| Movie | 1988 | The Big Blue | Johana Baker | |
| Movie | 1996 | Crash | Gabrielle | |
| Movie | 2000 | The Whole Nine Yards | Sophie Oseransky | |
| Movie | 1994 | Pulp Fiction | Jody | |
| Movie | 1997 | White Lies | Junkie Artist | |
| Movie | 1993 | Nowhere to Run | Clydie Anderson | |
| Movie | 1985 | After Hours | Marcy | |
| Movie | 1986 | 8 Million Ways to Die | Sarah | |
| Movie | 2009 | Northern Lights | Charlene Galligan | |
| Movie | 1985 | Silverado | Hannah | |
| Movie | 1985 | Desperately Seeking Susan | Roberta Glass | |
| Movie | 2022 | Body Parts | Self | |
| Movie | 1997 | Gone Fishin' | Rita | |
| Movie | 1998 | Buffalo '66 | Wendy Balsam | |
| Movie | 2023 | Sex on Screen | Self | |
| Movie | 1979 | More American Graffiti | Girl in Commune | |
| Movie | 2010 | Inhale | Dr. Rubin | |
| Movie | 2001 | Good Advice | Cathy Sherman | |
| Movie | 2005 | Iowa | Effie Harte | |
| Movie | 2009 | American Pie Presents: The Book of Love | Rob's Mom | |
| Movie | 1981 | S.O.B. | Babs | |
| Movie | 1983 | Baby It's You | Jill Rosen | |
| Movie | 1993 | The Wrong Man | Missy Mills | |
| Movie | 2006 | I-See-You.com | Lydia Ann Layton | |
| Movie | 1997 | Deceiver | Mrs. Kennesaw | |
| Movie | 2024 | Ex-Husbands | Maria Pearce | |
| Movie | 1994 | Fear City: A Family-Style Comedy | Rosanna Arquette | |
| Movie | 1997 | Trading Favors | Alex Langley | |
| Movie | 2001 | Diary of a Sex Addict | Grace Horn | |
| Movie | 2008 | Growing Op | Diana | |
| Movie | 1998 | Hell's Kitchen | Liz McNeary | |
| Movie | 2012 | The Divide | Marilyn | |
| Movie | 2008 | Ball Don't Lie | Francine | |
| Movie | 2007 | Battle for Terra | Professor Lina (voice) | |
| Movie | 1991 | The Linguini Incident | Lucy | |
| Movie | 1986 | Nobody's Fool | Cassie | |
| Movie | 1991 | Flight of the Intruder | Callie Joy | |
| Movie | 1982 | The Executioner's Song | Nicole Baker | |
| Movie | 1989 | Black Rainbow | Martha Travis | |
| Movie | 1978 | Zuma Beach | Beverly | |
| Movie | 1985 | The Aviator | Tillie Hansen | |
| Movie | 2024 | Succubus | Denise | |
| Movie | 2009 | Repo Chick | Lola | |
| Movie | 2009 | Madonna: Celebration - The Video Collection | Roberta Glass (video 'Into the Groove') | |
| Movie | 1992 | Fathers & Sons | Miss Athena | |
| Movie | 2013 | $ellebrity | Self | |
| Movie | 2001 | Things Behind the Sun | Pete | |
| Movie | 2011 | Peace, Love & Misunderstanding | Darcy | |
| Movie | 1992 | In the Deep Woods | Joanna Warren | |
| Movie | 2008 | Nick Nolte: No Exit | Self | |
| Movie | 2010 | The Westsiders | Narrator | |
| Movie | 2003 | Rush of Fear | Alex McGuire | |
| Movie | 1999 | Sugar Town | Eva | |
| Movie | 2002 | Searching for Debra Winger | Self | |
| Movie | 2012 | Hardflip | Bethany Jones | |
| Movie | 1981 | A Long Way Home | Rose Cavanaugh | |
| Movie | 1990 | Sweet Revenge | Kate Williams | |
| Movie | 2000 | Too Much Flesh | Amy | |
| Movie | 2022 | Signs of Love | Rosie | |
| Movie | 2024 | Futra Days | Dr. Felicia Walter | |
| Movie | 2011 | Exodus Fall | | |
| Movie | 2014 | Draft Day | Angie | |
| Movie | 1999 | Switched at Birth | Linda Wells | |
| Movie | 2005 | My Suicidal Sweetheart | Vera | |
