| Movie | 1994 | Pulp Fiction | Kathy Griffin | |
| Movie | 2010 | Shrek Forever After | Dancing Witch / Wagon Witch #1 (voice) | |
| Movie | 1996 | Kathy Griffin: HBO Comedy Hour | Self | |
| Movie | 2000 | A Diva's Christmas Carol | Ghost of Christmas Past | |
| Movie | 2003 | Beethoven's 5th | Evie Kling | |
| Movie | 1991 | Shakes the Clown | Lucy | |
| Movie | 2009 | Kathy Griffin: She'll Cut a Bitch | Self | |
| Movie | 2007 | Kathy Griffin: Straight to Hell | Self | |
| Movie | 2007 | Kathy Griffin: Everybody Can Suck It | Self | |
| Movie | 2004 | Kathy Griffin: Allegedly | Self | |
| Movie | 2009 | Kathy Griffin: Balls of Steel | Self | |
| Movie | 2006 | Kathy Griffin: Strong Black Woman | Self | |
| Movie | 2004 | Kathy Griffin: The D-List | Self | |
| Movie | 1994 | It's Pat | Kathy Griffin | |
| Movie | 2008 | History of the Joke | Self | |
| Movie | 2005 | Love Wrecked | Belinda | |
| Movie | 2007 | Heckler | Self | |
| Movie | 2005 | Dinotopia: Quest for the Ruby Sunstone | Rhoga (voice) | |
| Movie | 2007 | Judy Toll: The Funniest Woman You've Never Heard Of | Self | |
| Movie | 2010 | I Am Comic | Self | |
| Movie | 2010 | Joan Rivers: A Piece of Work | Self | |
| Movie | 1991 | Medusa: Dare to Be Truthful | Taffy | |
| Movie | 2010 | Kathy Griffin: Does the Bible Belt | Self | |
| Movie | 1997 | Courting Courtney | Ona Miller | |
| Movie | 2005 | Dirty Love | Madame Belly | |
| Movie | 2010 | Katt Williams: 9 Lives | Self | |
| Movie | 2011 | Kathy Griffin: Gurrl Down | Self | |
| Movie | 1991 | The Unborn | Connie Chicago | |
| Movie | 2012 | Kathy Griffin: Seaman 1st Class | Self | |
| Movie | 2011 | Kathy Griffin: Pants Off | Self | |
| Movie | 2010 | Kathy Griffin: Whores on Crutches | Self | |
| Movie | 2011 | Kathy Griffin: 50 And Not Pregnant | Self | |
| Movie | 2000 | Intern | Cornelia Crisp | |
| Movie | 2013 | Kathy Griffin: Kennedie Center On-Hers | Self | |
| Movie | 2011 | Kathy Griffin: Tired Hooker | Self | |
| Movie | 2013 | Why We Laugh: Funny Women | Self | |
| Movie | 2013 | Whoopi Goldberg Presents Moms Mabley | Self | |
| Movie | 2013 | Kathy Griffin: Calm Down Gurrl | Self | |
| Movie | 2000 | Enemies of Laughter | Cindy | |
| Movie | 2013 | Kathy Griffin: Record Breaker | Self | |
| Movie | 2014 | SVDDXNLY | Self | |
| Movie | 1980 | Battle Beyond the Stars | Alien Extra (uncredited) | |
| Movie | 1984 | Streets of Fire | Concertgoer (uncredited) | |
| Movie | 1995 | The Barefoot Executive | Mary | |
| Movie | 1996 | The Cable Guy | Cable Boy's Mother | |
| Movie | 1997 | Trojan War | Cashier | |
| Movie | 1997 | Who's the Caboose? | Katty | |
| Movie | 1999 | Muppets from Space | Female Armed Guard | |
| Movie | 2000 | Lion of Oz | Caroline (voice) | |
| Movie | 2005 | Her Minor Thing | Maggie | |
| Movie | 2020 | Together in Pride: You Are Not Alone | Self | |
| Movie | 2013 | The Improv: 50 Years Behind the Brick Wall | Self | |
| Movie | 2022 | Unconventional | | |
| Movie | 2020 | Women Behind Bars | Self - Host | |
| Movie | 2006 | Bachelor Party Vegas | She-Elvis | |
| Movie | 2002 | Run Ronnie Run | Self | |
| Movie | 1995 | Four Rooms | Betty | |
| Movie | 2022 | Cursed Friends | Stacy Friendship | |
| Movie | 2015 | Being Canadian | Self | |
| Movie | 1997 | The Big Fall | Sally | |
| Movie | 2009 | Comedy Central Roast of Joan Rivers | Self - Roast Master | |
| Movie | 2005 | Kathy Griffin: Is Not Nicole Kidman | Self | |
| Movie | 1999 | Can't Stop Dancing | Modeling Agent | |
| Movie | 2017 | Everybody Has an Andy Dick Story | | |
| Movie | 2009 | VH1 Divas 2009 | Self | |
| Movie | 2010 | A Turtle's Tale: Sammy's Adventures | Vera (voice) | |
| Movie | 1998 | Kathy Griffin: Hot Cup of Talk | Self | |
| Movie | 2007 | Mr. Warmth: The Don Rickles Project | Self | |
| Movie | 2019 | Kathy Griffin: A Hell of a Story | Self | |
| Movie | 2011 | Hall Pass | Kathy Griffin | |
| Movie | 2004 | Last Laugh '04 | Self | |
| Movie | 2021 | Hysterical | Self | |
| Movie | 1999 | Jackie's Back! | Kathy Griffin | |
