| Movie | 1986 | Stand by Me | The Writer | |
| Movie | 2006 | Poseidon | Richard Nelson | |
| Movie | 1975 | Jaws | Hooper | |
| Movie | 1995 | Mr. Holland's Opus | Glenn Holland | |
| Movie | 2022 | Nazis at Nuremberg: The Lost Testimony | Narrator (voice) | |
| Movie | 2008 | W. | Dick Cheney | |
| Movie | 1996 | James and the Giant Peach | Centipede (voice) | |
| Movie | 1973 | American Graffiti | Curt Henderson | |
| Movie | 1977 | Close Encounters of the Third Kind | Roy Neary | |
| Movie | 1991 | What About Bob? | Dr. Leo Marvin | |
| Movie | 1994 | It's Alive: The True Story of Frankenstein | Self | |
| Movie | 1987 | Tin Men | Bill 'BB' Babowsky | |
| Movie | 1987 | Stakeout | Det. Chris Lecce | |
| Movie | 1989 | Always | Pete Sandich | |
| Movie | 1976 | Victory at Entebbe | Colonel Yonatan 'Yonni' Netanyahu | |
| Movie | 2000 | Fail Safe | President | |
| Movie | 2009 | My Life in Ruins | Irv Gideon | |
| Movie | 1973 | Catch-22 | Yossarian | |
| Movie | 1990 | Postcards from the Edge | Dr. Frankenthal | |
| Movie | 1998 | Krippendorf's Tribe | Prof. Krippendorf | |
| Movie | 2024 | Waltzing with Brando | Seymour Kraft | |
| Movie | 1981 | Whose Life Is It Anyway? | Ken Harrison | |
| Movie | 1975 | Inserts | Boy Wonder | |
| Movie | 1993 | Another Stakeout | Det. Chris Lecce | |
| Movie | 1995 | The American President | Senator Rumson | |
| Movie | 2001 | Who Is Cletis Tout? | Micah Donnelly | |
| Movie | 2009 | Leaves of Grass | Pug Rothbaum | |
| Movie | 1988 | Moon Over Parador | Jack Noah | |
| Movie | 1986 | Down and Out in Beverly Hills | Dave Whiteman | |
| Movie | 1987 | Citizen Steve | Jedediah | |
| Movie | 1993 | Lost in Yonkers | Louie Kurnitz | |
| Movie | 1973 | Dillinger | Baby Face Nelson | |
| Movie | 1987 | Nuts | Aaron Levinsky | |
| Movie | 1980 | The Competition | Paul Dietrich | |
| Movie | 1977 | The Making of 'The Goodbye Girl' | Self | |
| Movie | 1978 | The Big Fix | Moses Wine | |
| Movie | 1969 | Hello Down There | Harold Webster | |
| Movie | 1974 | The Apprenticeship of Duddy Kravitz | Duddy | |
| Movie | 1977 | The Goodbye Girl | Elliot Garfield | |
| Movie | 2010 | Piranha 3D | Matthew Boyd | |
| Movie | 1984 | The Buddy System | Joe | |
| Movie | 1997 | Night Falls on Manhattan | Sam Vigoda | |
| Movie | 2010 | RED | Alexander Dunning | |
| Movie | 1996 | Mad Dog Time | Vic | |
| Movie | 1991 | Once Around | Sam Sharpe | |
| Movie | 2003 | Easy Riders, Raging Bulls: How the Sex 'n' Drugs 'n' Rock 'n' Roll Generation Saved Hollywood | Self | |
| Movie | 2001 | The Old Man Who Read Love Stories | | |
| Movie | 1997 | Oliver Twist | Fagin | |
| Movie | 1994 | Silent Fall | Dr. Jake Rainer | |
| Movie | 2023 | Elizabeth Montgomery: A Bewitched Life | Self | |
| Movie | 1977 | The Sentinel | Man on Sidewalk Talking to Girl in Red Sweater (uncredited) | |
| Movie | 2004 | Silver City | Chuck Raven | |
| Movie | 1991 | Rosencrantz & Guildenstern Are Dead | The Player | |
| Movie | 2009 | The Lightkeepers | Seth | |
| Movie | 2001 | The Day Reagan Was Shot | Alexander Haig | |
| Movie | 1989 | Let It Ride | Jay Trotter | |
| Movie | 2000 | The Crew | Bobby Bartellemeo / Narrator | |
| Movie | 2013 | Very Good Girls | Danny | |
| Movie | 1997 | The Call of the Wild: Dog of the Yukon | Narrator (voice) | |
| Movie | 1999 | Lansky | Meyer Lansky | |
