| Movie | 2010 | Teenage Paparazzo | Self | |
| Movie | 2023 | Downwind | | |
| Movie | 2006 | Accepted | Uncle Ben | |
| Movie | 2006 | Farce of the Penguins | Jimmy (voz) | |
| Movie | 2008 | History of the Joke | Host | |
| Movie | 2006 | Man of the Year | Eddie Langston | |
| Movie | 2007 | Heckler | Self | |
| Movie | 2010 | I Am Comic | Self | |
| Movie | 2011 | Brainwave | | |
| Movie | 2006 | Lewis Black: Red, White & Screwed | Self | |
| Movie | 2005 | The Aristocrats | Self | |
| Movie | 2004 | Lewis Black: Black on Broadway | Self | |
| Movie | 2003 | Lewis Black Unleashed | Self | |
| Movie | 2009 | Lewis Black: Stark Raving Black | Self | |
| Movie | 2010 | Kathleen Madigan: Gone Madigan | Self | |
| Movie | 2006 | Unaccompanied Minors | Oliver Porter | |
| Movie | 2023 | Lewis Black: Tragically, I Need You | Self | |
| Movie | 2002 | Lewis Black: Taxed Beyond Belief | Professor Black | |
| Movie | 2009 | Surviving the Holidays with Lewis Black | Self | |
| Movie | 2012 | Lewis Black: In God We Rust | Self | |
| Movie | 2011 | Afghan Luke | Lewis Black | |
| Movie | 2015 | Inside Out | Anger (voice) | |
| Movie | 2010 | Peep World | Narrator (voice) | |
| Movie | 2022 | The Kids in the Hall: Comedy Punks | Self | |
| Movie | 2010 | Basic Black: The Lewis Black Story | | |
| Movie | 2011 | Caris' Peace | Self | |
| Movie | 2013 | The Muslims Are Coming! | Self | |
| Movie | 2024 | Atrabilious | Roy Altman | |
| Movie | 2009 | Just For Laughs: Over The Edge | Self | |
| Movie | 2013 | Lewis Black: Old Yeller - Live at the Borgata | Self | |
| Movie | 2013 | The Improv: 50 Years Behind the Brick Wall | Self | |
| Movie | 2024 | Inside Out 2 | Anger (voice) | |
| Movie | 2005 | Celebrity Mix | Self (archive footage) | |
| Movie | 2015 | Misery Loves Comedy | Self | |
| Movie | 2016 | Better Off Single | Charlie's Therapist | |
| Movie | 2016 | Rock Dog | Linnux (voice) | |
| Movie | 2006 | Falling for Grace | Rob York | |
| Movie | 1993 | Joey Breaker | Pete Grimm | |
| Movie | 2015 | Mind Candy | Anger (voice) | |
| Movie | 2015 | Introducing Parker Dowd | Drew | |
| Movie | 2006 | Just for Laughs Stand Up, Vol. 2: On the Edge | Self | |
| Movie | 2016 | Lewis Black: Black to the Future | Self | |
| Movie | N/A | Untitled Mitch Hedberg documentary | Self | |
| Movie | 1986 | Hannah and Her Sisters | Paul | |
| Movie | 2017 | Imitation Girl | Lew | |
| Movie | 2017 | Gilbert | Self | |
| Movie | 2015 | Lewis Black & Friends - A Night to Let Freedom Laugh (Live in Washington D.C.) | Self | |
| Movie | 1990 | Jacob's Ladder | Jacob's Doctor | |
| Movie | 2018 | Robin Williams: Come Inside My Mind | Self | |
| Movie | 2008 | Comedy Central Roast of Bob Saget | Self | |
| Movie | 1991 | The Hard Way | Banker | |
| Movie | 2019 | The Last Laugh | Max Becker | |
| Movie | 1993 | The Night We Never Met | Marty Holder | |
| Movie | 2005 | The Happy Elf | Norbert (voice) | |
| Movie | 2020 | Have a Good Trip: Adventures in Psychedelics | Self | |
| Movie | 2011 | Give It Up for Greg Giraldo | Self | |
| Movie | 2006 | Last Laugh '06 | Self - Host | |
| Movie | 2014 | Comedy Warriors: Healing Through Humor | Self - Coach | |
| Movie | 2003 | The Gynecologists | Cookie LaMotte | |