| Movie | 1990 | Separation | Sarah Weiss | |
| Movie | 2012 | Final Cut: Ladies and Gentlemen | (archive footage) | |
| Movie | 2000 | Gun: Fatal Betrayal | | |
| Movie | 1990 | Wendy Cracked a Walnut | Wendy | |
| Movie | 2023 | Grapefruit | Evelyn | |
| Movie | 2000 | Poison | Dana | |
| Movie | 2000 | Voodoo Dawn | Jezzebelle | |
| Movie | 1995 | Search and Destroy | Lauren Mirkheim | |
| Movie | 1979 | Visions of Christmas Past | Debra Miller | |
| Movie | 1999 | Joni Mitchell: Painting with Words & Music | Self - Introduction | |
| Movie | 2011 | Convincing Clooney | JC | |
| Movie | 2001 | Big Bad Love | Velma | |
| Movie | 1998 | Floating Away | Maurey Talbot | |
| Movie | 1998 | I'm Losing You | Rachel Krohn | |
| Movie | 1983 | Off the Wall | Pam Smith | |
| Movie | 2001 | Joe Dirt | Charlene the Gator Farmer (uncredited) | |
| Movie | 1989 | New York Stories | Paulette | |
| Movie | 2007 | Indie Sex: Teens | | |
| Movie | 1998 | I Know What You Did | Stacey Keane | |
| Movie | 2015 | Asthma | Gus's Mother | |
| Movie | 1999 | Palmer's Pick-Up | Dawn | |
| Movie | 2016 | Frank & Lola | Patricia | |
| Movie | 1988 | Promised a Miracle | Alice Elizabeth 'Lucky' Parker | |
| Movie | 2015 | Kill Your Friends | Barbara | |
| Movie | 1979 | The Ordeal of Patty Hearst | Becky | |
| Movie | 2019 | QT8: The First Eight | Self (archive footage) | |
| Movie | 1980 | Gorp | Judy | |
| Movie | 2019 | The Cold Open | | |
| Movie | 2017 | Lovesong | Eleanor | |
| Movie | 1999 | The '60s | Hippie Mother (uncredited) | |
| Movie | 2005 | Dead Cool | Deirdre | |
| Movie | 2019 | Hal | Self | |
| Movie | 2013 | Quentin Tarantino: 20 Years of Filmmaking | Self | |
| Movie | 2018 | Billionaire Boys Club | Sydney's Mom | |
| Movie | 2015 | My Last Film | Actress | |
| Movie | 2017 | Maya Dardel | Leonora | |
| Movie | 2018 | Octavio Is Dead! | Joan | |
| Movie | 1994 | Nowhere to Hide | Sarah Blake | |
| Movie | 2016 | Falsely Accused | Beth | |
| Movie | 2017 | SPF-18 | Faye Cooper | |
| Movie | 2003 | Olive Thomas: The Most Beautiful Girl in the World | Self - Narrator | |
| Movie | 2018 | Half the Picture | Self | |
| Movie | 1999 | Pigeonholed | | |
| Movie | 2018 | The Etruscan Smile | Claudia | |
| Movie | 2017 | Born Guilty | Judith | |
| Movie | 2004 | Weird Sex and Snowshoes: A Trek Through the Canadian Cinematic Psyche | Gabrielle (archive footage) | |
| Movie | 2018 | For the Love of George | Dr. Faye Carter | |
| Movie | 2019 | Holy Lands | Monica | |
| Movie | 1984 | The Parade | Tilda Kirby | |
| Movie | 2005 | Kids in America | Abby Pratt | |
| Movie | 2019 | Untouchable | Self | |
| Movie | 1983 | One Cooks, the Other Doesn't | Tracy Boone | |
| Movie | 1977 | Having Babies II | Connie | |
| Movie | 2015 | Larry Gaye: Renegade Male Flight Attendant | TV Anchorwoman | |
| Movie | 2020 | You Cannot Kill David Arquette | Self (archive footage) | |
| Movie | 2021 | Love is Love is Love | Anne (segment "Late Lunch") | |
| Movie | 2020 | Puppy Love | Deb | |
| Movie | 1998 | Hope Floats | Connie Phillips (uncredited) | |
| Movie | 1982 | The Wall | Halinka Apt | |
| Movie | 2020 | Coachella: 20 Years in the Desert | Self | |
