| Movie | 2008 | The Rocker | Kerr | |
| Movie | 2006 | Tenacious D in The Pick of Destiny | Security Guard | |
| Movie | 2023 | The Super Mario Bros. Movie | Cranky Kong (voice) | |
| Movie | 2006 | Kiss Me Again | Professor Szabo | |
| Movie | 2008 | Baby Mama | Stroller Salesman | |
| Movie | 2006 | Deck the Halls | Gustave | |
| Movie | 2019 | Yo La Tengo: Hanukkah 2019 - Night One | | |
| Movie | 2006 | The Ex | Manny | |
| Movie | 2008 | The Promotion | Scott Fargas | |
| Movie | 2003 | Melvin Goes to Dinner | Vesa | |
| Movie | 2008 | Christmas on Mars | Philosophical and Hymn-Singing Astronaut | |
| Movie | 2011 | The Smurfs | Brainy Smurf (voice) | |
| Movie | 2019 | My View: Clem Burke | Self | |
| Movie | 2022 | The Kids in the Hall: Comedy Punks | Self | |
| Movie | 2025 | Fixed | Fetch (voice) | |
| Movie | 2011 | The Smurfs: A Christmas Carol | Brainy (voice) | |
| Movie | 2013 | The Smurfs: The Legend of Smurfy Hollow | Brainy Smurf (voice) | |
| Movie | 2013 | Revenge of the Mekons | Himself | |
| Movie | 2023 | The Contestant | Denpa Shonen Narrator (voice) | |
| Movie | 2010 | Gavin McInnes is a Fucking Asshole | Self (archive footage) | |
| Movie | 2009 | Confessions of a Shopaholic | Ryan Koenig | |
| Movie | 2007 | Aqua Teen Hunger Force Colon Movie Film for Theaters | Time Lincoln (voice) | |
| Movie | 2022 | Clerks III | Auditioner | |
| Movie | 2012 | The Secret Policeman's Ball | Self | |
| Movie | 2015 | 7 Days in Hell | Edward Pudding | |
| Movie | 2010 | Saturday Night | Self | |
| Movie | 2023 | Melomaniac | Himself | |
| Movie | 2015 | Addicted to Fresno | Gerald | |
| Movie | 2002 | I Am Trying to Break Your Heart: A Film About Wilco | Himself | |
| Movie | 2014 | Elf: Buddy's Musical Christmas | Chadwick (voice) | |
| Movie | 2008 | Largo | Self | |
| Movie | 2009 | Saturday Night Live: The Best of Amy Poehler | Various (archive footage) | |
| Movie | 2024 | Thelma the Unicorn | Danny Stallion (voice) | |
| Movie | 2015 | Salad Days: A Decade of Punk in Washington, DC (1980-90) | Self | |
| Movie | 2007 | The Shooting | Cop #2 | |
| Movie | 2016 | Resurgence: It's Early Albuquerque | Terry Dudley | |
| Movie | 2014 | My Depression (The Up and Down and Up of It) | Pill Bottle (voice) | |
| Movie | 2015 | Looney Tunes: Rabbits Run | Speedy Gonzales | |
| Movie | 2015 | Staten Island Summer | Victor | |
| Movie | 2006 | Griffin & Phoenix | | |
| Movie | 2016 | Zoolander 2 | VIP | |
| Movie | 2014 | The Celery Incident | Various characters | |
| Movie | 2015 | The Damned: Don't You Wish That We Were Dead | Self | |
| Movie | 2024 | Unfrosted | Mike Puntz | |
| Movie | 2007 | Goodbye Baby | Comic | |
| Movie | 2004 | Wake Up, Ron Burgundy: The Lost Movie | Tino | |
| Movie | N/A | Fred Armisen's Guide to Music and SXSW | | |
| Movie | 2010 | Cop Out | Russian Lawyer | |
| Movie | 2015 | George and the Vacuum | George | |
| Movie | 2009 | Post Grad | Guacanator Pitchman | |
| Movie | 2024 | Come and Save Me | Hugo | |
| Movie | 2016 | Ordinary World | Gary | |
| Movie | 2017 | The Lego Ninjago Movie | Cole (voice) | |
| Movie | 2017 | The Little Hours | Bishop Bartolomeo | |
| Movie | 2010 | Cats & Dogs: The Revenge of Kitty Galore | Freidrich | |
| Movie | 2024 | Never Mind | Manager Cat | |
| Movie | 2017 | Band Aid | Dave | |
| Movie | 2017 | Michael Bolton's Big, Sexy Valentine's Day Special | Peter Salanz | |
