| Movie | 2005 | Animal | Ramona | |
| Movie | 2021 | Muppets Haunted Mansion | The Bride | |
| Movie | 2005 | Hustle & Flow | Shug | |
| Movie | 2008 | The Curious Case of Benjamin Button | Queenie | |
| Movie | 2007 | Talk to Me | Vernell Watson | |
| Movie | 2009 | Hurricane Season | Dayna Collins | |
| Movie | 2005 | Four Brothers | Camille Mercer | |
| Movie | 2009 | I Can Do Bad All By Myself | April | |
| Movie | 2010 | Date Night | Detective Arroyo | |
| Movie | 2009 | Not Easily Broken | Clarice Clark | |
| Movie | 2006 | Something New | Nedra | |
| Movie | N/A | Sorcerority | | |
| Movie | 2008 | Tyler Perry's The Family That Preys | Pam | |
| Movie | 2010 | Once Fallen | Pearl | |
| Movie | 2001 | Baby Boy | Yvette | |
| Movie | 2010 | The Karate Kid | Sherry Parker | |
| Movie | 2011 | The Good Doctor | Nurse Theresa | |
| Movie | 2012 | Think Like a Man | Lauren Harris | |
| Movie | 2011 | Taken from Me: The Tiffany Rubin Story | Tiffany Rubin | |
| Movie | 2023 | The Color Purple | Shug Avery | |
| Movie | 2011 | Larry Crowne | B'Ella | |
| Movie | 2014 | No Good Deed | Terry | |
| Movie | 2004 | Hair Show | Tiffany | |
| Movie | 2014 | Think Like a Man Too | Lauren Harris | |
| Movie | 2013 | From the Rough | Catana Starks | |
| Movie | 2000 | Satan's School for Girls | Paige | |
| Movie | 2001 | Murder, She Wrote: The Last Free Man | Bess Pinckney | |
| Movie | 2023 | Going to Mars: The Nikki Giovanni Project | Self (voice) | |
| Movie | 2014 | Seasons of Love | Jackie | |
| Movie | 2014 | Top Five | Self | |
| Movie | 2022 | Savage X Fenty Show Vol. 4 | Self | |
| Movie | 2024 | Where’s Usher? | Self | |
| Movie | 2016 | Term Life | Samantha Thurman | |
| Movie | 2023 | Oprah & The Color Purple Journey | Self | |
| Movie | 2012 | Whitney Houston: We Will Always Love You | Self | |
| Movie | 2010 | Peep World | Mary | |
| Movie | 2024 | TIME100: The World's Most Influential People | Host | |
| Movie | 2016 | Ice Age: The Great Egg-Scapade | Ethel (voice) | |
| Movie | 2016 | Hidden Figures | Katherine G. Johnson | |
| Movie | N/A | Force | | |
| Movie | 2006 | Smokin' Aces | Sharice Watters | |
| Movie | 2000 | The Adventures of Rocky & Bullwinkle | Left-Wing Student | |
| Movie | 2013 | Madly Madagascar | Okapi (voice) | |
| Movie | 2018 | Proud Mary | Mary | |
| Movie | 2019 | The Best of Enemies | Ann Atwater | |
| Movie | 2018 | Acrimony | Melinda Moore Gayle | |
| Movie | 2017 | Taraji's White Hot Holiday Special | Self - Host / Mrs. Claus / Mary / Prancer | |
| Movie | 2019 | This Changes Everything | Self | |
| Movie | 2019 | What Men Want | Alison 'Ali' Davis | |
| Movie | 2018 | Ralph Breaks the Internet | Yesss (voice) | |
| Movie | 2020 | Coffee & Kareem | Vanessa Manning | |
| Movie | 2022 | Minions: The Rise of Gru | Belle Bottom (voice) | |
| Movie | 2020 | Feeding America Comedy Festival | Self | |
| Movie | 1998 | Streetwise | Tammy | |
| Movie | 2013 | Picasso Baby | Self | |
| Movie | 2021 | Mary J. Blige's My Life | Self | |
| Movie | 2021 | Annie Live! | Miss Hannigan | |
| Movie | 2009 | The Curious Birth of Benjamin Button | Self | |
| Movie | 2002 | Book of Love: The Definitive Reason Why Men Are Dogs | Date #4 / Ghetto Girl (as Taraji Henson) | |
| Movie | 2025 | STRAW | Janiyah Wiltkinson | |
| Movie | 2023 | PAW Patrol: The Mighty Movie | Victoria Vance (voice) | |
