| Movie | 2009 | I Hate Valentine's Day | Tammy's Date | |
| Movie | 2023 | Renfield | Tedward Lobo | |
| Movie | 2007 | New York City Serenade | Russ | |
| Movie | 2007 | Ysketball | | |
| Movie | 2010 | Peep World | Nathan | |
| Movie | 2024 | Sonic the Hedgehog 3 | Sonic (voice) | |
| Movie | 2013 | Turbo | Skid Mark (voice) | |
| Movie | 2013 | House of Lies Live | Self | |
| Movie | 2013 | Seth Rogen Is the Worst Person in the World | Ben Schwartz | |
| Movie | 2014 | Better Living Through Chemistry | Noah | |
| Movie | 2013 | Coffee Town | Gino | |
| Movie | 2023 | We Lost Our Human | Pud / Future Pud / Cow Pud / Kitten Pud / Puddling (voice) | |
| Movie | 2022 | Sonic Drone Home | Sonic the Hedgehog (voice) | |
| Movie | 2021 | Music | Rudy | |
| Movie | 2009 | Mystery Team | Dougie's Buddy | |
| Movie | 2022 | DC League of Super-Pets | Mark / Fire Guinea Pig (voice) | |
| Movie | 2015 | The Walk | Albert | |
| Movie | 2014 | This Is Where I Leave You | Rabbi Charles Grodner | |
| Movie | 2014 | The Interview | Publicist | |
| Movie | 2014 | I'm a Mitzvah | David | |
| Movie | 2016 | The Intervention | Jack | |
| Movie | 2013 | Runner Runner | Craig | |
| Movie | 2018 | An Actor Prepares | Jimmy | |
| Movie | 2010 | The Other Guys | Beaman's Assistant | |
| Movie | 2018 | Happy Anniversary | Sam | |
| Movie | 2018 | Blue Iguana | Paul Driggs | |
| Movie | 2018 | Outside In | Ted | |
| Movie | 2017 | How to Be a Latin Lover | Jimmy / Valet | |
| Movie | 2017 | DreamWorks Home: For the Holidays | Ben Schwartz (voice) | |
| Movie | 2015 | Star Wars: The Force Awakens | Stormtrooper (uncredited) | |
| Movie | 2018 | Night School | Marvin | |
| Movie | 2018 | DuckTales: Destination Adventure! | Dewey Duck (voice) | |
| Movie | 2018 | Monster Challenge | Self | |
| Movie | 2018 | A Legendary Christmas with John & Chrissy | Self | |
| Movie | 2019 | The Lego Movie 2: The Second Part | Banarnar (voice) | |
| Movie | 2020 | Standing Up, Falling Down | Scott | |
| Movie | 2021 | Flora & Ulysses | George | |
| Movie | 2021 | Rumble | Jimothy Brett-Chadley III (voice) | |
| Movie | 2016 | The Earliest Show: Outtakes & Bloopers | Josh Bath | |
| Movie | 2022 | Sonic the Hedgehog 2 | Sonic (voice) | |
| Movie | 2007 | Teddy Saw | Jason | |
| Movie | 2008 | Job Interview | Interviewee | |
| Movie | 2008 | Valentine's Break Up | | |
| Movie | 2006 | Cheating | Ben | |
| Movie | 2011 | Stay Awake Contest | | |
| Movie | 2010 | Perfect Audition | | |
| Movie | 2020 | A Parks and Recreation Special | Jean-Ralphio Sapperstein | |
| Movie | 2019 | Runnin' | | |
| Movie | 2020 | Sonic the Hedgehog | Sonic (voice) | |
| Movie | 2009 | Everybody's Fine | Writer | |
| Movie | 2020 | Sonic the Hedgehog - Around the World in 80 Seconds | Sonic (voice) | |
| Movie | 2022 | Rise of the Teenage Mutant Ninja Turtles: The Movie | Leo / Janitor Man (voice) | |
| Movie | 2020 | The Candlenights 2020 Special | Self | |
| Movie | 2020 | Best of Stand-up 2020 | Self | |
| Movie | 2026 | Mike & Nick & Nick & Alice | Symon | |
| Movie | N/A | DNA | | |
| Movie | 2027 | Sonic the Hedgehog 4 | Sonic (voice) | |
| Movie | N/A | Weezer: Security Threat | | |
| Movie | N/A | Bad Day | | |
| Movie | 2025 | Wicked: One Wonderful Night | Self | |
| Movie | 2014 | Transformers: Age of Extinction | Bumblebee (voice) (uncredited) | |
| Movie | N/A | Die Hart 2: Die Harter | Andre | |
| TV Show | 2020 | Staged | Tom | 3 |
| TV Show | 2022 | The Afterparty | Yasper | 9 |
| TV Show | 2019 | Human Discoveries | Leader Elk (voice) | 1 |
| TV Show | 2021 | Calls | Andy (voice) | 1 |
| TV Show | 2016 | The Earliest Show | Josh Bath | 6 |
| TV Show | 2012 | Good Mythical Morning | Self | 1 |
| TV Show | 2021 | Marvel's M.O.D.O.K. | Louis 'Lou' Tarleton (voice) | 10 |
| TV Show | 2019 | Bless the Harts | Bryce Aldredge (voice) | 1 |
| TV Show | 2008 | Mayne Street | Evan Mintz | 5 |
| TV Show | 2005 | American Dad! | Fire Marshall (voice) | 1 |
| TV Show | 2018 | Medal of Honor | Vito Bertoldo | 1 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self - Guest | 2 |
| TV Show | 2009 | Parks and Recreation | Jean-Ralphio Saperstein | 18 |
| TV Show | 2010 | Undercovers | Bill Hoyt | 11 |
