| Movie | 2001 | Wet Hot American Summer | Gail | |
| Movie | 2006 | Marie Antoinette | Aunt Victoire | |
| Movie | 2007 | Evan Almighty | Eve Adams | |
| Movie | 2023 | A Good Person | Diane | |
| Movie | 2003 | My Boss's Daughter | Audrey Bennett | |
| Movie | 2013 | Scary Movie 5 | Heather Darcy | |
| Movie | 2006 | Scary Movie 4 | Marilyn | |
| Movie | 1999 | Never Been Kissed | Anita | |
| Movie | 2003 | Good Boy! | Mrs. Baker | |
| Movie | 2003 | The Music Man | Mrs. Eulalie Mackechnie Shinn | |
| Movie | 2000 | How the Grinch Stole Christmas | Betty Lou Who | |
| Movie | 1998 | A Night at the Roxbury | Emily Sanderson | |
| Movie | 2001 | Osmosis Jones | Mrs. Boyd | |
| Movie | 1999 | Analyze This | Caroline | |
| Movie | 2007 | Year of the Dog | Peggy | |
| Movie | 1999 | Superstar | Mary Katherine Gallagher | |
| Movie | 2008 | Igor | Eva (voice) | |
| Movie | 2007 | Gray Matters | Carrie | |
| Movie | 1998 | The Thin Pink Line | Aani | |
| Movie | 2000 | My 5 Wives | Barbara Van Dyke | |
| Movie | 2006 | The Wedding Weekend | Trish | |
| Movie | 2009 | What Goes Up | Penelope Little | |
| Movie | 2012 | Hotel Transylvania | Wanda (voice) | |
| Movie | 1989 | The Phantom of the Opera | Meg (New York) | |
| Movie | 2007 | More of Me | Alice | |
| Movie | 2013 | Trust Me | Janice | |
| Movie | 2006 | The Amazing Screw-On Head | Patience the Vampire (voice) | |
| Movie | 2022 | Norm Macdonald: Nothing Special | Self | |
| Movie | 2014 | Life After Beth | Geenie Slocum | |
| Movie | 2002 | NBC 75th Anniversary Special | Self | |
| Movie | 2006 | Air Buddies | Molly (voice) | |
| Movie | 2011 | Bad Teacher | Melody (Garrett's Mom) | |
| Movie | 2001 | Serendipity | Eve | |
| Movie | 2003 | American Splendor | Stage Actor Joyce | |
| Movie | 2008 | Snow Buddies | Molly (voice) | |
| Movie | 2002 | The Santa Clause 2 | Tracy | |
| Movie | 2006 | Talladega Nights: The Ballad of Ricky Bobby | Mrs. Dennit | |
| Movie | 2002 | Saturday Night Live: The Best of Will Ferrell | Self / Various Characters (archive footage) | |
| Movie | 2015 | Addicted to Fresno | Margaret Lipka | |
| Movie | 1994 | Return to Two Moon Junction | Traci | |
| Movie | 1996 | Lawnmower Man 2: Beyond Cyberspace | Homeless Lady | |
| Movie | 1998 | Happiness | Nancy | |
| Movie | 2015 | Me and Earl and the Dying Girl | Denise Kushner | |
| Movie | 2002 | It's a Very Merry Muppet Christmas Movie | Self | |
| Movie | 2003 | Saturday Night Live: The Best of Chris Farley | Cyclist (archive footage) (uncredited) | |
| Movie | 2006 | Saturday Night Live: The Best of Commercial Parodies | | |
| Movie | 1998 | Saturday Night Live: The Best of Phil Hartman | Kelly | |
| Movie | 2017 | We Don't Belong Here | Deborah | |
| Movie | N/A | Bambi Cottages | | |
| Movie | 2014 | The (Dead Mothers) Club | Self | |
| Movie | 2018 | Half Magic | Mistress Valesca | |
| Movie | 2017 | The Layover | Nancy | |
| Movie | 2015 | Hurricane of Fun: The Making of Wet Hot | Self | |
| Movie | 2015 | I Am Chris Farley | Self | |
| Movie | 2017 | Miles | Pam Walton | |
| Movie | 2015 | Hotel Transylvania 2 | Wanda (voice) | |
| Movie | 2004 | 12 Days of Christmas Eve | Angie | |
| Movie | 2016 | Other People | Joanne Mulcahey | |
