| Movie | 1974 | The Godfather Part II | F.B.I. Man #1 | |
| Movie | 1967 | Cool Hand Luke | Tramp | |
| Movie | 1999 | The Straight Story | Lyle | |
| Movie | 1990 | Wild at Heart | Johnnie Farragut | |
| Movie | 1999 | The Green Mile | Toot-Toot | |
| Movie | 1981 | Escape from New York | Harold 'Brain' Helman | |
| Movie | 1984 | Paris, Texas | Travis | |
| Movie | 2006 | Inland Empire | Freddie Howard | |
| Movie | 1985 | The Care Bears Movie | Brave Heart Lion (singing voice) | |
| Movie | 1975 | Farewell, My Lovely | Billy Rolfe | |
| Movie | 2007 | Lynch 2 | Self | |
| Movie | 1998 | Fear and Loathing in Las Vegas | Judge | |
| Movie | 1984 | Red Dawn | Mr. Eckert | |
| Movie | 1980 | Private Benjamin | Sgt. Jim Ballard | |
| Movie | 1988 | The Last Temptation of Christ | Paulus | |
| Movie | 2007 | Being Michael Madsen | Self | |
| Movie | 1986 | Pretty in Pink | Jack Walsh | |
| Movie | 2001 | The Pledge | Floyd Cage | |
| Movie | 1970 | Kelly's Heroes | Pvt. Willard | |
| Movie | 2006 | Alpha Dog | Cosmo Gadabeeti | |
| Movie | 2007 | The Good Life | Gus | |
| Movie | 1984 | UFOria | Brother Bud Sanders | |
| Movie | 1956 | The Wrong Man | Department of Corrections Employee (uncredited) | |
| Movie | 1978 | Straight Time | Jerry Schue | |
| Movie | 1994 | Against the Wall | Hal | |
| Movie | 2012 | The Avengers | Security Guard | |
| Movie | 1962 | How the West Was Won | Gant Henchman (uncredited) | |
| Movie | 1983 | Christine | Rudolph Junkins | |
| Movie | 2005 | The Wendell Baker Story | Skip Summers | |
| Movie | 2006 | Buy the Ticket, Take the Ride | Self | |
| Movie | 1996 | Down Periscope | Lt. Howard | |
| Movie | 2006 | Alien Autopsy | Harvey | |
| Movie | 1968 | Day of the Evil Gun | Sergeant Parker | |
| Movie | 1998 | The Mighty | Grim | |
| Movie | 1971 | Two-Lane Blacktop | Oklahoma Hitchhiker | |
| Movie | 1974 | Cockfighter | Jack Burke | |
| Movie | 1985 | One Magic Christmas | Gideon | |
| Movie | 2002 | Sonny | Henry | |
| Movie | 1988 | Roy Orbison and Friends: A Black and White Night | Self - Audience Member | |
| Movie | 1973 | Dillinger | Homer Van Meter | |
| Movie | 1984 | Repo Man | Bud | |
| Movie | 1998 | A Civil Action | Land Watcher (uncredited) | |
| Movie | 1982 | One from the Heart | Moe | |
| Movie | 1979 | Wise Blood | Asa Hawks | |
| Movie | 1976 | The Missouri Breaks | Calvin | |
| Movie | 1975 | Rancho Deluxe | Curt | |
| Movie | 1970 | Rebel Rousers | Randolph Halverson | |
| Movie | 1966 | Ride in the Whirlwind | Blind Dick | |
| Movie | 2011 | Rango | Balthazar (voice) | |
| Movie | 1997 | She's So Lovely | Tony 'Shorty' Russo | |
| Movie | 1975 | 92 in the Shade | Carter | |
| Movie | 1979 | The Rose | Billy Ray | |
| Movie | 1982 | Young Doctors in Love | Dr. Oliver Ludwig | |
| Movie | 1990 | The Fourth War | Gen. Hackworth | |
