| Movie | 1996 | Flirting with Disaster | Pearl Coplin | |
| Movie | 1985 | Hollywood's Funniest All-Star Bloopers | Self (archive footage) | |
| Movie | 2011 | Classic TV Bloopers Uncensored | Laura Petrie (archive footage) | |
| Movie | 1967 | Thoroughly Modern Millie | Miss Dorothy Brown | |
| Movie | 2023 | Being Mary Tyler Moore | Self (archive footage) | |
| Movie | 1961 | X-15 | Pamela Stewart | |
| Movie | 1982 | I Love Liberty | Self | |
| Movie | 2002 | The Mary Tyler Moore Reunion | Self | |
| Movie | 1957 | Operation Mad Ball | Nurse (uncredited) | |
| Movie | 1958 | Once Upon a Horse... | Dance Hall Girl (uncredited) | |
| Movie | 1980 | Ordinary People | Beth Jarrett | |
| Movie | 1969 | Change of Habit | Sister Michelle Gallagher | |
| Movie | 1986 | Just Between Friends | Holly Davis | |
| Movie | 2003 | The Gin Game | Fonsia Dorsey | |
| Movie | 2012 | Betty White's 90th Birthday: A Tribute to America's Golden Girl | Self | |
| Movie | 1982 | Six Weeks | Charlotte Dreyfus | |
| Movie | 2011 | Sheldon Leonard's Wonderful Life | Self | |
| Movie | 2000 | Labor Pains | Esther Raymond | |
| Movie | 2017 | Mary Tyler Moore: Behind the Smile | Self (archive footage) | |
| Movie | 1997 | Keys to Tulsa | Cynthia Boudreau | |
| Movie | 1981 | Making 'M*A*S*H' | Narrator (voice) | |
| Movie | 1990 | The Last Best Year | Wendy Haller | |
| Movie | 2000 | Mary and Rhoda | Mary Richards-Cronin | |
| Movie | 1968 | Don't Just Stand There | Martine Randall | |
| Movie | 1984 | Heartsounds | Martha Weinman Lear | |
| Movie | 1978 | First, You Cry | Betty Rollin | |
| Movie | 1968 | What's So Bad About Feeling Good? | Liz | |
| Movie | 2013 | Inequality for All | Mary Richards (archive footage) | |
| Movie | 1997 | Payback | Kathryn Stanfill | |
| Movie | 1976 | Mary's Incredible Dream | Angel / Devil / Woman | |
| Movie | 1969 | Run a Crooked Mile | Elizabeth Sutton | |
| Movie | 2009 | Against the Current | Liz' Mom | |
| Movie | 2002 | Cheats | Mrs. Stark | |
| Movie | 1993 | Stolen Babies | Georgia Tann | |
| Movie | 1998 | Kids Are Punny | | |
| Movie | 1985 | Night of 100 Stars II | Self | |
| Movie | 1960 | The Fatal Impulse | Mary Snyder | |
| Movie | 2003 | The Golden Girls: Lifetime Intimate Portrait Series | Self | |
| Movie | 2015 | Mary Tyler Moore: A Celebration | Self / Various (archive footage) | |
| Movie | 2002 | Miss Lettie and Me | Lettie Anderson | |
| Movie | 2001 | Like Mother Like Son: The Strange Story of Sante and Kenny Kimes | Sante Chambers Kimes / Eva Guerrero | |
| Movie | 1989 | Saturday Night Live: 15th Anniversary | Self | |
| Movie | 1985 | Finnegan Begin Again | Liz DeHaan | |
| Movie | 1991 | Mary Tyler Moore: The 20th Anniversary Show | Herself - Host | |
| Movie | 2004 | The Dick Van Dyke Show Revisited | Laura Petrie | |
| Movie | 2003 | Blessings | Lydia Blessing | |
| Movie | 1969 | Dick Van Dyke and the Other Woman | Herself | |
| Movie | 1978 | How to Survive the '70s and Maybe Even Bump Into Happiness | Self | |
| Movie | 1990 | Thanksgiving Day | Paula Schloss | |
| Movie | 1996 | Stolen Memories: Secrets from the Rose Garden | Jessica | |
| Movie | 2005 | Snow Wonder | Lula | |
| Movie | 2020 | Bernadette Peters: A Special Concert | Self - Special Guest | |
| Movie | 1982 | Night of 100 Stars | Self | |
| Movie | 2002 | AFI's 100 Years... 100 Passions: America's Greatest Love Stories | Self | |
