| Movie | 2008 | Street Kings | Captain James Biggs | |
| Movie | 1999 | Stuart Little | Mr. Little | |
| Movie | 1995 | Sense and Sensibility | Mr. Palmer | |
| Movie | 2002 | Stuart Little 2 | Mr. Little | |
| Movie | 2013 | Bayou Maharajah: The Tragic Genius of James Booker | Self | |
| Movie | 1997 | Spice World | Poirot | |
| Movie | 1992 | Peter's Friends | Roger Charleston | |
| Movie | 1996 | 101 Dalmatians | Jasper | |
| Movie | 2004 | Flight of the Phoenix | Ian | |
| Movie | 2009 | B.O.B.'s Big Break | Dr. Cockroach Ph.D. (voice) | |
| Movie | 1997 | The Borrowers | Officer Steady | |
| Movie | 2000 | Lounge Act | | |
| Movie | 1998 | The Man in the Iron Mask | King's Advisor | |
| Movie | 2000 | Maybe Baby | Sam Bell | |
| Movie | 2001 | Chica de Río | Raymond | |
| Movie | 2005 | Valiant | Gutsy (voice) | |
| Movie | 2004 | Remember the Secret Policeman's Ball? | Self | |
| Movie | 2009 | Monsters vs Aliens | Dr. Cockroach Ph.D. (voice) | |
| Movie | 1999 | Santa's Last Christmas | Geoffrey the Seagull (voice) | |
| Movie | 1998 | Cousin Bette | Baron Hector Hulot | |
| Movie | 2011 | Arthur Christmas | Steve (voice) | |
| Movie | 2012 | FOX 25th Anniversary Special | Self | |
| Movie | 2011 | Hop | E.B.'s Dad (voice) | |
| Movie | 2004 | The Tale of Jack Frost | Narrator (voice) | |
| Movie | 2003 | The Young Visiters | Lord Bernard Clark | |
| Movie | 2009 | Mutant Pumpkins from Outer Space | Dr. Cockroach Ph.D. (voice) | |
| Movie | 1987 | The Secret Policeman’s Third Ball | Self | |
| Movie | 1989 | The Secret Policeman’s Biggest Ball | Self | |
| Movie | 1988 | Blackadder's Christmas Carol | Princes Regent / Pigmot | |
| Movie | 2011 | The Oranges | David Walling | |
| Movie | 2012 | Mr. Pip | Mr. Watts | |
| Movie | 1985 | Mrs Capper's Birthday | Bobby McMichael | |
| Movie | 1989 | Strapless | Colin | |
| Movie | 2023 | Blackadder: A Cunning Story | Self - Contributor | |
| Movie | 1995 | The Snow Queen | Peeps | |
| Movie | 1996 | The Snow Queen's Revenge | Peeps | |
| Movie | 2001 | Discovering the Real World of Harry Potter | Narrator (voice) | |
| Movie | 1982 | The Cellar Tapes | various | |
| Movie | 2012 | Jools Holland: My Life in Music | Self | |
| Movie | 2008 | Band from TV: Hoggin' All the Covers | Self | |
| Movie | 2000 | Carnivale | Cenzo (voice) | |
| Movie | 2013 | Hugh Laurie: Live on the Queen Mary | Himself | |
| Movie | 2011 | Hugh Laurie: Down by the River | | |
| Movie | 2013 | Hugh Laurie: Copper Bottom Blues | | |
| Movie | 1995 | A Pin for the Butterfly | Uncle | |
| Movie | 2023 | The Canterville Ghost | Grim Reaper / Gardener / Swordsman / Monster / Old Duke (voice) | |
| Movie | 2005 | The Big Empty | Doctor | |
| Movie | 1987 | Up Line | Howard Caprice | |
| Movie | 2011 | Let Them Talk: A Celebration of New Orleans Blues | Self | |
| Movie | 1993 | The Legends of Treasure Island | Squire Trelawney (voice) | |
| Movie | 2009 | SNL Presents: A Very Gilly Christmas | (archive footage) | |
| Movie | 1988 | Blackadder: The Cavalier Years | Roundhead with Cromwell (uncredited) | |
| Movie | 1999 | Blackadder: Back & Forth | George | |
| Movie | 2015 | Tomorrowland | David Nix | |
| Movie | 2007 | Stephen Fry: 50 Not Out | Self | |
| Movie | 2022 | The Amazing Maurice | Maurice (voice) | |
| Movie | 2005 | Stuart Little 3: Call of the Wild | Mr. Little (voice) | |
| Movie | 1985 | Plenty | Michael | |