| Movie | 2003 | The Beast Within: Making Alien | Self | |
| Movie | 1985 | Fool for Love | Old Man | |
| Movie | 1971 | Cisco Pike | Jesse Dupre | |
| Movie | 1980 | The Black Marble | Philo Skinner | |
| Movie | 2013 | The Last Stand | Mr. Parson | |
| Movie | 2011 | This Must Be the Place | Robert Plath | |
| Movie | 1979 | Flatbed Annie & Sweetie Pie: Lady Truckers | C.W. Douglas | |
| Movie | 1988 | Mr. North | Henry Simmons | |
| Movie | 2012 | Seven Psychopaths | Man in Hat | |
| Movie | 1989 | Twister | Cleveland | |
| Movie | 1987 | Slam Dance | Det. Benjamin Smiley | |
| Movie | 1974 | Zandy's Bride | Songer | |
| Movie | 1967 | The Hostage | Eddie (as Dean Stanton) | |
| Movie | 1968 | The Mini-Skirt Mob | Spook | |
| Movie | 1958 | The Proud Rebel | Jeb Burleigh | |
| Movie | 1957 | Revolt at Fort Laramie | Rinty | |
| Movie | 1975 | Rafferty and the Gold Dust Twins | Billy Winston | |
| Movie | 1974 | Where the Lilies Bloom | Kiser Pease | |
| Movie | 1988 | Stars & Bars | Loomis Gage | |
| Movie | 2013 | Harry Dean Stanton: Partly Fiction | Self | |
| Movie | 1989 | Monster Maker | Chancey Bellow | |
| Movie | 2013 | 9 Full Moons | Dimitri | |
| Movie | 1999 | Stephen King: Shining in the Dark | Self | |
| Movie | 1962 | Hero's Island | Dixey Gates | |
| Movie | 1996 | Playback | Ernie Fontenot | |
| Movie | 2011 | Harry Dean Stanton: Crossing Mulholland | | |
| Movie | 2004 | Sam Peckinpah's West: Legacy of a Hollywood Renegade | Self | |
| Movie | 1984 | The Bear | Coach Thomas | |
| Movie | 1992 | Cruise Control | | |
| Movie | 1979 | Young Maverick - Dead Man's Hand | Pokey Tindle | |
| Movie | 2014 | Fishtail | Narrator | |
| Movie | 2012 | Char·ac·ter | Self | |
| Movie | 1978 | Renaldo and Clara | Lafkezio | |
| Movie | 1989 | Dream a Little Dream | Ike Baker | |
| Movie | 1994 | Blue Tiger | Smith | |
| Movie | 2004 | Dig! | Self | |
| Movie | 2022 | American Badass: A Michael Madsen Retrospective | Self | |
| Movie | 1972 | Cry for Me, Billy | Luke Todd | |
| Movie | 1995 | Never Talk to Strangers | Max Cheski | |
| Movie | 1997 | Fire Down Below | Cotton Harry | |
| Movie | 1966 | The Dangerous Days of Kiowa Jones | Jelly | |
| Movie | 1970 | The Intruders | Whit Dykstra (as Dean Stanton) | |
| Movie | 1992 | Man Trouble | Redmond Layls | |
| Movie | 1960 | Escape to Sonoita | Lemon | |
| Movie | 1988 | The Cowboy and the Frenchman | Slim | |
| Movie | 1967 | A Time for Killing | Sgt. Dan Way | |
| Movie | 2014 | Walking the Mile | Self (archive footage) | |
| Movie | 1988 | The French as Seen by… | (Segment "The Cowboy and the Frenchman") | |
| Movie | 1973 | Pat Garrett & Billy the Kid | Luke | |
| Movie | 1963 | The Man from the Diners' Club | Beatnik (uncredited) | |
| Movie | 1980 | The Oldest Living Graduate | Mike | |
| Movie | 1975 | The Legendary Curse of the Hope Diamond | President Warren G. Harding | |
