| Movie | 1982 | E.T. the Extra-Terrestrial | Mary | |
| Movie | 2007 | Halloween | Cynthia Strode | |
| Movie | 2006 | Abominable | Ethel Hoss | |
| Movie | 2021 | Every Time a Bell Rings | Donna | |
| Movie | 1986 | Critters | Helen Brown | |
| Movie | 1996 | The Frighteners | Patricia Bradley | |
| Movie | 1983 | Cujo | Donna Trenton | |
| Movie | 2009 | Stay Cool | Mrs. McCarthy | |
| Movie | 1981 | The Howling | Karen White | |
| Movie | 2009 | The Haunted World of El Superbeasto | Trixie (voice) | |
| Movie | 2007 | Bone Dry | Joanne | |
| Movie | 1985 | Secret Admirer | Connie Ryan | |
| Movie | 2018 | After Emma | | |
| Movie | 2002 | E.T. the Extra-Terrestrial 20th Anniversary Special | Self | |
| Movie | 1996 | The Making of 'E.T. the Extra-Terrestrial' | Self | |
| Movie | 1979 | 10 | Mary Lewis | |
| Movie | 1977 | The Hills Have Eyes | Lynne Wood | |
| Movie | 2022 | In Search of Darkness: Part III | Self | |
| Movie | 2002 | Sex and the Teenage Mind | Francine Heitmeyer | |
| Movie | 2009 | The House of the Devil | Landlady | |
| Movie | 2016 | Charlie's Gift | | |
| Movie | 2005 | Headspace | Dr. Denise Bell | |
| Movie | 2005 | Scar | Isabella | |
| Movie | 2023 | Incubus: New Beginnings | Zura Valentine | |
| Movie | 1991 | Alligator 2: The Mutation | Christine Hodges | |
| Movie | 2023 | Butch Cassidy and the Wild Bunch | Alice Cassidy | |
| Movie | 1995 | Best of the Best 3: No Turning Back | Georgia | |
| Movie | 2006 | Witch's Dungeon: 40 Years of Chills | Self | |
| Movie | 2009 | Dark Fields | Jean Applebe | |
| Movie | 2006 | The Plague | Nora | |
| Movie | 1996 | Invisible Mom | Laura Griffin | |
| Movie | 2010 | Bedrooms | Marnie | |
| Movie | 1982 | Jimmy the Kid | May | |
| Movie | 1991 | Popcorn | Suzanne | |
| Movie | 1986 | Club Life | Tilly Francesca | |
| Movie | 2011 | Pound of Flesh | Dean Jean Clark | |
| Movie | 2021 | Courageous Warriors Beauty from the Ashes | Narrator | |
| Movie | 2006 | Expiration Date | Lucille | |
| Movie | 1997 | Black Circle Boys | Barbara Sullivan | |
| Movie | 2024 | Stream | Linda Spring | |
| Movie | 2019 | Sunrise in Heaven | Marion | |
| Movie | 2023 | The Little Mermaid | Sea Witch Revina (voice) | |
| Movie | 2023 | Lena's Dance | Lena Swain | |
| Movie | 2011 | Exit Humanity | Eve | |
| Movie | 1998 | Bad As I Wanna Be: The Dennis Rodman Story | Rodman's stepmother | |
| Movie | 1994 | Runaway Daughters | Mrs. Gordon | |
| Movie | 1987 | The Christmas Visitor | Elizabeth O'Day | |
| Movie | 2013 | The Lords of Salem | Sonny | |
| Movie | 1995 | The Phoenix and the Magic Carpet | Mother | |
| Movie | 2006 | The Eden Formula | Rhonda | |
| Movie | 1994 | Huck and the King of Hearts | Darlene | |
| Movie | 2008 | Matchmaker Mary | Aunt Karen | |
| Movie | 1992 | Rescue Me | Sarah Sweeney | |
| Movie | 2012 | Collision Course | Polly | |
