| Movie | 2017 | Springfield of Dreams: The Legend of Homer Simpson | Self | |
| Movie | 2006 | Last Days on Earth | Self | |
| Movie | N/A | MiP: The Journey Across the Universe | Neil deGrasse Tyson (voice) | |
| Movie | 2009 | 400 Years of the Telescope | Narrator (voice) | |
| Movie | 2012 | The Reality of Me | Self | |
| Movie | 2023 | Albert Brooks: Defending My Life | Self | |
| Movie | 2022 | Carbon: The Unauthorised Biography | Self | |
| Movie | 2019 | Timelapse of the Future: A Journey to the End of Time | Self - Narrator (archive sound) | |
| Movie | 2009 | How Life Began | Self | |
| Movie | 2015 | Hot Sugar's Cold World | Self | |
| Movie | 2024 | This Is Me…Now | Taurus | |
| Movie | N/A | Gracie | Self | |
| Movie | 2024 | The Greatest Love Story Never Told | Self | |
| Movie | 2016 | Ice Age: Collision Course | Neil deBuck Weasel (voice) | |
| Movie | 2016 | Zoolander 2 | Neil deGrasse Tyson | |
| Movie | 2016 | Batman v Superman: Dawn of Justice | Neil deGrasse Tyson | |
| Movie | 2024 | Sigourney Weaver - Actionheldin und Stil-Ikone | Self | |
| Movie | 2016 | For the Love of Spock | Self | |
| Movie | 2016 | Scrat: Spaced Out | Narrator | |
| Movie | 2017 | Food Evolution | Narrator | |
| Movie | 2016 | Fight For Space | Self | |
| Movie | 2008 | Einstein | Neil deGrasse Tyson | |
| Movie | 2017 | Logic's Everybody Documentary | Self | |
| Movie | 2017 | The Mars Generation | Self | |
| Movie | 2016 | The Atheist Delusion | Self (archive footage) | |
| Movie | 2017 | The Truth Is in the Stars | Self | |
| Movie | 2017 | Bill Nye: Science Guy | Self | |
| Movie | 2002 | Unfolding Universe | Self | |
| Movie | 2006 | Nova: Monster Of The Milky Way | Self | |
| Movie | N/A | Neil deGrasse Tyson - Conspiracy Theories & Skepticism | Self | |
| Movie | 2018 | The Last Sharknado: It's About Time | Merlin | |
| Movie | 2018 | MARS: Inside SpaceX | Self | |
| Movie | 2013 | Dark Universe | Self - Narrator (voice) | |
| Movie | 2017 | The Boundary | Neil deGrasse Tyson | |
| Movie | 2015 | Hubble's Cosmic Journey | Narrator (voice) | |
| Movie | 2017 | Katy Perry: Will You Be My Witness? | Self | |
| Movie | 2016 | Lazer Team | Self | |
| Movie | 2018 | Black Hole Apocalypse | Self | |
| Movie | 2021 | Woman in Motion | Self | |
| Movie | 2024 | Fortitude: Forging the Trillion Dollar Space Economy | Self | |
| Movie | 2018 | Turning Point | Self | |
| Movie | 2017 | Future '38 | Neil deGrasse Tyson | |
| Movie | 2011 | Where Did We Come From? | Self | |
| TV Show | 2005 | The Colbert Report | Self | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 8 |
| TV Show | 2019 | Retro Tech | Self - Astrophysicist, Planetary Scientist & Author | 1 |
| TV Show | 2021 | This Is Pop | Self (archive footage) | 1 |
| TV Show | 2014 | Cosmos | Self - Host | 26 |
| TV Show | 1974 | NOVA | Self - Narrator | 1 |
| TV Show | 1974 | NOVA | Self - Host | 5 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 2 |
| TV Show | 2015 | StarTalk with Neil deGrasse Tyson | Self - Host | 76 |
| TV Show | 2012 | Gravity Falls | Waddles' Machine (voice) | 1 |
| TV Show | 2017 | Talking with Chris Hardwick | Self | 1 |
| TV Show | 2016 | Chelsea | Self | 2 |
| TV Show | 2015 | Hot Ones | Self | 1 |
| TV Show | 2012 | The Inexplicable Universe: Unsolved Mysteries | Self | 6 |
| TV Show | 2022 | Pantheon | Dr. Moore (voice) | 1 |
| TV Show | 2007 | The Big Bang Theory | Neil deGrasse Tyson | 2 |
| TV Show | 2003 | MythBusters | Self | 1 |
| TV Show | 2022 | Sherri | Self - Guest | 2 |
| TV Show | 2013 | @midnight with Chris Hardwick | Self - Guest | 1 |
| TV Show | 2019 | Scooby-Doo and Guess Who? | Neil deGrasse Tyson (voice) | 1 |
| TV Show | 2016 | Match Game | Self - Panelist | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2015 | Celebrity Family Feud | Self | 1 |
| TV Show | 1997 | The View | Self | 3 |
| TV Show | 2005 | NOVA scienceNOW | Host | 29 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 2010 | Regular Show | Self (voice) | 1 |
| TV Show | 2004 | Stargate Atlantis | Neil deGrasse Tyson | 1 |
| TV Show | 2013 | Brooklyn Nine-Nine | Neil deGrasse Tyson | 1 |
| TV Show | 2015 | Miles from Tomorrowland | Main Title Narration (voice) | 39 |
| TV Show | 2023 | Velma | Neil deGrasse Tyson (voice) | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 2 |
| TV Show | 2008 | Q&A | Self - Panellist | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 13 |
| TV Show | 2015 | Jay Leno's Garage | Self | 1 |
| TV Show | 2014 | BoJack Horseman | Planetarium Narrator (voice) | 1 |
| TV Show | 1989 | The Simpsons | Neil deGrasse Tyson (voice) | 1 |
| TV Show | 2019 | Could You Survive The Movies? | Self | 1 |
| TV Show | 1999 | Family Guy | Neil deGrasse Tyson (voice) | 2 |
| TV Show | 2017 | Bill Nye Saves the World | Self - Voice of Coffee Maker | 1 |
| TV Show | 2018 | Firing Line with Margaret Hoover | | 1 |
| TV Show | 2023 | UFOs: Investigating the Unknown | Self - Director, Hayden Planetarium | 1 |
| TV Show | 2021 | Celebrity Wheel of Fortune | Self - Contestant | 1 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self | 1 |
| TV Show | 1999 | Futurama | Neil deGrasse Tyson (voice) | 1 |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 2022 | Who's Talking to Chris Wallace? | Self | 1 |
| TV Show | 2022 | Celebrity Jeopardy! | Self | 1 |
| TV Show | 2024 | Hasan Minhaj Doesn't Know | Self | 1 |
