| Movie | 2006 | American Dreamz | Chet Krogl | |
| Movie | 2004 | See This Movie | Jake Barrymore | |
| Movie | 2023 | Late Night Nightmare | Self | |
| Movie | 2009 | Spring Breakdown | William | |
| Movie | 2011 | I Don't Know How She Does It | Chris Bunce | |
| Movie | 1995 | Village of the Damned | Trooper (uncredited) | |
| Movie | 2008 | Journey to the Center of the Earth | Professor Alan Kitzens | |
| Movie | 2005 | Perception | Steven | |
| Movie | 2013 | Nantucket Film Festival's 2nd Comedy Roundtable | Self | |
| Movie | 2012 | The Secret Policeman's Ball | Self | |
| Movie | 2011 | New Year's Eve | Griffin Byrne | |
| Movie | 2010 | Saturday Night | Self | |
| Movie | 2024 | I'm "George Lucas": A Connor Ratliff Story | Self (archive footage) | |
| Movie | 2022 | Bros | Harvey Milk (uncredited) | |
| Movie | 2009 | Saturday Night Live: The Best of Amy Poehler | Various (archive footage) | |
| Movie | 2018 | Always at The Carlyle | Self (archive footage) | |
| Movie | 2024 | Good One: A Show About Jokes | Self | |
| Movie | 2008 | Nick and Norah's Infinite Playlist | Drunk Guy in Yugo | |
| Movie | 2016 | HyperNormalisation | Self (archive footage) | |
| Movie | 2012 | 12-12-12 | The Concert for Sandy Relief | Self | |
| Movie | 2014 | The Interview | Self (uncredited) | |
| Movie | 2017 | Night of Too Many Stars: America Unites for Autism Programs | Self | |
| Movie | 2010 | The Women of SNL | Various (archive footage) | |
| Movie | 2019 | Late Night | Himself | |
| Movie | 2019 | Seth Meyers: Lobby Baby | Self | |
| Movie | 2020 | Feeding America Comedy Festival | Self | |
| Movie | 2024 | Will & Harper | Self | |
| Movie | 2024 | Seth Meyers: Dad Man Walking | Self | |
| Movie | 2024 | 2024 Back That Year Up with Kevin Hart & Kenan Thompson | Self | |
| Movie | 2024 | The Day Drinking with Seth Meyers New Year's Special | Self - Host | |
| Movie | 2024 | Late Night with Seth Meyers at PaleyFest LA 2024 | Self | |
| Movie | N/A | The Adventures of Big Handsome Guy and His Little Friend | Disgruntled Dork | |
| TV Show | 1996 | Spin City | Doug | 1 |
| TV Show | 2012 | Finding Your Roots | Self | 1 |
| TV Show | 2005 | The Colbert Report | | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 4 |
| TV Show | 2008 | Saturday Night Live Weekend Update Thursday | Weekend Update Anchor | 9 |
| TV Show | 2013 | The Awesomes | Prock (voice) | 30 |
| TV Show | 2010 | The Marriage Ref | Self - Panelist | 1 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 261 |
| TV Show | 2011 | Portlandia | Chad Koop | 1 |
| TV Show | 2011 | Billy on the Street | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2012 | The Mindy Project | Seth Meyers | 1 |
| TV Show | 2012 | The Mindy Project | Matt | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 5 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 2019 | Tamron Hall | Self - Guest | 1 |
| TV Show | 2006 | The Howard Stern Interview | Self | 1 |
| TV Show | 2016 | This Is Us | Seth Meyers (uncredited) | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 3 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 8 |
| TV Show | 2015 | Hot Ones | Self | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self - Host | 1689 |
| TV Show | 2018 | The Great American Read | Himself | 1 |
| TV Show | 2012 | Comedians in Cars Getting Coffee | Self | 1 |
| TV Show | 2012 | NFL Honors | Himself | 1 |
| TV Show | 1981 | Entertainment Tonight | Self | 2 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2014 | Car Matchmaker with Spike Feresten | Self | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Host | 1 |
| TV Show | 2021 | American Auto | Seth Meyers | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 3 |
| TV Show | 2021 | Late Night with Seth Meyers: Corrections | Self - Host | 146 |
| TV Show | 2009 | Late Night with Jimmy Fallon | Self | 1 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self - Guest Star | 1 |
| TV Show | 2005 | The Office | Seth Meyers | 1 |
| TV Show | 1975 | Saturday Night Live | Self | 1 |
| TV Show | 2019 | Desus & Mero | Self - Illustrious Guest | 1 |
| TV Show | 2017 | Crashing | | 1 |
| TV Show | 1983 | Frontline | Self (archive footage) | 1 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 4 |
| TV Show | 2019 | The Kelly Clarkson Show | | 1 |
| TV Show | 2025 | Good Hang with Amy Poehler | | 3 |
| TV Show | 2007 | Say Yes to the Dress | Self | 1 |
| TV Show | 2023 | Off Script with The Hollywood Reporter | Self | 1 |
| TV Show | 2015 | Difficult People | Dog Park Guy | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee | 1 |
| TV Show | 2023 | Digman! | Chortles | 1 |
