| Movie | 2007 | The 50 Greatest Television Dramas | Self | |
| Movie | 2005 | Harry Potter and the Goblet of Fire | Barty Crouch Junior | |
| Movie | 2013 | Doctor Who Live: The Afterparty | The Doctor (archive footage) | |
| Movie | 2013 | Doctor Who Explained | Self | |
| Movie | 2012 | The Science of Doctor Who | The Doctor (archive footage) | |
| Movie | 2007 | David Tennant's Video Diary | Self | |
| Movie | 2022 | The Amazing Maurice | Dangerous Beans (voice) | |
| Movie | 2011 | The Decoy Bride | James Arber | |
| Movie | 2009 | Hamlet | Hamlet | |
| Movie | 2015 | Mickey Mouse Clubhouse: Mickey's Monster Musical | Igor the Door (voice) | |
| Movie | 2009 | Glorious 39 | Hector | |
| Movie | 2021 | An Audience with Adele | Self | |
| Movie | 2023 | Comic Relief 2023 | Self - Host | |
| Movie | 2008 | Einstein and Eddington | Arthur Eddington | |
| Movie | 2003 | Bright Young Things | Ginger Littlejohn | |
| Movie | 1999 | L.A. Without a Map | Richard | |
| Movie | 2009 | St Trinian's 2: The Legend of Fritton's Gold | Captain Lord Pomfrey / Sir Piers Pomfrey | |
| Movie | 2011 | United | Jimmy Murphy | |
| Movie | 2013 | Doctor Who: Farewell to Matt Smith | | |
| Movie | 2005 | The Quatermass Experiment | Doctor Gordon Briscoe | |
| Movie | 2000 | The Last September | Captain Gerald Colthurst | |
| Movie | 2014 | Doctor Who: The Ultimate Time Lord with Peter Davison | Self | |
| Movie | 2012 | The Pirates! In an Adventure with Scientists! | Charles Darwin (voice) | |
| Movie | 2011 | Polar Bear - Spy on the Ice | Narrator | |
| Movie | 2004 | Traffic Warden | Traffic Warden | |
| Movie | 2005 | Sweetnightgoodheart | Pete | |
| Movie | 2011 | Fright Night | Peter Vincent | |
| Movie | 2008 | Human Footprint | Narrator (self) | |
| Movie | 2009 | Doctor Who: Music of the Spheres - Doctor Who at the Proms 2008 | The Doctor (Uncredited) | |
| Movie | 2020 | The Big Night In | Mr. Logan | |
| Movie | 2011 | The Ballad of Russell & Julie | Russell T. Davies / Self | |
| Movie | 2011 | Catherine Tate: Laughing at the Noughties | Self | |
| Movie | 2011 | The Itch of the Golden Nit | Radio Newsreader / Stretchy McStretch (voice) | |
| Movie | 2004 | Old Street | Mr. Watson | |
| Movie | 2012 | Nativity 2: Danger in the Manger! | Donald / Roderick Peterson | |
| Movie | 2013 | Earthflight | Himself - Narrator | |
| Movie | 2007 | Learners | Chris | |
| Movie | 2011 | Much Ado About Nothing | Benedick | |
| Movie | 2002 | Nine 1/2 Minutes | Charlie | |
| Movie | 2011 | Discovering Hamlet | Self | |
| Movie | 2022 | Chip 'n Dale: Rescue Rangers | Scrooge McDuck (voice) | |
| Movie | 2011 | Lachlan Macquarie: The Father of Australia | Narrator | |
| Movie | 2018 | Spy in the Snow | Narrator | |
| Movie | 2013 | The Five(ish) Doctors Reboot | Self | |
| Movie | 2014 | Postman Pat: The Movie | Wilf (voice) | |
| Movie | 2023 | Talking Doctor Who | Self - Presenter | |
| Movie | 2014 | What We Did on Our Holiday | Doug McLeod | |
| Movie | 2013 | Royal Shakespeare Company - Richard II | Richard II | |
| Movie | 2009 | Doctor Who: The Waters of Mars | The Doctor | |
