| Movie | 1987 | Police Academy 4: Citizens on Patrol | Kyle | |
| Movie | 2006 | Comedy Club Shoot-out: Vol. 1 | Self | |
| Movie | 2001 | Joe Dirt | Joe Dirt | |
| Movie | 1995 | Tommy Boy | Richard Hayden | |
| Movie | 2000 | The Emperor's New Groove | Kuzco (voice) | |
| Movie | 1998 | Senseless | Scott Thorpe | |
| Movie | 2006 | The Benchwarmers | Richie | |
| Movie | 1993 | Coneheads | Eli Turnbull, INS Agent | |
| Movie | 2005 | Kronk's New Groove | Kuzco (voice) | |
| Movie | 2003 | Dickie Roberts: Former Child Star | Dickie Roberts | |
| Movie | 1997 | 8 Heads in a Duffel Bag | Ernie | |
| Movie | 1996 | Black Sheep | Steve Dodds | |
| Movie | 1994 | PCU | Rand McPherson | |
| Movie | 1998 | The Rugrats Movie | Ranger Frank (voice) | |
| Movie | 1992 | Light Sleeper | Theological Cokehead | |
| Movie | 2002 | Paul McCartney: Back in the U.S. | Self | |
| Movie | 2010 | Grown Ups | Marcus Higgins | |
| Movie | 1999 | Lost & Found | Dylan Ramsey | |
| Movie | 2011 | Jack and Jill | Monica | |
| Movie | 1998 | David Spade: Take the Hit | Himself | |
| Movie | 2012 | Hotel Transylvania | Griffin (voice) | |
| Movie | 1993 | Buddy | Buddy 2 | |
| Movie | 2002 | The Sweatbox | Self | |
| Movie | 2013 | Grown Ups 2 | Marcus Higgins | |
| Movie | 2022 | David Spade: Nothing Personal | Self | |
| Movie | 2022 | Norm Macdonald: Nothing Special | Self | |
| Movie | 2023 | Once Upon a Studio | Kuzco (voice) (archive footage) | |
| Movie | 1989 | The 13th Annual Young Comedians Show | | |
| Movie | 2014 | David Spade: My Fake Problems | Self | |
| Movie | 2017 | Mad Families | Johnny Jon-John | |
| Movie | 1990 | Rita Rudner: Born to be Mild | Stage Assistant | |
| Movie | 2005 | Comedy Central Roast of Pamela Anderson | Self | |
| Movie | N/A | Best of the Improv Vol. 1 | Self (archive footage) | |
| Movie | 2015 | Hotel Transylvania 2 | Griffin (voice) | |
| Movie | 2003 | Saturday Night Live: The Best of Chris Farley | Various (archive footage) (uncredited) | |
| Movie | 1998 | Saturday Night Live: The Best of Phil Hartman | The Receptionist | |
| Movie | 2005 | Racing Stripes | Scuzz (voice) | |
| Movie | 2015 | Joe Dirt 2: Beautiful Loser | Joe Dirt | |
| Movie | 2015 | Entourage | David Spade | |
| Movie | 2015 | The Ridiculous 6 | General George Custer | |
| Movie | 2015 | I Am Chris Farley | Self | |
| Movie | N/A | Outcome | | |
| Movie | 2005 | Saturday Night Live: The Best of David Spade | | |
| Movie | 2016 | The Do-Over | Charlie | |
| Movie | 2016 | Comedy Central Roast of Rob Lowe | Self - Roastmaster | |
| Movie | 1998 | Bad Boys of Saturday Night Live | Self / Various (archive footage) | |
| Movie | 2007 | I Now Pronounce You Chuck & Larry | Transvestite Groupie | |
| Movie | 2017 | Sandy Wexler | Testimonial | |
| Movie | 2011 | Hollywood & Wine | Harvey Harrison (uncredited) | |
| Movie | 2018 | Warning Shot | Bobby | |
| Movie | 2018 | Hotel Transylvania 3: Summer Vacation | Griffin (voice) | |
| Movie | 2018 | Father of the Year | Wayne | |
| Movie | 2017 | Saturdays | | |
| Movie | 2001 | The Concert for New York City | Self | |
| Movie | 2020 | The Wrong Missy | Tim Morris | |
| Movie | 1998 | Saturday Night Live: A Tribute to Chris Farley | Self | |
| Movie | 2005 | Lil' Pimp | Principal Nixon (voice) | |
| Movie | 1994 | Reality Bites | The "Wienerschnitzel" Manager (Uncredited) | |
| Movie | 2006 | Grandma's Boy | Shiloh | |
| Movie | 2000 | Loser | Video Store Clerk (uncredited) | |
| Movie | 1996 | A Very Brady Sequel | Sergio (uncredited) | |
| Movie | 2019 | Chris Farley: Anything for a Laugh | | |