| Movie | 1997 | Treasure Island | Squire Trelawney | |
| Movie | 2001 | Second Star to the Left | Archie (voice) | |
| Movie | 2000 | Victoria Wood with All the Trimmings | John Malkovich | |
| Movie | 2015 | A Life On Screen: Stephen Fry | Self | |
| Movie | 1997 | The Ugly Duckling | Tarquin (voice) | |
| Movie | 1987 | The Laughing Prisoner | Assistant | |
| Movie | 2010 | Fry and Laurie Reunited | Self | |
| Movie | 2018 | Holmes & Watson | Mycroft Holmes (uncredited) | |
| Movie | 2008 | Blackadder Exclusive: The Whole Rotten Saga | Self | |
| Movie | 2013 | Monsters vs Aliens Stories | | |
| Movie | 2019 | The Personal History of David Copperfield | Mr. Dick | |
| Movie | 1986 | Dangerous Brothers Present: World of Danger | | |
| Movie | 1995 | The Adventures of Mole | Toad | |
| Movie | 2002 | Lost in the Snow | Teddy | |
| Movie | 2001 | Baldrick's Video Diary - A Blackadder in the Making | Self | |
| Movie | 1991 | Brown Bear's Wedding | Owl / Mice (voice) | |
| Movie | 1992 | White Bear's Secret | Owl (voice) | |
| Movie | 2008 | Blackadder Rides Again | Self | |
| Movie | 2012 | Dreamworks Spooky Stories | Dr. Cockroach Ph.D. (voice) | |
| Movie | 1996 | The Adventures of Toad | Toad | |
| Movie | 1986 | The Comic Relief Utterly Utterly Rude Video Live | Self | |
| Movie | 2008 | Blackadder's Most Cunning Moments | Self | |
| Movie | 2012 | Shrek's Thrilling Tales | Dr. Cockroach Ph.D. (voice) | |
| Movie | 1989 | Employees From Hell | | |
| Movie | 1999 | Stuart Little: Making It Big | Self | |
| Movie | 1992 | Annie Lennox: Totally Diva | | |
| Movie | 2012 | House M.D.: The Doctor Directs | | |
| Movie | 1996 | The World of Peter Rabbit and Friends: The Tale of Two Bad Mice and Johnny Town-Mouse | Johnny Town-Mouse (voice) | |
| Movie | N/A | Experiment IV | Second Assistant | |
| Movie | 1985 | Happy Families | Jim | |
| Movie | 1989 | Customer Service From Hell | | |
| Movie | 1989 | Teams from Hell | | |
| Movie | 1989 | Colleagues From Hell | | |
| Movie | 1989 | Interviewers From Hell | | |
| Movie | 2005 | The Funny Blokes of British Comedy | Lieutenant George St. Barleigh (archive footage) (uncredited) | |
| Movie | 2012 | House: Swan Song | 休·劳瑞 | |
| Movie | 1988 | Nelson Mandela 70th Birthday Tribute | Self | |
| TV Show | 1983 | Alfresco | Various | 13 |
| TV Show | 1983 | Alfresco | Admissions Officer | 7 |
| TV Show | 1993 | Shooting Stars | Self | 1 |
| TV Show | 1989 | A Bit of Fry & Laurie | | 25 |
| TV Show | 1989 | The Simpsons | Roger (voice) | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 2 |
| TV Show | 2004 | House | Gregory House | 176 |
| TV Show | 2005 | Monkey Trousers | | 7 |
| TV Show | 1999 | Family Guy | Bar Patron (voice) | 1 |
| TV Show | 1990 | Jeeves and Wooster | Bertie Wooster | 23 |
| TV Show | 1984 | The Bill | | 1 |
| TV Show | 1985 | Girls On Top | Tom | 1 |
| TV Show | 1996 | Tracey Takes On... | | 4 |
| TV Show | 1992 | The Tonight Show with Jay Leno | Self | 7 |
| TV Show | 2000 | Randall & Hopkirk (Deceased) | | 1 |
| TV Show | 1976 | The Secret Policeman's Ball | Self | 15 |
| TV Show | 2002 | Spooks | Jools Siviter | 2 |
| TV Show | 2002 | American Idol | Self | 2 |
| TV Show | 1982 | The Young Ones | Lord Monty | 1 |
| TV Show | 1987 | The New Statesman | Waiter | 1 |
| TV Show | 2009 | The Jay Leno Show | Self | 1 |
| TV Show | 1986 | Omnibus Presents Comic Relief | | 1 |
