| Movie | 1991 | Naked Lunch | Bill Lee | |
| Movie | 1985 | A Killing Affair | Baston Morris | |
| Movie | 1987 | RoboCop | Officer Alex J. Murphy / RoboCop | |
| Movie | 1990 | RoboCop 2 | RoboCop | |
| Movie | 1984 | The Adventures of Buckaroo Banzai Across the 8th Dimension | Buckaroo Banzai | |
| Movie | 1995 | Mighty Aphrodite | Jerry Bender | |
| Movie | 1995 | Decoy | Baxter | |
| Movie | 1995 | Screamers | Colonel Hendricksson | |
| Movie | 1999 | Diplomatic Siege | Steve Parker | |
| Movie | 2003 | The Order | Driscoll | |
| Movie | 2000 | Ivansxtc | Don West | |
| Movie | 1993 | Fifty/Fifty | Jake Wyer | |
| Movie | 1989 | Cat Chaser | George Moran | |
| Movie | 1994 | The New Age | Peter Witner | |
| Movie | 2007 | Prey | Tom Newman | |
| Movie | 1989 | Leviathan | Steven Beck | |
| Movie | 1983 | Of Unknown Origin | Bart Hughes | |
| Movie | 1979 | Butch and Sundance: The Early Days | Joe Le Fors | |
| Movie | 1997 | Top of the World | Ray Mercer | |
| Movie | 2010 | Once Fallen | Eddie | |
| Movie | 1988 | Shakedown | Roland Dalton | |
| Movie | 1983 | Kentucky Woman | Deke | |
| Movie | 2005 | Undiscovered | Wick Treadway | |
| Movie | 2000 | Contaminated Man | Joseph Müller | |
| Movie | 2010 | William S. Burroughs: A Man Within | Self - Narrator | |
| Movie | 1982 | Shoot the Moon | Frank Henderson | |
| Movie | 2013 | Star Trek Into Darkness | Admiral Alexander Marcus | |
| Movie | 1998 | Tower of the First Born | John Shannon | |
| Movie | 1984 | Firstborn | Sam | |
| Movie | 2023 | Exterminate All Rational Thought | Self | |
| Movie | 2012 | Dragon Eyes | Mr. V | |
| Movie | 2012 | Batman: The Dark Knight Returns, Part 1 | Batman / Bruce Wayne (voice) | |
| Movie | 2013 | Batman: The Dark Knight Returns, Part 2 | Batman / Bruce Wayne (voice) | |
| Movie | 1986 | Apology | Rad Hungate | |
| Movie | 2011 | Forced To Fight | Danny G. | |
| Movie | 1994 | The Substitute Wife | Martin Hightower | |
| Movie | 1980 | Just Tell Me What You Want | Steven Routledge | |
| Movie | 1988 | The Tunnel | Juan Pablo Castell | |
| Movie | 1997 | End of Summer | Theo Remmington | |
| Movie | 2001 | Styx | Nelson | |
| Movie | 1991 | Road to Ruin | Jack Sloan | |
| Movie | 1993 | Sunset Grill | Ryder Hart | |
| Movie | 1990 | Rainbow Drive | Mike Gallagher | |
| Movie | 1992 | Naked Making Lunch | Self | |
| Movie | 1990 | Celebrity Guide to Wine | Self | |
| Movie | 2010 | God of War: Unearthing the Legend | Host | |
| Movie | 1994 | Lakota Woman: Siege at Wounded Knee | Uncredited | |
| Movie | 1990 | Women and Men: Stories of Seduction | Hobie | |
| Movie | 2006 | Egypt: Engineering an Empire | Host | |
| Movie | 2014 | Skin Trade | Costello | |
| Movie | 2015 | The Tao of Buckaroo | | |
| Movie | 2017 | Yamasong: March of the Hollows | Brujt (voice) | |
| Movie | 2006 | The Hard Easy | Ed Koster | |
| Movie | 2007 | Dating Vietnam | Jack Newton | |
| Movie | 2000 | Shadow Hours | Stuart Chappell | |
| Movie | 1983 | Two Kinds of Love | Joe Farley | |
| Movie | 2017 | Corporate Wars: The Making of 'RoboCop 2' | Self (archive footage) | |
| Movie | 1995 | Beyond the Clouds | Husband | |
| Movie | 2002 | Buckaroo Banzai Declassified | Self | |
| Movie | 2013 | Batman: The Dark Knight Returns | Bruce Wayne / Batman (voice) | |
| Movie | 2000 | Dark Prince: The True Story of Dracula | Father Stefan | |
| Movie | 1987 | The Dancing Princesses | The Soldier | |
| Movie | 2005 | The Poseidon Adventure | Captain Paul Gallico | |
| Movie | 2014 | Repentance | Meyer | |
| Movie | 2001 | Flesh + Steel: The Making of 'RoboCop' | Himself | |
| Movie | 1993 | Partners | Doctor | |
| Movie | 2000 | Falling Through | Lou | |
| Movie | 1975 | The Silence | Red Sash | |
| Movie | 1973 | The Man Without a Country | Lt. Fellows | |
| Movie | 2025 | Bang | | |
| TV Show | 1977 | Lou Grant | | 1 |
| TV Show | 2001 | Star Trek: Enterprise | John Frederick Paxton | 2 |
| TV Show | 2002 | Monk | Actor Playing Stottlemeyer | 1 |
| TV Show | 2002 | Odyssey 5 | Chuck Taggart | 20 |
| TV Show | 2001 | 24 | Christopher Henderson | 11 |
| TV Show | 2005 | Engineering an Empire | Himself / Host | 14 |
| TV Show | 2003 | The Handler | | 1 |
| TV Show | 2012 | Longmire | | 1 |
| TV Show | 2023 | Rabbit Hole | Distinguished Man (voice) | 1 |
| TV Show | 2006 | Dexter | | 8 |
| TV Show | 2023 | Rabbit Hole | Distinguished Man | 3 |
| TV Show | 2018 | Forever | The Traveler | 2 |
| TV Show | 2006 | Psych | Yin / Karl Rotmensen | 1 |
| TV Show | 2010 | Hawaii Five-0 | Hookman, Curt Stoner | 1 |
| TV Show | 2011 | Franklin & Bash | Bert Mazzani | 1 |
| TV Show | 2019 | The Movies That Made Us | Self (Archival Footage) | 1 |
| TV Show | 2023 | RoboDoc: The Creation of RoboCop | Self | 4 |
| TV Show | 2008 | Fringe | Alistair Peck | 1 |
| TV Show | 1982 | Faerie Tale Theatre | The Soldier | 1 |
| TV Show | 1978 | Mourning Becomes Electra | Peter | 5 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 2008 | Sons of Anarchy | Charles 'Charlie' Barosky | 11 |
| TV Show | 2004 | House | Dr. Penza | 1 |
| TV Show | 2016 | MacGyver | Elliot Mason | 3 |
| TV Show | 2022 | Guillermo del Toro's Cabinet of Curiosities | Lionel Lassiter | 1 |
| TV Show | 2023 | Marvel's Moon Girl and Devil Dinosaur | Dr. Stern (voice) | 2 |
| TV Show | 2014 | The Real History of Science Fiction | Himself | 1 |
| TV Show | 2012 | Longmire | Lucian Connally | 6 |
| TV Show | 2012 | Honest Trailers | Alexander Marcus (archive footage) | 1 |
| TV Show | 2014 | The Last Ship | Dr. Paul Vellek | 7 |