| Movie | 1996 | Valley Girls | Shelly von Schetekel | |
| Movie | 1982 | Johnny Belinda | Belinda McAdam | |
| Movie | 2022 | Brainwashed: Sex-Camera-Power | Self | |
| Movie | 2021 | Quentin Tarantino: From a Movie Buff to a Hollywood Legend | Self (archive footage) | |
| Movie | 1987 | Amazon Women on the Moon | Karen (segment "Two I.D.'s") | |
| Movie | 2015 | Rickie Lee Jones: The Other Side of Desire | Self | |
| Movie | 2024 | Here's Yanni! | Amelia | |
| Movie | 1997 | Gun | Lilly Difideli | |
| Movie | N/A | The Moment | | |
| Movie | 2002 | Pulp Fiction: The Facts | Self (archive footage) | |
| Movie | N/A | Corporate Retreat | | |
| Movie | 2005 | Welcome to California | Prostitute | |
| Movie | 2007 | Alexis Arquette: She's My Brother | Self | |
| TV Show | 2005 | Medium | Michelle Todd | 1 |
| TV Show | 2007 | Dirt | | 1 |
| TV Show | 2005 | Grey's Anatomy | Constance Ferguson | 1 |
| TV Show | 2000 | Malcolm in the Middle | Anita | 1 |
| TV Show | 2004 | The L Word | Cherie Jaffe | 4 |
| TV Show | 2006 | What About Brian | Nicole Varzi | 24 |
| TV Show | 1997 | The Practice | Brenda Miller | 1 |
| TV Show | 2004 | Summerland | Ronnie | 1 |
| TV Show | 2007 | Private Practice | Corinne Davis | 2 |
| TV Show | 2001 | Law & Order: Criminal Intent | Kay Connelly | 1 |
| TV Show | 1977 | Eight Is Enough | | 1 |
| TV Show | 1998 | Will & Grace | Julie | 2 |
| TV Show | 1993 | Homicide: Life on the Street | | 1 |
| TV Show | 2000 | The Huntress | | 1 |
| TV Show | 1997 | Gun | Lilly Difideli | 6 |
| TV Show | 2008 | Lipstick Jungle | Tina Atwood | 1 |
| TV Show | 2003 | Celebrities Uncensored | Self | 2 |
| TV Show | 1993 | Intimate Portrait | Self | 2 |
| TV Show | 1980 | Here's Boomer | | 1 |
| TV Show | 1978 | The Runaways | | 1 |
| TV Show | 1979 | Shirley | Debra Miller | 13 |
| TV Show | 2009 | Eastwick | | 2 |
| TV Show | 2021 | Catch and Kill: The Podcast Tapes | Self | 1 |
| TV Show | 1977 | What Really Happened to the Class of '65? | | 1 |
| TV Show | 1978 | The Dark Secret of Harvest Home | Kate Constantine | 2 |
| TV Show | 2016 | Roadies | Abby Van Ness | 1 |
| TV Show | 1999 | Law & Order: Special Victims Unit | Alexa Pierson | 1 |
| TV Show | 2020 | Ratched | Anna | 2 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 2013 | Ray Donovan | Linda | 6 |
| TV Show | 2012 | Girls | Petula | 1 |
| TV Show | 2023 | Florida Man | Rose | 1 |
| TV Show | 2023 | Paul T. Goldman | Genevieve | 1 |
| TV Show | 1991 | Son of the Morning Star | Libby Custer | 2 |
| TV Show | 2007 | Indie Sex | Self | 3 |
| TV Show | 2005 | Hell's Kitchen | Self - Restaurant Patron | 1 |
| TV Show | 2018 | Sideswiped | Mary | 8 |
| TV Show | 2007 | Head Case | Self | 1 |
| TV Show | 2016 | Hollywood Medium with Tyler Henry | Self - Guest | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2013 | The Frame | Gabrielle | 1 |
| TV Show | 2020 | Big Sky | Virginia 'GiGi' Cessna | 2 |
| TV Show | 2024 | Presumed Innocent | Kate | 1 |
| TV Show | 1988 | The Play on One | Sarah | 1 |
| TV Show | 1982 | The Executioner's Song | Nicole Baker | 2 |
| TV Show | 2006 | The Megan Mullally Show | Self - Guest | 1 |
| TV Show | 1987 | Sacrée soirée | Self | 1 |