| Movie | 1994 | Search and Rescue | Morgan | |
| Movie | 2001 | Killer Instinct | Sarah Fairchild | |
| Movie | 1993 | Prophet of Evil: The Ervil LeBaron Story | Jackie Fields (as Dee Wallace-Stone) | |
| Movie | 2002 | Fish Don't Blink | Dr. Roswell | |
| Movie | 1995 | The Skateboard Kid II | Lois Curtis | |
| Movie | 2013 | As High as the Sky | Aunt Deborah (voice) | |
| Movie | 2013 | Hansel & Gretel | Lilith | |
| Movie | 1997 | Love's Deadly Triangle: The Texas Cadet Murder | Linda Jones | |
| Movie | 2012 | Final Cut: Ladies and Gentlemen | (archive footage) | |
| Movie | 1999 | To Love, Honor, & Betray | Julia Brennan (as Dee Wallace Stone) | |
| Movie | 2006 | Kalamazoo? | Susan | |
| Movie | 2013 | RoboCroc | Dr. Riley | |
| Movie | 2013 | Grand Piano | Marjorie Green | |
| Movie | 2013 | Bonnie & Clyde: Justified | Emma | |
| Movie | 1996 | Subliminal Seduction | Sissy Bonner | |
| Movie | 1999 | Invisible Mom II | Laura Griffin (as Dee Wallace-Stone) | |
| Movie | 1995 | Temptress | Allison Mackie | |
| Movie | 1999 | Pirates of the Plain | Glenna (as Dee Wallace-Stone) | |
| Movie | 2002 | She's No Angel | Maureen Shawnessy | |
| Movie | 2022 | The Munsters | Good Morning Transylvania Host | |
| Movie | 2022 | Killer Design | Elana | |
| Movie | 2023 | House of Dolls | Celine Charles | |
| Movie | 1986 | Sin of Innocence | Vicki McGary | |
| Movie | N/A | Unhallowed | Rita Harrison | |
| Movie | 2015 | Zombie Killers: Elephant's Graveyard | Sharon Sommers | |
| Movie | 2012 | Fuzz Track City | Dawn Lockwood | |
| Movie | 2014 | Snow Moon: Cinderella Chronicles Saga | Gram Pearl | |
| Movie | 2010 | The Guardian | Mom | |
| Movie | 2009 | Stem Cell | The Healer | |
| Movie | 1997 | Skeletons | Heather Crane | |
| Movie | 2014 | 2 Bedroom 1 Bath | Rose | |
| Movie | 2007 | Curse of the Weeping Woman: J-ok'el | Helen Moret | |
| Movie | 1997 | Mutual Needs | Patricia | |
| Movie | 2020 | Six feet of separation | Self | |
| Movie | 1983 | Wait Till Your Mother Gets Home | Pat Peters | |
| Movie | 1981 | A Whale for the Killing | Janet Landon | |
| Movie | 1990 | I'm Dangerous Tonight | Wanda | |
| Movie | N/A | The Pitchfork Retreat | Helen | |
| Movie | 1988 | Addicted to His Love | Betty Ann Brennan | |
| Movie | 2007 | Dog Days: The Making of 'Cujo' | Self | |
| Movie | 2022 | Making I'm Dangerous Tonight | Herself | |
| Movie | 1977 | All the King's Horses | Sandy Benson | |
| Movie | 1984 | The Shepherd | | |
| Movie | 1993 | Alone in the Dark | Linda Grant (as Dee Wallace Stone) | |
| Movie | 2018 | Death House | Dr. Eileen Fletcher | |
| Movie | 1987 | Legend of the White Horse | Alta (as Dee Wallace-Stone) | |
| Movie | 1975 | The Stepford Wives | Nettie the Maid | |
| Movie | 1995 | Brothers' Destiny | Lucille Bastian | |
| Movie | 1995 | Here Come the Munsters | Mrs. Walker | |
| Movie | 2015 | Flowers in December | Hannah | |