| Movie | 2014 | Carlos Spills the Beans | Rhino | |
| Movie | 1979 | Alien | Brett | |
| Movie | 1991 | Payoff | Hook | |
| Movie | 2009 | The Open Road | Amon | |
| Movie | 2004 | The Big Bounce | Bob Rogers, Sr. | |
| Movie | 2017 | Lucky | Lucky | |
| Movie | 2017 | Sick of it All | Harry The News Reporter | |
| Movie | 2003 | Bukowski: Born Into This | Self | |
| Movie | 1999 | Ballad of the Nightingale | Jean-Paul | |
| Movie | 2000 | The Man Who Cried | Felix Perlman | |
| Movie | 1997 | Midnight Blue | Eric | |
| Movie | 1959 | Pork Chop Hill | BAR Soldier (uncredited) | |
| Movie | 1992 | Hostages | Frank Reed | |
| Movie | 2007 | Mr. Warmth: The Don Rickles Project | Self | |
| Movie | 2001 | The Animal | Hunter (uncredited) | |
| Movie | 2020 | Frank and Ava | Sheriff Lloyd | |
| Movie | 1992 | Twin Peaks: Fire Walk with Me | Carl Rodd | |
| Movie | 1990 | Motion and Emotion: The Road to 'Paris, Texas' | Self | |
| Movie | 2004 | Chrystal | Pa Da | |
| Movie | 1959 | A Dog's Best Friend | Roy Janney | |
| Movie | 1957 | Tomahawk Trail | Pvt. Miller | |
| Movie | 1959 | The Jayhawkers! | Deputy Smallwood | |
| Movie | 1960 | The Adventures of Huckleberry Finn | Slave Catcher | |
| Movie | 1969 | Lanton Mills | Lanton | |
| Movie | 1975 | Win, Place or Steal | Jack | |
| Movie | 1975 | The Fortune | Prisoner in Holding Cell (uncredited) | |
| Movie | 1987 | Faerie Tale Theatre: Rip Van Winkle | Rip Van Winkle | |
| Movie | 2003 | Hunter Goes to Hollywood | Himself | |
| Movie | 2006 | Harry Zen Stanton | Himself | |
| Movie | 1990 | Motion and Emotion: The Films of Wim Wenders | Self | |
| Movie | 2000 | Sand | Leo | |
| Movie | 2003 | Anger Management | Blind Man (uncredited) | |
| Movie | 1975 | The Ransom of Red Chief | Sam | |
| Movie | 2019 | Linda Ronstadt: The Sound of My Voice | Self (archive footage) | |
| Movie | 2006 | You, Me and Dupree | Curly (uncredited) | |
| Movie | 2003 | Ginostra | Del Piero | |
| Movie | 1980 | Death Watch | Vincent Ferriman | |
| Movie | 2010 | Athena | Bill | |
| Movie | 2020 | Wim Wenders, Desperado | Self (archive footage) | |
| Movie | 1995 | One Hundred and One Nights | Mute Actor in Hollywood (uncredited) | |
| Movie | 1983 | I Want to Live | Emmett Perkins | |
| Movie | 2010 | On Holiday | Josh the Roommate's Dad | |
| Movie | 1993 | Warren Oates: Across the Border | Self | |
| Movie | N/A | Sinatra! Eternity | Sherif Lloyd | |
| Movie | 2002 | The Short Films of David Lynch | Self | |
| Movie | 2003 | Return to 'Escape from New York' | Himself | |
| TV Show | 1960 | The Andy Griffith Show | Proprietor | 1 |
| TV Show | 1961 | Cain's Hundred | Hood | 1 |
| TV Show | 2003 | Two and a Half Men | Harry Dean Stanton | 1 |
| TV Show | 1996 | E! True Hollywood Story | | 1 |
| TV Show | 1963 | Petticoat Junction | | 1 |
| TV Show | 1967 | Mannix | | 1 |
