| Movie | 2002 | Real Women Have Curves | Mr. Guzman | |
| Movie | 2010 | The Spy Next Door | Glaze | |
| Movie | 1990 | Ski Patrol | Eddie Martinez | |
| Movie | 2021 | Christmas in Tahoe | Otis | |
| Movie | 2022 | North of the 10 | The Man | |
| Movie | 2007 | Balls of Fury | Agent Ernie Rodriquez | |
| Movie | 2010 | Valentine's Day | Alphonso Rodriguez | |
| Movie | 2002 | The Original Latin Kings of Comedy | Himself | |
| Movie | 2003 | Richard Pryor: I Ain't Dead Yet, #*%$#@!! | Self | |
| Movie | 2008 | Henry Poole Is Here | Father Salizar | |
| Movie | 2009 | Just for Laughs: Launching Pad | | |
| Movie | 2020 | At Last | Diego | |
| Movie | 2009 | George Lopez: Tall, Dark & Chicano | Himself | |
| Movie | 2011 | The Smurfs | Grouchy Smurf (voice) | |
| Movie | 2008 | Beverly Hills Chihuahua | Papi (voice) | |
| Movie | 2005 | The Adventures of Sharkboy and Lavagirl | Mr. Electricidad / Tobor / Ice Guardian | |
| Movie | 2010 | Marmaduke | Carlos (voice) | |
| Movie | 2005 | George Lopez: Why You Crying? | Himself | |
| Movie | 2011 | Rio | Rafael (voice) | |
| Movie | 2007 | Brown Is the New Green: George Lopez and the American Dream | Himself | |
| Movie | 2013 | Escape from Planet Earth | Thurman (voice) | |
| Movie | 2007 | George Lopez: America's Mexican | Himself | |
| Movie | 2009 | Mr. Troop Mom | Eddie Serrano | |
| Movie | 2008 | Tortilla Heaven | Everardo | |
| Movie | 2011 | Beverly Hills Chihuahua 2 | Papi (voice) | |
| Movie | 2013 | The Smurfs 2 | Grouchy Smurf (voice) | |
| Movie | 2011 | The Smurfs: A Christmas Carol | Grouchy (voice) | |
| Movie | 2012 | Beverly Hills Chihuahua 3: Viva la Fiesta! | Papi (voice) | |
| Movie | 2020 | LA Originals | Self | |
| Movie | 2010 | Back From Hell: A Tribute to Sam Kinison | Self | |
| Movie | 2023 | Blue Beetle | Rudy Reyes | |
| Movie | 2012 | George Lopez: It's Not Me, It's You | Self | |
| Movie | 2023 | Fool's Paradise | George Lopez | |
| Movie | 2014 | School Dance | Oscar | |
| Movie | 2015 | Spare Parts | Fredi Cameron | |
| Movie | 2023 | How the Gringo Stole Christmas | Bennie | |
| Movie | 2014 | Rio 2 | Rafael (voice) | |
| Movie | 2000 | Bread and Roses | Perez | |
| Movie | 2014 | Richard Pryor: Icon | Himself | |
| Movie | 2014 | The Concert for Valor | Self | |
| Movie | 2024 | The Underdoggs | Coach Feis | |
| Movie | 2008 | Swing Vote | John Sweeney | |
| Movie | 2022 | The Boss Baby: Christmas Bonus | Santa (voice) | |
| Movie | 2023 | Gone Before His Time: Freddie Prinze Sr. | Self (archive footage) | |
| Movie | 2008 | Viva la Causa | Narrator | |
| Movie | 2015 | The Latin Explosion: A New America | Self | |
| Movie | 2016 | Meet the Blacks | President El Bama | |
| Movie | 2013 | Richard Pryor: Omit the Logic | Self | |
| Movie | 2013 | April Apocalypse | Dr. Lyle | |
| Movie | 2004 | Naughty or Nice | Henry Ramiro | |
| Movie | 2016 | Habla y vota | Himself | |
| Movie | 2007 | Mr. Warmth: The Don Rickles Project | Self | |
| Movie | 2017 | I Am Battle Comic | | |
| Movie | 2017 | Car Dogs | Christian | |
| Movie | 2017 | George Lopez: The Wall | Himself | |
| Movie | 2017 | Gnome Alone | Zook (voice) | |
| Movie | 2008 | Loco Comedy Jam Volume 1 | Self | |
| Movie | 2018 | Survivor's Guide to Prison | Self | |
| Movie | 2020 | The Tax Collector | Uncle Louis | |
| Movie | 2018 | River Runs Red | Javier | |
| Movie | 2019 | El Chicano | Captain Gomez | |
| Movie | 2002 | Outta Time | Felix | |
| Movie | 2008 | The Naked Brothers Band: Polar Bears | Self | |
| Movie | 2020 | This Is Stand-Up | Self | |
