| Movie | 2004 | Ocean's Twelve | François Toulour | |
| Movie | 2007 | Ocean's Thirteen | François Toulour | |
| Movie | 1995 | La Haine | Vinz | |
| Movie | 2002 | Irreversible | Marcus | |
| Movie | 2001 | Birthday Girl | Alexei | |
| Movie | 2001 | Shrek | Monsieur Hood (voice) | |
| Movie | 2007 | Eastern Promises | Kirill | |
| Movie | 2004 | Renegade | Mike Blueberry | |
| Movie | 1999 | The Messenger: The Story of Joan of Arc | Gilles de Rais | |
| Movie | 1997 | Dobermann | Yann Le Pentrec aka Dobermann | |
| Movie | 2023 | One Night With Asterix & Obelix | Self - Actor | |
| Movie | 1992 | Hot Chocolate | Dédé | |
| Movie | 1999 | Guest House Paradiso | Gino Bolognese | |
| Movie | 1998 | Elizabeth | Duc d'Anjou | |
| Movie | 2001 | Read My Lips | Paul Angeli | |
| Movie | 2001 | Brotherhood of the Wolf | Jean-François de Morangias | |
| Movie | 1996 | The Apartment | Max | |
| Movie | 2005 | Derailed | LaRoche | |
| Movie | 2004 | The Reckoning | Lord De Guise | |
| Movie | 2004 | Secret Agents | Brisseau | |
| Movie | 2021 | Becoming Cousteau | (voice) | |
| Movie | 2007 | His Majesty Minor | Satyre | |
| Movie | 2008 | Mesrine: Killer Instinct | Jacques Mesrine | |
| Movie | 2006 | Satan | Joseph | |
| Movie | 2024 | Saint-Exupéry | Henri Guillaumet | |
| Movie | 2024 | Damaged | Walker Bravo | |
| Movie | 2000 | The Crimson Rivers | Max Kerkerian | |
| Movie | 2008 | Mesrine: Public Enemy #1 | Jacques Mesrine | |
| Movie | 2010 | Black Swan | Thomas Leroy / The Gentleman | |
| Movie | 1998 | Pleasure (And Its Little Inconveniences) | Michael | |
| Movie | 2009 | Adrift | Matias | |
| Movie | 2011 | The Monk | Frère Ambrosio | |
| Movie | 1993 | Métisse | Max | |
| Movie | 2011 | A Dangerous Method | Otto Gross | |
| Movie | 2013 | Trance | Franck | |
| Movie | 2009 | Round Da Way | Tony Merguez (voice) | |
| Movie | 2010 | Our Day Will Come | Patrick | |
| Movie | 1989 | Les cigognes n'en font qu'à leur tête | Pierre | |
| Movie | 1999 | Unruly | Pitou | |
| Movie | 1995 | Adultery (A User's Guide) | Bruno | |
| Movie | 2011 | Belmondo, itinéraire... | Self | |
| Movie | 1996 | The Pupil | Julien | |
| Movie | 2001 | Les Rivières pourpres: L'enquête | Self | |
| Movie | 1995 | Women | Eric | |
| Movie | 2014 | Beauty and the Beast | The Beast | |
| Movie | 2025 | The Shrouds | Karsh | |
| Movie | 2021 | Irréversible : à l'envers et contre tout | Self | |
| Movie | 2015 | Partisan | Gregori | |
| Movie | 2023 | Au cœur du Papotin | Self | |
| Movie | 2015 | Tale of Tales | King of Strongcliff | |
| Movie | 2015 | Child 44 | Major Kuzmin | |
| Movie | 2016 | Xavier Dolan: Bound to Impossible | Self | |
| Movie | 2014 | Rio, I Love You | Zé (segment "A Musa") | |
| Movie | 2015 | My King | Georgio Milevski | |
| Movie | 2019 | The Irreversible Odyssey | Self | |
| Movie | 2017 | The Movie of My Life | Nicolas Terranova | |
| Movie | 2015 | One Wild Moment | Laurent | |
| Movie | 1993 | Dose mortelle | | |
| Movie | 2025 | The Opera! Arias for an Eclipse | Charon | |
| Movie | 2016 | Jason Bourne | Asset | |
| Movie | 2025 | Banger | Luis / Scorpex | |
| Movie | 2005 | Philippe Nahon, de l'acteur fétiche à l'icône | Self | |
| Movie | 2016 | It's Only the End of the World | Antoine | |