| TV Show | 1998 | That '70s Show | Christine St. George | 3 |
| TV Show | 1994 | Inside the Actors Studio | Self | 1 |
| TV Show | 1958 | 77 Sunset Strip | | 1 |
| TV Show | 1974 | Rhoda | | 3 |
| TV Show | 1979 | The Mary Tyler Moore Hour | Mary McKinnon | 11 |
| TV Show | 1959 | Bourbon Street Beat | | 2 |
| TV Show | 1997 | King of the Hill | Reverend Karen Stroup (voice) | 1 |
| TV Show | 1961 | The Dick Van Dyke Show | Laura Petrie | 158 |
| TV Show | 1960 | Checkmate | | 1 |
| TV Show | 1997 | The View | Self | 3 |
| TV Show | 1996 | E! True Hollywood Story | Self | 1 |
| TV Show | 1959 | The David Susskind Show | Self | 1 |
| TV Show | 1993 | Frasier | Marjorie (voice) | 1 |
| TV Show | 1960 | Surfside 6 | Kathy Murlow | 1 |
| TV Show | 1970 | The Mary Tyler Moore Show | Mary Richards | 168 |
| TV Show | 1959 | Hawaiian Eye | | 1 |
| TV Show | 1959 | Johnny Staccato | | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 2 |
| TV Show | 1961 | Straightaway | | 1 |
| TV Show | 1960 | The Tab Hunter Show | Brunette | 32 |
| TV Show | 1955 | The Millionaire | Linda | 1 |
| TV Show | 1985 | Mary | Mary Brenner | 13 |
| TV Show | 1960 | Thriller | Mary Snyder | 1 |
| TV Show | 1993 | Intimate Portrait | Self | 2 |
| TV Show | 1960 | The Aquanauts | Dana March | 1 |
| TV Show | 1951 | Schlitz Playhouse of Stars | Student | 1 |
| TV Show | 1995 | New York News | Louise Felcott | 13 |
| TV Show | 1957 | Richard Diamond, Private Detective | Sam (voice) (uncredited) | 1 |
| TV Show | 1958 | Bronco | | 1 |
| TV Show | 1959 | Lock-Up | | 1 |
| TV Show | 1958 | Wanted: Dead or Alive | Sophie Anderson | 1 |
| TV Show | 1959 | Riverboat | Lily Belle de Lesseps | 1 |
| TV Show | 2004 | TV Revolution | | 1 |
| TV Show | 1988 | Annie McGuire | Annie McGuire | 11 |
| TV Show | 1960 | Overland Trail | Joan Ransom | 17 |
| TV Show | 1953 | The Oscars | Self | 1 |
| TV Show | 1949 | The Emmy Awards | Self | 1 |
| TV Show | 2010 | Hot in Cleveland | Diane | 2 |
| TV Show | 1975 | Saturday Night Live | Self - Host | 1 |
| TV Show | 1952 | The Adventures of Ozzie and Harriet | Happy Hotpoint (uncredited) | 1 |
| TV Show | 1988 | Lincoln | Mary Todd Lincoln | 2 |
| TV Show | 1958 | 77 Sunset Strip | Girl on Telephone (uncredited) | 1 |
| TV Show | 1982 | Wogan | Self | 1 |
| TV Show | 1960 | Thriller | Sherry Smith | 1 |
| TV Show | 1996 | The Rosie O'Donnell Show | Self - Guest | 1 |
| TV Show | 1959 | Hawaiian Eye | Susan Hart | 1 |
| TV Show | 1956 | Tony Awards | Self - Host | 1 |
| TV Show | 1959 | The Deputy | Amy Collins | 1 |
| TV Show | 1971 | The Pet Set | Self | 1 |
| TV Show | 1956 | Tony Awards | Self - Presenter | 3 |
| TV Show | 1958 | 77 Sunset Strip | Marie Drew | 1 |
| TV Show | 1995 | The Naked Truth | Catherine Wilde | 4 |
| TV Show | 1994 | Ellen | Mary Tyler Moore | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee / Presenter | 1 |
| TV Show | 1944 | Golden Globe Awards | Self - Nominee | 1 |
| TV Show | 2008 | Lipstick Jungle | Joyce | 2 |
| TV Show | 1963 | The Danny Kaye Show | Self | 5 |
| TV Show | 1956 | Tony Awards | Self - Memoriam (archive footage) | 1 |
| TV Show | 1962 | The Tonight Show Starring Johnny Carson | Self | 1 |
| TV Show | 1956 | Tony Awards | Self - Hostess / Presenter / Special Award Recipient | 1 |
| TV Show | 1959 | Hawaiian Eye | Vanessa Kinard | 1 |
| TV Show | 1959 | Hawaiian Eye | Peggy Regan | 1 |