| Movie | 2023 | Doctor Who Children in Need Special 2023 | The Doctor | |
| Movie | 2006 | Doctor Who: The Runaway Bride | The Doctor | |
| Movie | 2009 | Doctor Who: Planet of the Dead | The Doctor | |
| Movie | 2013 | The Day of the Doctor: Cinema Intro | The Doctor (10) | |
| Movie | 2023 | Doctor Who: The Bedtime Story | The Doctor | |
| Movie | 2023 | imagine… Russell T Davies: The Doctor and Me | Self | |
| Movie | 2010 | Stealing Shakespeare | Narrator | |
| Movie | 2008 | Doctor Who: The Next Doctor | The Doctor | |
| Movie | 2013 | Doctor Who: The Day of the Doctor | The Doctor (10) | |
| Movie | 1997 | Bite | | |
| Movie | 2022 | The Paloni Show! Halloween Special! | Roach Chef (voice) | |
| Movie | 2007 | Doctor Who: Voyage of the Damned | The Doctor | |
| Movie | 1996 | Jude | Drunk Undergraduate | |
| Movie | 2007 | Recovery | Alan Hamilton | |
| Movie | 2006 | The Chatterley Affair | Richard Hoggart | |
| Movie | 2024 | Comic Relief 2024: Funny for Money | Self | |
| Movie | 2023 | National Theatre Live: Good | Professor John Halder/Johnny | |
| Movie | 2021 | Beauty and the Beast: A Comic Relief Pantomime for Christmas | Self | |
| Movie | 2017 | Mad to Be Normal | RD Laing | |
| Movie | 2006 | Doctor Who: A Celebration | Self - Host | |
| Movie | 2015 | A Grand Night In: The Story of Aardman | Self - Voice of Charles Darwin | |
| Movie | 2015 | 96 Ways to Say I Love You | Mark | |
| Movie | 2020 | Heart to Heart | Heart | |
| Movie | 2009 | The Catherine Tate Show: Nan's Christmas Carol | Ghost of Christmas Present | |
| Movie | 2000 | Being Considered | | |
| Movie | 2025 | The Thursday Murder Club | Ian Ventham | |
| Movie | 2016 | Shakespeare Live! From the RSC | Self - Host | |
| Movie | 2005 | Doctor Who: A New Dimension | Self - Narrator (voice) | |
| Movie | 2015 | Dames of Classic Drama at the BBC | Narrator | |
| Movie | 2014 | Wings 3D | Narrator (voice) | |
| Movie | 2005 | Doctor Who: Born Again | The Doctor (10) | |
| Movie | 2015 | Knights of Classic Drama at the BBC | Narrator | |
| Movie | 2009 | Monty Python in Aberystwyth | Narrator | |
| Movie | 2023 | Doctor Who: 60th Anniversary Specials | The Doctor (archive footage) | |
| Movie | 2015 | Inside Einstein's Mind: The Enigma of Space and Time | Narrator (Voice UK) | |
| Movie | 2009 | Endgame | Self - Host (uncredited) | |
| Movie | 2012 | So You Want To Be A Pirate! | Charles Darwin | |
| Movie | 2007 | Doctor Who: Time Crash | The Doctor (10) | |
| Movie | 2004 | The Deputy | Christopher Williams | |
| Movie | 2017 | Ferdinand | Angus (voice) | |
| Movie | 2018 | You, Me and Him | John | |
| Movie | 2007 | Doctor Who: The Infinite Quest | The Doctor (voice) | |
| Movie | 2018 | Mary Queen of Scots | John Knox | |
| Movie | 2018 | Bad Samaritan | Cale Erendreich | |
| Movie | 2013 | Doctor Who: The Ultimate Guide | Self | |
| Movie | 2018 | The Highway Rat | The Highway Rat (voice) | |
| Movie | 2017 | Proclaimers: This Is the Story | Self | |
| Movie | 2007 | The Friday Night Project - Unleashed | Guest Host | |
| Movie | 2011 | Doctor Who: Tales Lost in Time | | |