| Movie | 2017 | Take the 10 | The Driver | |
| Movie | 2024 | Hang On a Second | Self | |
| Movie | 2013 | The Smurfs 2 | Brainy Smurf (voice) | |
| Movie | 2017 | Battle of the Sexes | Rheo Blair | |
| Movie | 2017 | Man in the Camo Jacket | Self | |
| Movie | 2017 | Cabiria, Charity, Chastity | Aldo the Instructor | |
| Movie | 2012 | The Dictator | Waiter / Minister | |
| Movie | 2017 | Night of Too Many Stars: America Unites for Autism Programs | Self | |
| Movie | 2018 | Fred Armisen: Standup for Drummers | The Drummer | |
| Movie | 2019 | The House of Tomorrow | Tour Video Narrator (voice) | |
| Movie | 2018 | You Can Color Outside the Lines... The Big Boys | | |
| Movie | 2018 | Game Over, Man! | Fred Armisen | |
| Movie | 2010 | Easy A | Pastor | |
| Movie | 2004 | EuroTrip | Creepy Italian Guy | |
| Movie | 2019 | Brainiac: Transmissions After Zero | Himself | |
| Movie | 2007 | Fred Armisen Presents: Complicated Drumming Technique Jens Hannemann | Jens Hannemann | |
| Movie | 2011 | Inside Portlandia | Self | |
| Movie | 2006 | Saturday Night Live: The Best of Saturday TV Funhouse | Self | |
| Movie | 2010 | The Women of SNL | Various (archive footage) | |
| Movie | 2019 | Jay and Silent Bob Reboot | Merkin | |
| Movie | 2013 | AMEX Unstaged Presents: Vampire Weekend | Ian Rubbish | |
| Movie | 2020 | All Together Now | Mr. Franks | |
| Movie | 2019 | The Kacey Musgraves Christmas Show | Self | |
| Movie | 2005 | Looking for a Thrill: An Anthology of Inspiration | Self | |
| Movie | 2014 | The Maya Rudolph Show | Self | |
| Movie | 2006 | Book Club | Himself | |
| Movie | 2020 | Unbreakable Kimmy Schmidt: Kimmy vs. the Reverend | Robert Durst / Robertina Durst | |
| Movie | 2005 | Saturday Night Live: The Best of David Spade | | |
| Movie | 2004 | Anchorman: The Legend of Ron Burgundy | Tino | |
| Movie | 2002 | Like Mike | New Age Dad | |
| Movie | 2020 | Sarah Cooper: Everything's Fine | Scooter | |
| Movie | 2005 | Deuce Bigalow: European Gigolo | Frenchman (uncredited) | |
| Movie | 2021 | How It Ends | Manny | |
| Movie | 2020 | The Imminent Expiration of Seth Dodson | Dr. Greengrass | |
| Movie | 2020 | Magnum Dopus | Self | |
| Movie | 2022 | The Bubble | Darren Eigen | |
| Movie | 2021 | The Sparks Brothers | Self | |
| Movie | 2021 | The Mitchells vs. the Machines | Deborahbot 5000 (voice) | |
| Movie | 2021 | Too Late | Fredo Muñoz | |
| Movie | 2017 | A Christmas Story Live! | Elf | |
| Movie | 2019 | Adams | Adams | |
| Movie | 2022 | Spin Me Round | Ricky | |
| Movie | 2010 | Presidential Reunion | Barack Obama | |
| Movie | 2024 | Will & Harper | Self | |
| Movie | 2021 | Bob Mould & Fred Armisen: Come What May - Hardly Strictly Bluegrass | | |
| Movie | 2024 | Resynator | Self | |
| Movie | 2024 | Age of Audio | Self | |
| Movie | 2023 | Resurgence | Record shopper 2 | |
| Movie | 2024 | Music Box: Yacht Rock: A DOCKumentary | Self | |
| Movie | 2025 | Ladies & Gentlemen... 50 Years of SNL Music | Self | |
| Movie | 2025 | G*ve a F*ck LA: A Benefit for LA Fire Relief | | |
| Movie | 2025 | SNL50: The Homecoming Concert | Self | |
| Movie | N/A | New Year's Rev | | |
| Movie | 2011 | Saturday Night Live: The Best of '09/'10 | Barack Obama | |
| Movie | 2025 | DIY: The Rise and Fall and Rise of Punk | Self | |
| Movie | 2025 | Netflix Tudum 2025 | Self | |
| TV Show | 2005 | Squidbillies | Miguel | 85 |
