| Movie | 1995 | Canadian Bacon | Deputy Honey | |
| Movie | 2006 | 10 Items or Less | Mrs. D | |
| Movie | 2000 | How to Marry a Billionaire: A Christmas Tale | Jacqueline Kennedy | |
| Movie | 1996 | Matilda | Zinnia Wormwood | |
| Movie | 1992 | Class Act | Miss Simpson | |
| Movie | 1996 | Carpool | Martha | |
| Movie | 1988 | A Family Again | Aunt Dee | |
| Movie | 2008 | Beethoven's Big Break | Patricia | |
| Movie | 1996 | Sunset Park | Phyllis Saroka | |
| Movie | 1993 | A Place to Be Loved | Jerry Blair | |
| Movie | 2000 | Painful Secrets | Dr. Parella | |
| Movie | 1993 | We're Back! A Dinosaur's Story | Mother Bird (voice) | |
| Movie | 1992 | To Grandmother's House We Go | Shirley | |
| Movie | 1982 | Love Child | June Burns | |
| Movie | 2023 | You People | Bubby | |
| Movie | 2008 | The Christmas Choir | Sister Agatha | |
| Movie | 1991 | Ted & Venus | Grace | |
| Movie | 2007 | Love Comes Lately | Reisel | |
| Movie | 2011 | The Trouble With Bliss | Maria (uncredited) | |
| Movie | 2023 | Barbie | Ruth | |
| Movie | 1972 | Hot Dogs for Gauguin | Woman on Ferry | |
| Movie | 1984 | The Ratings Game | Francine Kester | |
| Movie | 1991 | The Last Halloween | Mrs. Gizborne | |
| Movie | 2011 | Oliver's Ghost | Eloise | |
| Movie | 2005 | My Movie About Making 'Matilda' by Mara Wilson | Self | |
| Movie | 2005 | Matilda's Movie Magic: The Making of 'Matilda' | Herself | |
| Movie | 1986 | My Little Pony: The Movie | Reeka (voice) | |
| Movie | 2022 | 13: The Musical | Grandma Ruth | |
| Movie | 2002 | NBC 75th Anniversary Special | Self | |
| Movie | 1987 | Stamp of a Killer | Claudia | |
| Movie | 1992 | There Goes the Neighborhood | Lydia Nunn | |
| Movie | 1998 | In the Doghouse | Phil Markowitz | |
| Movie | 2015 | I'll See You in My Dreams | Sally | |
| Movie | 1998 | Houdini | Esther | |
| Movie | 1989 | Two Daddies? | Rose Johnson (voice) | |
| Movie | 1979 | Swap Meet | Mother | |
| Movie | 1977 | Mary Jane Harper Cried Last Night | Judy | |
| Movie | 2016 | Must See TV: An All Star Tribute to James Burrows | Self | |
| Movie | 1990 | Amazing Stories: The Movie II | Lois (archive footage) | |
| Movie | 1990 | The Earth Day Special | Paula | |
| Movie | 1976 | I Want to Keep My Baby! | Rae Finer | |
| Movie | 1979 | Like Normal People | Jan | |
| Movie | 1988 | Mickey's 60th Birthday | Carla Tortelli | |
| Movie | 2017 | Lemon | Esther | |
| Movie | 1987 | Funny, You Don't Look 200: A Constitutional Vaudeville | Maisy - Constitutional Caterer | |
| Movie | 2009 | The Nightman Cometh: Live | Gladys | |
| Movie | 2016 | Sing | Judith (voice) | |
| Movie | 1999 | H.E. Double Hockey Sticks | Ms. Beelzebub | |
| Movie | 2012 | The Sessions | Mikvah Lady | |
| Movie | 1976 | The Selling of Vince D'Angelo | Vince's Wife | |
| Movie | 1982 | Drop-Out Father | Tawney Shapiro | |
| Movie | 1975 | Minestrone | Tessy | |
| Movie | 2000 | A Tale of Two Bunnies | Thelma | |
| Movie | 2019 | Poms | Alice | |
| Movie | 2019 | Saving Flora | Gabriella | |
| Movie | 1990 | Enid Is Sleeping | Mavis | |
| Movie | 1988 | Sesame Street | Put Down the Duckie: An All-Star Musical Special | Self | |
| Movie | 1994 | Spoils of War | Emma | |
| Movie | 2021 | Funny Face | Fernie | |
| Movie | 1977 | Intimate Strangers | Barbara | |
| Movie | 1994 | The World of Jim Henson | Self (archive footage) | |
| Movie | 1990 | Disneyland's 35th Anniversary Special | Self | |
| Movie | 1985 | Happily Ever After | Rose Johnson (voice) | |
| Movie | 2020 | Mr. Bungle: The Night They Came Home | Spooky Narration | |