| Movie | 2016 | Derren Brown: Pushed to the Edge | Himself | |
| Movie | 2018 | DuckTales: Destination Adventure! | Scrooge McDuck (voice) | |
| Movie | 2019 | How to Train Your Dragon: The Hidden World | Spitelout / Ivar the Whitless (voice) | |
| Movie | 2010 | How to Train Your Dragon | Spitelout (voice) | |
| Movie | 2008 | Doctor Who: Music of the Spheres | The Doctor | |
| Movie | 2014 | Doctor Who: The Ultimate Companion | Self / The Doctor (archive footage) | |
| Movie | 2019 | Children In Need 2019: Got It Covered | Self | |
| Movie | 2020 | The National Television Awards Celebrate 25 Years | Self | |
| Movie | 2018 | The Muppets Take The O2 | Self | |
| Movie | 1993 | Spaces | Vinny | |
| Movie | 2020 | Good Omens: Lockdown | Crowley (voice) | |
| Movie | 2020 | Our Sarah Jane – The Life of Elisabeth Sladen | Self | |
| Movie | 2011 | Shrek: Once Upon a Time | Self / Narrator | |
| Movie | 2011 | Gerry Rafferty: Right Down the Line | Narrator | |
| Movie | 2015 | The Nation's Favourite Beatles Number One | Self | |
| Movie | 2020 | The Real Des: The Dennis Nilsen Story | Narrator (voice) | |
| Movie | 2020 | Screening | Timothy | |
| Movie | 2012 | Shakespeare's Sonnets | | |
| Movie | 2020 | Cinderella: A Comic Relief Pantomime for Christmas | Self | |
| Movie | 2021 | The Loud House Movie | Angus (voice) | |
| Movie | 1989 | Biting the Hands | 3rd Squaddie | |
| Movie | 2009 | Doctor Who: The End of Time Part 1 | The Doctor | |
| Movie | 2010 | Doctor Who: The End of Time Part 2 | The Doctor | |
| Movie | 2013 | Doctor Who: Tales from the TARDIS | Self | |
| Movie | 2025 | Macbeth | Macbeth | |
| Movie | 2024 | Doctor Who at the Proms | The Doctor (14) (10) (archive footage) | |
| Movie | 2017 | Fireman Sam: Alien Alert! The Movie | Buck Douglas (voice) | |
| Movie | 2015 | Doctor Who: The Husbands of River Song | The Doctor (10) (picture) (uncredited) | |
| Movie | 2011 | Come in Number Five | Presenter | |
| Movie | 2005 | Bring Something Back: The Making of 'The Quatermass Experiment' | | |
| Movie | 2025 | Doctor Who: Wish World & The Reality War | The Doctor / The Doctor (archive footage) (uncredited) | |
| Movie | 2023 | Doctor Who: The Star Beast | The Doctor | |
| Movie | N/A | The Minor Character | Will | |
| Movie | 2007 | Doctor Who: Blink | Tenth Doctor | |
| Movie | 2024 | Dolphins 4-D Experience | Self (Narrator) | |
| TV Show | 2002 | Top Gear | Self | 2 |
| TV Show | 2006 | Totally Doctor Who | Self | 5 |
| TV Show | 2007 | The Sarah Jane Adventures | The Doctor | 2 |
| TV Show | 2013 | Broadchurch | DI Alec Hardy | 24 |
| TV Show | 2004 | Blackpool | DI Peter Carlisle | 6 |
| TV Show | 2003 | QI | Self | 1 |
| TV Show | 1983 | Dramarama | | 1 |
| TV Show | 1994 | Takin' Over the Asylum | Campbell | 6 |
| TV Show | 2000 | Randall & Hopkirk (Deceased) | | 1 |
| TV Show | 2004 | Who Do You Think You Are? | Self | 1 |
| TV Show | 2002 | Foyle's War | Theo Howard | 1 |
| TV Show | 2008 | Star Wars: The Clone Wars | Huyang (voice) | 2 |
| TV Show | 2012 | DreamWorks Dragons | Spitelout (voice) | 2 |
| TV Show | 2015 | Dragons: Race to the Edge | Spitelout (voice) | 12 |