| Movie | 2001 | Saturday Night Live: The Best of Molly Shannon | Self, various characters | |
| Movie | 2017 | The Little Hours | Sister Marea | |
| Movie | 2026 | Balls Up | Burgess | |
| Movie | 2017 | Fun Mom Dinner | Jamie | |
| Movie | 2015 | Larry Gaye: Renegade Male Flight Attendant | Emily McCoy | |
| Movie | 2005 | Here Comes Peter Cottontail: The Movie | Jackie Frost (voice) | |
| Movie | 2018 | Private Life | Cynthia Grimes | |
| Movie | 2007 | Mastersons of Manhattan | Amanda Masterson | |
| Movie | 2018 | The 2018 Rose Parade Hosted by Cord & Tish | Tish Cattigan | |
| Movie | 2018 | Wild Nights with Emily | Emily Dickinson | |
| Movie | 2018 | Hotel Transylvania 3: Summer Vacation | Wanda (voice) | |
| Movie | 2018 | The Royal Wedding Live with Cord and Tish! | Tish Cattigan | |
| Movie | 2001 | Shallow Hal | Mrs. Mary Larson (uncredited) | |
| Movie | 2019 | The 2019 Rose Parade with Cord & Tish | Tish Cattigan | |
| Movie | 2012 | Casa de Mi Padre | Sheila | |
| Movie | 2010 | The Women of SNL | Various (archive footage) | |
| Movie | 2019 | Jay and Silent Bob Reboot | SouthBest Airlines Lady | |
| Movie | 2020 | Promising Young Woman | Mrs. Fisher | |
| Movie | 2012 | The Five-Year Engagement | Onion Chef | |
| Movie | 2019 | Sextuplets | Linda | |
| Movie | 2020 | Horse Girl | Joan | |
| Movie | 2006 | Little Man | Soccer Mom | |
| Movie | 2016 | Nerdland | Business Woman (voice) | |
| Movie | 1997 | Dinner and Driving | Arguing Woman in Cafe | |
| Movie | 2019 | Chris Farley: Anything for a Laugh | Self | |
| Movie | 2015 | Live from New York! | Self | |
| Movie | 1999 | Saturday Night Live: 25th Anniversary Special | Self | |
| Movie | 2022 | Hotel Transylvania: Transformania | Wanda (voice) | |
| Movie | 2022 | Spin Me Round | Deb | |
| Movie | 2026 | People We Meet on Vacation | Wanda Wright | |
| Movie | 2024 | Will & Harper | Self | |
| Movie | 2025 | SNL50: The Homecoming Concert | Self | |
| Movie | 2025 | Ladies & Gentlemen... 50 Years of SNL Music | Self | |
| Movie | 2025 | Driver's Ed | | |
| Movie | 2025 | Downey Wrote That | Self | |
| Movie | 2007 | Saturday Night Live in the '90s: Pop Culture Nation | Self | |
| Movie | 1999 | Saturday Night Live: Christmas | Self | |
| TV Show | 2017 | Wet Hot American Summer: Ten Years Later | Gail | 3 |
| TV Show | 2009 | The Middle | Janet | 2 |
| TV Show | 2021 | The White Lotus | Kitty Patton | 2 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 2 |
| TV Show | 2000 | Ed | Linda Berringer | 1 |
| TV Show | 2008 | Kath & Kim | Kath Day | 17 |
| TV Show | 1995 | The Single Guy | Melody Pugh | 1 |
| TV Show | 1997 | The View | Self | 4 |
| TV Show | 1998 | Will & Grace | Val Bassett | 5 |
| TV Show | 1994 | Ellen | Woman | 1 |
| TV Show | 2005 | Kathy Griffin: My Life on the D-List | Self | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Various Characters | 125 |
| TV Show | 2005 | American Dad! | Kristy (voice) | 3 |
| TV Show | 2006 | 30 Rock | Katherine Catherine | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | Self | 2 |
| TV Show | 2009 | Glee | Brenda Castle | 2 |
| TV Show | 1952 | Today | Self | 1 |
| TV Show | 1989 | Seinfeld | Sam | 1 |
| TV Show | 2008 | Web Therapy | Kirsten Noble | 3 |