| TV Show | 1976 | Laverne & Shirley | | 1 |
| TV Show | 1955 | Gunsmoke | Alvy | 1 |
| TV Show | 1962 | Combat! | Pvt. Beecham | 1 |
| TV Show | 2006 | Big Love | Roman Grant | 37 |
| TV Show | 1958 | Man with a Camera | | 1 |
| TV Show | 1959 | The Lawless Years | | 4 |
| TV Show | 1958 | Westinghouse Desilu Playhouse | | 1 |
| TV Show | 1959 | Rawhide | Jess Hobson | 1 |
| TV Show | 1957 | Have Gun, Will Travel | | 2 |
| TV Show | 1967 | Cimarron Strip | | 1 |
| TV Show | 1964 | Daniel Boone | Jeb Girty | 1 |
| TV Show | 1963 | The Fugitive | Randy | 1 |
| TV Show | 1967 | The High Chaparral | Johnny Faro | 1 |
| TV Show | 1965 | The Big Valley | Swain | 1 |
| TV Show | 1954 | The Adventures of Rin Tin Tin | | 1 |
| TV Show | 1959 | Lock-Up | | 1 |
| TV Show | 1958 | The Rifleman | | 1 |
| TV Show | 1958 | Bat Masterson | Jay Simms | 1 |
| TV Show | 1959 | Laramie | | 1 |
| TV Show | 1967 | The Guns of Will Sonnett | | 1 |
| TV Show | 1958 | The Texan | | 2 |
| TV Show | 1956 | Dick Powell's Zane Grey Theatre | Robert MacPherson | 1 |
| TV Show | 1954 | Inner Sanctum | | 1 |
| TV Show | 1962 | Stoney Burke | | 1 |
| TV Show | 1959 | Johnny Ringo | Frank Brogger | 1 |
| TV Show | 1957 | The Walter Winchell File | | 1 |
| TV Show | 1960 | The Roaring 20's | | 1 |
| TV Show | 2009 | Alice | Caterpillar | 2 |
| TV Show | 2011 | Mongo Wrestling Alliance | | 10 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 1996 | Dead Man's Walk | Shadrach | 3 |
| TV Show | 2007 | Chuck | Harry | 1 |
| TV Show | 1955 | Alfred Hitchcock Presents | Lemon | 1 |
| TV Show | 1959 | Rawhide | Dexter | 1 |
| TV Show | 1959 | Rawhide | Joe Spanish | 1 |
| TV Show | 1955 | Gunsmoke | Harley | 1 |
| TV Show | 1955 | Gunsmoke | Nate | 1 |
| TV Show | 1955 | Gunsmoke | Leroy | 1 |
| TV Show | 1955 | Gunsmoke | Young Man | 1 |
| TV Show | 1955 | Gunsmoke | Leader | 1 |
| TV Show | 1955 | Gunsmoke | Rainey | 1 |
| TV Show | 1955 | Gunsmoke | Hodge | 1 |
| TV Show | 1968 | Adam-12 | Harry Fletcher | 1 |
| TV Show | 1956 | Dick Powell's Zane Grey Theatre | Toby - Ranch Hand | 1 |
| TV Show | 1956 | Dick Powell's Zane Grey Theatre | Fletcher | 1 |
| TV Show | 1964 | Daniel Boone | Crane | 1 |
| TV Show | 1968 | The Name of the Game | Joe Joe | 1 |
| TV Show | 1982 | Faerie Tale Theatre | Rip Van Winkle | 1 |
| TV Show | 1993 | Hotel Room | Moe Boca | 3 |
| TV Show | 1958 | The Further Adventures of Ellery Queen | George Gilbert | 1 |
| TV Show | 1959 | Bonanza | Billy | 1 |
| TV Show | 1955 | Playwrights '56 | | 1 |
| TV Show | 1990 | Twin Peaks | Carl Rodd | 5 |
| TV Show | 1959 | Bonanza | Stiles | 1 |
| TV Show | 1957 | Suspicion | Bill | 1 |
| TV Show | 2013 | Getting On | Leonard Butler | 3 |
| TV Show | 1960 | Checkmate | The Singer | 1 |
| TV Show | 1958 | Westinghouse Desilu Playhouse | Gordon | 1 |
| TV Show | 1961 | Gunslinger | Stacey | 1 |