| Movie | 2021 | Christmas in Harmony | Mama | |
| Movie | 1992 | Class Act | Blade's Mom | |
| Movie | 1997 | Hoodlum | Pigfoot Mary | |
| Movie | 1996 | The Preacher's Wife | Beverly | |
| Movie | 1995 | Waiting to Exhale | Gloria | |
| Movie | 1999 | Love Kills | Sylvia Finkelstein | |
| Movie | 2000 | Urban Legends: Final Cut | Reese | |
| Movie | 1998 | Urban Legend | Reese Wilson | |
| Movie | 2010 | Death at a Funeral | Cynthia | |
| Movie | 2006 | Dirty Laundry | Evelyn | |
| Movie | 2008 | Beverly Hills Chihuahua | Delta (voice) | |
| Movie | 2008 | First Sunday | Sister Doris | |
| Movie | 2010 | Lottery Ticket | Grandma | |
| Movie | 2007 | This Christmas | Shirley Ann "Ma'Dere" Whitfield | |
| Movie | 1991 | Livin' Large! | Nadine Biggs | |
| Movie | 1997 | Don King: Only in America | Connie Harper | |
| Movie | 2000 | Punks | Health Counselor | |
| Movie | 2004 | Woman Thou Art Loosed | Cassey Jordan | |
| Movie | 2010 | My Son, My Son, What Have Ye Done | Miss Roberts | |
| Movie | 2010 | For Colored Girls | Juanita / Green | |
| Movie | 2011 | Madea's Big Happy Family | Shirley | |
| Movie | 2011 | Politics of Love | Shirlee Gupta | |
| Movie | 1999 | Introducing Dorothy Dandridge | Ruby Dandridge | |
| Movie | 2011 | Jumping the Broom | Mrs. Taylor | |
| Movie | 2021 | Christmas Déjà Vu | Crystal | |
| Movie | 1997 | The Price of Kissing | Jackee | |
| Movie | 1998 | Down in the Delta | Zenia | |
| Movie | 1997 | Lover Girl | Leticia / 'Coco' | |
| Movie | 1991 | The Colored Museum | Janine | |
| Movie | 1997 | Clover | Everleen | |
| Movie | 1988 | Sticky Fingers | Diane | |
| Movie | 2013 | Khumba | Mama V (voice) | |
| Movie | 2012 | In the Hive | Mrs. Inez | |
| Movie | 2022 | Diary of a Wimpy Kid: Rodrick Rules | Irene (voice) | |
| Movie | 2014 | Doc Mcstuffins: A Little Cuddle Goes A Long Way | Hallie | |
| Movie | 1999 | Funny Valentines | Dearie B. | |
| Movie | 2016 | Norm of the North | Tamecia (voice) | |
| Movie | 2005 | Crash | Shaniqua Johnson | |
| Movie | 2015 | Doc McStuffins: Cuddle Me Lambie | Hallie (voice) (archive footage) | |
| Movie | 2001 | Kingdom Come | Marguerite Slocumb | |
| Movie | 1991 | Caged Fear | Judy | |
| Movie | 2000 | Best Actress | Connie Travers | |
| Movie | 2014 | You're Not You | Marilyn | |
| Movie | 2022 | Doc McStuffins: The Doc Is 10! | Hallie (voice) | |
| Movie | 2024 | Bull Street | Mrs. Big-Gal | |
| Movie | 2024 | Lost & Found in Cleveland | Joy Morris | |
| Movie | 2001 | I Am Sam | Margaret Calgrove | |
| Movie | 1990 | Stanley & Iris | Bertha | |
| Movie | 2022 | All I Didn't Want for Christmas | Lorraine | |
| Movie | 2015 | Back to School Mom | Meghan Graham | |
| Movie | 2023 | A Snowy Day in Oakland | Jeanette | |
| Movie | N/A | Break the Cycle | | |
| Movie | 2014 | Welcome to Me | Barb Vaughn | |
| Movie | 2006 | Dreamgirls | Jazz Singer | |
| Movie | 2000 | Freedom Song | Evelyn Walker | |
| Movie | 2017 | Broadway: The Next Generation | Self | |