| TV Show | 2005 | The Showbiz Show with David Spade | | 1 |
| TV Show | 2010 | Neighbors from Hell | Tina Hellman (voice) | 10 |
| TV Show | 1990 | In Living Color | | 1 |
| TV Show | 2006 | The New Adventures of Old Christine | Jeannie | 1 |
| TV Show | 1990 | Twin Peaks | Judy Swain | 1 |
| TV Show | 1975 | Saturday Night Live | Self - Cameo (uncredited) | 2 |
| TV Show | 2014 | Benched | Judge Conner | 1 |
| TV Show | 2011 | Bob's Burgers | Millie (voice) | 8 |
| TV Show | 2015 | Wet Hot American Summer: First Day of Camp | Gail von Kleinenstein | 8 |
| TV Show | 2015 | The Spoils Before Dying | Tricksy | 6 |
| TV Show | 2015 | Moonbeam City | Silca (voice) | 1 |
| TV Show | 1993 | Intimate Portrait | Self | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 2 |
| TV Show | 2016 | Divorce | Diane | 24 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 3 |
| TV Show | 2010 | Raising Hope | Maxine | 2 |
| TV Show | 2007 | Pushing Daisies | Dilly Balsam | 1 |
| TV Show | 2008 | Childrens Hospital | Paula Reilly | 1 |
| TV Show | 2022 | I Love That for You | Jackie Stilton | 8 |
| TV Show | 2013 | Getting On | Phyllis Marmatan | 3 |
| TV Show | 2020 | The Drew Barrymore Show | Self | 1 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self - Guest | 1 |
| TV Show | 2010 | Who Do You Think You Are? | Self | 1 |
| TV Show | 2014 | The Spoils of Babylon | Meredith Sennheiser | 6 |
| TV Show | 2015 | Close Up with The Hollywood Reporter | Self | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 7 |
| TV Show | 2019 | Biography: Comedy Icons | Self | 1 |
| TV Show | 2011 | Web Therapy | Kirsten Noble | 2 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 4 |
| TV Show | 2019 | The Other Two | Pat Dubek | 26 |
| TV Show | 2011 | Up All Night | Nancy | 2 |
| TV Show | 2015 | Life in Pieces | Allie | 1 |
| TV Show | 1993 | The John Larroquette Show | Vivian | 1 |
| TV Show | 2011 | Jessie | Beverly Shannon | 1 |
| TV Show | 1975 | Saturday Night Live | Self | 1 |
| TV Show | 2017 | Will & Grace | Val Bassett | 3 |
| TV Show | 2004 | On Air with Ryan Seacrest | Self | 1 |
| TV Show | 1998 | Sex and the City | Lily Martin | 3 |
| TV Show | 2014 | Mulaney | Markie | 1 |
| TV Show | 2013 | Hollywood Game Night | Self | 2 |
| TV Show | 2001 | Primetime Glick | | 1 |
| TV Show | 2016 | Rhett & Link's Buddy System | Rhonda | 1 |
| TV Show | 2013 | Hannibal | Kidnapper | 1 |
| TV Show | 2021 | Only Murders in the Building | Bev Melon | 7 |
| TV Show | 1989 | The Simpsons | Katya (voice) | 1 |
| TV Show | 2014 | Variety Studio: Actors on Actors | Self | 1 |
| TV Show | 2019 | Today with Jenna & Sheinelle | Self - Guest | 1 |
| TV Show | 2025 | Everybody's Live with John Mulaney | Self - Actress and Comedian | 1 |
| TV Show | 2013 | The Millers | Miss Pam | 1 |
| TV Show | 2013 | Super Fun Night | Jane Spencer | 1 |
| TV Show | 1994 | Sister, Sister | Checker | 1 |
| TV Show | N/A | The Hawk | Stacy | 1 |
| TV Show | 2004 | Dog Whisperer | Peggy in "Year of the Dog" (archive footage) | 1 |
| TV Show | 2014 | Late Night with Seth Meyers | Self - Guest | 1 |
| TV Show | 2025 | SNL50: Beyond Saturday Night | Self | 1 |
| TV Show | 2004 | Cracking Up | Lesley Shackleton | 12 |
| TV Show | 2001 | Scrubs | Denise Lemmon | 1 |