| Movie | 1999 | Dill Scallion | Tina | |
| Movie | 2024 | The Little Pageant That Could | Self (archive footage) | |
| Movie | 2007 | An Evening with Dr. Katz: Live from the Comedy Central Stage | Self | |
| TV Show | 1989 | The Simpsons | Francine (voice) | 1 |
| TV Show | 1989 | Seinfeld | Sally Weaver | 2 |
| TV Show | 1994 | Ellen | Peggy | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 1 |
| TV Show | 1996 | Suddenly Susan | Vicki Groener | 93 |
| TV Show | 2005 | Kathy Griffin: My Life on the D-List | Self | 48 |
| TV Show | 1990 | The Fresh Prince of Bel-Air | Susan Klein | 1 |
| TV Show | 1997 | The View | Self | 6 |
| TV Show | 1995 | Dr. Katz, Professional Therapist | Kathy (voice) | 2 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Self | 1 |
| TV Show | 2003 | Ill-ustrated | | 2 |
| TV Show | 2012 | Inside Comedy | Self | 1 |
| TV Show | 2005 | Too Late with Adam Carolla | | 1 |
| TV Show | 2003 | Stripperella | | 1 |
| TV Show | 1993 | The X-Files | Betty Templeton / Lulu Pfeiffer | 1 |
| TV Show | 2009 | The Jay Leno Show | Self | 1 |
| TV Show | 1997 | Premium Blend | | 97 |
| TV Show | 1996 | Saturday Night Special | | 6 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 2006 | The Greg Behrendt Show | | 1 |
| TV Show | 2010 | The Marriage Ref | Self - Panelist | 2 |
| TV Show | 2008 | Bravo A-List Awards | | 3 |
| TV Show | 2008 | The Wendy Williams Show | | 1 |
| TV Show | 2012 | Kathy | | 24 |
| TV Show | 2011 | Whitney | Lindsay | 1 |
| TV Show | 1992 | Mad About You | Brenda | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 2 |
| TV Show | 1997 | The View | Self - Guest | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | Kathy Griffin | 1 |
| TV Show | 2017 | Str8UpGayPorn Awards | Self - Host | 1 |
| TV Show | 2010 | The Green Room with Paul Provenza | Self | 1 |
| TV Show | 2016 | Martha & Snoop's Potluck Dinner Party | Self | 1 |
| TV Show | 1999 | Futurama | Captain Cranky (voice) | 1 |
| TV Show | 2009 | Drop Dead Diva | Jenna Kaswell-Bailey | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 8 |
| TV Show | 2003 | America's Next Top Model | Self - Guest | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Babs Duffy | 1 |
| TV Show | 2000 | Big Brother | Self - Celebrity Guest | 2 |
| TV Show | 2006 | Gameshow Marathon | | 1 |
| TV Show | 2011 | My Favorite Place | Self | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 2 |
| TV Show | 2005 | The Reichen Show | Self - Guest | 1 |
| TV Show | 2010 | When I Was 17 | Self | 1 |
| TV Show | 2003 | Spider-Man: The New Animated Series | Roxanne Gaines (voice) | 2 |
| TV Show | 1995 | The Drew Carey Show | Kathy | 1 |
| TV Show | 2002 | What's New, Scooby-Doo? | Autumn Summerfield (voice) | 1 |
| TV Show | 2007 | The Graham Norton Show | Self | 1 |
| TV Show | 1999 | Dilbert | Alice (voice) | 18 |
| TV Show | 2009 | Glee | Tammy Jean Albertson | 1 |
| TV Show | 2002 | Half & Half | Dr. Morgan | 1 |
| TV Show | 2009 | RuPaul's Drag Race | Self - Guest Judge | 2 |
| TV Show | 2009 | RuPaul's Drag Race | Self - Special Guest | 1 |
| TV Show | 2016 | Search Party | Liquorice | 4 |
| TV Show | 1990 | Dream On | Dawn | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 3 |
| TV Show | 2018 | You | Self | 1 |
| TV Show | 2005 | American Dad! | Kelly (voice) | 1 |
| TV Show | 2013 | Kirstie | Kathy Griffin | 1 |
| TV Show | 2000 | Strong Medicine | Matchmaker | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 2 |
| TV Show | 1995 | Caroline in the City | DMV Clerk | 1 |
| TV Show | 1998 | Whose Line Is It Anyway? | Self | 4 |
| TV Show | 2007 | Keeping Up with the Kardashians | Self | 1 |
| TV Show | 2010 | Conan | Self | 2 |
| TV Show | 1994 | ER | Dolores Minky | 1 |
| TV Show | 2010 | The Defenders | Sally Scott | 1 |
| TV Show | 1995 | Ned and Stacey | Jeannie | 2 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 1998 | GayVN Awards | Self - Host | 1 |
| TV Show | 2025 | Unconventional | Dr. Edie Ellis | 3 |
| TV Show | 2007 | Say Yes to the Dress | Self | 1 |