| TV Show | 1990 | Have I Got News for You | Self - Host | 1 |
| TV Show | 2024 | ARK: The Animated Series | Sir Edmund Rockwell (voice) | 6 |
| TV Show | 2005 | Casanova | Giacomo Casanova | 3 |
| TV Show | 2012 | Comedy World Cup | Host | 7 |
| TV Show | 1996 | A Mug's Game | | 1 |
| TV Show | 2009 | Doctor Who: Dreamland | The Doctor (voice) | 6 |
| TV Show | 1993 | GMTV | Self | 1 |
| TV Show | 2024 | Rivals | Tony Baddingham | 8 |
| TV Show | 1998 | Duck Patrol | Simon 'Darwin' Brown | 7 |
| TV Show | 2009 | Live from Studio Five | Self | 2 |
| TV Show | 2002 | Ant & Dec's Saturday Night Takeaway | Self - Guest Announcer | 2 |
| TV Show | 2023 | Ahsoka | Huyang (voice) | 8 |
| TV Show | 2001 | Terri McIntyre - Classy Bitch | Greig Miller | 14 |
| TV Show | 1990 | Have I Got News for You | Host | 1 |
| TV Show | 2011 | Earthflight | | 6 |
| TV Show | 2010 | The National Television Awards Backstage Live | | 1 |
| TV Show | 2013 | Spies of Warsaw | Jean-François Mercier | 2 |
| TV Show | 2010 | Ask Rhod Gilbert | Self | 1 |
| TV Show | 2005 | Doctor Who | Doctor (10) | 0 |
| TV Show | 2013 | The Politician's Husband | Aiden Hoynes | 3 |
| TV Show | 2011 | Twenty Twelve | Narrator (voice) | 13 |
| TV Show | 2005 | Doctor Who | The Doctor | 40 |
| TV Show | 2005 | The Late Late Show with Craig Ferguson | Self | 1 |
| TV Show | 2012 | Wild About Pandas | Narrator | 1 |
| TV Show | 2003 | Spine Chillers | Dr. Krull | 1 |
| TV Show | 2014 | Gracepoint | Emmett Carver | 10 |
| TV Show | 2013 | The Escape Artist | Will Burton | 3 |
| TV Show | 2015 | Marvel's Jessica Jones | Kilgrave | 14 |
| TV Show | 2012 | Shakespeare Uncovered | Himself | 1 |
| TV Show | 2010 | Single Father | Dave | 4 |
| TV Show | 2023 | Clone High | David Tennant (voice) | 1 |
| TV Show | 2010 | Rex Is Not Your Lawyer | Rex Alexander | 1 |
| TV Show | 2023 | Spy in the Ocean, A Nature Miniseries | Narrator | 4 |
| TV Show | 2012 | True Love | Nick | 1 |
| TV Show | 2004 | Big Fat Quiz | Self - Guest | 1 |
| TV Show | 2007 | Derren Brown: Trick or Treat | Himself | 2 |
| TV Show | 2002 | Dead Ringers | Regenerated Tony Blair | 1 |
| TV Show | 1999 | Love in the 21st Century | John | 1 |
| TV Show | 1999 | People Like Us | Rob Harker | 1 |
| TV Show | 1994 | The Tales of Para Handy | John MacBryde | 1 |
| TV Show | 1983 | Natural World | Narrator | 1 |
| TV Show | 1996 | Never Mind the Buzzcocks | Self - Presenter | 1 |
| TV Show | 1990 | Rab C. Nesbitt | Davina | 1 |
| TV Show | 2007 | The Graham Norton Show | Self | 9 |
| TV Show | 2022 | The Legend of Vox Machina | General Kreig (voice) | 2 |
| TV Show | 2003 | Doctor Who: Scream of the Shalka | Young Custodian (voice) (uncredited) | 1 |
| TV Show | 2009 | Doctor Who Greatest Moments | Self | 3 |
| TV Show | 2006 | The One Show | Self | 3 |
| TV Show | 2010 | Fish Hooks | Oscar's Brain (voice) | 2 |
| TV Show | 2005 | Secret Smile | Brendan | 2 |
| TV Show | 2019 | Good Omens | Crowley | 12 |
| TV Show | 2017 | Spy in the Wild | Himself - Narrator | 9 |
| TV Show | 2018 | Final Space | Lord Commander (voice) | 10 |