| TV Show | 2000 | Aqua Teen Hunger Force | | 1 |
| TV Show | 2004 | The Tony Danza Show | Self - Guest | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 220 |
| TV Show | 2006 | Freak Show | | 2 |
| TV Show | 2004 | Tom Goes to the Mayor | Phillip Priest (voice) | 1 |
| TV Show | 2021 | Schmigadoon! | Reverend Howard Layton | 6 |
| TV Show | 2012 | Finding Your Roots | Self | 1 |
| TV Show | 2006 | 30 Rock | Raheem Haddad | 1 |
| TV Show | 2007 | Human Giant | Dr. Marker | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 2 |
| TV Show | 2008 | Saturday Night Live Weekend Update Thursday | | 9 |
| TV Show | 2020 | The Second City Presents: The Last Show Left on Earth | Self - Guest | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 6 |
| TV Show | 2023 | Unstable | Leslie | 10 |
| TV Show | 2023 | Agent Elvis | Charles Manson (voice) | 1 |
| TV Show | 2016 | Match Game | Self - Panelist | 1 |
| TV Show | 2023 | Royal Crackers | Brent (voice) | 1 |
| TV Show | 2001 | Next Caller | | 2 |
| TV Show | 2015 | Man Seeking Woman | Jesus | 1 |
| TV Show | 2011 | The Looney Tunes Show | Speedy Gonzales (voice) | 52 |
| TV Show | 2013 | Brooklyn Nine-Nine | Melipnos | 4 |
| TV Show | 2018 | Barry | Nestor | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 4 |
| TV Show | 2009 | Archer | Gustavo Calderón (voice) | 5 |
| TV Show | 2011 | Portlandia | Various Characters | 77 |
| TV Show | 2010 | Ugly Americans | Larry King (voice) | 1 |
| TV Show | 2021 | Centaurworld | Splendib / Bimbam (voice) | 1 |
| TV Show | 2019 | I Think You Should Leave with Tim Robinson | | 1 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 1 |
| TV Show | 2012 | Comedians in Cars Getting Coffee | Self | 1 |
| TV Show | 2014 | Deadbeat | Janitor | 1 |
| TV Show | 2015 | Documentary Now! | Various Characters | 27 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self - Guest | 3 |
| TV Show | 2014 | Broad City | David the baby | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2021 | Saturday Morning All Star Hits! | (voice) | 8 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 24 |
| TV Show | 2016 | Party Legends | | 1 |
| TV Show | 2021 | Do, Re & Mi | Juan Peacock (voice) | 23 |
| TV Show | 2021 | Centaurworld | Splendib / Kittentaur / Malandrew (voice) | 1 |
| TV Show | 2021 | Centaurworld | Splendib / Message Bird / Teacher Birdtaur (voice) | 1 |
| TV Show | 2021 | Centaurworld | Message Bird (voice) | 1 |
| TV Show | 2021 | Centaurworld | Malandrew (voice) | 1 |
| TV Show | 2021 | Centaurworld | Splendib / Malandrew / Message Bird (voice) | 1 |
| TV Show | 2021 | Centaurworld | Splendib / Guard / Human Man (voice) | 1 |
| TV Show | 2022 | Toast of Tinseltown | Russ Nightlife | 5 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 1 |
| TV Show | 2021 | Baking It | Self | 1 |
| TV Show | 2011 | New Girl | Brandon | 1 |
| TV Show | 2006 | 30 Rock | Various Characters | 1 |
| TV Show | 2022 | Our Flag Means Death | Geraldo | 3 |
| TV Show | 2000 | Aqua Teen Hunger Force | Robot Husband (voice) | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | K.J. Nutt | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Sal & Al's Customer | 1 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Self | 1 |
| TV Show | 2017 | The Gong Show | Self - Judge | 2 |
| TV Show | 2011 | Bob's Burgers | Tommy (voice) | 1 |
| TV Show | 2017 | Big Mouth | Elliot Birch (voice) | 81 |
