie | 2024 | De "Matrix" à "Sense8", la révolution Wachowski | Self - actor (archive footage) | |
| Movie | 2018 | Replicas | William Foster | |
| Movie | 2016 | Mifune: The Last Samurai | Self - Narrator (voice) | |
| Movie | 2018 | Siberia | Lucas Hill | |
| Movie | 1986 | Act of Vengeance | Buddy Martin | |
| Movie | 2012 | Sunset Strip | Self | |
| Movie | 2012 | My Own Private River | Scott Favor (archive footage) | |
| Movie | 2017 | SPF-18 | Keanu Reeves | |
| Movie | 2016 | Quantum Is Calling | The One (voice) | |
| Movie | 2018 | Destination Wedding | Frank | |
| Movie | 2011 | A Man's Story | Self | |
| Movie | 2004 | The Matrix Revolutions Revisited | Self | |
| Movie | 2020 | Bill & Ted Face the Music | Ted | |
| Movie | 2005 | The Making of ‘My Own Private Idaho’ | Self | |
| Movie | 2019 | Always Be My Maybe | Keanu Reeves | |
| Movie | 2017 | A Happening of Monumental Proportions | Bob | |
| Movie | 2019 | Toy Story 4 | Duke Caboom (voice) | |
| Movie | 1985 | Letting Go | Stereo Teen #1 | |
| Movie | 2003 | MTV Reloaded | Neo (archive footage) | |
| Movie | 2005 | Ellie Parker | Self (Member of the group Dogstar) | |
| Movie | 2023 | John Wick: Chapter 4 | John Wick | |
| Movie | 2006 | One Summer in Austin: The Story of Filming 'A Scanner Darkly' | Self / Bob Arctor | |
| Movie | 2015 | John Wick: Calling in the Cavalry | Self | |
| Movie | 2015 | Don't F*#% With John Wick | Self | |
| Movie | 2017 | Training 'John Wick' | Self | |
| Movie | 2017 | Friends, Confidantes: The Keanu/Chad Partnership | Self | |
| Movie | 2017 | Chamber Check: Evolution of a Fight Scene | Self | |
| Movie | 2004 | The Matrix Reloaded Revisited | Self | |
| Movie | 2015 | John Wick: Assassin's Code | John Wick | |
| Movie | 2021 | The Matrix Resurrections | Neo / Thomas Anderson | |
| Movie | N/A | Past Midnight | | |
| Movie | 2019 | Between Two Ferns: The Movie | Keanu Reeves | |
| Movie | 2020 | The SpongeBob Movie: Sponge on the Run | Sage | |
| Movie | 2005 | Echo | Narcissus | |
| Movie | 2003 | Keanu Reeves: Journey to Success | Self | |
| Movie | 2017 | John Wick Chapter 2: Wick-vizzed | Self | |
| Movie | 1999 | Making 'The Matrix' | Self | |
| Movie | 2004 | Mind Over Matter: The Physicality of the Matrix Future | Self | |
| Movie | 2003 | The Matrix Reloaded: Pre-Load | Self | |
| Movie | 2004 | The Matrix Revolutions: Neo Realism - Evolution of Bullet Time | Self | |
| Movie | 1992 | Bram Stoker's Dracula | Jonathan Harker | |
| Movie | 2007 | The Blood Is the Life: The Making of 'Bram Stoker's Dracula' | Self (archive footage) | |
| Movie | 2007 | In Camera: The Naïve Visual Effects of 'Bram Stoker's Dracula' | Self (archive footage) | |
| Movie | 2021 | The Thanksgiving Play | Caden | |
| Movie | N/A | Constantine 2 | John Constantine | |
| Movie | N/A | BRZRKR | B | |
| Movie | 2022 | DC League of Super-Pets | Bruce Wayne / Batman (voice) | |
| Movie | 2024 | Keanu Reeves: The One and Only | Himself | |
| Movie | 2024 | A Very Sonic Christmas | Shadow (voice) | |
| Movie | N/A | Untitled Animated John Wick Prequel | John Wick | |
| Movie | N/A | John Wick: Chapter 5 | John Wick | |
