| Movie | 1993 | Judgment Night | Fallon | |
| Movie | 1999 | The Thomas Crown Affair | Det. Michael McCann | |
| Movie | 2002 | Ice Age | Diego (voice) | |
| Movie | 2006 | Ice Age: The Meltdown | Diego (voice) | |
| Movie | 1997 | Wag the Dog | Fad King | |
| Movie | 1997 | Suicide Kings | Lono Veccio | |
| Movie | 1994 | The Ref | Gus | |
| Movie | 1997 | The Matchmaker | Nick | |
| Movie | 1998 | Monument Ave. | Bobby O'Grady | |
| Movie | 2001 | Final | Bill | |
| Movie | 1993 | The Sandlot | Bill | |
| Movie | 1998 | Small Soldiers | Gil Mars | |
| Movie | 1993 | Gunmen | Armor O'Malley | |
| Movie | 2009 | Ice Age: Dawn of the Dinosaurs | Diego (voice) | |
| Movie | 1997 | Denis Leary: Lock 'N Load | Himself | |
| Movie | 2000 | Jesus' Son | Wayne | |
| Movie | 1998 | A Bug's Life | Francis (voice) | |
| Movie | 1993 | Demolition Man | Edgar Friendly | |
| Movie | 1993 | Who's the Man? | Sgt. Cooper | |
| Movie | 1998 | Wide Awake | Mr. Beal | |
| Movie | 1993 | National Lampoon's Loaded Weapon 1 | Mike McCracken | |
| Movie | 2002 | The Secret Lives of Dentists | Slater | |
| Movie | 1993 | Denis Leary: No Cure for Cancer | Himself | |
| Movie | 1995 | Operation Dumbo Drop | Lt. David Poole | |
| Movie | 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self | |
| Movie | 2001 | Double Whammy | Ray Pluto | |
| Movie | 2008 | Recount | Michael Whouley | |
| Movie | 1998 | The Real Blonde | Doug | |
| Movie | 2005 | Merry F#%$in' Christmas | Self | |
| Movie | 2000 | Company Man | Officer Fry | |
| Movie | 1999 | Do Not Disturb | Simon | |
| Movie | 2002 | Dawg | Douglas 'Dawg' Menford | |
| Movie | 1995 | The Neon Bible | Frank | |
| Movie | 1996 | Two If by Sea | Francis 'Frank' O'Brien | |
| Movie | 2011 | Denis Leary and Friends Present: Douchebags and Donuts | Himself | |
| Movie | 2004 | Reverse of the Curse of the Bambino | Himself | |
| Movie | 2003 | The Curse of the Bambino | Himself | |
| Movie | 2012 | Ice Age: Continental Drift | Diego (voice) | |
| Movie | 1996 | Underworld | Johnny Crown / Johnny Alt | |
| Movie | 2011 | Ice Age: A Mammoth Christmas | Diego (voice) | |
| Movie | 2014 | The Amazing Spider-Man 2 | Captain Stacy (uncredited) | |
| Movie | 2010 | Back From Hell: A Tribute to Sam Kinison | Self | |
| Movie | 1995 | National Lampoon's Favorite Deadly Sins | Jake | |
| Movie | 2014 | Draft Day | Vince Penn | |
| Movie | 2000 | Lakeboat | Fireman | |
| Movie | 1997 | Love Walked In | Jack Hanaway | |
| Movie | 2015 | Freaks of Nature | Rick Wilson | |
| Movie | 2022 | Spider-Man: All Roads Lead to No Way Home | Self (archive footage) | |
| Movie | 2012 | The Amazing Spider-Man | Captain Stacy | |
| Movie | 2003 | When Stand Up Stood Out | Self | |
| Movie | 2021 | Patrice O'Neal: Killing Is Easy | Self | |
| Movie | 1997 | The Second Civil War | Vinnie Franco | |
| Movie | 1999 | True Crime | Bob Findley | |
| Movie | 2000 | Sand | Teddy | |
| Movie | 1993 | Denis Leary: MTV Unplugged | Himself | |
| Movie | 2003 | Comedy Central Roast of Denis Leary | Self | |
| Movie | 2005 | Comedy Central Roast of Jeff Foxworthy | Self | |
| Movie | 2016 | Ice Age: Collision Course | Diego (voice) | |
| Movie | 2005 | NHL: Vintage Collection: Greatest Goals | | |