| Movie | 2002 | American Dummy | Club Owner | |
| Movie | 2020 | Lewis Black: Thanks For Risking Your Life | Self | |
| Movie | 2015 | Riley's First Date? | Anger (voice) | |
| Movie | 2003 | 60 Spins Around the Sun | Self | |
| Movie | 2005 | Last Laugh '05 | Self | |
| Movie | 2014 | The Rant Is Due: Live From Napa | Self | |
| Movie | 2021 | Too Soon: Comedy After 9/11 | Self | |
| Movie | 2024 | Spongebob and Sandy’s Country Christmas | Santa Claus | |
| TV Show | 1992 | Mad About You | Pizza Slice | 1 |
| TV Show | 1990 | Law & Order | Director Franklin Frome | 1 |
| TV Show | 2007 | The Big Bang Theory | Professor Crawley | 1 |
| TV Show | 2000 | Harvey Birdman, Attorney at Law | The Deadly Duplicator (voice) | 4 |
| TV Show | 1996 | The Daily Show | Self | 7 |
| TV Show | 1997 | The View | Self | 4 |
| TV Show | 1999 | Law & Order: Special Victims Unit | B.J. Cameron | 1 |
| TV Show | 1979 | CBS News Sunday Morning | Self | 1 |
| TV Show | 1998 | Comedy Central Presents | Self | 3 |
| TV Show | 1993 | Homicide: Life on the Street | Laszlo 'Punchy' DeLeon | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 8 |
| TV Show | 2008 | Lewis Black's Root of All Evil | Self - Host | 18 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 2006 | Live at Gotham | Self | 1 |
| TV Show | 2010 | Robotomy | Gore-Ax | 10 |
| TV Show | 2014 | Late Night with Seth Meyers | Self - Guest | 2 |
| TV Show | 1999 | SpongeBob SquarePants | Santa Claus (voice) | 2 |
| TV Show | 2021 | Kamp Koral: SpongeBob's Under Years | Santa Claus (voice) | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Comedy Guest | 3 |
| TV Show | 2003 | Duck Dodgers | Manobrain (voice) | 1 |
| TV Show | 2010 | The Green Room with Paul Provenza | Self | 1 |
| TV Show | 2012 | Gotham Comedy Live | Self - Host | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 2 |
| TV Show | 2017 | The History of Comedy | Self | 14 |
| TV Show | 2008 | The Penguins of Madagascar | Dale (voice) | 1 |
| TV Show | 2016 | Crisis in Six Scenes | Al | 6 |
| TV Show | 1996 | The Daily Show | Self - Guest Correspondent | 1 |
| TV Show | 2016 | Madoff | Gregory Perkins | 4 |
| TV Show | 2012 | Comedians in Cars Getting Coffee | Self | 1 |
| TV Show | 2009 | Celebrity Ghost Stories | Self | 1 |
| TV Show | 1987 | The Days and Nights of Molly Dodd | Bernie | 5 |
| TV Show | 2012 | Teenage Mutant Ninja Turtles | Vic / Spider Bytez (voice) | 1 |
| TV Show | 2003 | Comedy Central Roasts | Self | 1 |
| TV Show | 2010 | Robotomy | The Gore-Ax/The Scrap Metal Spirit of Insanus | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self - Guest | 1 |
| TV Show | 2010 | Scooby-Doo! Mystery Incorporated | Mr. E (voice) | 22 |
| TV Show | 2010 | Scooby-Doo! Mystery Incorporated | Mr. E / Ricky Owens (voice) | 1 |
| TV Show | 2024 | Dream Productions | Anger (voice) | 4 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 2018 | The Epic Tales of Captain Underpants | Ragely J. Snarlingtooth (voice) | 1 |
| TV Show | 1996 | Full Frontal Comedy | self | 1 |
| TV Show | 2000 | The Brak Show | Movie Zorak (voice) | 1 |
| TV Show | 2000 | The Brak Show | The Slug (voice) | 1 |
| TV Show | 2024 | Have I Got News for You | Self | 1 |
| TV Show | 2015 | Be Cool, Scooby-Doo! | Mayor Stoughton (voice) | 1 |