| Movie | 2018 | The Matchmaker | Irene | |
| Movie | 2022 | Marvelous and the Black Hole | Margot | |
| Movie | 1998 | Monty Python: Live at Aspen | Audience Member (uncredited) | |
| Movie | 1976 | Stalk the Wild Child | Jean | |
| Movie | 1994 | Sesame Street | All-Star 25th Birthday: Stars and Street Forever! | Worm TV Host | |
| Movie | 1982 | National Lampoon's Movie Madness | Little Jewish Prostitute ("Municipalians") | |
| Movie | 1990 | Sesame Street: Sing Yourself Silly! | | |
| TV Show | 1982 | St. Elsewhere | | 1 |
| TV Show | 1982 | Cheers | Carla Tortelli | 269 |
| TV Show | 1992 | Mad About You | Mrs. Ramona DiChristophoro | 1 |
| TV Show | 1989 | The Simpsons | Carla Tortelli (voice) | 1 |
| TV Show | 2003 | The Ellen DeGeneres Show | Self | 1 |
| TV Show | 1986 | My Little Pony | | 65 |
| TV Show | 1997 | Ally McBeal | Dr. Helen Tooth | 1 |
| TV Show | 2006 | Crumbs | Camille Spadaro | 1 |
| TV Show | 1994 | The Critic | Ardeth (voice) | 2 |
| TV Show | 1986 | Matlock | | 1 |
| TV Show | 1997 | The View | Self | 1 |
| TV Show | 2005 | Fat Actress | Rhea Perlman | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Roxana Fox | 1 |
| TV Show | 1993 | Frasier | Carla Tortelli | 1 |
| TV Show | 1998 | Becker | Dr. Katherine Simmons | 1 |
| TV Show | 1990 | Blossom | | 1 |
| TV Show | 2004 | Kevin Hill | Eleanor Frank | 1 |
| TV Show | 1991 | Roc | | 1 |
| TV Show | 1995 | Almost Perfect | | 1 |
| TV Show | 1996 | Pearl | Pearl Caraldo | 22 |
| TV Show | 2021 | Star Wars: The Bad Batch | Cid (voice) | 11 |
| TV Show | 2011 | Wilfred | Mittens | 1 |
| TV Show | 2001 | Kate Brasher | Abbie Schaeffer | 7 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 1997 | Union Square | Eileen Mulrooney | 1 |
| TV Show | 2023 | Not Dead Yet | Janice | 1 |
| TV Show | 1985 | Amazing Stories | Lois | 1 |
| TV Show | 2005 | It's Always Sunny in Philadelphia | Bertha Fussy | 1 |
| TV Show | 1978 | Taxi | Zena Sherman | 5 |
| TV Show | 2012 | The Mindy Project | Annette Castellano | 17 |
| TV Show | 2013 | Mom | Anya | 1 |
| TV Show | 2012 | Robot and Monster | Nessie (voice) | 50 |
| TV Show | 2013 | Brooklyn Nine-Nine | Estelle | 1 |
| TV Show | 2017 | Me and My Grandma | Grandma | 6 |
| TV Show | 2009 | Hung | | 2 |
| TV Show | 2023 | Curses! | Margie (voice) | 10 |
| TV Show | 1996 | The Rosie O'Donnell Show | Self - Guest | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 1992 | Shelley Duvall's Bedtime Stories | Narrator (Voice) | 1 |
| TV Show | 2019 | Harley Quinn | Golda (voice) | 1 |
| TV Show | 2025 | Too Much | Dottie | 10 |
| TV Show | 2002 | What's New, Scooby-Doo? | Agnes (voice) | 1 |
| TV Show | 2013 | Kirstie | Thelma Katz | 12 |
| TV Show | 2014 | Tim and Eric's Bedtime Stories | Maureen | 1 |
| TV Show | 2016 | Shooter | Supreme Court Justice Gibson | 2 |
| TV Show | 2013 | The Goldbergs | Margot Letien | 1 |
| TV Show | 2010 | Hot in Cleveland | Jacki | 1 |
| TV Show | 2005 | American Dad! | Old Stripper (voice) | 1 |
| TV Show | 2023 | Poker Face | Beatrix Hasp (voice) | 1 |
| TV Show | 2006 | The Megan Mullally Show | Self - Guest | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Audience Member | 2 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee | 2 |
| TV Show | 1944 | Golden Globe Awards | Self | 1 |
| TV Show | 2025 | Mid-Century Modern | Judy | 1 |
| TV Show | 2025 | The Studio | Matt's Mom (voice) | 1 |
| TV Show | 2025 | The Studio | Matt's Mom | 1 |
| TV Show | 2023 | Poker Face | Beatrix Hasp | 4 |
| TV Show | 2013 | Getting On | Crystal Buff | 1 |
