| Movie | 1986 | Stand by Me | Vern Tessio | |
| Movie | 2000 | Mission to Mars | Phil Ohlmyer | |
| Movie | 2006 | Room 6 | Lucas Dylan | |
| Movie | 2003 | Kangaroo Jack | Charlie Carbone | |
| Movie | 2001 | Tomcats | Michael Delaney | |
| Movie | 1997 | Scream 2 | Derek Feldman | |
| Movie | 2013 | Scary Movie 5 | Christian Grey | |
| Movie | 2023 | The Donor Party | Tim | |
| Movie | 2021 | Pups Alone | Charlie (voice) | |
| Movie | 1999 | The '60s | Brian Herlihy | |
| Movie | 2004 | Fat Slags | Sean Cooley | |
| Movie | 1996 | Joe's Apartment | Joe | |
| Movie | 2009 | Nora Roberts' Midnight Bayou | Declan Fitzpatrick | |
| Movie | 2006 | Man About Town | David Lilly | |
| Movie | 1996 | Jerry Maguire | Frank Cushman | |
| Movie | 2002 | Buying the Cow | David Collins | |
| Movie | 1999 | Body Shots | Michael Penorisi | |
| Movie | 2006 | The Alibi | Businessman | |
| Movie | 2010 | Piranha 3D | Derrick Jones | |
| Movie | 2010 | Superman/Shazam!: The Return of Black Adam | Captain Marvel (voice) | |
| Movie | 2011 | Still Screaming: The Ultimate Scary Movie Retrospective | Self | |
| Movie | 1995 | The Ranger, the Cook and a Hole in the Sky | Mac | |
| Movie | 2009 | Obsessed | Ben | |
| Movie | 2009 | Baby on Board | Curtis Marks | |
| Movie | 1988 | Ollie Hopnoodle's Haven of Bliss | Young Ralphie | |
| Movie | 1995 | Blue River | Lawrence Sellars | |
| Movie | 2000 | Walking the Tracks: The Summer of Stand by Me | Self | |
| Movie | 1993 | Calendar Girl | Scott Foreman | |
| Movie | 1987 | The Room Upstairs | Carl | |
| Movie | 2014 | Space Station 76 | Steve | |
| Movie | 2014 | Veronica Mars | Sheriff Dan Lamb | |
| Movie | 2014 | The Lookalike | Joe Mulligan | |
| Movie | 2022 | Play Dead | The Coroner | |
| Movie | 2015 | Justice League: Throne of Atlantis | Superman / Clark Kent / Kal-El (voice) | |
| Movie | 2005 | Yours, Mine & Ours | Max Algrant | |
| Movie | 1997 | What the Deaf Man Heard | Reverend Perry Ray Pruitt | |
| Movie | 2016 | Justice League vs. Teen Titans | Clark Kent / Superman (voice) | |
| Movie | 2016 | Trolland | Hayden (voice) | |
| Movie | 2017 | Love Locks | Jack Burrow | |
| Movie | 2017 | Justice League Dark | Superman (voice) | |
| Movie | 2016 | Be Good For Rachel | Lt. Sebastian Lowe | |
| Movie | 2017 | A Mermaid's Tale | Matt | |
| Movie | 2003 | Overnight | Self | |
| Movie | 2012 | Mockingbird Lane | Herman Munster | |
| Movie | 2017 | Wish Upon | Lawrence Hart (uncredited) | |
| Movie | 2018 | The Death of Superman | Clark Kent / Superman (voice) | |
| Movie | 2019 | Reign of the Supermen | Clark Kent / Superman / Cyborg Superman (voice) | |
| Movie | 2019 | Deep Murder | Doug | |
| Movie | 2018 | Wetware | Blaine | |
| Movie | 2018 | Cool Dad - Official Trailer | Ted Apples | |
| Movie | 2020 | The Secret: Dare to Dream | Tucker Wells | |
| Movie | 2019 | Batman: Hush | Superman / Kal-El / Clark Kent (voice) | |
| Movie | 2020 | The F**k-It List | Jeffrey Blackmore | |
| Movie | 2019 | Satanic Panic | Samuel Ross | |
| Movie | 2019 | The Death and Return of Superman | Clark Kent / Superman (voice) | |
| Movie | 2010 | DC Showcase Original Shorts Collection | Captain Marvel (segment "The Return of Black Adam") (voice) | |
| Movie | 2019 | Boy Band | Chad Bixley | |
| Movie | 2020 | Justice League Dark: Apokolips War | Clark Kent / Superman (voice) | |
| Movie | 2020 | Ballbuster | Rich | |
| Movie | 1998 | Can't Hardly Wait | Trip McNeely (uncredited) | |
| Movie | 2021 | Wendy Williams: What a Mess! | Self | |
| Movie | 2021 | Endangered Species | Mitch Hanover | |
| Movie | 2021 | A Soldier's Play | Captain Charles Taylor | |
| Movie | 2002 | The New Guy | Highland High Party Twin #1 | |
| Movie | 2023 | Summer Gold | Rick Brackett | |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 4 |
| TV Show | 2004 | The Tony Danza Show | Self | 4 |
| TV Show | 1984 | Charles in Charge | David Landon | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 4 |
| TV Show | 1995 | Sliders | Quinn Mallory | 69 |