| Movie | 1996 | Rebound: The Legend of Earl 'The Goat' Manigault | Miss Mary | |
| Movie | 2016 | Caged No More | Aggie | |
| Movie | 2013 | A Very Larry Christmas | Mrs. Claus | |
| Movie | 2006 | Life Is Not a Fairytale: The Fantasia Barrino Story | Addie Collins | |
| Movie | 2016 | No Regrets | Ms. Carey | |
| Movie | 2016 | Grandma's House | | |
| Movie | 2015 | The Sound and the Fury | Dilsey | |
| Movie | 2016 | Brett Gelman's Dinner in America | Herself | |
| Movie | 2013 | Saving Westbrook High | Doris | |
| Movie | 2017 | Chapter & Verse | Miss Maddy | |
| Movie | 2017 | Naked | Carol | |
| Movie | 2000 | What Women Want | Flo | |
| Movie | 1993 | The American Clock | | |
| Movie | 1993 | Amos & Andrew | Ula | |
| Movie | 2011 | Beverly Hills Chihuahua 2 | Delta (voice) | |
| Movie | 2018 | Behind the Movement | Jo Ann Robinson | |
| Movie | 2020 | Always and Forever | Elda | |
| Movie | 2018 | Jingle Belle | Emory Simons | |
| Movie | 2018 | The Doc McStuffins Christmas Special | Hallie (voice) | |
| Movie | 2018 | Urban Legacy: The Story Behind Urban Legend | Self | |
| Movie | 2005 | King's Ransom | Miss Gladys | |
| Movie | 2019 | The Trap | Mama Jay | |
| Movie | 1999 | The Breaks | Floria | |
| Movie | 2002 | Book of Love: The Definitive Reason Why Men Are Dogs | | |
| Movie | 2021 | The Starling | Velma | |
| Movie | 2019 | Horror Noire: A History of Black Horror | Self | |
| Movie | 2019 | A Sweet Christmas Romance | Loretta | |
| Movie | 2015 | For the Love of Ruth | Naomi | |
| Movie | 2019 | A Family Reunion Christmas | Amelia 'M'Dear' McKellan | |
| Movie | 1989 | Parent Trap III | Thelma | |
| Movie | 1983 | Anna to the Infinite Power | Mrs. Benson | |
| Movie | 2014 | Comeback Dad | Malinda | |
| Movie | 2018 | Sierra Burgess Is a Loser | Ms. Thomson | |
| Movie | 2009 | Spring Breakdown | Dr. Marguerite | |
| Movie | 2019 | Postmarked | Hattie | |
| Movie | 2020 | Spell | Eloise | |
| Movie | 2021 | Queen Bees | Sally | |
| Movie | 1988 | Little Nikita | Verna McLaughlin | |
| Movie | 2007 | Cougar Club | Dolly | |
| Movie | 1981 | Will | Jean | |
| Movie | 2022 | Mack & Rita | Sharon | |
| Movie | 2021 | Broadway: Beyond the Golden Age | Self | |
| Movie | 1999 | Jackie's Back! | Snookie Tate (Jackie's Childhood Friend) | |
| Movie | 2025 | Finding Faith | | |
| Movie | 2009 | Hollywood Singing & Dancing: A Musical History - 1980s, 1990s and 2000s | Self | |
| Movie | 2024 | Tempted by Love | Miss Mimi | |
| Movie | N/A | Lottery Ticket 2 | Grandma | |
| Movie | 1987 | A Different World | Stevie Rallen | |
| TV Show | 1987 | A Different World | Stevie Rallen | 9 |
| TV Show | 2000 | Boston Public | Marla Hendricks | 81 |
| TV Show | 2008 | Eli Stone | Patti Dellacroix | 26 |
| TV Show | 2005 | Everybody Hates Chris | Maxine | 1 |
| TV Show | 2005 | Grey's Anatomy | Adele Webber | 22 |
| TV Show | 2002 | Half & Half | Erika Duke | 2 |
| TV Show | 1997 | Ally McBeal | Nora Mills | 1 |
| TV Show | 1994 | Touched by an Angel | Tonya Hawkins | 1 |