| TV Show | 2014 | W1A | Narrator (voice) | 14 |
| TV Show | 2015 | Thunderbirds Are Go! | Tyco Reeves (Voice) | 1 |
| TV Show | 2018 | Camping | Walt | 8 |
| TV Show | 2023 | Doctor Who: Video Commentaries | Self - The Doctor | 5 |
| TV Show | 2013 | The Last Leg | Self | 7 |
| TV Show | 2013 | Penguins: Spy in the Huddle | Narrator (voice) | 3 |
| TV Show | 2004 | He Knew He Was Right | Mr. Gibson | 4 |
| TV Show | 2014 | Dolphins: Spy in the Pod | Narrator | 2 |
| TV Show | 1989 | The Simpsons | Pa MacWeldon (voice) | 1 |
| TV Show | 2005 | Doctor Who Confidential | Self | 39 |
| TV Show | 2017 | DuckTales | Scrooge McDuck (Voice) | 69 |
| TV Show | 1994 | Room 101 | Self | 1 |
| TV Show | 2012 | Tree Fu Tom | Twigs (voice) | 72 |
| TV Show | N/A | Have I Got a Bit More News for You | Self - Presenter | 9 |
| TV Show | 2009 | CBeebies Bedtime Stories | Self | 1 |
| TV Show | 2018 | There She Goes | Simon | 10 |
| TV Show | 2022 | The Sandman | Don (voice) | 1 |
| TV Show | 2019 | gen:LOCK | Dr. Weller (voice) | 8 |
| TV Show | 2022 | Inside Man | Harry Watling | 4 |
| TV Show | 2020 | Red Dwarf: The First Three Million Years | Self - Narrator (voice) | 3 |
| TV Show | 2023 | Marvel's Moon Girl and Devil Dinosaur | Franklin (voice) | 1 |
| TV Show | 2012 | Teenage Mutant Ninja Turtles | Fugitoid (voice) | 2 |
| TV Show | 2019 | Criminal: UK | Dr. Edgar Fallon | 1 |
| TV Show | 2024 | Rob Beckett's Smart TV | Self - Guest | 1 |
| TV Show | 2020 | Deadwater Fell | Tom Kendrick | 4 |
| TV Show | 2025 | Standing By | | 1 |
| TV Show | 2023 | Doctor Who: Video Commentaries | Self | 2 |
| TV Show | 2020 | Des | Dennis Nilsen | 3 |
| TV Show | 2021 | Around the World in 80 Days | Phileas Fogg | 8 |
| TV Show | 2013 | Doctor Who: The Doctors Revisited | Self | 11 |
| TV Show | 2014 | The Real History of Science Fiction | Himself | 2 |
| TV Show | 2022 | Ant & Dec's Limitless Win | Self | 1 |
| TV Show | 1998 | The Mrs Bradley Mysteries | Max Valentine | 1 |
| TV Show | 2009 | Swarm: Nature's Incredible Invasions | Narrator (voice) | 2 |
| TV Show | 1994 | Ready Steady Cook | Self - Contestant | 2 |
| TV Show | 2014 | Off Camera with Sam Jones | Self | 1 |
| TV Show | 2015 | Marvel's Jessica Jones | Kilgrave (voice) | 1 |
| TV Show | 2020 | Staged | David | 20 |
| TV Show | 2012 | DreamWorks Dragons | Spitelout (voice) | 0 |
| TV Show | 2023 | Star Wars: Young Jedi Adventures | Huyang (voice) | 1 |
| TV Show | 2025 | The Genius Game | The Creator | 8 |
| TV Show | 2018 | Hang Ups | Martin Lamb | 1 |
| TV Show | 2016 | Top Gear: Extra Gear | Self | 1 |
| TV Show | 2005 | The Friday Night Project | Self - Host | 2 |
| TV Show | N/A | The Hack | Nick Davies | 1 |
| TV Show | 2022 | Chibiverse | Scrooge McDuck (Voice) | 1 |
| TV Show | 1990 | Have I Got News for You | Self - Guest Host | 1 |
| TV Show | 2025 | The Assembly | Self - Interviewee | 1 |
| TV Show | 2024 | Doctor Who | The Doctor (archive footage) (uncredited) | 1 |
| TV Show | 2019 | I'm a LA... Get Me Out of Here! | Self - Contestant | 23 |
| TV Show | 2022 | Litvinenko | Alexander Litvinenko | 2 |
