| Movie | 2010 | Shrek Forever After | Patrol Witch / Wagon Witch #2 (voice) | |
| Movie | 2008 | Prop 8: The Musical | Scary Catholic School Girls From Hell | |
| Movie | 2009 | It's Complicated | Agness Adler | |
| Movie | 2008 | What Happens in Vegas | Tipper | |
| Movie | 2008 | Pride and Glory | Megan Egan | |
| Movie | 2008 | Over Her Dead Body | Ashley | |
| Movie | 2011 | No Strings Attached | Lucy | |
| Movie | 2010 | Burning Palms | Maryjane | |
| Movie | 2011 | A Good Old Fashioned Orgy | Alison Lobel | |
| Movie | 2008 | Under Still Waters | Charlie | |
| Movie | 2012 | Black Rock | Lou | |
| Movie | 2011 | Little Murder | Corey Little | |
| Movie | 2002 | Speakeasy | Sara Marnikov | |
| Movie | 2004 | Slammed | Gina Micelli | |
| Movie | 2024 | Mother, Couch | Anne | |
| Movie | 2013 | In a World... | Carol Solomon | |
| Movie | 2014 | Million Dollar Arm | Brenda Paauwe | |
| Movie | 2014 | Mr. Peabody & Sherman | Mona Lisa (voice) | |
| Movie | 2006 | Rampage: The Hillside Strangler Murders | Jillian | |
| Movie | 2015 | No Escape | Annie Dwyer | |
| Movie | 2022 | Black Panther: Wakanda Forever | Dr. Graham | |
| Movie | 2015 | Man Up | Nancy Patterson | |
| Movie | 2022 | The Conspiracy | | |
| Movie | 2016 | The Secret Life of Pets | Chloe (voice) | |
| Movie | 2017 | Shot Caller | Kate Harlon | |
| Movie | 2003 | War Stories | Nora Stone | |
| Movie | 2017 | I Do... Until I Don't | Alice Brewing | |
| Movie | 2016 | The 4%: Film's Gender Problem | Self | |
| Movie | 2025 | Under the Lights | | |
| Movie | 2017 | Home Again | Zoey Bell | |
| Movie | 2018 | Time of Day | Self | |
| Movie | 2018 | Spider-Man: Into the Spider-Verse | Vanessa Fisk (voice) | |
| Movie | 2019 | The Secret Life of Pets 2 | Chloe (voice) | |
| Movie | 2018 | Be Natural: The Untold Story of Alice Guy-Blaché | Self | |
| Movie | 2009 | Source of Pride: The Making of "Pride and Glory" | Self | |
| Movie | 2003 | I Love Your Work | Felicia | |
| Movie | 2021 | Cryptozoo | Lauren Grey (voice) | |
| Movie | 2022 | Summering | Laura | |
| Movie | 2011 | Home for Actresses | Lake | |
| Movie | 2011 | Nick Kroll: Thank You Very Cool | Gun Girl | |
| TV Show | 2011 | New Girl | Amanda | 1 |
| TV Show | 2003 | Miss Match | Victoria Carlson | 18 |
| TV Show | 2020 | Medical Police | Cat Black | 4 |
| TV Show | 2005 | Surface | Laura Daughtery | 15 |
| TV Show | 1997 | The Practice | Sally Heep | 4 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 1 |
| TV Show | 2019 | A Little Late with Lilly Singh | Self | 1 |
| TV Show | 2003 | E!'s 101 | Self | 1 |
| TV Show | 2010 | How to Make It in America | Rachel Chapman | 16 |
| TV Show | 2008 | Childrens Hospital | Cat Black | 91 |
| TV Show | 2021 | What If...? | Natasha Romanoff / Black Widow (voice) | 5 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 2015 | Wet Hot American Summer: First Day of Camp | Donna Berman | 8 |
| TV Show | 2004 | Boston Legal | Sally Heep | 13 |
| TV Show | 1994 | ER | Jody Holmes | 2 |
| TV Show | 2017 | Wet Hot American Summer: Ten Years Later | Donna | 8 |
| TV Show | 2021 | What If...? | Natasha Romanoff (voice) | 1 |
| TV Show | 2019 | Harley Quinn | Poison Ivy (voice) | 57 |
| TV Show | 2009 | The League | Brooke | 1 |
| TV Show | 2019 | Bless This Mess | Rio Levine-Young | 26 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2022 | Stay Tooned | Self - Guest | 1 |
| TV Show | 2014 | BoJack Horseman | Katrina Peanutbutter / Cargo Ship Captain / Chloe (voice) | 1 |
| TV Show | 2014 | BoJack Horseman | Katrina Peanutbutter (voice) | 8 |
| TV Show | 2012 | TRON: Uprising | Lux | 1 |
| TV Show | 2014 | Off Camera with Sam Jones | Self | 1 |
| TV Show | 2024 | Kite Man: Hell Yeah! | Poison Ivy / The Cheetah (voice) | 1 |
| TV Show | 2024 | After Midnight | Self | 1 |
| TV Show | 2025 | The Chair Company | Barb Trosper | 8 |
| TV Show | 2007 | Phineas and Ferb | Katherine Marshall (voice) | 1 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 1 |