| TV Show | 1988 | LIVE with Kelly and Mark | | 2 |
| TV Show | 1988 | My Secret Identity | Andrew Clements | 72 |
| TV Show | 2003 | Las Vegas | Detective Woody Hoyt | 5 |
| TV Show | 2001 | Crossing Jordan | Woody Hoyt | 70 |
| TV Show | 2006 | Rachael Ray | | 1 |
| TV Show | 1997 | The View | Self | 3 |
| TV Show | 2007 | Samantha Who? | Craig | 1 |
| TV Show | 2019 | The Ready Room | Self | 1 |
| TV Show | 2007 | Carpoolers | Laird Holcomb | 13 |
| TV Show | 2004 | The Celebrity Apprentice | | 2 |
| TV Show | 2002 | American Idol | Self | 1 |
| TV Show | 1985 | The Equalizer | Bobby | 1 |
| TV Show | 2014 | The Librarians | Lancelot du Lac (uncredited) | 1 |
| TV Show | 2006 | Ugly Betty | Joel | 1 |
| TV Show | 2001 | Night Visions | Andy (segment "Rest Stop") | 1 |
| TV Show | 2008 | Do Not Disturb | Neal | 6 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 3 |
| TV Show | 1951 | Hallmark Hall of Fame | Carl | 1 |
| TV Show | 1992 | Camp Wilder | Brody Wilder | 19 |
| TV Show | 2008 | The Wendy Williams Show | Self | 1 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self | 1 |
| TV Show | 2009 | Eastwick | | 1 |
| TV Show | 2011 | OK! TV | | 1 |
| TV Show | 2010 | Fish Hooks | Sterling Hamsterton | 0 |
| TV Show | 2010 | The Defenders | Pete Kaczmarek | 18 |
| TV Show | 2004 | Justice League Unlimited | Captain Marvel (voice) | 1 |
| TV Show | 2014 | Marry Me | Daniel | 1 |
| TV Show | 2011 | Jake and the Never Land Pirates | Pip the Pirate Genie | 1 |
| TV Show | 2013 | We Are Men | Stuart Weber | 11 |
| TV Show | 2022 | Star Trek: Strange New Worlds | Commander Jack Ransom (voice) | 1 |
| TV Show | 1999 | Rove | Self | 1 |
| TV Show | 2000 | Curb Your Enthusiasm | TV Detective #2 | 1 |
| TV Show | 2014 | Young & Hungry | Nick Diamond | 1 |
| TV Show | 2010 | The Talk | Self - Host | 135 |
| TV Show | 2012 | Burning Love | Henry | 14 |
| TV Show | 2015 | Scream Queens | Dr. Mike | 3 |
| TV Show | 2018 | The Neighborhood | Jerry O'Connell | 1 |
| TV Show | 2010 | Fish Hooks | Sterling Hamsterton (voice) | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 3 |
| TV Show | 2012 | Mockingbird Lane | Herman Munster | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 23 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 2007 | The Big Bang Theory | Georgie Cooper | 3 |
| TV Show | 2016 | Match Game | Self - Panelist | 1 |
| TV Show | 1951 | Hallmark Hall of Fame | Reverend Perry Ray Pruitt | 1 |
| TV Show | 2004 | The Batman | Nightwing (voice) | 2 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 2018 | Carter | Harley Carter | 20 |
| TV Show | 2013 | Deal With It | Self | 1 |
| TV Show | 2024 | After Midnight | Self | 3 |
| TV Show | 2018 | Bravo's Play by Play | Himself - Host | 3 |
| TV Show | 2009 | The League | Father Muldoon | 1 |
| TV Show | 2010 | Rex Is Not Your Lawyer | Attorney | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 2 |
| TV Show | 2022 | The Real Love Boat | Self - Host | 12 |
| TV Show | 2019 | Where's Waldo? | Jason (voice) | 1 |
| TV Show | 2022 | Pictionary | Self - Host | 526 |
| TV Show | 2020 | Star Trek: Lower Decks | Jack Ransom (voice) | 50 |
| TV Show | 2004 | On Air with Ryan Seacrest | Self | 1 |
| TV Show | 2016 | Billions | Steven Birch | 4 |
| TV Show | 2001 | Going to California | Pete Rossock | 1 |
| TV Show | 2014 | The Mysteries of Laura | Jon Dunham | 2 |
| TV Show | 2001 | Crossing Jordan | Detective Woody Hoyt | 17 |
| TV Show | 2015 | Significant Mother | Bob Babcock | 1 |
| TV Show | 2009 | Late Night with Jimmy Fallon | Self | 1 |
| TV Show | 2002 | Without a Trace | Joe Gibson | 1 |
| TV Show | 2016 | Justice League Action | Atom (voice) | 3 |
| TV Show | 2016 | Justice League Action | Ray Palmer / The Atom (voice) | 1 |
| TV Show | 2000 | Big Brother | Self - Host | 1 |
| TV Show | 2010 | G.I. Joe: Renegades | Gabriel Kelly/Barbecue (voice) | 1 |
| TV Show | 2020 | Solar Opposites | Jerry O'Connell / Barry Hatfield (voice) | 1 |
| TV Show | 2011 | Workaholics | Teddy | 1 |