| Movie | 2006 | Ten Years of La Haine | Self | |
| Movie | 2018 | The Great Mystical Circus | Jean Paul | |
| Movie | 2015 | Violence en réunion | Vincent Battisti | |
| Movie | 2017 | Gauguin: Voyage to Tahiti | Paul Gauguin | |
| Movie | 2018 | Black Tide | François | |
| Movie | 1995 | Blood of the Hunter | Pastamoo | |
| Movie | 2013 | Kourtrajmé Vol 1 | Vincent | |
| Movie | 1995 | Jefferson in Paris | Camille Desmoulins | |
| Movie | 1994 | Putain de porte | Vincent | |
| Movie | 1991 | Les Dessous de la passion | Christopher/The Photograph | |
| Movie | 1995 | Valse Nocturne | Vincent | |
| Movie | 1994 | Elle voulait faire quelque chose | Vincent | |
| Movie | 1999 | Femmes enragées | Vincent | |
| Movie | 1998 | Compromis | Le jeune premier | |
| Movie | 1992 | Un dimanche sans ailes | | |
| Movie | 1997 | As You Want Me | Pasquale | |
| Movie | 2002 | La barbichette | Vinz | |
| Movie | 2006 | FBI Zoo | Walt | |
| Movie | 1991 | Les clés du Paradis | Vincent | |
| Movie | 2018 | The Emperor of Paris | Vidocq | |
| Movie | 2006 | The Making of Derailed | Self | |
| Movie | 1999 | The Making of 'Guest House Paradiso' | Self | |
| Movie | 2011 | Black Swan: Metamorphosis | Self | |
| Movie | 2020 | Underwater | Captain Lucien | |
| Movie | 2017 | The Man Who Unlocked the Universe | Narrator | |
| Movie | 2018 | Default | IMF Managing Director | |
| Movie | 2010 | 14 Actors Acting | Self | |
| Movie | 2025 | Heart of Darkness | (Voice) | |
| Movie | 2019 | The Specials | Bruno Haroche | |
| Movie | 2020 | A Friendly Tale... | Marc | |
| Movie | 2001 | Dear Father | | |
| Movie | 2023 | Asterix & Obelix: The Middle Kingdom | Jules César | |
| Movie | 2012 | Il était une fois... « La Haine » | Self | |
| Movie | 2018 | Li Na: My Life | | |
| Movie | 2021 | Fake News | Actor in Guillaume Kekchoz's new film | |
| Movie | 2023 | The Three Musketeers: D'Artagnan | Athos | |
| Movie | 2001 | Tarubi, l'arabe strait 2 | Vinz | |
| Movie | 2003 | Le Chat d'la grand mère d'Abdel Krim | Vinz | |
| Movie | 2023 | The Three Musketeers: Milady | Athos | |
| Movie | 2018 | The World Is Yours | Henri | |
| Movie | 2025 | Sacrifice | Bracken | |
| Movie | N/A | Parallel Tales | | |
| Movie | 2027 | Dumas: Black Devil | | |
| Movie | N/A | Quasimodo | Quasimodo | |
| TV Show | 2021 | 6 x confiné.e.s | Scorpex | 1 |
| TV Show | 2009 | C à vous | Self - Guest | 1 |
| TV Show | 2023 | Liaison | Gabriel Delage | 6 |
| TV Show | 2010 | Great Migrations | | 7 |
| TV Show | 2011 | Platane | Vincent Cassel | 1 |
| TV Show | 1998 | Lascars | Graffeur | 60 |
| TV Show | 1994 | C'est mon histoire | Vincent | 1 |
| TV Show | 2002 | Alice Nevers, le juge est une femme | Corsini | 0 |
| TV Show | 1992 | Warburg: A Man of Influence | Vincent | 1 |
| TV Show | 1995 | 3000 scénarios contre un virus | | 30 |
| TV Show | 2023 | Beau geste | Self | 1 |
| TV Show | 2022 | Le Late avec Alain Chabat | Self | 1 |
| TV Show | 2024 | Fiasco | Robin Jacomet | 3 |
| TV Show | 2001 | Burger Quiz | Self | 1 |
| TV Show | 2016 | Westworld | Serac | 8 |
| TV Show | 1998 | Vivement dimanche | Self | 1 |
| TV Show | 2023 | Têtàtête(s) | Self - Guest | 1 |
| TV Show | 2013 | Clique | Self - Guest | 1 |
| TV Show | 2022 | Hot Ones | Self - Guest | 1 |