| TV Show | 2003 | Cold Case | Chandra Patterson (2009) | 1 |
| TV Show | 2000 | Girlfriends | Judge Vashti Jackson | 2 |
| TV Show | 1988 | Murphy Brown | Nurse Hawking | 1 |
| TV Show | 2019 | Tamron Hall | Self - Guest | 1 |
| TV Show | 1996 | Moesha | | 1 |
| TV Show | 2000 | Strong Medicine | | 1 |
| TV Show | 1999 | The PJs | Muriel Stubbs (voice) | 43 |
| TV Show | 2004 | Boston Legal | Judge Victoria Thomson | 2 |
| TV Show | 2003 | Wild Card | M. Pearl McGuire | 36 |
| TV Show | 1999 | Family Law | Gloria Rivers | 1 |
| TV Show | 1996 | Promised Land | Tonya Hawkins | 1 |
| TV Show | 1990 | Cop Rock | | 1 |
| TV Show | N/A | Legally Mad | Jeanette Harris | 1 |
| TV Show | 2009 | Party Down | Diane Ellison | 1 |
| TV Show | 1990 | Sugar and Spice | | 7 |
| TV Show | 2020 | P-Valley | Ernestine | 9 |
| TV Show | 2012 | The Client List | Georgia Cummings | 25 |
| TV Show | 2023 | Young Love | Gigi Young (voice) | 12 |
| TV Show | 2011 | State of Georgia | Honey Dupree | 12 |
| TV Show | 2012 | Doc McStuffins | Nurse Hallie (voice) | 242 |
| TV Show | 2005 | Supernatural | Missouri Moseley | 3 |
| TV Show | 2009 | RuPaul's Drag Race | Self - Guest Judge | 1 |
| TV Show | 2015 | The Carmichael Show | Cynthia Carmichael | 32 |
| TV Show | 2021 | Teenage Euthanasia | | 1 |
| TV Show | 2023 | Doc McStuffins: The Doc and Bella Are In! | Hallie (voice) | 10 |
| TV Show | 2013 | The Doc Files | Hallie (voice) | 10 |
| TV Show | 2012 | Doc McStuffins | Hattie (voice) | 1 |
| TV Show | 1991 | Roc | | 1 |
| TV Show | 1991 | Roc | Cynthia | 4 |
| TV Show | 2019 | The Kelly Clarkson Show | | 1 |
| TV Show | 1995 | Happily Ever After: Fairy Tales for Every Child | Mother (voice) | 1 |
| TV Show | 2021 | Days of Our Lives: Beyond Salem | Angela | 5 |
| TV Show | 2018 | Summer Camp Island | Sea Cow (voice) | 1 |
| TV Show | 2019 | A Black Lady Sketch Show | Marrier | 1 |
| TV Show | 2019 | Family Reunion | M'Dear | 44 |
| TV Show | 2020 | Secret Celebrity RuPaul's Drag Race | Fabulosity - Contestant | 2 |
| TV Show | 1992 | Out All Night | Crystal | 1 |
| TV Show | 2009 | Glee | Sister Mary Constance | 1 |
| TV Show | 2020 | Connecting... | Dayleen | 2 |
| TV Show | 2014 | black-ish | Lynette | 3 |
| TV Show | 2017 | Dear White People | Sorbet (voice) | 1 |
| TV Show | 1988 | The Murder of Mary Phagan | Annie Maude Carter | 2 |
| TV Show | 2014 | Sirens | Hank's Mother | 3 |
| TV Show | 2020 | GAME ON: A Comedy Crossover Event | Amelia 'M'Dear' McKellan | 1 |
| TV Show | 2009 | Watch What Happens Live with Andy Cohen | Self - Guest | 1 |
| TV Show | 1992 | Love & War | | 1 |
| TV Show | 2010 | Shake It Up | Marsha Sanders | 1 |
| TV Show | 2006 | Psych | Melba Birdson | 1 |
| TV Show | 1971 | Great Performances | Janine | 1 |
| TV Show | 2024 | Everybody Still Hates Chris | (voice) | 1 |
| TV Show | 1995 | Ned and Stacey | Mrs. Duncan | 1 |
| TV Show | 2024 | Doctor Odyssey | Jill Manafort | 1 |
| TV Show | 2024 | Holidazed | Linda Lewin | 8 |
| TV Show | 2012 | The Soul Man | Della Ballentine | 2 |