| Movie | 2003 | Lord Stanley's Cup: Hockey's Ultimate Prize | | |
| Movie | 2015 | Cosmic Scrat-tastrophe | Diego (voice) | |
| Movie | 2016 | Ice Age: The Great Egg-Scapade | Diego (voice) | |
| Movie | 2025 | Oh. What. Fun. | | |
| Movie | 2012 | Vanilla Ice Archive | Self (archive footage) | |
| Movie | 2004 | 2004 Boston Red Sox: The Official World Series Film | Narrator | |
| Movie | 1991 | Strictly Business | Jake | |
| Movie | 2011 | Scrat's Continental Crack-Up: Part 2 | Diego (voice) | |
| Movie | 1987 | A Long Walk To Forever | Newt | |
| Movie | 2006 | Kings of Comedy USA | Self (archive footage) | |
| Movie | 1997 | Subway Stories | Wheelchair Man (segment "The Red Shoes") | |
| Movie | 2011 | Give It Up for Greg Giraldo | Self | |
| Movie | 1995 | The State's 43rd Annual All-Star Halloween Special | Self | |
| Movie | 2006 | World's Greatest Stand Up: Volume One | self | |
| Movie | 2004 | Last Laugh '04 | Self | |
| Movie | 2016 | 9/11: Fifteen Years Later | Self - Host | |
| Movie | 2026 | Ice Age 6 | Diego (voice) | |
| Movie | 2012 | Rite of Passage: The Amazing Spider-Man Reborn | Self | |
| TV Show | 2001 | The Job | Mike McNeil | 19 |
| TV Show | 1989 | The Simpsons | Denis Leary (voice) | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 1 |
| TV Show | 2004 | The Tony Danza Show | Self | 1 |
| TV Show | 2002 | Tough Crowd with Colin Quinn | | 57 |
| TV Show | 1996 | The Daily Show | Self | 12 |
| TV Show | 2002 | Crank Yankers | | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | | 1 |
| TV Show | 1997 | The View | Self | 8 |
| TV Show | 1999 | The Early Show | Self | 1 |
| TV Show | 1995 | Dr. Katz, Professional Therapist | Dennis (voice) | 1 |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 3 |
| TV Show | 1979 | CBS News Sunday Morning | Self | 1 |
| TV Show | 2004 | Rescue Me | Tommy Gavin | 93 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 6 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2002 | Contest Searchlight | | 4 |
| TV Show | 2004 | Fashion Rocks | Self | 2 |
| TV Show | 1998 | Fantasy World Cup | Self | 1 |
| TV Show | 2015 | Sex&Drugs&Rock&Roll | Johnny Rock | 20 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 2 |
| TV Show | 2021 | Law & Order: Organized Crime | Frank Donnelly | 9 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 3 |
| TV Show | 2004 | Father of the Pride | Chaz (voice) | 1 |
| TV Show | 1994 | Space Ghost Coast to Coast | | 1 |
| TV Show | 2002 | Last Call with Carson Daly | Self | 1 |
| TV Show | 2024 | No Good Deed | Mikey | 8 |
| TV Show | 2016 | Animal Kingdom | Billy | 10 |
| TV Show | 2006 | Rachael Ray | | 3 |
| TV Show | 2019 | The Moodys | Sean Moody Sr. | 14 |
| TV Show | 2003 | Comedy Central Roasts | Self | 1 |
| TV Show | 2025 | Going Dutch | Colonel Patrick Quinn | 10 |
| TV Show | 1999 | Family Guy | Car Mechanic (voice) | 1 |
| TV Show | 2009 | Late Night with Jimmy Fallon | Self | 1 |
| TV Show | 2010 | Conan | Self | 2 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 2 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2012 | Honest Trailers | George Stacy (archive footage) | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 1 |