| TV Show | 1996 | Dennis the Menace and Gnasher | Mr. Abercrombie (voice) | 1 |
| TV Show | 1987 | The Lenny Henry Show | Professor | 7 |
| TV Show | 1993 | The Legends of Treasure Island | Squire Trelawney (voice) | 26 |
| TV Show | 2003 | Stuart Little: The Animated Series | Mr. Frederick Little (voice) | 13 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 3 |
| TV Show | 2003 | Fortysomething | Paul Slippery | 6 |
| TV Show | 1982 | There's Nothing to Worry About! | Various | 3 |
| TV Show | 1988 | Friday Night Live | | 1 |
| TV Show | 1988 | Comic Relief | | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 2 |
| TV Show | 2016 | The Night Manager | Richard Roper | 12 |
| TV Show | 1999 | Family Guy | Dr. Gregory House (voice) | 1 |
| TV Show | 1981 | Wetten, dass..? | Self | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2003 | QI | Self | 1 |
| TV Show | 2016 | Chance | Eldon Chance | 20 |
| TV Show | 1983 | Blackadder | The Prince Regent | 6 |
| TV Show | 1983 | Blackadder | Lieutenant The Honourable George Colthurst St. Barleigh | 6 |
| TV Show | 2023 | All the Light We Cannot See | Etienne LeBlanc | 4 |
| TV Show | 1994 | Friends | Gentleman on the Plane | 1 |
| TV Show | 1997 | Ruby | Self | 1 |
| TV Show | 2011 | Perspectives | Himself | 1 |
| TV Show | 1983 | Blackadder | Simon Partridge | 1 |
| TV Show | 1983 | Blackadder | Prince Ludwig | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2022 | Why Didn't They Ask Evans? | Dr. James Nicholson | 2 |
| TV Show | 1982 | Wogan | Self | 2 |
| TV Show | 1993 | All or Nothing at All | Leo Hopkins | 3 |
| TV Show | 2001 | Life with Judy Garland: Me and My Shadows | Vincente Minnelli | 2 |
| TV Show | 2003 | MechaNick | Narrator | 80 |
| TV Show | 2005 | The Reichen Show | Self | 1 |
| TV Show | 2024 | In the Know | Self | 1 |
| TV Show | 2014 | A Life on Screen | Self | 1 |
| TV Show | 2012 | Veep | Tom James | 20 |
| TV Show | 2007 | The Graham Norton Show | Self - Guest | 1 |
| TV Show | 2007 | The Graham Norton Show | Self | 5 |
| TV Show | 2020 | Avenue 5 | Ryan Clark | 17 |
| TV Show | 2019 | Catch-22 | Major de Coverley | 3 |
| TV Show | 2000 | Preston Pig | Mr. Wolf | 26 |
| TV Show | 1992 | The World of Peter Rabbit and Friends | Johnny Town-Mouse (voice) | 1 |
| TV Show | 2000 | The Nearly Complete and Utter History of Everything | | 2 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self - Guest | 2 |
| TV Show | 1986 | Saturday Live | | 30 |
| TV Show | 1986 | The Dangerous Brothers | | 1 |
| TV Show | 1987 | Filthy Rich & Catflap | N'Bend | 1 |
| TV Show | 2011 | Perspectives | | 1 |
| TV Show | 2020 | Roadkill | Peter Laurence | 4 |
| TV Show | 1983 | The Crystal Cube | Max Belhaven / Various Roles | 1 |
| TV Show | 2010 | Conan | Self | 1 |
| TV Show | 1998 | Parkinson | Self | 2 |
| TV Show | 2020 | Tehran | Eric Peterson | 8 |
| TV Show | 1985 | Happy Families | Jim | 2 |
| TV Show | 2004 | The Culture Show | | 1 |
| TV Show | 1971 | Great Performances | | 1 |
| TV Show | N/A | The Wanted Man | Felix Carmichael | 0 |
| TV Show | 2003 | DreamWorks 6 Spooky Stories Collection | Dr. Cockroach Ph.D. (voice) | 1 |
| TV Show | 1995 | Look at the State We're In! | Sir Michael Jaffa | 1 |
| TV Show | 1995 | Look at the State We're In! | Director | 1 |
| TV Show | N/A | Dig | Neville | 1 |
| TV Show | 1979 | Friday Night, Saturday Morning | | 1 |
| TV Show | 1991 | Murder Most Horrid | Jerry Bryce | 1 |