| Movie | 2009 | The Shark Is Still Working: The Impact & Legacy of "Jaws" | Self | |
| Movie | 1997 | Frank Capra's American Dream | Self | |
| Movie | 2005 | The Adventures of Errol Flynn | Self - Actor | |
| Movie | 2003 | Teddy Roosevelt: An American Lion | Theodore Roosevelt | |
| Movie | 2000 | Walking the Tracks: The Summer of Stand by Me | Self | |
| Movie | 2013 | Paranoia | Frank Cassidy | |
| Movie | 2004 | A Legacy of Filmmakers: The Early Years of American Zoetrope | Narrator | |
| Movie | 1997 | In the Teeth of Jaws | Self | |
| Movie | 2013 | Cas & Dylan | Dr. Cas Pepper | |
| Movie | 2011 | The Two Million Year Old Boy | Narrator | |
| Movie | 2022 | Murder at Yellowstone City | Edgar | |
| Movie | 1991 | Prisoner of Honor | Col. Picquart | |
| Movie | 1968 | The Young Runaways | Terry | |
| Movie | 2023 | Sweetwater | Maurice Podoloff | |
| Movie | 1974 | The Second Coming of Suzanne | Clavius | |
| Movie | 2009 | Waking Sleeping Beauty | David 'Dave' Whiteman (archive footage) | |
| Movie | 2014 | Squatters | David Silverman | |
| Movie | 2004 | Coast to Coast | Barnaby Pierce | |
| Movie | 1997 | Audrey Hepburn: The Fairest Lady | Self | |
| Movie | 1972 | The Shadow of a Gunman | Tommy Owen | |
| Movie | 1967 | The Graduate | Boarding House Resident (uncredited) | |
| Movie | 1995 | The Making of 'Jaws' | Self | |
| Movie | 2020 | Audrey | Self - Actor | |
| Movie | 1995 | The Last Word | Larry | |
| Movie | 2015 | Zipper | George Hiller | |
| Movie | 2013 | Milius | Self | |
| Movie | 1973 | Me | Greg | |
| Movie | 2014 | Caserta Palace Dream | Luigi Vanvitelli | |
| Movie | 2022 | Save Christmas | Santa | |
| Movie | 1977 | The Amazing Miss Cummings: An Actress at Work and Play | | |
| Movie | 1967 | Valley of the Dolls | Assistant Stage Manager (uncredited) | |
| Movie | 1997 | Henry Fonda: Hollywood's Quiet Hero | Self | |
| Movie | 1985 | Night of 100 Stars II | Self | |
| Movie | 2010 | Jaws: The Inside Story | Self | |
| Movie | N/A | I Refuse to Kill: He Went to War with War | Self | |
| Movie | 2008 | America Betrayed | Narrator | |
| Movie | 2007 | AFI: 100 Years... 100 Movies... 10th Anniversary Edition | Self | |
| Movie | 2018 | Third Party President: Citizen Rocky | Self | |
| Movie | 1998 | The Making of 'American Graffiti' | Self | |
| Movie | 1998 | Lost at Sea: The Search for Longitude | Narrator | |
| Movie | 2009 | I Knew It Was You: Rediscovering John Cazale | Self | |
| Movie | 1987 | Funny, You Don't Look 200: A Constitutional Vaudeville | Self | |
| Movie | 2001 | The Making of 'Close Encounters of the Third Kind' | Self | |
| Movie | 2017 | Spielberg | Self | |
| Movie | 2018 | Book Club | George | |
| Movie | 2018 | Bayou Caviar | Yuri | |
| Movie | 2018 | Asher | Avi | |
| Movie | 1996 | The Universal Story | Self | |
| Movie | 2007 | Ocean of Fear | Narrator | |
| Movie | 2019 | The Last Laugh | Buddy Green | |
| Movie | 2019 | Polar | Porter | |
| Movie | 2019 | Daughter of the Wolf | Father | |
| Movie | 2019 | Astronaut | Angus | |
| Movie | 1987 | James Stewart: A Wonderful Life | Self | |
| Movie | 2014 | And the Oscar Goes To... | Self (archive footage) | |
| Movie | 1974 | New England Our Way | Self | |
| Movie | 2001 | Rudolph the Red-Nosed Reindeer & the Island of Misfit Toys | Scoop the Snowman (voice) | |