| Movie | 2022 | Time Pirates | The Crone | |
| Movie | 1994 | Witness to the Execution | Emily Dawson (as Dee Wallace-Stone) | |
| Movie | 1997 | Nevada | Ruby (as Dee Wallace Stone) | |
| Movie | 2022 | Jeepers Creepers: Reborn | Marie | |
| Movie | 1983 | I Take These Men | Elaine Zakarian | |
| Movie | 2004 | The Perfect Husband: The Laci Peterson Story | Sharon Rocha | |
| Movie | 2025 | Roswell Delirium | Betty | |
| Movie | 1998 | The Making of 'The Frighteners' | Herself | |
| Movie | 2024 | The Forest Hills | Angela | |
| Movie | 2014 | Haunting of Cellblock 11 | Ms. Simon | |
| Movie | N/A | Campfire | Mrs. Hallowell | |
| Movie | 2008 | Little Red Devil | Mother | |
| Movie | 2009 | The Mother of Invention | Nancy Dooly | |
| Movie | 1982 | Skeezer | Lucille | |
| Movie | 2007 | The Return of the Living Dead: The Decade of Darkness | Self | |
| Movie | 2023 | Love By Design | Diane Yeardly | |
| Movie | 2006 | The Lost | Barbara Hanlon | |
| Movie | 2024 | The Legend of Catclaws Mountain | Maggie Porter | |
| Movie | 1994 | Vanishing Son IV | Megan | |
| Movie | 2011 | Sam Steele and the Crystal Chalice | Ms. Jenkins | |
| Movie | 2017 | Ayla | Susan | |
| Movie | 2024 | Last Night on Earth | Carla | |
| Movie | 2016 | Red Christmas | Diane | |
| Movie | 1985 | Hostage Flight | Laura Kenrick | |
| Movie | N/A | Bits | Fallen One | |
| Movie | 2016 | All Hallow's Eve | Haidy Hallow | |
| Movie | 2012 | I Heart Monster Movies | Herself | |
| Movie | 2009 | Happy in the Valley | Gloria | |
| Movie | 2010 | Extraordinary Measures | Sal | |
| Movie | N/A | If It Bleeds | Kelly | |
| Movie | 1994 | Moment of Truth: Cradle of Conspiracy | Suzanne Guthrie (as Dee Wallace-Stone) | |
| Movie | 2012 | Sebastian | Barbara Sample | |
| Movie | 1980 | The Secret War of Jackie's Girls | Maxine | |
| Movie | 2013 | My Stepbrother Is a Vampire!?! | Tabitha the Cat (voice) | |
| Movie | 1988 | Stranger on My Land | Annie Whitman | |
| Movie | 2004 | Welcome to Werewolfland | | |
| Movie | 2001 | Out of the Black | Penny Hart | |
| Movie | 2004 | Dead End Road | Mrs. Makepiece | |
| Movie | 2018 | Beyond The Sky | Lucille | |
| Movie | 2005 | Boo | Nurse Russell | |
| Movie | 2010 | Raven | LuAnne | |
| Movie | 1986 | Shadow Play | Morgan Hanna | |
| Movie | 2014 | Ejecta | Ashley Winnington-Ball (uncredited) | |
| Movie | 2006 | Voodoo Moon | Mary-Ann | |
| Movie | 2015 | The Abundance Factor | Herself | |
| Movie | 1993 | Lightning in a Bottle | Jean Markley | |
| Movie | 1981 | The Five of Me | Ann | |
| Movie | 2012 | The Boarder | Elizabeth | |
| Movie | 2018 | Ouija House | Katherine Fields | |
| Movie | 2017 | The Fuzz | Dawn Lockwood | |
| Movie | 2019 | 3 from Hell | Greta | |
| Movie | 2017 | This Old Machine | Irene | |
| Movie | 2018 | Every Other Holiday | Mimi | |
| Movie | 2018 | Jingle Belle | Shelby | |
| Movie | 1995 | Cops n Roberts | | |
