| Movie | 2010 | Team Coco Presents the Conan Writers Live | | |
| Movie | 2009 | The Yes Men Fix the World | Himself | |
| Movie | 2025 | Sour Party | Reggie | |
| Movie | 2010 | Reggie Watts: Why Shit So Crazy? | Himself | |
| Movie | N/A | Legend - With Reggie Watts | All Voices | |
| Movie | 2012 | Reggie Watts: A Live At Central Park | Himself | |
| Movie | 2022 | The Kids in the Hall: Comedy Punks | Self | |
| Movie | 2013 | Radiolab Live: Apocalyptical | Self | |
| Movie | 2016 | The Late Late Show Carpool Karaoke Primetime Special | Self - Musical Director | |
| Movie | 2014 | Fort Tilden | Reggie Watts | |
| Movie | 2022 | Chop & Steele | Self | |
| Movie | 2012 | The Secret Policeman's Ball | Self | |
| Movie | 2011 | Tell Your Friends! The Concert Film! | Self | |
| Movie | 2014 | The Film That Buys the Cinema | | |
| Movie | 2022 | The Sound of 007 | Self | |
| Movie | 2016 | Creative Control | Reggie Watts | |
| Movie | 2015 | Brasilia: City of the Future | | |
| Movie | 2009 | The Buyer of the Harp | The Owner | |
| Movie | 2014 | Thanksgiving | Timothy | |
| Movie | 2015 | Keep in Touch | Dr. Harry Clark | |
| Movie | 2015 | Welcome to Bridgetown | Self | |
| Movie | 2015 | Pitch Perfect 2 | Tone Hangers | |
| Movie | 2024 | Never Mind | Self | |
| Movie | 2016 | My Entire High School Sinking Into the Sea | Assaf/Male Newscaster (voice) | |
| Movie | 2007 | Dresden Dolls: Live at the Roundhouse London | | |
| Movie | 2016 | Dad Friends | Robbie | |
| Movie | 2016 | Reggie Watts: Spatial | Self | |
| Movie | 2017 | Snowy Bing Bongs Across the North Star Combat Zone | Ron | |
| Movie | 2018 | Duck Duck Goose | Carl (voice) | |
| Movie | 2019 | It Started As a Joke | Self | |
| Movie | 2012 | Shut Up and Play the Hits | Self | |
| Movie | 2013 | Transition | | |
| Movie | 2021 | Extinct | Hoss / Ernest Shackleton (voice) | |
| Movie | 2020 | Nine Minutes | | |
| Movie | 2019 | Runnin' | | |
| Movie | 2020 | Have a Good Trip: Adventures in Psychedelics | Self | |
| Movie | 2020 | Kaufmania! | Self | |
| Movie | 2011 | Conan O'Brien Can't Stop | Self | |
| Movie | 2020 | The SpongeBob Movie: Sponge on the Run | Chancellor (voice) | |
| Movie | 2021 | Monty Python's Best Bits Celebrated | Self | |
| Movie | 2011 | LCD Soundsystem: The Long Goodbye | Self | |
| Movie | 2016 | Ellie Kemper: Unbreakable Comedy Gala | | |
| Movie | 2025 | G*ve a F*ck LA: A Benefit for LA Fire Relief | | |
| Movie | 2025 | Conan O'Brien: The Kennedy Center Mark Twain Prize for American Humor | Self | |
| TV Show | 2019 | A Little Late with Lilly Singh | Self | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Bandleader | 1198 |
| TV Show | 2012 | Comedy Bang! Bang! | Self - Co-Host | 90 |
| TV Show | 2016 | The Earliest Show | Self | 1 |
| TV Show | 2019 | Tuca & Bertie | Pastry Pete | 30 |
| TV Show | 2012 | Mash Up | | 1 |
| TV Show | 2016 | Ask the Storybots | | 1 |
| TV Show | 2015 | The Mr. Peabody & Sherman Show | REJGIE (voice) | 1 |
| TV Show | 2004 | The Soup | | 1 |
| TV Show | 2016 | Wonderland | Himself | 1 |
| TV Show | 2017 | The High Court | Guest Bailiff | 1 |
| TV Show | 2003 | America's Next Top Model | Guest | 1 |
| TV Show | 2020 | The Drew Barrymore Show | | 1 |
| TV Show | 2018 | Taskmaster | Self - Taskmaster | 8 |
| TV Show | 2022 | The Jennifer Hudson Show | | 1 |
| TV Show | 2024 | After Midnight | Self | 4 |
| TV Show | 2018 | James Cameron's Story of Science Fiction | Self | 1 |
| TV Show | 2022 | Celebrity Jeopardy! | Self | 1 |
| TV Show | 2018 | Nailed It! | Self - Judge | 1 |
| TV Show | 2021 | The Great North | Quay (voice) | 5 |
| TV Show | 2016 | HarmonQuest | Graelgdogh / Quinzelplip / Goblock | 1 |
| TV Show | 2023 | History of the World: Part II | German Wallbreaker | 1 |
| TV Show | 2017 | One Day at a Time | Mr. Mann | 1 |
| TV Show | 2013 | @midnight with Chris Hardwick | Self | 1 |
| TV Show | 2010 | Conan | Self | 6 |
| TV Show | 2020 | Who Wants to Be a Millionaire | Self - Contestant | 1 |
| TV Show | 2009 | Michael & Michael Have Issues | | 1 |
| TV Show | 2012 | Comedy Bang! Bang! | Self | 1 |
| TV Show | 2025 | Hollywood Squares | Self | 1 |
| TV Show | 2022 | The Horne Section TV Show | Reggie Watts | 6 |
| TV Show | 2004 | The Venture Bros. | Delivery Guy (voice) | 1 |
| TV Show | 1996 | The Daily Show | Self | 1 |
