| Movie | 2005 | The Life Coach | Milos | |
| Movie | 2015 | Undivided: The Preston and Steve Experience | Self - Comedian | |
| Movie | 2003 | House of 1000 Corpses | Jerry Goldsmith | |
| Movie | 2009 | Halloween II | David Newman | |
| Movie | 2012 | The Destinations of Doctor Who | | |
| Movie | 2010 | LEGO: The Adventures of Clutch Powers | Bones (voice) | |
| Movie | 2010 | I Am Comic | Self | |
| Movie | 1997 | Courting Courtney | Tim | |
| Movie | 2002 | Media Whore | Himself | |
| Movie | 2012 | Chris Hardwick: Mandroid | Himself | |
| Movie | 2011 | Extremely Loud & Incredibly Close | Estate Sale Organizer | |
| Movie | 2023 | Attack of the Doc! | Self | |
| Movie | 1998 | Art House | Weston Craig | |
| Movie | 2022 | Spider-Man: All Roads Lead to No Way Home | Self (archive footage) | |
| Movie | 2014 | Video Games: The Movie | Self | |
| Movie | 2015 | Misery Loves Comedy | Self | |
| Movie | 2022 | Halloween in Hollywood | Self - Host | |
| Movie | 2013 | The Walking Dead: A Decade of Dead | Self | |
| Movie | 2014 | Harmontown | Self | |
| Movie | 2014 | Marvel Studios: Assembling a Universe | Self | |
| Movie | 2020 | A Very Special G4 Holiday Reunion Special | Self | |
| Movie | 2009 | The Mother of Invention | Drake Wooderson | |
| Movie | 1996 | Beach House | Ross | |
| Movie | 2016 | Chris Hardwick: Funcomfortable | Himself | |
| Movie | 2014 | Comedy Central's All-Star Non-Denominational Christmas Special | Self | |
| Movie | 2016 | Ear Buds: The Podcasting Documentary | Self | |
| Movie | 2017 | The Lego Batman Movie | Reporter #3 (voice) | |
| Movie | 2017 | Comedy Central's Colossal Clusterfest | Host | |
| Movie | 2010 | LEGO® Clutch Powers: Bad Hair Day | Bones (Voice) | |
| Movie | 2017 | The Lego Ninjago Movie | Radio DJ (voice) | |
| Movie | 2017 | The Robot Chicken Walking Dead Special: Look Who's Walking | Chris Hardwick (voice) | |
| Movie | 2018 | Making Fun: The Story of Funko | Self | |
| Movie | 2018 | Seth Rogen's Hilarity for Charity | Self | |
| Movie | 2012 | Grimm Fairy Tales Animated | Hansel/Hank | |
| Movie | 2003 | Terminator 3: Rise of the Machines | 2nd Engineer | |
| Movie | 2002 | Jane White Is Sick & Twisted | Burger | |
| Movie | 2013 | The Fire Rises: The Creation and Impact of The Dark Knight Trilogy | Self | |
| Movie | 2004 | Johnson Family Vacation | Arson Investigator | |
| Movie | 2012 | All Star Bowling Trick Shots | | |
| Movie | 2016 | Ellie Kemper: Unbreakable Comedy Gala | | |
| TV Show | 1987 | thirtysomething | | 1 |
| TV Show | 2004 | The Batman | Green Arrow (voice) | 3 |
| TV Show | 1993 | Boy Meets World | Chris Hardwick | 1 |
| TV Show | 2005 | Attack of the Show! | Self | 2 |
| TV Show | 2000 | CSI: Crime Scene Investigation | Mikey Shoemaker | 1 |
| TV Show | 2010 | Scooby-Doo! Mystery Incorporated | Evallo Von Meanskrieg (voice) | 1 |
| TV Show | 2017 | Talking with Chris Hardwick | Self - Host | 23 |
| TV Show | 2005 | The X's | | 1 |
| TV Show | 2005 | The X's | Glowface (voice) | 20 |
| TV Show | 2001 | The Zeta Project | Ro's Brother (voice) | 1 |
| TV Show | 1995 | MADtv | Self | 1 |
| TV Show | 1998 | Guys Like Us | | 13 |
| TV Show | 2005 | Zoey 101 | Garth Berman | 1 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 2 |
| TV Show | 2007 | WIRED Science | | 11 |
| TV Show | 2009 | Web Soup | | 51 |
| TV Show | 2010 | Scooby-Doo! Mystery Incorporated | Maxwell (voice) | 1 |
| TV Show | 2010 | The Benson Interruption | | 1 |
| TV Show | 2013 | Talking Bad | Self - Host | 8 |
| TV Show | 2013 | @midnight with Chris Hardwick | Self - Host | 600 |
| TV Show | N/A | The Nerdist | Self | 18 |
| TV Show | 2011 | Talking Dead | Self - Host | 230 |
| TV Show | 2013 | Sanjay and Craig | Craig (voice) | 114 |
| TV Show | 2018 | Eli Roth's History of Horror | Self | 4 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 2 |
| TV Show | 2013 | Whose Line Is It Anyway? | Self | 1 |
| TV Show | 2016 | Join or Die with Craig Ferguson | Self | 1 |
| TV Show | 2016 | Talking Saul | Self - Host | 6 |
| TV Show | 2010 | The Green Room with Paul Provenza | Self | 1 |
| TV Show | 2012 | Mash Up | | 1 |
| TV Show | 2009 | The Streamy Awards | Self - Host | 1 |
| TV Show | 2004 | The Soup | | 1 |
| TV Show | 1987 | Married... with Children | Dan Inwood | 2 |
| TV Show | 2016 | Chelsea | Self | 1 |
| TV Show | 2016 | The Wall | Self - Host | 89 |
| TV Show | 2016 | Force Grey: Giant Hunters | Whil Wee-Tawn | 7 |
| TV Show | 2023 | Krapopolis | (voice) | 1 |
| TV Show | 2007 | Back at the Barnyard | Otis | 97 |
| TV Show | 2022 | The Jennifer Hudson Show | | 2 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 3 |
| TV Show | 2022 | Barmageddon | Self - Contestant | 1 |
| TV Show | 2012 | TableTop | Self - Guest | 2 |
| TV Show | 2017 | Danger & Eggs | Pete Peril (voice) | 1 |
| TV Show | 2024 | Up For Auction | Himself | 8 |
| TV Show | 2013 | Turbo FAST | Turblows47 (voice) | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2015 | Jay Leno's Garage | Self | 1 |
| TV Show | 2015 | Critical Role | Gern Blanston | 1 |
| TV Show | 1999 | Family Guy | Johnny Lawrence (voice) | 1 |
| TV Show | 2003 | Real Time with Bill Maher | Self | 1 |
| TV Show | 2009 | Late Night with Jimmy Fallon | Self | 1 |
| TV Show | 2014 | Garfunkel and Oates | Himself | 1 |
| TV Show | 2014 | The Wil Wheaton Project | Self | 1 |
| TV Show | 2010 | Conan | Self | 2 |
| TV Show | 2011 | My Drunk Kitchen | Self | 1 |
| TV Show | 2012 | The Legend of Korra | Sokka (voice) | 1 |