| Movie | 2020 | The Netflix Afterparty: The Best Shows of The Worst Year | Self | |
| Movie | 2021 | Fate: The Winx Saga - The Afterparty | Self - Host | |
| Movie | 2021 | Ginny & Georgia - The Afterparty | Self - Host | |
| Movie | 2005 | Last Laugh '05 | Self | |
| Movie | 2021 | Shadow and Bone - The Afterparty | Self - Host | |
| Movie | 2022 | Hotel Transylvania: Transformania | Griffin (voice) | |
| Movie | 2021 | The Circle: The Afterparty | Self | |
| Movie | 2021 | The Upshaws - The Afterparty | Self - Host | |
| Movie | N/A | Busboys | | |
| Movie | 2025 | David Spade: Dandelion | Self | |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 4 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 100 |
| TV Show | 2005 | The Showbiz Show with David Spade | Self - Host | 38 |
| TV Show | 1992 | The Larry Sanders Show | David Spade | 1 |
| TV Show | 2007 | Rules of Engagement | Russell Dunbar | 100 |
| TV Show | 2015 | Fameless Prankers | Self - Host | 18 |
| TV Show | 1997 | Just Shoot Me! | Dennis Finch | 148 |
| TV Show | 2015 | Dana White: Lookin' for a Fight | | 1 |
| TV Show | 2021 | Mr. Mayor | Himself | 1 |
| TV Show | 1986 | ALF | Larry Siotkin | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 2 |
| TV Show | 2013 | Norm Macdonald Live | Self | 1 |
| TV Show | 2002 | 8 Simple Rules | C.J. Barnes | 38 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | David Spade | 1 |
| TV Show | 2016 | Chelsea | Self | 1 |
| TV Show | 2021 | HouseBroken | David Spade (voice) | 1 |
| TV Show | 1989 | Baywatch | B.J. | 1 |
| TV Show | 1999 | Rove | Self | 1 |
| TV Show | 2016 | Crowded | Kyle Sullivan | 1 |
| TV Show | 2023 | Snake Oil | Self - Host | 10 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest Host | 1 |
| TV Show | 1992 | MTV Movie & TV Awards | Self - Presenter | 1 |
| TV Show | 2016 | Love | Steven Hopkins | 3 |
| TV Show | 2011 | Ridiculousness | Self | 1 |
| TV Show | 2017 | The Mayor | Ed Gunt | 3 |
| TV Show | 2004 | Father of the Pride | Tommy (voice) | 1 |
| TV Show | 2020 | Home Movie: The Princess Bride | Westley | 1 |
| TV Show | 2021 | Sammy | Sammy Blake / James Blake (voice) | 13 |
| TV Show | 2007 | Diners, Drive-Ins and Dives | Self | 1 |
| TV Show | 2014 | The Spoils of Babylon | Talc Munson | 6 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 2 |
| TV Show | 2015 | Lip Sync Battle | Self | 1 |
| TV Show | 2013 | @midnight with Chris Hardwick | Self | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 4 |
| TV Show | 2019 | Biography: Comedy Icons | Himself | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 2005 | The Reichen Show | Self | 1 |
| TV Show | 2018 | Norm Macdonald Has a Show | Self - Guest | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 2019 | Lights Out with David Spade | Self - Host | 107 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 4 |
| TV Show | 2019 | Good Talk with Anthony Jeselnik | Self | 1 |
| TV Show | 1993 | Beavis and Butt-Head | Ticket Attendant (voice) | 1 |
| TV Show | 1993 | Beavis and Butt-Head | Mr. Candy (voice) | 1 |
| TV Show | 1993 | Beavis and Butt-Head | Mr. Manners (voice) | 1 |
| TV Show | 2015 | Jay Leno's Garage | Self | 1 |
| TV Show | 2013 | The Goldbergs | Gus | 1 |
| TV Show | 2003 | Comedy Central Roasts | Self | 1 |
| TV Show | 2010 | Hot in Cleveland | Christopher | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self | 1 |
| TV Show | 1992 | MTV Movie & TV Awards | Self | 1 |
| TV Show | 2021 | The Netflix Afterparty | Self - Host | 4 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 4 |