| TV Show | 2008 | Eli Stone | Angela Scott | 3 |
| TV Show | 1993 | Saved by the Bell: The New Class | Girl | 1 |
| TV Show | 2004 | House | Moira | 1 |
| TV Show | 2011 | Person of Interest | Joss Carter | 90 |
| TV Show | 2000 | CSI: Crime Scene Investigation | Christina | 1 |
| TV Show | 2002 | Half & Half | Gabrielle | 1 |
| TV Show | 2003 | All of Us | | 1 |
| TV Show | 2001 | The Division | Raina Washington | 66 |
| TV Show | 1997 | Smart Guy | | 2 |
| TV Show | 1994 | Sister, Sister | Briana | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 1995 | The Parent 'Hood | | 1 |
| TV Show | 2000 | Strong Medicine | Crystal | 1 |
| TV Show | 1994 | ER | Patrice Robbins | 2 |
| TV Show | 2019 | A Little Late with Lilly Singh | Self | 1 |
| TV Show | 2009 | The Cleveland Show | | 1 |
| TV Show | 2021 | That's My Jam | Self | 1 |
| TV Show | 2021 | Abbott Elementary | Vanetta | 2 |
| TV Show | 2018 | The Alec Baldwin Show | Self | 1 |
| TV Show | 1974 | American Music Awards | Self - Host | 1 |
| TV Show | 2015 | Empire | Cookie Lyon | 102 |
| TV Show | 1996 | The Daily Show | Self | 2 |
| TV Show | 2015 | Lip Sync Battle | Self | 2 |
| TV Show | 2023 | Celebrity Prank Wars | Self | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self | 1 |
| TV Show | 2004 | Boston Legal | Whitney Rome | 20 |
| TV Show | 2021 | That's My Jam | Self - Guest | 1 |
| TV Show | 2017 | Carpool Karaoke: The Series | Self | 1 |
| TV Show | 2020 | Celebrity IOU | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 2 |
| TV Show | 2019 | The Kelly Clarkson Show | Self - Guest Host | 1 |
| TV Show | 2015 | Close Up with The Hollywood Reporter | Self | 2 |
| TV Show | 2015 | Hot Ones | Self | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 2 |
| TV Show | 2022 | Sherri | Self - Guest | 3 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 1 |
| TV Show | 2014 | Variety Studio: Actors on Actors | Self | 4 |
| TV Show | 2020 | Legendary | Self - Guest Judge | 1 |
| TV Show | 2013 | Hollywood Game Night | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2021 | Hart to Heart | Self | 1 |
| TV Show | 2015 | Taraji's White Hot Holidays | Herself - Host | 3 |
| TV Show | 2015 | The Late Late Show with James Corden | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2024 | Fight Night: The Million Dollar Heist | Vivian Thoma | 8 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 2010 | RuPaul's Drag Race: Untucked | Self - Guest | 1 |
| TV Show | 1981 | Entertainment Tonight | Self | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 5 |
| TV Show | 2004 | Project Runway | Self - Guest Judge | 1 |
| TV Show | 2010 | Conan | Herself | 1 |
| TV Show | 2009 | RuPaul's Drag Race | Self - Guest Judge | 1 |
| TV Show | 1998 | Felicity | R.A. #2 | 1 |
| TV Show | 1998 | Felicity | Art Student | 1 |
| TV Show | 1989 | The Simpsons | Praline (voice) | 1 |
| TV Show | 2023 | The Wine Down with Mary J. Blige | Self | 1 |
| TV Show | 2020 | History 101 | Self (archive footage) | 1 |
| TV Show | 1994 | ER | Elan | 1 |
| TV Show | 1996 | Pacific Blue | Rhonda | 1 |
| TV Show | 2018 | Lie Detector | Self | 1 |
| TV Show | 2019 | Today with Hoda & Jenna | Self | 1 |
| TV Show | 2025 | Number One on the Call Sheet | Self | 1 |
| TV Show | 2025 | My Happy Place | Self | 6 |
| TV Show | 2001 | BET Awards | Self - Host | 2 |