| Movie | 2020 | Feeding America Comedy Festival | Self | |
| Movie | 2009 | We Are One: The Obama Inaugural Celebration at the Lincoln Memorial | Self | |
| Movie | 2020 | George Lopez: We'll Do It for Half | Self | |
| Movie | 2020 | Cats & Dogs 3: Paws Unite | Pablo the Parrot (voice) | |
| Movie | 2021 | No Man's Land | Ramirez | |
| Movie | 2020 | In Search of the Sanderson Sisters: A Hocus Pocus Hulaween Takeover | Bargain Book | |
| Movie | 2020 | Best of Stand-up 2020 | Self | |
| Movie | 2021 | Walking with Herb | Herb | |
| Movie | 1993 | Fatal Instinct | Murder Investigator | |
| Movie | 2025 | George Lopez: Muy Católico | Self | |
| Movie | 2021 | Save Ralph | Ralph (voice) | |
| Movie | 2025 | The SpongeBob Movie: Search for SquarePants | (voice) | |
| TV Show | 2005 | Freddie | Himself | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 5 |
| TV Show | 2004 | The Tony Danza Show | Self | 2 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 8 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2003 | Punk'd | Self | 1 |
| TV Show | 2003 | Reno 911! | Mayor Hernandez | 3 |
| TV Show | 1997 | The View | Self | 4 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 2002 | George Lopez | George Lopez | 120 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 3 |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 2005 | Sit Down Comedy with David Steinberg | | 1 |
| TV Show | 2009 | Lopez Tonight | | 214 |
| TV Show | 2001 | Good Day Live | Self | 3 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self | 1 |
| TV Show | 1999 | Teen Choice Awards | Self | 2 |
| TV Show | 2003 | Spike TV VGA Video Game Awards | | 10 |
| TV Show | 2019 | Harley Quinn | George Lopez (voice) | 1 |
| TV Show | 2000 | The Brothers García | Mr. Fender | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | George Lopez | 1 |
| TV Show | 2016 | Lopez | George Lopez | 24 |
| TV Show | 2015 | The Late Late Show with James Corden | Self | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2000 | Latin Grammy Awards | Self | 2 |
| TV Show | 2016 | Martha & Snoop's Potluck Dinner Party | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | | 1 |
| TV Show | 2022 | Sherri | Self - Guest | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 2 |
| TV Show | 1944 | Golden Globe Awards | Self - Presenter | 1 |
| TV Show | 2018 | The Great American Read | Himself | 1 |
| TV Show | 2019 | Victor and Valentino | José Guadalupe Posada (voice) | 1 |
| TV Show | 2022 | Lopez vs Lopez | George Lopez | 45 |
| TV Show | 2015 | Celebrity Family Feud | Self | 1 |
| TV Show | 2013 | The Arsenio Hall Show | Self | 1 |
| TV Show | 1993 | Raw | | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2016 | To Tell the Truth | Self - Panelist | 2 |
| TV Show | 2018 | The Neighborhood | Victor | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 2 |
| TV Show | 2014 | Saint George | George | 10 |
| TV Show | 2017 | The Comedy Get Down | George Lopez | 10 |
| TV Show | 2021 | Home Town: Ben's Workshop | George Lopez | 1 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 2010 | Shake It Up | George Martinez | 1 |
| TV Show | 2019 | The Casagrandes | Ernesto Estrella (voice) | 1 |
| TV Show | 2005 | Unscripted | Self | 1 |
| TV Show | 2010 | Conan | Self | 2 |
| TV Show | 2006 | The Megan Mullally Show | Self - Guest | 2 |
| TV Show | 2020 | Close Enough | Wurst Bros. Leader (voice) | 1 |
| TV Show | 1997 | Make Me Laugh (Comedy Central) | Comedian | 1 |
| TV Show | 1996 | Full Frontal Comedy | self | 1 |
| TV Show | 2022 | Reno 911! Defunded | Mayor Dwayne Hernandez | 1 |
