| Movie | 1991 | Bernard and the Genie | Josephus the Genie | |
| Movie | 2006 | Penelope | Krull | |
| Movie | 2014 | Rik Mayall: Lord of Misrule | Self | |
| Movie | 2004 | Remember the Secret Policeman's Ball? | Self | |
| Movie | 2012 | The Pirates! In an Adventure with Scientists! | Peg Leg Hastings (voice) | |
| Movie | 1991 | True Identity | Miles Pope | |
| Movie | 1987 | The Secret Policeman’s Third Ball | Self | |
| Movie | 1989 | The Secret Policeman’s Biggest Ball | Self | |
| Movie | 1988 | The Suicide Club | Cam | |
| Movie | 2017 | Comic Relief: Red Nose Day | Self - Presenter | |
| Movie | 1989 | Lenny Live and Unleashed | Himself & various characters | |
| Movie | 2021 | Parkinson at 50 | Self (archive footage) | |
| Movie | 2002 | The Best of French & Saunders | Various | |
| Movie | 1987 | Coast to Coast | Ritchie Lee | |
| Movie | 1996 | Famous Fred | Fred (voice) | |
| Movie | 1989 | Work Experience | Terence | |
| Movie | 2022 | My Name Is Leon | Mr. Johnson | |
| Movie | 2011 | The Secret Life of Bob Monkhouse | | |
| Movie | 2016 | Let's Do It: A Tribute to Victoria Wood | Self | |
| Movie | 2022 | Birmingham 2022 Commonwealth Games Opening Ceremony | Self | |
| Movie | 2011 | Red Nose Day: 25 Monster Years | Self | |
| Movie | 1990 | South Atlantic Raiders: Part 1 | Warder | |
| Movie | 2022 | The Lord of the Rings: The Rings of Power Global Fan Screening | Sadoc Burrows | |
| Movie | 1990 | Oxford | Steve Wild | |
| Movie | 2023 | An Audience with Kylie | Self | |
| Movie | 2016 | Our Queen at Ninety | Self | |
| Movie | 2005 | The Comic Strip - A Retrospective | Self | |
| Movie | 1989 | Just Like That! | Self | |
| Movie | 1991 | Lenny Go Home | Self | |
| Movie | 1991 | Alive and Kicking | Stevie 'Smudger' Smith | |
| Movie | 2005 | MirrorMask | Cops 1-4 | |
| Movie | 2024 | Comic Relief 2024: Funny for Money | Self | |
| Movie | 2005 | Lenny Henry Live - So Much Things To Say | | |
| Movie | 2015 | Danny & the Human Zoo | Samson | |
| Movie | 2021 | Beauty and the Beast: A Comic Relief Pantomime for Christmas | Self | |
| Movie | 2025 | The Magic Faraway Tree | | |
| Movie | 2024 | Wallace & Gromit: Vengeance Most Fowl | Mr. Convenience (voice) | |
| Movie | 2009 | Now That’s What I Call Comedy | Himself | |
| Movie | 2016 | Neil Gaiman: Dream Dangerously | Self | |
| Movie | 2025 | Grand Prix of Europe | Erwin (voice) | |
| Movie | 2024 | Art Matters | Self | |
| Movie | 1999 | Rude For A Reason: Live from Brixton Academy | Himself | |
| Movie | 2004 | Harry Potter and the Prisoner of Azkaban | Shrunken Head (voice) | |
| Movie | 1992 | In Dreams | Lenny/Michael Jackson/Prince | |
| Movie | 1994 | White Goods | Charlie Collins | |
| Movie | 2012 | National Theatre Live: The Comedy of Errors | Antipholus of Syracuse | |
| Movie | 2018 | Zog | Himself - Narrator (voice) | |
| Movie | 2019 | Happy Birthday OU: 50 Years of the Open University | Himself - Presenter | |
| Movie | 1992 | Black and White in Colour | Himself | |
| Movie | 1997 | The Story of Bean | Self | |
| Movie | 2020 | The Big Night In | Self - Presenter | |
| Movie | 1986 | The Comic Relief Utterly Utterly Rude Video Live | Self | |
| Movie | 2020 | Black Classical Music: The Forgotten History | Self - Presenter | |
| Movie | 2021 | Zog and the Flying Doctors | Narrator (voice) | |
| Movie | 2020 | Billy Connolly: It’s Been a Pleasure... | Self | |
| Movie | N/A | Tommy Cooper at the BBC | Presenter | |
| Movie | 2006 | It Started with Swap Shop | Self | |
| Movie | 2012 | The Diamond Jubilee Concert 2012 | Self - Presenter | |
| Movie | 2003 | Lying To Michael Jackson | Michael Jackson | |
| Movie | 2008 | Gaybo Laughs Back | Self | |
| Movie | N/A | The Lenny Henry Birthday Show | | |
| Movie | 1999 | The Man | Dennis Jackson | |
| Movie | 1994 | Lenny Henry: Live and Loud! Tour 1994 | | |