| Movie | 2003 | The Johnstown Flood | narrator | |
| Movie | 2001 | R2-D2: Beneath the Dome | Self | |
| Movie | 2001 | In Search of Peace | Yitzhak Rabin (voice) | |
| Movie | 2003 | The John Garfield Story | Self | |
| Movie | 2007 | The Man Who Shot Chinatown: The Life and Work of John A. Alonzo | Self | |
| Movie | 2002 | Manassas: End of Innocence | Narrator | |
| Movie | 2021 | Every Last One of Them | Murphy | |
| Movie | 2021 | Crime Story | Ben Myers | |
| Movie | 1972 | Two for the Money | Morris Gap | |
| Movie | 2012 | Casting By | Self | |
| Movie | 1992 | Lincoln | William Tecumsah Sherman (voice) | |
| Movie | 2006 | Boffo! Tinseltown's Bombs and Blockbusters | Self | |
| Movie | 2025 | Into the Deep | Seamus | |
| Movie | 2025 | Jaws @ 50: The Definitive Inside Story | Self | |
| TV Show | 2005 | Weeds | Warren Schiff | 4 |
| TV Show | 1994 | Inside the Actors Studio | Self | 1 |
| TV Show | 1999 | Family Guy | Richard Dreyfuss / Narrator (voice) | 1 |
| TV Show | 1965 | Gidget | | 1 |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 1966 | That Girl | | 1 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 1969 | Room 222 | | 1 |
| TV Show | 1968 | The Mod Squad | | 2 |
| TV Show | 1955 | Gunsmoke | Gearshon Gorofsky | 1 |
| TV Show | 2018 | The Great Celebrity Bake Off for Stand Up To Cancer | Self - Guest | 1 |
| TV Show | 1964 | Bewitched | | 1 |
| TV Show | 1966 | Felony Squad | | 1 |
| TV Show | 2001 | The Education of Max Bickford | Max Bickford | 22 |
| TV Show | 1964 | Karen | David Rowe III | 27 |
| TV Show | 1966 | Hey Landlord! | | 1 |
| TV Show | 2007 | Tin Man | Mystic Man | 3 |
| TV Show | 1967 | Judd for the Defense | | 1 |
| TV Show | 1969 | The New People | | 1 |
| TV Show | 1966 | Occasional Wife | | 1 |
| TV Show | 1961 | Ben Casey | | 1 |
| TV Show | 1995 | The Frank Skinner Show | Self | 1 |
| TV Show | 1997 | The Wonderful World of Disney | | 1 |
| TV Show | 1999 | Where Are They Now? | Self | 1 |
| TV Show | 1953 | The Oscars | Self | 3 |
| TV Show | 1973 | A Touch of Grace | | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2017 | Shots Fired | Arlen Cox | 10 |
| TV Show | 2018 | Firing Line with Margaret Hoover | Self | 1 |
| TV Show | 2015 | Your Family or Mine | Louis | 10 |
| TV Show | 2012 | Coma | Professor Hillside | 2 |
| TV Show | 1999 | Family Guy | Richard Dreyfuss (voice) | 1 |
| TV Show | 2016 | Madoff | Bernie Madoff | 4 |
| TV Show | N/A | Ocean of Fear | Narrator (voice) | 6 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 1996 | The Rosie O'Donnell Show | Self - Guest | 1 |
| TV Show | 2005 | The Reichen Show | Self | 1 |
| TV Show | 1965 | The Big Valley | Lud | 1 |
| TV Show | 1992 | Shelley Duvall's Bedtime Stories | Narrator (Voice) | 1 |
| TV Show | N/A | Happiness Isn't Everything | Jerry Hamburger | 1 |
| TV Show | 2020 | Stars in the House | Self | 1 |
| TV Show | 2014 | The Real History of Science Fiction | Self | 2 |
| TV Show | 2010 | Parenthood | Gilliam T. Blount | 4 |
| TV Show | 1970 | Treffpunkte | Self | 1 |
| TV Show | 2011 | Bubble Guppies | Captain Acrab | 1 |
| TV Show | 1971 | Great Performances | Self | 1 |
| TV Show | 1961 | The Mike Douglas Show | Self | 1 |
| TV Show | 1956 | Tony Awards | Self - Presenter | 1 |
| TV Show | 1998 | The Entertainment Biz | Self | 1 |
