| Movie | 2003 | Party Monster | Kioki | |
| Movie | 2006 | Fast Food Nation | Raul | |
| Movie | 2004 | Clifford's Really Big Movie | Rodrigo (voice) | |
| Movie | 2008 | Columbus Day | Max | |
| Movie | 2005 | Beauty Shop | Corky | |
| Movie | 2010 | The Dry Land | Raymond Gonzales | |
| Movie | 2007 | The Dead One | Diego de la Muerte | |
| Movie | 2007 | The Condor | Tony Valdez / The Condor (voice) | |
| Movie | 2006 | Unaccompanied Minors | Zach Van Bourke | |
| Movie | 2012 | FOX 25th Anniversary Special | Self | |
| Movie | 2011 | From Prada to Nada | Bruno | |
| Movie | 2011 | Larry Crowne | Dell Gordo | |
| Movie | 2020 | LA Originals | Self | |
| Movie | 2007 | The Manufacturing of 'Fast Food Nation' | Self | |
| Movie | 2024 | A Sudden Case of Christmas | Jacob Randall | |
| Movie | 2014 | School Dance | Flaco | |
| Movie | 2012 | Una Hora Por Favora | Arturo | |
| Movie | 2016 | The Adderall Diaries | Josh | |
| Movie | 2008 | Handy Manny: Fixing It Right | Manny (voice) | |
| Movie | 2015 | The Girl Is in Trouble | Angel | |
| Movie | 2009 | Handy Manny: A Very Handy Holiday | Manuel Esteviez "Manny" Garcia | |
| Movie | 2009 | Handy Manny: Big Motorcycle Adventure | Manuel Esteviez "Manny" Garcia | |
| Movie | 2010 | Handy Manny: Big Construction Job | Manuel Esteviez "Manny" Garcia | |
| Movie | 2010 | Handy Manny: Big Race | Manuel Esteviez "Manny" Garcia | |
| Movie | 2009 | Handy Manny: Manny's Green Team | Manuel Esteviez "Manny" Garcia | |
| Movie | 2007 | Handy Manny: Tooling Around | Manny | |
| Movie | 2008 | Handy Manny: Manny's Pet Roundup | Handy Manny | |
| Movie | 2008 | Cheech & Chong Roasted | Self | |
| Movie | 2024 | NCISverse: The First 1,000 | Self | |
| Movie | 2008 | Days of Wrath | Danny Boy | |
| Movie | 2006 | The Darwin Awards | Documentary Filmmaker | |
| Movie | 2018 | Charming | Prince Philippe Charming (voice) | |
| Movie | 2015 | Sock 'Em Dead | Wilmer Valderrama | |
| Movie | 2017 | Demi Lovato: Simply Complicated | Self | |
| Movie | 2017 | Double Dutchess: Seeing Double | | |
| Movie | 2015 | To Whom It May Concern | Sam | |
| Movie | 2019 | Trouble | Thurman (voice) | |
| Movie | 2021 | Blast Beat | Ernesto | |
| Movie | 2017 | Stayin' Alive: A Grammy Salute to the Music of the Bee Gees | Self - Presenter | |
| Movie | 2020 | Onward | Gaxton (voice) | |
| Movie | 2001 | Summer Catch | Mickey Dominguez | |
| Movie | 2021 | Encanto | Agustín Madrigal (voice) | |
| Movie | 2011 | Handy Manny: Movie Night | Manny(voice) | |
| TV Show | 1998 | That '70s Show | Fez | 200 |
| TV Show | 1999 | The Sopranos | Wilmer Valderrama | 1 |
| TV Show | 2004 | The Tony Danza Show | Self | 1 |
| TV Show | 2005 | Robot Chicken | | 1 |
| TV Show | 2003 | Jimmy Kimmel Live! | Self | 4 |
| TV Show | 1988 | LIVE with Kelly and Mark | | 1 |
| TV Show | 2003 | Punk'd | Self | 3 |
| TV Show | 1997 | The View | Self | 2 |
| TV Show | 2019 | Tamron Hall | Self - Guest | 1 |
| TV Show | 1996 | E! True Hollywood Story | Self | 1 |
| TV Show | 1992 | The Tonight Show with Jay Leno | | 1 |
| TV Show | 2006 | Shorty McShorts' Shorts | Nestor (voice) | 1 |
| TV Show | 2001 | Grounded for Life | | 1 |
| TV Show | 1993 | Late Night with Conan O'Brien | Self - Guest | 2 |
| TV Show | 1988 | LIVE with Kelly and Mark | Self - Guest | 3 |
| TV Show | 2009 | The Cleveland Show | | 1 |
| TV Show | 2006 | Handy Manny | Manny Garcia (voice) | 208 |
| TV Show | 1999 | The Late Late Show with Craig Kilborn | Self | 1 |
| TV Show | 2012 | Awake | Detective Efrem Vega | 13 |
| TV Show | 2012 | Men At Work | Rodrigo (uncredited) | 1 |
| TV Show | 1996 | The Daily Show | Self | 1 |
| TV Show | 2015 | Minority Report | Will Blake | 10 |
| TV Show | 2014 | From Dusk Till Dawn: The Series | Carlos Madrigal | 30 |
| TV Show | 1999 | Teen Choice Awards | Self - Presenter | 2 |
| TV Show | 2018 | Busy Tonight | Self - Guest | 1 |
| TV Show | 2003 | NCIS | Nick Torres | 181 |
| TV Show | 2017 | The Hollywood Puppet Show | Self - Host | 16 |
| TV Show | 2015 | The Late Show with Stephen Colbert | Self | 2 |
| TV Show | 2021 | NCIS: Hawaiʻi | Nick Torres | 2 |
| TV Show | 2021 | Power On: The Story of Xbox | Self (archive footage) (uncredited) | 1 |
| TV Show | 2016 | The Ranch | Umberto | 1 |
| TV Show | 2016 | Martha & Snoop's Potluck Dinner Party | Self | 1 |
| TV Show | 2015 | Lip Sync Battle | Self | 1 |
| TV Show | 2022 | The Jennifer Hudson Show | Self | 1 |
| TV Show | 2019 | The Kelly Clarkson Show | Self | 2 |
| TV Show | 2005 | Grey's Anatomy | Kyle Diaz | 5 |
| TV Show | 2009 | NCIS: Los Angeles | Nick Torres | 1 |
| TV Show | 2007 | Wizards of Waverly Place | Ernesto Larkin | 1 |
| TV Show | 2006 | Rachael Ray | | 1 |
| TV Show | 2020 | Celebrity IOU | Self | 1 |
| TV Show | 2023 | That '90s Show | Fez | 3 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 2009 | RuPaul's Drag Race | Self - Special Guest | 1 |
| TV Show | 2013 | Hollywood Game Night | Self | 1 |
| TV Show | 2006 | Yo Momma | Self - Host | 45 |
| TV Show | 2011 | Suburgatory | Yoni | 2 |
| TV Show | 2014 | Last Week Tonight with John Oliver | Advice-Giving Bird | 1 |
| TV Show | 2015 | Celebrity Family Feud | Self | 1 |
| TV Show | 1998 | Hollywood Squares | | 5 |
| TV Show | 2010 | Raising Hope | Roberto | 2 |
| TV Show | 2010 | Raising Hope | Ricardo | 1 |
| TV Show | 1998 | Four Corners | Antonio | 1 |
| TV Show | 2022 | Sherri | Self - Guest | 1 |
| TV Show | 1959 | The Grammys | Self | 1 |
| TV Show | N/A | Rhona Who Lives by the River | Pablo/Wilmer | 1 |