| Movie | 2025 | Jay Kelly | | |
| TV Show | 1999 | Hope and Glory | Ian George | 10 |
| TV Show | 1993 | Shooting Stars | Self | 1 |
| TV Show | 1974 | Tiswas | | 302 |
| TV Show | 2006 | The One Show | Self | 2 |
| TV Show | 1993 | Chef | Gareth Blackstock | 20 |
| TV Show | 1981 | Three of a Kind | Self / Various Characters | 16 |
| TV Show | 1976 | The Secret Policeman's Ball | Self | 15 |
| TV Show | 1982 | The Young Ones | Postman | 1 |
| TV Show | 1986 | Omnibus Presents Comic Relief | | 1 |
| TV Show | 1949 | The BAFTA Awards | Host | 1 |
| TV Show | 1987 | The Lenny Henry Show | | 13 |
| TV Show | 1982 | O.T.T. | | 13 |
| TV Show | 2000 | Lenny Henry in Pieces | | 15 |
| TV Show | 1975 | The Summer Show | | 5 |
| TV Show | 1989 | Saturday Night Clive | | 1 |
| TV Show | 2004 | The Lenny Henry Show | | 16 |
| TV Show | 2010 | Los cuentos de Tinga Tinga | | 52 |
| TV Show | 2002 | V Graham Norton | Self | 1 |
| TV Show | 1983 | Natural World | Narrator | 1 |
| TV Show | 1998 | Lenny Goes to Town | | 6 |
| TV Show | 2007 | Lenny's Britain | Himself - Presenter | 4 |
| TV Show | 1986 | Lenny Henry Tonite | | 6 |
| TV Show | 1984 | Aspel & Company | | 1 |
| TV Show | 2008 | Lenry Henry.TV | | 6 |
| TV Show | 1981 | Six Fifty-Five Special | Self | 1 |
| TV Show | 2008 | Big & Small | | 78 |
| TV Show | 2022 | The Witcher: Blood Origin | Chief Sage Balor | 4 |
| TV Show | 1984 | The Lenny Henry Show | Self / Various | 12 |
| TV Show | 2012 | The Syndicate | Godfrey Watson | 6 |
| TV Show | 1998 | Windrush | Himself | 4 |
| TV Show | 2007 | A Bucket O' French and Saunders | | 1 |
| TV Show | 2006 | The One Show | Self - Guest | 1 |
| TV Show | 1985 | Happy Families | Hollywood Hobo | 1 |
| TV Show | 2005 | Harry & Paul | | 1 |
| TV Show | 2013 | Broadchurch | Ed Burnett | 8 |
| TV Show | 2014 | W1A | Self | 1 |
| TV Show | 1982 | Wogan | Self | 3 |
| TV Show | 2006 | Great British Menu | Self - Guest Judge | 1 |
| TV Show | 2022 | Lenny Henry's Caribbean Britain | Presenter | 2 |
| TV Show | 1987 | Going Live! | Self | 2 |
| TV Show | 2014 | A Life on Screen | Himself | 1 |
| TV Show | 2022 | The Sandman | Martin Tenbones (voice) | 3 |
| TV Show | 2018 | The Long Song | Godfrey | 3 |
| TV Show | 2011 | Famous, Rich And In The Slums with Comic Relief | Himself | 2 |
| TV Show | 2011 | The Magicians | Self | 5 |
| TV Show | 2003 | Little Robots | Sporty (voice) | 13 |
| TV Show | 2025 | Missing You | Clint Donovan | 5 |
| TV Show | 2013 | The Last Leg | Self | 2 |
| TV Show | 2016 | John Bishop: In Conversation with... | Self | 1 |
| TV Show | 1988 | Comic Relief | Self - Presenter | 2 |
| TV Show | 2010 | Tinga Tinga Tales | Elephant (voice) | 2 |
| TV Show | 2019 | Trust Morecambe & Wise | Self - Presenter | 4 |
| TV Show | 2019 | Lenny Henry's Race Through Comedy | Presenter | 3 |
| TV Show | 2005 | Doctor Who | Daniel Barton | 2 |
| TV Show | 2007 | The Graham Norton Show | Self | 3 |
| TV Show | 2008 | Q&A | Self - Panellist | 1 |
| TV Show | 2000 | The Nearly Complete and Utter History of Everything | | 2 |
| TV Show | 1982 | The Comic Strip Presents... | Warder | 1 |
| TV Show | 1982 | The Comic Strip Presents... | Steve Wild | 1 |
| TV Show | 2011 | Perspectives | | 1 |
| TV Show | 1987 | French & Saunders | Richard | 1 |
| TV Show | 1987 | French & Saunders | Lt. Chris Clark | 1 |
| TV Show | 2022 | The Lord of the Rings: The Rings of Power | Sadoc Burrows | 8 |
| TV Show | 2020 | Back to the… | Self | 1 |
| TV Show | 1998 | Parkinson | Self | 3 |
| TV Show | 1964 | Top of the Pops | Self - Host | 1 |
| TV Show | 2024 | Legends of Comedy with Lenny Henry | Self - Host | 4 |
| TV Show | 1988 | This Morning | Self | 1 |
| TV Show | 2025 | Alison Hammond's Big Weekend | Self - Interviewed Guest | 1 |
| TV Show | 2025 | Shark! Celebrity Infested Waters | Self - Contestant | 5 |
