| Movie | 2001 | Heartbreakers | Bill | |
| Movie | 2008 | Visioneers | George | |
| Movie | 2009 | Up in the Air | Steve | |
| Movie | 2007 | The Comedians of Comedy: Live at The Troubadour | Self | |
| Movie | 2009 | Youth in Revolt | Jerry | |
| Movie | 2013 | Justin Bieber's Believe | Self | |
| Movie | 2025 | Lilo & Stitch | Jumba | |
| Movie | 2008 | What Happens in Vegas | Dave the Bear | |
| Movie | 2002 | Below | Weird Wally | |
| Movie | 2001 | Bubble Boy | Bus Stop Man | |
| Movie | 2010 | Operation: Endgame | Hermit | |
| Movie | 2010 | Due Date | Ethan Tremblay | |
| Movie | 2007 | Super High Me | Self | |
| Movie | 2001 | Out Cold | Luke | |
| Movie | 2021 | Ron's Gone Wrong | Ron (voice) | |
| Movie | 2008 | Gigantic | Homeless Man | |
| Movie | 2010 | It's Kind of a Funny Story | Bobby | |
| Movie | 2011 | The Hangover Part II | Alan Garner | |
| Movie | 2005 | The Comedians of Comedy | Self | |
| Movie | 2007 | Zach Galifianakis: Live at the Purple Onion | Himself / Seth Galifianakis | |
| Movie | 2005 | Zach Galifianakis: Look Who it Isn't | Himself | |
| Movie | 2010 | Dinner for Schmucks | Therman | |
| Movie | 2009 | The Hangover | Alan Garner | |
| Movie | 2022 | The Bob's Burgers Movie | Felix Fischoeder (voice) | |
| Movie | 2023 | The Beanie Bubble | Ty | |
| Movie | 2009 | Little Fish, Strange Pond | Bucky | |
| Movie | 2009 | G-Force | Ben | |
| Movie | 2012 | The Campaign | Marty Huggins | |
| Movie | 2012 | Mansome | Self | |
| Movie | 2013 | The Hangover Part III | Alan Garner | |
| Movie | 2012 | The Bitter Buddha | Self | |
| Movie | 2006 | The Pity Card | Zach | |
| Movie | 2014 | Birdman or (The Unexpected Virtue of Ignorance) | Jake | |
| Movie | 2013 | Are You Here | Ben Baker | |
| Movie | 2012 | Tim and Eric's Billion Dollar Movie | Jim Joe Kelly | |
| Movie | 2017 | Tulip Fever | Gerrit | |
| Movie | 2007 | Into the Wild | Kevin | |
| Movie | 2016 | Masterminds | David Ghantt | |
| Movie | 2005 | Fiona Apple: Extraordinary Machine | Himself | |
| Movie | 2014 | Muppets Most Wanted | Hobo Joe | |
| Movie | 2011 | The Muppets | Hobo Joe | |
| Movie | 2008 | Largo | Self | |
| Movie | 2024 | Thelma the Unicorn | Crusty Trucker (voice) | |
| Movie | 2024 | Winner | Ronald Winner | |
| Movie | 2016 | Keeping Up with the Joneses | Jeff Gaffney | |
| Movie | 2010 | Fantasia in Best Show Minor | | |
| Movie | 2015 | Tig | Self | |
| Movie | 1999 | Flushed | Pathetic Guy | |
| Movie | 2025 | The Wizard of the Kremlin | | |
| Movie | 2013 | Wolfpack Only: The Hangover Retrospective | Self | |
| Movie | 2002 | Stella Shorts 1998-2002 | Santa | |
| Movie | 2016 | Queen Mimi | Self | |
| Movie | 2010 | Tim and Eric Awesome Show, Great Job! Chrimbus Special | Tairy Greene | |
| Movie | 2017 | The Lego Batman Movie | Joker (voice) | |
| Movie | 2004 | Zach and Avery of Fergus | Homeless Man | |
| Movie | 2011 | Puss in Boots | Humpty Dumpty (voice) | |
| Movie | 2018 | A Wrinkle in Time | The Happy Medium | |
| Movie | 2019 | Missing Link | Mr. Susan Link (voice) | |
| Movie | 2017 | One Brick at a Time: Making the LEGO Batman Movie | Self | |
| Movie | 2015 | Birdman: All-Access (A View From the Wings) | Self | |
| Movie | 2018 | A Legendary Christmas with John & Chrissy | Self | |
| Movie | 2020 | The Sunlit Night | Haldor | |
| Movie | 2017 | Batman Is Just Not That Into You | Joker (voice) | |