| Movie | 2018 | The Wrong Teacher | Dr. Smith | |
| Movie | 1985 | Suburban Beat | Joanna | |
| Movie | 2021 | 13 Fanboy | Dee Wallace | |
| Movie | 1983 | Happy | Marilyn | |
| Movie | 2020 | Critters Attack! | Dee | |
| Movie | 2018 | They Bite!: The Making of Critters | Self | |
| Movie | 2003 | Looking Back at 'The Hills Have Eyes' | Self | |
| Movie | 2017 | Horror Movie: A Low Budget Nightmare | Self | |
| Movie | 2019 | Dolls | Margaret | |
| Movie | 2012 | The 'E.T.' Journals | Self | |
| Movie | 2001 | A Month of Sundays | Sarah McCabe (as Dee Wallace Stone) | |
| Movie | 1994 | Discretion Assured | | |
| Movie | 1991 | Rock-A-Doodle | Dory (voice) | |
| Movie | 2011 | Bad Actress | Dee Wallace | |
| Movie | 2019 | Christmas in Louisiana | Doris | |
| Movie | 2010 | Between Heaven and Hell | Dr. Isabel Greenlee | |
| Movie | 2019 | To Hell and Back: The Making of 3 From Hell | Self | |
| Movie | 2004 | Illusion Infinity | Patricia (as Dee Wallace Stone) | |
| Movie | 2019 | Renovation of the Heart | Diane Dover | |
| Movie | 2007 | The Blue Rose | Mrs. Garrison | |
| Movie | 2022 | In Search of Tomorrow | Self - Interviewee | |
| Movie | 2020 | Await the Dawn | Annie | |
| Movie | 2020 | Day 14 | | |
| Movie | 2008 | Michael Lives: The Making of Halloween | Self | |
| Movie | 2020 | Stay Home | Herself | |
| Movie | 2003 | Unleashing the Beast: Making ‘The Howling’ | | |
| Movie | 1998 | The Christmas Path | Jenny | |
| Movie | 1981 | Child Bride of Short Creek | Mary Jacobs | |
| Movie | 2020 | The Gift of Christmas | Ellen Rodgers | |
| Movie | 2021 | The Nest | Marissa | |
| Movie | 1979 | Young Love, First Love | Leslie | |
| Movie | 1984 | The Sky's No Limit | Dr. Maureen Harris | |
| Movie | 2020 | Rondo and Bob | Self | |
| Movie | 2019 | The Wrong Mommy | Carol | |
| Movie | 1995 | My Family Treasure | Alex Danieloff | |
| Movie | 2022 | Nix | Donna | |
| Movie | N/A | Curse of Vandor | Ethel Gordon | |
| Movie | 2012 | Margarine Wars | Madge Havershank | |
| Movie | N/A | Howl: Inside the Forest Hills | Self | |
| Movie | 1991 | Critters 3 | Mom (archive footage) | |
| Movie | 2022 | 1982: Greatest Geek Year Ever! | Self | |
| Movie | 2005 | The Loch Ness Monster | Elizabeth Horner | |
| Movie | 2010 | Soupernatural | Mrs. Conners | |
| Movie | 2009 | Babysitters Beware | Ms. Greene | |
| Movie | 2025 | The Lies We Bury | Lynn Wright | |
| Movie | 1987 | Happy 100th Birthday, Hollywood | Self | |
| Movie | N/A | The Boy from Below | Sybil | |
| Movie | N/A | 25 Miles to Normal | Deborah | |
| Movie | 2012 | Aliens from Uranus | Olga | |
| Movie | N/A | American Blend | | |
| Movie | N/A | Water Rites | Caroline | |
| Movie | 1997 | The Perfect Mother | Gina Mitrou | |
| TV Show | 1984 | Murder, She Wrote | Mildred Terhune | 1 |
| TV Show | 1977 | CHiPs | | 1 |
| TV Show | 1979 | Mrs. Columbo | | 1 |