| TV Show | 2012 | House of Lies | Clyde Oberholt | 58 |
| TV Show | 2014 | HitRECord on TV with Joseph Gordon-Levitt | | 1 |
| TV Show | 2021 | Rugrats | Lord Crater (voice) | 1 |
| TV Show | 2012 | Comedy Bang! Bang! | Rodney Wayber | 2 |
| TV Show | 2023 | The Muppets Mayhem | Gus D’Vore | 1 |
| TV Show | 2007 | Starveillance | Glenn - Host | 3 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 2 |
| TV Show | 2017 | The New V.I.P.'s | Lenny | 1 |
| TV Show | 2003 | Arrested Development | John Beard Jr. | 1 |
| TV Show | 2015 | The Late Late Show with James Corden | Self - Guest | 2 |
| TV Show | 2022 | The Boys Presents: Diabolical | Kingdom’s Dad (voice) | 1 |
| TV Show | 2022 | The Boys Presents: Diabolical | Simon (voice) | 1 |
| TV Show | 2011 | Bob's Burgers | Josh (voice) | 3 |
| TV Show | 2017 | DuckTales | Dewey Duck (Voice) | 69 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 2 |
| TV Show | 2011 | Bob's Burgers | Rick (voice) | 1 |
| TV Show | 2021 | INVINCIBLE | Shapesmith / Rus / Punk Thug (voice) | 1 |
| TV Show | 2021 | INVINCIBLE | Shapesmith (voice) | 5 |
| TV Show | 2014 | The Game Awards | Self | 1 |
| TV Show | 2022 | Lightning Wolves | | 8 |
| TV Show | 2018 | Rise of the Teenage Mutant Ninja Turtles | Leonardo (voice) | 70 |
| TV Show | 2016 | Match Game | Self - Panelist | 1 |
| TV Show | 2024 | Superhot: The Spicy World of Pepper People | Self - Narrator (voice) | 10 |
| TV Show | 2014 | Late Night with Seth Meyers | Self | 1 |
| TV Show | 2009 | Modern Family | Nick | 3 |
| TV Show | 2016 | A Little of Your Time with Quinn Marcus | Himself | 1 |
| TV Show | 2012 | Randy Cunningham: 9th Grade Ninja | Randy Cunningham / The Ninja (voice) | 100 |
| TV Show | 2008 | Hardly Working | | 1 |
| TV Show | N/A | Happiness Isn't Everything | Jacky Hamburger | 1 |
| TV Show | 2016 | Bajillion Dollar Propertie$ | Quistian Gayle | 2 |
| TV Show | 2021 | INVINCIBLE | Shapesmith / Rus / Tech Trooper #2 (voice) | 1 |
| TV Show | 2021 | INVINCIBLE | Shapesmith / Rus / Corey (voice) | 1 |
| TV Show | 2008 | All-Nighters | Branch Windwood | 1 |
| TV Show | 2008 | All-Nighters | Ben | 1 |
| TV Show | 2020 | Staged | Ben | 1 |
| TV Show | 2022 | Stay Tooned | Self - Guest | 1 |
| TV Show | 2020 | Space Force | F. Tony Scarapiducci | 17 |
| TV Show | 2017 | Carpool Karaoke: The Series | Self | 1 |
| TV Show | 2014 | BoJack Horseman | Rutabaga Rabitowitz / Tawnie's Boyfriend (voice) | 1 |
| TV Show | 2014 | BoJack Horseman | Rutabaga Rabitowitz (voice) | 8 |
| TV Show | 2024 | Knuckles | Sonic the Hedgehog (voice) | 1 |
| TV Show | 2012 | TRON: Uprising | Rilo | 1 |
| TV Show | 2021 | Star Wars: The Bad Batch | TAY-0 (voice) | 1 |
| TV Show | 1989 | The Simpsons | The Raw Barn Clerk (voice) | 1 |
| TV Show | 2020 | Middleditch & Schwartz | Self | 3 |
| TV Show | 2005 | American Dad! | Brigham (voice) | 1 |
| TV Show | 2020 | Crossing Swords | Keefer (voice) | 2 |
| TV Show | 2007 | The Sarah Silverman Program. | Writer | 1 |
| TV Show | 2005 | American Dad! | (voice) | 1 |
| TV Show | 2014 | The Tonight Show Starring Jimmy Fallon | Self | 1 |
| TV Show | 2024 | Dinner Time Live with David Chang | Self | 1 |
| TV Show | 2020 | Die Hart | Andre | 7 |
| TV Show | 2022 | Make Some Noise | Self - Player | 2 |
| TV Show | 2021 | INVINCIBLE | Shapesmith / Rus Livingston / Doctor (voice) | 1 |
| TV Show | 2021 | INVINCIBLE | Rus (voice) | 1 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Spokesman | 1 |
| TV Show | 2022 | Chibiverse | Dewey Duck (voice) | 2 |
| TV Show | 2021 | Celebrity Wheel of Fortune | Self - Contestant | 1 |
| TV Show | 2025 | Long Story Short | (voice) | 1 |
| TV Show | 2005 | Robot Chicken | Scaredy Smurf / Roger Radcliffe / Toy Announcer (voice) | 1 |
| TV Show | 2025 | LEGO Star Wars: Rebuild the Galaxy - Pieces of the Past | Jaxxon T. Tumperakki (voice) | 1 |
| TV Show | 2022 | Make Some Noise | Self - Gift Prompt (video footage) | 1 |
| TV Show | 2005 | Robot Chicken | Dickwax / Oog (voice) | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self - Guest | 1 |
| TV Show | 2007 | Bronx World Travelers | Ben | 5 |
| TV Show | 2012 | House of Lies: Fridays at Galweather | Clyde Oberholt | 6 |
| TV Show | 2009 | Accidentally on Purpose | Max | 1 |