| Movie | 2019 | Between Two Ferns: The Movie | Zach Galifianakis | |
| Movie | 2001 | Corky Romano | Computer Hacker Dexter | |
| Movie | 2014 | Comedy Warriors: Healing Through Humor | Self - Coach | |
| Movie | 2012 | Smile | | |
| Movie | 2020 | Joker: Put on a Happy Face | Self | |
| Movie | 2013 | Here Comes the Night Time | Captain Zach the Astronaut | |
| Movie | 2010 | Just 3 Boyz | Zach | |
| Movie | 2008 | A Vodka Movie | Zach | |
| Movie | 2004 | Last Laugh '04 | Jesus | |
| Movie | N/A | The Gallerist | | |
| Movie | 2008 | David's Situation | Self | |
| Movie | 2025 | SNL50: The Homecoming Concert | Self | |
| Movie | 2011 | Saturday Night Live: The Best of '09/'10 | | |
| TV Show | 2005 | American Dad! | Heavyset Man and Norman (voice) | 1 |
| TV Show | 2005 | Wonder Showzen | | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | | 2 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Tairy Greene | 5 |
| TV Show | 2006 | Dog Bites Man | Alan Finger | 10 |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 2003 | Reno 911! | Frisbee | 4 |
| TV Show | 2003 | Tru Calling | Davis | 26 |
| TV Show | 2004 | Tom Goes to the Mayor | Dr. Vickerson (voice) | 2 |
| TV Show | 2012 | Inside Comedy | Self | 1 |
| TV Show | 2005 | Too Late with Adam Carolla | | 1 |
| TV Show | 1998 | Comedy Central Presents | | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Comedy Guest | 2 |
| TV Show | 2002 | Late World with Zach | Himself | 35 |
| TV Show | 2005 | Comedians of Comedy | Self | 6 |
| TV Show | 2009 | Bored to Death | Ray Hueston | 24 |
| TV Show | 2001 | Next Caller | | 2 |
| TV Show | 2008 | Between Two Ferns with Zach Galifianakis | Self - Host | 21 |
| TV Show | 2011 | Bob's Burgers | Felix Fischoeder (voice) | 1 |
| TV Show | 2016 | Baskets | Chip Baskets / Dale Baskets | 40 |
| TV Show | 2005 | American Dad! | Juror (voice) | 1 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 5 |
| TV Show | 2016 | America Divided | Self | 8 |
| TV Show | 2007 | Tim and Eric Awesome Show, Great Job! | Tairy Greene as The Snuggler | 1 |
| TV Show | 2017 | The Gong Show | Self - Judge | 1 |
| TV Show | 2011 | Bob's Burgers | Chet (voice) | 1 |
| TV Show | 2011 | Bob's Burgers | Felix (voice) | 12 |
| TV Show | 2017 | Big Mouth | Gratitoad (voice) | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 3 |
| TV Show | 2012 | Comedians in Cars Getting Coffee | Self | 1 |
| TV Show | 2016 | Bajillion Dollar Propertie$ | The Bloodhound | 1 |
| TV Show | 2018 | My Next Guest Needs No Introduction with David Letterman | Self | 1 |
| TV Show | 2014 | Tim and Eric's Bedtime Stories | Zach | 1 |
| TV Show | 1975 | Saturday Night Live | Self | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 4 |
| TV Show | 2001 | Next! | | 2 |
| TV Show | 1989 | The Simpsons | Lucas Bortner (voice) | 1 |
| TV Show | 2014 | Off Camera with Sam Jones | Self | 1 |
| TV Show | 2007 | Tim and Eric Nite Live! | Richard Dunn | 1 |
| TV Show | 2007 | The Sarah Silverman Program. | Fred Blorth | 1 |
| TV Show | 1996 | Boston Common | Bobby | 5 |
| TV Show | 2013 | Brody Stevens: Enjoy It! | Himself | 12 |
| TV Show | 2012 | Brody Stevens: Enjoy It! | Himself | 1 |
| TV Show | 2021 | Only Murders in the Building | Zach Galifianakis | 7 |
| TV Show | 2020 | Dicktown | Charlie | 1 |
| TV Show | 2010 | Conan | Self | 2 |
| TV Show | N/A | The Audacity | Carl Bardolph | 0 |