| TV Show | 2018 | Final Space | KVN (voice) | 36 |
| TV Show | 2015 | The Last Man on Earth | Karl | 3 |
| TV Show | 2019 | Miracle Workers | Percival Forthwind | 1 |
| TV Show | 2015 | Long Live the Royals | Gavin, Brody | 4 |
| TV Show | 2022 | Super Pumped: The Battle for Uber | Erich England | 1 |
| TV Show | 2023 | Carol & the End of the World | (voice) | 1 |
| TV Show | 2020 | Moonbase 8 | Skip | 6 |
| TV Show | 2018 | Forever | Oscar | 8 |
| TV Show | 2019 | What We Do in the Shadows | Tom 'Doctor Tom' Schmidt | 1 |
| TV Show | 2015 | Man Seeking Woman | Tanaka (voice) | 1 |
| TV Show | 2011 | Up All Night | Gideon Kirk | 1 |
| TV Show | 2005 | Robot Chicken | Archie Andrews (voice) | 1 |
| TV Show | 2022 | Wednesday | Uncle Fester | 1 |
| TV Show | 2009 | Modern Family | Langham | 1 |
| TV Show | 2021 | That's My Jam | Self - Guest | 1 |
| TV Show | 2012 | Unsupervised | Martin (voice) | 6 |
| TV Show | 2024 | Fallout | DJ Carl | 1 |
| TV Show | 2019 | Lights Out with David Spade | Self - Panelist | 1 |
| TV Show | 2018 | Fortune Rookie | Fred | 2 |
| TV Show | 1975 | Saturday Night Live | Self | 1 |
| TV Show | 2019 | Los Espookys | Uncle Tico | 1 |
| TV Show | 2001 | Next! | | 2 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 2 |
| TV Show | 2018 | Star Wars Resistance | Lechee (voice) | 1 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Sweet Potato (voice) / Tomatillo (voice) | 1 |
| TV Show | 2024 | John Mulaney Presents: Everybody's in L.A. | Self | 1 |
| TV Show | 2005 | American Dad! | Derrick (voice) | 1 |
| TV Show | 2015 | Superstore | Kyle | 1 |
| TV Show | 2015 | Close Up with The Hollywood Reporter | Self | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | Wally | 1 |
| TV Show | 2017 | Carpool Karaoke: The Series | Self | 1 |
| TV Show | 2009 | Parks and Recreation | Raul | 1 |
| TV Show | 2015 | Unbreakable Kimmy Schmidt | Robert Durst | 4 |
| TV Show | 2013 | Hollywood Game Night | Self | 1 |
| TV Show | 2015 | Unbreakable Kimmy Schmidt | Robertina Durst | 1 |
| TV Show | 1989 | The Simpsons | Terrence (voice) | 2 |
| TV Show | 2014 | Off Camera with Sam Jones | Self | 1 |
| TV Show | 2023 | History of the World: Part II | Glorp | 1 |
| TV Show | 2020 | Central Park | Esposito (voice) | 1 |
| TV Show | 2007 | Tim and Eric Nite Live! | Dr. Pat Gordon Hall | 1 |
| TV Show | 2024 | Universal Basic Guys | David (voice) | 13 |
| TV Show | 2009 | Late Night with Jimmy Fallon | Self | 1 |
| TV Show | 2007 | The Sarah Silverman Program. | Taylor Magenheim | 1 |
| TV Show | 2025 | Randroid | Randroid (voice) | 1 |
| TV Show | 2019 | Los Espookys | Tico | 6 |
| TV Show | 2010 | Conan | Self | 3 |
| TV Show | 2022 | This Fool | Richard Rowell | 1 |
| TV Show | 2021 | Cinema Toast | | 10 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 4 |
| TV Show | 2009 | Late Night with Jimmy Fallon | Self - Guest | 1 |
| TV Show | 2025 | Everybody's Live with John Mulaney | Self | 2 |
| TV Show | 2025 | Good Hang with Amy Poehler | | 1 |
| TV Show | 2025 | Lubach | | 1 |
| TV Show | 2025 | Everybody's Live with John Mulaney | Self - Musical Guest | 1 |
| TV Show | 2015 | Difficult People | Garry Epstein | 3 |
| TV Show | 2013 | Super Fun Night | Brian Headfoot | 1 |
| TV Show | N/A | Rhona Who Lives by the River | Mr. Kortle/Remi's Mom | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 1 |
