| Movie | 2002 | Star Trek: Nemesis | Admiral Janeway | |
| Movie | 2014 | Divine Discontent: Charles Proteus Steinmetz | Narrator | |
| Movie | 1985 | Remo Williams: The Adventure Begins | Maj. Rayner Fleming | |
| Movie | 1982 | A Stranger Is Watching | Sharon Martin | |
| Movie | 1976 | The American Woman: Portraits of Courage | Deborah Sampson | |
| Movie | 1987 | Throw Momma from the Train | Margaret Donner | |
| Movie | 1995 | Captain Nuke and the Bomber Boys | Mrs. Pescoe | |
| Movie | 1994 | Camp Nowhere | Rachel Prescott | |
| Movie | 1979 | Jennifer: A Woman’s Story | Joan Russell | |
| Movie | 2023 | The Magnificent Meyersons | Dr. Terri Meyerson | |
| Movie | 2011 | The Captains | Herself | |
| Movie | 1988 | Roots: The Gift | Hattie Carraway | |
| Movie | 1999 | Riddler's Moon | Victoria Riddler | |
| Movie | 1981 | Lovespell | Isolt | |
| Movie | 2015 | Half-Shell Heroes: Blast to the Past | General Zera (voice) | |
| Movie | 2024 | To the Journey: Looking Back at Star Trek: Voyager | Self | |
| Movie | 2005 | Perception | Mary | |
| Movie | 1991 | Daddy | Sara Watson | |
| Movie | 2010 | The Captains of The Final Frontier | Self | |
| Movie | 1986 | My Town | Laura Adams | |
| Movie | 2012 | Flatland²: Sphereland | Over-Sphere (voice) | |
| Movie | 2022 | She | Narrator | |
| Movie | 2010 | The Best and the Brightest | The Player's Wife | |
| Movie | 1992 | Round Numbers | Judith Schweitzer | |
| Movie | 1991 | Fatal Friendship | Sue Bradley | |
| Movie | 1993 | For Love and Glory | Antonia Doyle | |
| Movie | 2014 | The Principle | Narrator | |
| Movie | 1995 | Launch of Star Trek: Voyager | Herself | |
| Movie | 1995 | E! Inside Star Trek: Voyager | Herself | |
| Movie | N/A | Columbarium | | |
| Movie | 2008 | The Response | Colonel Simms | |
| Movie | 1998 | Rocketships | Narrator | |
| Movie | 2017 | Drawing Home | Edith Morse Robb | |
| Movie | 1996 | Star Trek: 30 Years and Beyond | Self | |
| Movie | 2006 | William Shatner in Concert | Self | |
| Movie | 1980 | A Time for Miracles | Mother Elizabeth Bayley Seton | |
| Movie | 1975 | Alien Lover | Susan | |
| Movie | 1995 | Star Trek: Voyager - Inside the New Adventure | Self | |
| Movie | 2001 | Sisters in Resistance | Narrator (voice) | |
| Movie | 1999 | Star Trek: Voyager - Dark Frontier | Kathryn Janeway | |
| Movie | 2007 | Star Trek: Beyond the Final Frontier | Self | |
| Movie | 1997 | Trekkies | Self | |
| Movie | 1985 | A Letter to Three Wives | Addie Ross (voice) | |
| Movie | 2025 | Elio | Museum Exhibit Narrator (voice) | |
| TV Show | 1982 | St. Elsewhere | | 1 |
| TV Show | 1984 | Murder, She Wrote | Sonny Greer | 1 |
| TV Show | 1982 | Cheers | Janet Eldridge | 3 |
| TV Show | 2013 | Orange Is the New Black | Galina 'Red' Reznikov | 91 |
| TV Show | 1979 | Mrs. Columbo | Kate Columbo/Kate Callahan | 13 |
| TV Show | 1995 | Star Trek: Voyager | Kathryn Janeway | 169 |
| TV Show | 1994 | Gargoyles | Anastasia Renard/Titania (voice) | 1 |
| TV Show | 1988 | Murphy Brown | | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Donna Geysen | 1 |
| TV Show | 1994 | Aladdin | | 1 |
| TV Show | 1982 | Hotel | | 1 |
| TV Show | 1991 | The Pirates of Dark Water | Cressa (voice) | 1 |
| TV Show | 1978 | Dallas | Garnet McGee | 1 |
| TV Show | 2009 | Mercy | | 8 |
| TV Show | 1988 | HeartBeat | Dr. Joanne Springsteen | 18 |
| TV Show | 1991 | Man of the People | Lisbeth Chardin | 12 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self - Guest | 2 |
| TV Show | 1994 | Gargoyles | Titania (voice) | 3 |
| TV Show | 2021 | Star Trek: Prodigy | Kathryn Janeway (voice) | 39 |
| TV Show | 2011 | NTSF:SD:SUV:: | Kove | 39 |
| TV Show | 1992 | Batman: The Animated Series | Red Claw (voice) | 3 |
| TV Show | 1981 | The Manions of America | Rachel Clement | 3 |
| TV Show | 1984 | Murder, She Wrote | Joanna Rollins | 1 |
| TV Show | 1984 | Murder, She Wrote | Maude Gillis | 1 |
| TV Show | 2019 | The Ready Room | Self | 2 |
| TV Show | 2021 | The Center Seat: 55 Years of Star Trek | Self | 1 |
| TV Show | 2020 | Star Trek Day | Self | 1 |
| TV Show | 1978 | The Word | Tony Nicholson | 4 |
| TV Show | 2022 | The First Lady | Susan Sher | 4 |
| TV Show | 2022 | The Man Who Fell to Earth | Drew Finch | 10 |
| TV Show | 2022 | Flowers in the Attic: The Origin | Mrs. Steiner | 4 |
| TV Show | 1996 | The Rosie O'Donnell Show | Self - Guest | 1 |
| TV Show | 2021 | Dogs in Space | Mavis (voice) | 1 |
| TV Show | 2009 | Warehouse 13 | Jane Lattimer | 6 |
| TV Show | 2025 | Dope Thief | Theresa Bowers | 8 |
| TV Show | 1982 | St. Elsewhere | Helen O'Casey | 1 |
| TV Show | 2017 | Mr. Mercedes | Alma Lane | 9 |
| TV Show | 2013 | The Captains Close Up | Self | 2 |
| TV Show | 2005 | American Dad! | June Rosewood (voice) | 1 |
| TV Show | 2007 | The Black Donnellys | Helen Donnelly | 3 |
| TV Show | 2019 | Infinity Train | The Cat (voice) | 7 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee | 1 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 1975 | Ryan's Hope | Mary Ryan Fenelli | 56 |
| TV Show | 1990 | Captain Planet and the Planeteers | Dr. Derek (voice) | 1 |
| TV Show | 1994 | Gargoyles | Anastasia Renard (voice) | 1 |
| TV Show | 1974 | Dinah! | Self | 1 |