| Movie | N/A | Untitled Weezer Film | Self | |
| Movie | 2025 | Wick Is Pain | Self | |
| Movie | N/A | Untitled Amazon MGM Romantic Thriller | | |
| Movie | 2006 | The Weight of the Line: Animation Tales | Self | |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 3 |
| TV Show | 2006 | The One Show | Self - Guest | 1 |
| TV Show | 1987 | The Tracey Ullman Show | Jesse Walker | 81 |
| TV Show | 1988 | LIVE with Kelly and Mark | | 1 |
| TV Show | 1952 | Today | Self | 1 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 4 |
| TV Show | N/A | BRZRKR | B (voice) | 1 |
| TV Show | 1995 | MADtv | Self | 1 |
| TV Show | 2003 | Celebrities Uncensored | Self | 2 |
| TV Show | 1981 | Hangin' In | Teen Client | 10 |
| TV Show | 2005 | Unscripted | Self | 1 |
| TV Show | 1953 | The Oscars | Self | 5 |
| TV Show | 2014 | The Noite com Danilo Gentili | Self | 1 |
| TV Show | 2018 | James Cameron's Story of Science Fiction | Self | 6 |
| TV Show | 1990 | Bill & Ted's Excellent Adventures | Ted Logan (voice) | 13 |
| TV Show | 2008 | Easy to Assemble | Vorste Feirron | 51 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 4 |
| TV Show | 2018 | Red Table Talk | Self | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2016 | Ride with Norman Reedus | Self | 1 |
| TV Show | 2023 | 100 Years of Warner Bros. | Self | 3 |
| TV Show | 2007 | The Graham Norton Show | Self | 4 |
| TV Show | 1992 | MTV Movie & TV Awards | Self - Presenter | 1 |
| TV Show | 2023 | Brawn: The Impossible Formula 1 Story | Self - Narrator (voice) | 4 |
| TV Show | 2020 | The Drew Barrymore Show | Self | 1 |
| TV Show | 2014 | The Game Awards | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self - Musical Guest | 1 |
| TV Show | 2017 | The Russell Howard Hour | Self | 1 |
| TV Show | 1996 | Mundo VIP | Himself | 1 |
| TV Show | 1985 | Night Heat | Mugger | 1 |
| TV Show | 1985 | Night Heat | Thug #1 | 1 |
| TV Show | 2013 | The Frame | Neo | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 3 |
| TV Show | 1948 | Bambi-Verleihung | Self | 1 |
| TV Show | 2002 | Sucré salé | Self | 1 |
| TV Show | 1951 | Sanremo Music Festival | Self - Special Guest | 1 |
| TV Show | 2003 | The Animatrix | Neo (voice) | 1 |
| TV Show | 2014 | Car Matchmaker with Spike Feresten | Self | 1 |
| TV Show | 2015 | Jay Leno's Garage | Self | 1 |
| TV Show | 1994 | Hi Octane | Self | 1 |
| TV Show | 2020 | A World of Calm | Narrator | 1 |
| TV Show | 2016 | Swedish Dicks | Tex Johnson | 13 |
| TV Show | N/A | Conquest | | 1 |
| TV Show | 1992 | HBO First Look | | 1 |
| TV Show | 1997 | Taff | Self | 1 |
| TV Show | 2023 | Team ZARCO | HimSelf | 1 |
| TV Show | 1999 | Action | Keanu Reeves | 1 |
| TV Show | 2024 | Action | Self | 6 |
| TV Show | 1985 | The Comedy Factory | Crackers | 1 |
| TV Show | 2024 | Secret Level | Pilot (voice) | 1 |
| TV Show | 2022 | Severance | Animated Lumon Administrative Building (voice) (uncredited) | 1 |
| TV Show | 2025 | Visionaries | Self | 8 |
| TV Show | 2025 | Dying for Sex | Jack Traven (archive footage) (uncredited) | 1 |
| TV Show | 2019 | Gemini Home Entertainment | Jhon wick | 16 |