| TV Show | 1979 | Trapper John, M.D. | | 1 |
| TV Show | 1986 | L.A. Law | Elaine Weston | 1 |
| TV Show | 1975 | Starsky & Hutch | | 1 |
| TV Show | 2005 | Ghost Whisperer | Claire Taylor | 1 |
| TV Show | 2001 | The Division | Paula Meeks | 1 |
| TV Show | 2006 | Sons & Daughters | Colleen Halbert | 11 |
| TV Show | 2005 | Bones | Special Agent Callie Warner | 1 |
| TV Show | 1981 | Simon & Simon | | 1 |
| TV Show | 1985 | The Twilight Zone | (segment "Wish Bank") | 1 |
| TV Show | 2005 | The Office | Ellen Bernard | 1 |
| TV Show | 2003 | Cold Case | Charlotte Jones | 1 |
| TV Show | 1972 | The Streets of San Francisco | | 1 |
| TV Show | 1982 | Hotel | | 3 |
| TV Show | 2002 | Without a Trace | Lara Duncan | 1 |
| TV Show | 2005 | Criminal Minds | Dr. Jan Mohikian | 1 |
| TV Show | 1979 | Hart to Hart | | 1 |
| TV Show | 1995 | JAG | Adele DeLong | 1 |
| TV Show | 2005 | Close to Home | Joan Monroe | 1 |
| TV Show | 1997 | Ally McBeal | Gail Clarkson | 1 |
| TV Show | 1980 | Skag | | 2 |
| TV Show | 1974 | Police Woman | | 1 |
| TV Show | 1986 | Together We Stand | | 19 |
| TV Show | 1973 | Police Story | | 1 |
| TV Show | 2007 | Saving Grace | | 1 |
| TV Show | 1989 | The New Lassie | Dee McCullough | 52 |
| TV Show | 1991 | P.S. I Luv U | | 1 |
| TV Show | 1975 | Ellery Queen | | 1 |
| TV Show | 1977 | The San Pedro Beach Bums | | 1 |
| TV Show | 1995 | High Sierra Search and Rescue | | 8 |
| TV Show | 2023 | Paul T. Goldman | Terri Jay | 1 |
| TV Show | 1977 | Man from Atlantis | Hot Dog Stand Owner (as Dee Wallace-Stone) | 1 |
| TV Show | 1998 | Felicity | Allison Covington | 2 |
| TV Show | 2011 | Switched at Birth | Lorena McGowen | 2 |
| TV Show | 2015 | The Whispers | Willie Starling (Grammy) | 1 |
| TV Show | 2005 | Grey's Anatomy | Joan Waring | 1 |
| TV Show | 1978 | Taxi | Joyce | 1 |
| TV Show | 2005 | Supernatural | Mildred Baker | 1 |
| TV Show | 2016 | Just Add Magic | Grandma | 50 |
| TV Show | 2010 | Law & Order: LA | Ellen Powell | 1 |
| TV Show | 2018 | 9-1-1 | Margaret Buckley | 6 |
| TV Show | 2011 | Grimm | Alice | 3 |
| TV Show | 2019 | The Very Very Best of the 70s | Self - Commentator | 1 |
| TV Show | 2009 | Celebrity Ghost Stories | Self | 1 |
| TV Show | 2009 | Warehouse 13 | Mrs. Garner | 1 |
| TV Show | 1984 | Finder of Lost Loves | Gail Aames | 1 |
| TV Show | 2005 | My Name Is Earl | Governor Katherine Hazelwood | 3 |
| TV Show | 2016 | Shooter | Katherine Mayfield | 1 |
| TV Show | 2002 | She Spies | Daphne | 1 |
| TV Show | 1984 | Murder, She Wrote | Ellen Wicker | 1 |
| TV Show | 2003 | NCIS | Claire Hall | 1 |
| TV Show | 1994 | Touched by an Angel | Sandra Browner | 1 |
| TV Show | 2001 | Crossing Jordan | Lorraine Heeley | 1 |
| TV Show | 2023 | Fatal Attraction | Emma Rauch | 3 |
| TV Show | 2014 | You're the Worst | Gail | 1 |
| TV Show | 1994 | Vanishing Son | Megan | 1 |
