| Movie | 2013 | Rich Girl Problems | Lucretia | |
| Movie | 2023 | Happiness for Beginners | Helen Carpenter | |
| Movie | 2012 | 21 Jump Street | Ms. Griggs | |
| Movie | 2010 | Somewhere | Claire | |
| Movie | 2011 | Bridesmaids | Becca | |
| Movie | 2018 | Party Monster: Scratching the Surface | Kimmy Schmidt | |
| Movie | 2009 | Mystery Team | Jamie | |
| Movie | 2014 | Sex Tape | Tess | |
| Movie | 2014 | They Came Together | Karen | |
| Movie | 2014 | The Nobodies | Julie | |
| Movie | 2016 | The Secret Life of Pets | Katie (voice) | |
| Movie | 2014 | Laggies | Allison | |
| Movie | 2022 | The Great American Baking Show: Celebrity Holiday | Self - Host | |
| Movie | 2017 | The Lego Batman Movie | Phyllis (voice) | |
| Movie | 2017 | Smurfs: The Lost Village | Smurfblossom (voice) | |
| Movie | 2009 | Cayman Went | Girl in Bar | |
| Movie | 2013 | Identity Thief | Flo | |
| Movie | 2010 | Get Him to the Greek | Pinnacle Executive | |
| Movie | 2017 | Night of Too Many Stars: America Unites for Autism Programs | Self | |
| Movie | 2019 | The Secret Life of Pets 2 | Katie (voice) | |
| Movie | 2019 | Live in Front of a Studio Audience: Norman Lear's "All in the Family" and "The Jeffersons" | Gloria Stivic | |
| Movie | 2020 | The Stand In | Jenna Jones | |
| Movie | 2021 | Home Sweet Home Alone | Pam McKenzie | |
| Movie | 2019 | Live in Front of a Studio Audience: "All in the Family" and "Good Times" | Gloria Stivic | |
| Movie | 2020 | Unbreakable Kimmy Schmidt: Kimmy vs. the Reverend | Kimmy Schmidt | |
| Movie | 2020 | Unbreakable Kimmy Schmidt: Kimmy vs. the Music: A Live Singing Contest (That's Live) | Self | |
| Movie | 2020 | We Bare Bears: The Movie | Lucy (voice) | |
| Movie | 2011 | Conan O'Brien Can't Stop | Self | |
| Movie | 2018 | Sofia the First: Forever Royal | Crackle (voice) | |
| Movie | 2011 | Home for Actresses | Ellie | |
| Movie | 2016 | Ellie Kemper: Unbreakable Comedy Gala | | |
| Movie | 2007 | Blowjob Girl | Blowjob Girl | |
| Movie | 2013 | Sofia The First: Ready To Be A Princess | Crackle (archive footage) (voice) | |
| Movie | 2013 | Brenda Forever | Brenda Miller | |
| TV Show | 2005 | The Office | Erin Hannon | 101 |
| TV Show | 2015 | We Bare Bears | Produce Lucy (voice) | 1 |
| TV Show | 2015 | We Bare Bears | Lucy (voice) | 3 |
| TV Show | 2019 | You're Not a Monster | Elsa Brenner | 3 |
| TV Show | 2013 | The Birthday Boys | | 1 |
| TV Show | 2015 | Unbreakable Kimmy Schmidt | Kimmy Schmidt | 51 |
| TV Show | 2013 | Drunk History | Nellie Bly | 1 |
| TV Show | 2014 | All Hail King Julien | Karen (voice) | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self | 1 |
| TV Show | 2012 | The Mindy Project | Heather | 3 |
| TV Show | 2010 | Conan | Rachel the Intern | 1 |
| TV Show | 2020 | The Drew Barrymore Show | Self - Guest | 3 |
| TV Show | 2023 | The Great American Baking Show | Self - Host | 6 |
| TV Show | 1993 | Late Show with David Letterman | Self | 1 |
| TV Show | 2015 | Long Live the Royals | Mudria | 4 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 5 |
| TV Show | 2016 | Match Game | Self - Panelist | 10 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 1 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 2013 | Sofia the First | Crackle (voice) | 3 |
| TV Show | 2020 | Stars in the House | Self | 1 |
| TV Show | 2005 | American Dad! | Jenna (voice) | 1 |
| TV Show | 2015 | Close Up with The Hollywood Reporter | Self | 1 |
| TV Show | 2013 | Hollywood Game Night | Self | 2 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 1 |
| TV Show | 2020 | Some Good News | Self | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 3 |
| TV Show | 1989 | The Simpsons | Mary Tannenbaum (voice) | 1 |
| TV Show | 2010 | Conan | Self | 1 |
| TV Show | 2021 | Celebrity Wheel of Fortune | Self - Contestant | 1 |
| TV Show | 2017 | Julie's Greenroom | | 2 |
| TV Show | 2005 | Robot Chicken | Tracy / Woman / Bella Swan (voice) | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self - Guest | 2 |
| TV Show | 1993 | Late Night with Conan O'Brien | | 1 |
| TV Show | 1995 | The Actor Awards Presented by SAG-AFTRA | Self | 1 |
| TV Show | 1953 | The Oscars | Self - Presenter | 1 |
